| 1 | Mon Apr 6 | vs Guardians | W2-0 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 2 | Wed Apr 8 | vs Guardians | L0-2 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Thu Apr 9 | vs Guardians | L1-5 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 4 | Fri Apr 10 | at Rangers | W5-1 | 2-2 | .500 | Globe Life Field · Arlington, TX |
| 5 | Sat Apr 11 | at Rangers | L2-6 | 2-3 | .400 | Globe Life Field · Arlington, TX |
| 6 | Sun Apr 12 | at Rangers | W6-4 (14) | 3-3 | .500 | Globe Life Field · Arlington, TX |
| 7 | Mon Apr 13 | vs Athletics | L1-8 | 3-4 | .429 | Minute Maid Park · Houston, TX |
| 8 | Tue Apr 14 | vs Athletics | L0-4 | 3-5 | .375 | Minute Maid Park · Houston, TX |
| 9 | Wed Apr 15 | vs Athletics | W6-1 | 4-5 | .444 | Minute Maid Park · Houston, TX |
| 10 | Fri Apr 17 | vs Angels | L3-6 | 4-6 | .400 | Minute Maid Park · Houston, TX |
| 11 | Sat Apr 18 | vs Angels | W4-0 | 5-6 | .455 | Minute Maid Park · Houston, TX |
| 12 | Sun Apr 19 | vs Angels | W4-3 | 6-6 | .500 | Minute Maid Park · Houston, TX |
| 13 | Mon Apr 20 | at Mariners | W7-5 | 7-6 | .538 | T-Mobile Park · Seattle, WA |
| 14 | Tue Apr 21 | at Mariners | W6-3 | 8-6 | .571 | T-Mobile Park · Seattle, WA |
| 15 | Wed Apr 22 | at Mariners | L2-3 | 8-7 | .533 | T-Mobile Park · Seattle, WA |
| 16 | Fri Apr 24 | at Athletics | W5-4 (11) | 9-7 | .563 | RingCentral Coliseum · Oakland, CA |
| 17 | Sat Apr 25 | at Athletics | W9-3 | 10-7 | .588 | RingCentral Coliseum · Oakland, CA |
| 18 | Sun Apr 26 | at Athletics | W7-6 | 11-7 | .611 | RingCentral Coliseum · Oakland, CA |
| 19 | Mon Apr 27 | at Padres | W9-4 | 12-7 | .632 | Petco Park · San Diego, CA |
| 20 | Tue Apr 28 | at Padres | W14-3 | 13-7 | .650 | Petco Park · San Diego, CA |
| 21 | Wed Apr 29 | at Padres | W7-2 | 14-7 | .667 | Petco Park · San Diego, CA |
| 22 | Thu Apr 30 | vs Mariners | W3-2 (10) | 15-7 | .682 | Minute Maid Park · Houston, TX |
| 23 | Fri May 1 | vs Mariners | W4-3 | 16-7 | .696 | Minute Maid Park · Houston, TX |
| 24 | Sat May 2 | vs Mariners | W11-4 | 17-7 | .708 | Minute Maid Park · Houston, TX |
| 25 | Sun May 3 | vs Mariners | W7-6 | 18-7 | .720 | Minute Maid Park · Houston, TX |
| 26 | Mon May 4 | vs Rangers | L1-2 | 18-8 | .692 | Minute Maid Park · Houston, TX |
| 27 | Tue May 5 | vs Rangers | L1-7 | 18-9 | .667 | Minute Maid Park · Houston, TX |
| 28 | Wed May 6 | vs Rangers | L3-11 | 18-10 | .643 | Minute Maid Park · Houston, TX |
| 29 | Thu May 7 | at Angels | W3-2 | 19-10 | .655 | Angel Stadium · Anaheim, CA |
| 30 | Fri May 8 | at Angels | L0-2 | 19-11 | .633 | Angel Stadium · Anaheim, CA |
| 31 | Sat May 9 | at Angels | W6-5 | 20-11 | .645 | Angel Stadium · Anaheim, CA |
| 32 | Sun May 10 | at Angels | L1-3 | 20-12 | .625 | Angel Stadium · Anaheim, CA |
| 33 | Tue May 12 | vs Giants | L1-8 | 20-13 | .606 | Minute Maid Park · Houston, TX |
| 34 | Wed May 13 | vs Giants | W4-3 | 21-13 | .618 | Minute Maid Park · Houston, TX |
| 35 | Thu May 14 | vs Blue Jays | W6-4 | 22-13 | .629 | Minute Maid Park · Houston, TX |
| 36 | Fri May 15 | vs Blue Jays | W8-4 | 23-13 | .639 | Minute Maid Park · Houston, TX |
| 37 | Sat May 16 | vs Blue Jays | W6-5 | 24-13 | .649 | Minute Maid Park · Houston, TX |
| 38 | Sun May 17 | vs Blue Jays | W4-2 | 25-13 | .658 | Minute Maid Park · Houston, TX |
| 39 | Mon May 18 | vs Athletics | L1-2 | 25-14 | .641 | Minute Maid Park · Houston, TX |
| 40 | Tue May 19 | vs Athletics | W6-4 | 26-14 | .650 | Minute Maid Park · Houston, TX |
| 41 | Wed May 20 | vs Athletics | W6-1 | 27-14 | .659 | Minute Maid Park · Houston, TX |
| 42 | Thu May 21 | at Tigers | L5-6 (11) | 27-15 | .643 | Comerica Park · Detroit, MI |
| 43 | Fri May 22 | at Tigers | L2-6 | 27-16 | .628 | Comerica Park · Detroit, MI |
| 44 | Sat May 23 | at Tigers | W3-2 | 28-16 | .636 | Comerica Park · Detroit, MI |
| 45 | Sun May 24 | at Tigers | W10-8 | 29-16 | .644 | Comerica Park · Detroit, MI |
| 46 | Mon May 25 | at Orioles | L3-4 | 29-17 | .630 | Camden Yards · Baltimore, MD |
| 47 | Tue May 26 | at Orioles | W4-1 | 30-17 | .638 | Camden Yards · Baltimore, MD |
| 48 | Wed May 27 | at Orioles | L4-5 | 30-18 | .625 | Camden Yards · Baltimore, MD |
| 49 | Fri May 29 | vs White Sox | L3-6 (11) | 30-19 | .612 | Minute Maid Park · Houston, TX |
| 50 | Sat May 30 | vs White Sox | W3-0 | 31-19 | .620 | Minute Maid Park · Houston, TX |
| 51 | Sun May 31 | vs White Sox | L0-6 | 31-20 | .608 | Minute Maid Park · Houston, TX |
| 52 | Mon Jun 1 | vs Orioles | W5-2 | 32-20 | .615 | Minute Maid Park · Houston, TX |
| 53 | Tue Jun 2 | vs Orioles | W6-4 | 33-20 | .623 | Minute Maid Park · Houston, TX |
| 54 | Wed Jun 3 | vs Orioles | W3-1 | 34-20 | .630 | Minute Maid Park · Houston, TX |
| 55 | Thu Jun 4 | vs Orioles | L2-3 | 34-21 | .618 | Minute Maid Park · Houston, TX |
| 56 | Fri Jun 5 | at Blue Jays | L2-6 | 34-22 | .607 | Rogers Centre · Toronto, ON |
| 57 | Sat Jun 6 | at Blue Jays | L2-7 | 34-23 | .596 | Rogers Centre · Toronto, ON |
| 58 | Sun Jun 7 | at Blue Jays | L6-7 | 34-24 | .586 | Rogers Centre · Toronto, ON |
| 59 | Mon Jun 8 | at White Sox | L1-3 | 34-25 | .576 | Guaranteed Rate Field · Chicago, IL |
| 60 | Tue Jun 9 | at White Sox | L2-4 | 34-26 | .567 | Guaranteed Rate Field · Chicago, IL |
| 61 | Wed Jun 10 | at White Sox | L1-4 | 34-27 | .557 | Guaranteed Rate Field · Chicago, IL |
| 62 | Fri Jun 12 | vs Mariners | W10-0 | 35-27 | .565 | Minute Maid Park · Houston, TX |
| 63 | Sat Jun 13 | vs Mariners | L1-8 | 35-28 | .556 | Minute Maid Park · Houston, TX |
| 64 | Sun Jun 14 | vs Mariners | W13-0 | 36-28 | .563 | Minute Maid Park · Houston, TX |
| 65 | Mon Jun 15 | vs Rockies | W6-3 | 37-28 | .569 | Minute Maid Park · Houston, TX |
| 66 | Tue Jun 16 | vs Rockies | W8-5 | 38-28 | .576 | Minute Maid Park · Houston, TX |
| 67 | Wed Jun 17 | at Rockies | W8-4 | 39-28 | .582 | Coors Field · Denver, CO |
| 68 | Thu Jun 18 | at Rockies | W8-4 | 40-28 | .588 | Coors Field · Denver, CO |
| 69 | Fri Jun 19 | at Mariners | L2-5 | 40-29 | .580 | T-Mobile Park · Seattle, WA |
| 70 | Sat Jun 20 | at Mariners | L3-6 | 40-30 | .571 | T-Mobile Park · Seattle, WA |
| 71 | Sun Jun 21 | at Mariners | W6-2 | 41-30 | .577 | T-Mobile Park · Seattle, WA |
| 72 | Mon Jun 22 | at Angels | L3-4 | 41-31 | .569 | Angel Stadium · Anaheim, CA |
| 73 | Tue Jun 23 | at Angels | W13-3 | 42-31 | .575 | Angel Stadium · Anaheim, CA |
| 74 | Wed Jun 24 | at Angels | L1-2 (13) | 42-32 | .568 | Angel Stadium · Anaheim, CA |
| 75 | Thu Jun 25 | vs Yankees | W4-0 | 43-32 | .573 | Minute Maid Park · Houston, TX |
| 76 | Fri Jun 26 | vs Yankees | L2-3 | 43-33 | .566 | Minute Maid Park · Houston, TX |
| 77 | Sat Jun 27 | vs Yankees | L6-9 | 43-34 | .558 | Minute Maid Park · Houston, TX |
| 78 | Sun Jun 28 | vs Yankees | W3-1 | 44-34 | .564 | Minute Maid Park · Houston, TX |
| 79 | Mon Jun 29 | vs Royals | W6-1 | 45-34 | .570 | Minute Maid Park · Houston, TX |
| 80 | Tue Jun 30 | vs Royals | W4-0 | 46-34 | .575 | Minute Maid Park · Houston, TX |
| 81 | Wed Jul 1 | vs Royals | W6-5 | 47-34 | .580 | Minute Maid Park · Houston, TX |
| 82 | Fri Jul 3 | at Red Sox | W12-8 (10) | 48-34 | .585 | Fenway Park · Boston, MA |
| 83 | Sat Jul 4 | at Red Sox | L1-6 | 48-35 | .578 | Fenway Park · Boston, MA |
| 84 | Sun Jul 5 | at Red Sox | L4-5 | 48-36 | .571 | Fenway Park · Boston, MA |
| 85 | Mon Jul 6 | at Guardians | W9-4 | 49-36 | .576 | Progressive Field · Cleveland, OH |
| 86 | Tue Jul 7 | at Guardians | L0-2 | 49-37 | .570 | Progressive Field · Cleveland, OH |
| 87 | Wed Jul 8 | at Guardians | L2-4 | 49-38 | .563 | Progressive Field · Cleveland, OH |
| 88 | Thu Jul 9 | at Guardians | L1-3 | 49-39 | .557 | Progressive Field · Cleveland, OH |
| 89 | Fri Jul 10 | at Rays | L1-3 | 49-40 | .551 | Tropicana Field · St. Petersburg, FL |
| 90 | Sat Jul 11 | at Rays | L0-3 | 49-41 | .544 | Tropicana Field · St. Petersburg, FL |
| 91 | Sun Jul 12 | at Rays | L3-4 | 49-42 | .538 | Tropicana Field · St. Petersburg, FL |
| 92 | Fri Jul 17 | vs Rangers | W3-2 | 50-42 | .543 | Minute Maid Park · Houston, TX |
| 93 | Sat Jul 18 | vs Rangers | L6-7 | 50-43 | .538 | Minute Maid Park · Houston, TX |
| 94 | Sun Jul 19 | vs Rangers | W10-0 | 51-43 | .543 | Minute Maid Park · Houston, TX |
| 95 | Tue Jul 21 | vs Red Sox | W8-3 | 52-43 | .547 | Minute Maid Park · Houston, TX |
| 96 | Wed Jul 22 | vs Red Sox | W4-2 | 53-43 | .552 | Minute Maid Park · Houston, TX |
| 97 | Thu Jul 23 | vs Red Sox | W5-4 | 54-43 | .557 | Minute Maid Park · Houston, TX |
| 98 | Fri Jul 24 | at Royals | W4-0 | 55-43 | .561 | Kauffman Stadium · Kansas City, MO |
| 99 | Sat Jul 25 | at Royals | L1-2 (10) | 55-44 | .556 | Kauffman Stadium · Kansas City, MO |
| 100 | Sun Jul 26 | at Royals | L1-5 | 55-45 | .550 | Kauffman Stadium · Kansas City, MO |
| 101 | Tue Jul 28 | vs Angels | W10-5 | 56-45 | .554 | Minute Maid Park · Houston, TX |
| 102 | Wed Jul 29 | vs Angels | W6-3 | 57-45 | .559 | Minute Maid Park · Houston, TX |
| 103 | Thu Jul 30 | vs Angels | W3-0 | 58-45 | .563 | Minute Maid Park · Houston, TX |
| 104 | Fri Jul 31 | vs D-backs | L4-6 (10) | 58-46 | .558 | Minute Maid Park · Houston, TX |
| 105 | Sat Aug 1 | vs D-backs | W9-2 | 59-46 | .562 | Minute Maid Park · Houston, TX |
| 106 | Sun Aug 2 | vs D-backs | W4-1 | 60-46 | .566 | Minute Maid Park · Houston, TX |
| 107 | Mon Aug 3 | at Rangers | L9-12 | 60-47 | .561 | Globe Life Field · Arlington, TX |
| 108 | Tue Aug 4 | at Rangers | L3-4 | 60-48 | .556 | Globe Life Field · Arlington, TX |
| 109 | Wed Aug 5 | at Rangers | L3-4 | 60-49 | .550 | Globe Life Field · Arlington, TX |
| 110 | Thu Aug 6 | at Athletics | W5-4 (10) | 61-49 | .555 | RingCentral Coliseum · Oakland, CA |
| 111 | Fri Aug 7 | at Athletics | L1-3 | 61-50 | .550 | RingCentral Coliseum · Oakland, CA |
| 112 | Sat Aug 8 | at Athletics | L1-2 | 61-51 | .545 | RingCentral Coliseum · Oakland, CA |
| 113 | Sun Aug 9 | at Athletics | L4-5 | 61-52 | .540 | RingCentral Coliseum · Oakland, CA |
| 114 | Tue Aug 11 | at Giants | L1-3 | 61-53 | .535 | Oracle Park · San Francisco, CA |
| 115 | Wed Aug 12 | at Giants | W2-0 | 62-53 | .539 | Oracle Park · San Francisco, CA |
| 116 | Fri Aug 14 | vs Tigers | W5-1 | 63-53 | .543 | Minute Maid Park · Houston, TX |
| 117 | Sat Aug 15 | vs Tigers | L2-4 (11) | 63-54 | .538 | Minute Maid Park · Houston, TX |
| 118 | Sun Aug 16 | vs Tigers | W6-5 | 64-54 | .542 | Minute Maid Park · Houston, TX |
| 119 | Mon Aug 17 | vs Rays | L2-9 | 64-55 | .538 | Minute Maid Park · Houston, TX |
| 120 | Tue Aug 18 | vs Rays | W3-2 (10) | 65-55 | .542 | Minute Maid Park · Houston, TX |
| 121 | Wed Aug 19 | vs Rays | W3-2 (13) | 66-55 | .545 | Minute Maid Park · Houston, TX |
| 122 | Thu Aug 20 | vs Rays | L0-1 | 66-56 | .541 | Minute Maid Park · Houston, TX |
| 123 | Fri Aug 21 | vs Dodgers | W3-0 | 67-56 | .545 | Minute Maid Park · Houston, TX |
| 124 | Sat Aug 22 | vs Dodgers | W3-1 | 68-56 | .548 | Minute Maid Park · Houston, TX |
| 125 | Sun Aug 23 | vs Dodgers | W3-2 (10) | 69-56 | .552 | Minute Maid Park · Houston, TX |
| 126 | Mon Aug 24 | at Yankees | L0-1 | 69-57 | .548 | Yankee Stadium · The Bronx, NY |
| 127 | Tue Aug 25 | at Yankees | W15-1 | 70-57 | .551 | Yankee Stadium · The Bronx, NY |
| 128 | Wed Aug 26 | at Yankees | W6-2 | 71-57 | .555 | Yankee Stadium · The Bronx, NY |
| 129 | Fri Aug 28 | at Twins | L0-3 | 71-58 | .550 | Target Field · Minneapolis, MN |
| 130 | Sat Aug 29 | at Twins | W4-1 | 72-58 | .554 | Target Field · Minneapolis, MN |
| 131 | Sun Aug 30 | at Twins | L5-7 | 72-59 | .550 | Target Field · Minneapolis, MN |
| 132 | Mon Aug 31 | vs Mariners | W8-3 | 73-59 | .553 | Minute Maid Park · Houston, TX |
| 133 | Tue Sep 1 | vs Mariners | L5-7 | 73-60 | .549 | Minute Maid Park · Houston, TX |
| 134 | Wed Sep 2 | vs Mariners | L3-8 | 73-61 | .545 | Minute Maid Park · Houston, TX |
| 135 | Fri Sep 4 | vs Twins | W8-0 | 74-61 | .548 | Minute Maid Park · Houston, TX |
| 136 | Sat Sep 5 | vs Twins | L2-3 | 74-62 | .544 | Minute Maid Park · Houston, TX |
| 137 | Sun Sep 6 | vs Twins | W8-5 | 75-62 | .547 | Minute Maid Park · Houston, TX |
| 138 | Mon Sep 7 | at Athletics | L9-10 | 75-63 | .543 | RingCentral Coliseum · Oakland, CA |
| 139 | Tue Sep 8 | at Athletics | L0-4 | 75-64 | .540 | RingCentral Coliseum · Oakland, CA |
| 140 | Wed Sep 9 | at Athletics | W11-5 | 76-64 | .543 | RingCentral Coliseum · Oakland, CA |
| 141 | Fri Sep 11 | at Angels | L2-3 | 76-65 | .539 | Angel Stadium · Anaheim, CA |
| 142 | Sat Sep 12 | at Angels | L2-3 | 76-66 | .535 | Angel Stadium · Anaheim, CA |
| 143 | Sun Sep 13 | at Angels | W5-3 | 77-66 | .538 | Angel Stadium · Anaheim, CA |
| 144 | Mon Sep 14 | at Rangers | L3-5 | 77-67 | .535 | Globe Life Field · Arlington, TX |
| 145 | Tue Sep 15 | at Rangers | L5-6 | 77-68 | .531 | Globe Life Field · Arlington, TX |
| 146 | Wed Sep 16 | at Rangers | L3-14 | 77-69 | .527 | Globe Life Field · Arlington, TX |
| 147 | Thu Sep 17 | at Rangers | L2-8 | 77-70 | .524 | Globe Life Field · Arlington, TX |
| 148 | Fri Sep 18 | vs Athletics | L3-4 | 77-71 | .520 | Minute Maid Park · Houston, TX |
| 149 | Sat Sep 19 | vs Athletics | W10-6 | 78-71 | .523 | Minute Maid Park · Houston, TX |
| 150 | Sun Sep 20 | vs Athletics | W5-1 | 79-71 | .527 | Minute Maid Park · Houston, TX |
| 151 | Mon Sep 21 | vs Angels | W6-3 | 80-71 | .530 | Minute Maid Park · Houston, TX |
| 152 | Tue Sep 22 | vs Angels | L3-4 | 80-72 | .526 | Minute Maid Park · Houston, TX |
| 153 | Wed Sep 23 | vs Angels | L5-6 | 80-73 | .523 | Minute Maid Park · Houston, TX |
| 154 | Fri Sep 25 | vs Rangers | L2-6 | 80-74 | .519 | Minute Maid Park · Houston, TX |
| 155 | Sat Sep 26 | vs Rangers | W9-7 | 81-74 | .523 | Minute Maid Park · Houston, TX |
| 156 | Sun Sep 27 | vs Rangers | W4-2 | 82-74 | .526 | Minute Maid Park · Houston, TX |
| 157 | Mon Sep 28 | at Mariners | W3-2 | 83-74 | .529 | T-Mobile Park · Seattle, WA |
| 158 | Tue Sep 29 | at Mariners | L4-6 | 83-75 | .525 | T-Mobile Park · Seattle, WA |
| 159 | Wed Sep 30 | at Mariners | W7-6 | 84-75 | .528 | T-Mobile Park · Seattle, WA |
| 160 | Fri Oct 2 | at D-backs | W21-5 | 85-75 | .531 | Chase Field · Phoenix, AZ |
| 161 | Sat Oct 3 | at D-backs | W6-2 | 86-75 | .534 | Chase Field · Phoenix, AZ |
| 162 | Sun Oct 4 | at D-backs | L3-5 | 86-76 | .531 | Chase Field · Phoenix, AZ |
| 163 | Tue Oct 6 | at Yankees | W3-0 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Thu Oct 8 | at Royals | W5-2 | 1-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 165 | Fri Oct 9 | at Royals | L4-5 | 1-1 | .500 | Kauffman Stadium · Kansas City, MO |
| 166 | Sun Oct 11 | vs Royals | W4-2 | 2-1 | .667 | Minute Maid Park · Houston, TX |
| 167 | Mon Oct 12 | vs Royals | L6-9 | 2-2 | .500 | Minute Maid Park · Houston, TX |
| 168 | Wed Oct 14 | at Royals | L2-7 | 2-3 | .400 | Kauffman Stadium · Kansas City, MO |