| 1 | Thu Mar 27 | vs Mets | W3-1 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 2 | Fri Mar 28 | vs Mets | L1-3 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Sat Mar 29 | vs Mets | W2-1 | 2-1 | .667 | Minute Maid Park · Houston, TX |
| 4 | Mon Mar 31 | vs Giants | L2-7 | 2-2 | .500 | Minute Maid Park · Houston, TX |
| 5 | Tue Apr 1 | vs Giants | L1-3 | 2-3 | .400 | Minute Maid Park · Houston, TX |
| 6 | Wed Apr 2 | vs Giants | L3-6 | 2-4 | .333 | Minute Maid Park · Houston, TX |
| 7 | Thu Apr 3 | at Twins | W5-2 | 3-4 | .429 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 5 | at Twins | L1-6 | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 6 | at Twins | W9-7 (10) | 4-5 | .444 | Target Field · Minneapolis, MN |
| 10 | Mon Apr 7 | at Mariners | L3-4 | 4-6 | .400 | T-Mobile Park · Seattle, WA |
| 11 | Tue Apr 8 | at Mariners | W2-1 (12) | 5-6 | .455 | T-Mobile Park · Seattle, WA |
| 12 | Wed Apr 9 | at Mariners | L6-7 | 5-7 | .417 | T-Mobile Park · Seattle, WA |
| 13 | Fri Apr 11 | vs Angels | W14-3 | 6-7 | .462 | Minute Maid Park · Houston, TX |
| 14 | Sat Apr 12 | vs Angels | L1-4 | 6-8 | .429 | Minute Maid Park · Houston, TX |
| 15 | Sun Apr 13 | vs Angels | W7-3 | 7-8 | .467 | Minute Maid Park · Houston, TX |
| 16 | Mon Apr 14 | at Cardinals | L3-8 | 7-9 | .438 | Busch Stadium · St. Louis, MO |
| 17 | Tue Apr 15 | at Cardinals | W2-0 | 8-9 | .471 | Busch Stadium · St. Louis, MO |
| 18 | Wed Apr 16 | at Cardinals | L1-4 | 8-10 | .444 | Busch Stadium · St. Louis, MO |
| 19 | Fri Apr 18 | vs Padres | W6-4 | 9-10 | .474 | Minute Maid Park · Houston, TX |
| 20 | Sat Apr 19 | vs Padres | W3-2 | 10-10 | .500 | Minute Maid Park · Houston, TX |
| 21 | Sun Apr 20 | vs Padres | L2-3 | 10-11 | .476 | Minute Maid Park · Houston, TX |
| 22 | Mon Apr 21 | vs Blue Jays | W7-0 | 11-11 | .500 | Minute Maid Park · Houston, TX |
| 23 | Tue Apr 22 | vs Blue Jays | W5-1 | 12-11 | .522 | Minute Maid Park · Houston, TX |
| 24 | Wed Apr 23 | vs Blue Jays | W3-1 | 13-11 | .542 | Minute Maid Park · Houston, TX |
| 25 | Fri Apr 25 | at Royals | L0-2 | 13-12 | .520 | Kauffman Stadium · Kansas City, MO |
| 26 | Sat Apr 26 | at Royals | L0-2 | 13-13 | .500 | Kauffman Stadium · Kansas City, MO |
| 27 | Sun Apr 27 | at Royals | W7-3 | 14-13 | .519 | Kauffman Stadium · Kansas City, MO |
| 28 | Mon Apr 28 | vs Tigers | W8-5 | 15-13 | .536 | Minute Maid Park · Houston, TX |
| 29 | Tue Apr 29 | vs Tigers | W6-4 | 16-13 | .552 | Minute Maid Park · Houston, TX |
| 30 | Wed Apr 30 | vs Tigers | L4-7 | 16-14 | .533 | Minute Maid Park · Houston, TX |
| 31 | Fri May 2 | at White Sox | L3-7 | 16-15 | .516 | Guaranteed Rate Field · Chicago, IL |
| 32 | Sat May 3 | at White Sox | W8-3 | 17-15 | .531 | Guaranteed Rate Field · Chicago, IL |
| 33 | Sun May 4 | at White Sox | L4-5 | 17-16 | .515 | Guaranteed Rate Field · Chicago, IL |
| 34 | Mon May 5 | at Brewers | L1-5 | 17-17 | .500 | American Family Field · Milwaukee, WI |
| 35 | Tue May 6 | at Brewers | L3-4 | 17-18 | .486 | American Family Field · Milwaukee, WI |
| 36 | Wed May 7 | at Brewers | W9-1 | 18-18 | .500 | American Family Field · Milwaukee, WI |
| 37 | Fri May 9 | vs Reds | W3-0 | 19-18 | .514 | Minute Maid Park · Houston, TX |
| 38 | Sat May 10 | vs Reds | L9-13 | 19-19 | .500 | Minute Maid Park · Houston, TX |
| 39 | Sun May 11 | vs Reds | W6-0 | 20-19 | .513 | Minute Maid Park · Houston, TX |
| 40 | Mon May 12 | vs Royals | L5-7 | 20-20 | .500 | Minute Maid Park · Houston, TX |
| 41 | Tue May 13 | vs Royals | W2-1 | 21-20 | .512 | Minute Maid Park · Houston, TX |
| 42 | Wed May 14 | vs Royals | W4-3 | 22-20 | .524 | Minute Maid Park · Houston, TX |
| 43 | Thu May 15 | at Rangers | L0-1 | 22-21 | .512 | Globe Life Field · Arlington, TX |
| 44 | Fri May 16 | at Rangers | W6-3 | 23-21 | .523 | Globe Life Field · Arlington, TX |
| 45 | Sat May 17 | at Rangers | L1-5 | 23-22 | .511 | Globe Life Field · Arlington, TX |
| 46 | Sun May 18 | at Rangers | W4-3 | 24-22 | .522 | Globe Life Field · Arlington, TX |
| 47 | Mon May 19 | at Rays | W4-3 | 25-22 | .532 | Tropicana Field · St. Petersburg, FL |
| 48 | Tue May 20 | at Rays | L2-3 | 25-23 | .521 | Tropicana Field · St. Petersburg, FL |
| 49 | Wed May 21 | at Rays | L4-8 | 25-24 | .510 | Tropicana Field · St. Petersburg, FL |
| 50 | Thu May 22 | vs Mariners | W9-2 | 26-24 | .520 | Minute Maid Park · Houston, TX |
| 51 | Fri May 23 | vs Mariners | L3-5 | 26-25 | .510 | Minute Maid Park · Houston, TX |
| 52 | Sat May 24 | vs Mariners | W2-1 | 27-25 | .519 | Minute Maid Park · Houston, TX |
| 53 | Sun May 25 | vs Mariners | W5-3 | 28-25 | .528 | Minute Maid Park · Houston, TX |
| 54 | Tue May 27 | vs Athletics | W11-1 | 29-25 | .537 | Minute Maid Park · Houston, TX |
| 55 | Wed May 28 | vs Athletics | W5-3 | 30-25 | .545 | Minute Maid Park · Houston, TX |
| 56 | Thu May 29 | vs Rays | L3-13 | 30-26 | .536 | Minute Maid Park · Houston, TX |
| 57 | Fri May 30 | vs Rays | W2-1 | 31-26 | .544 | Minute Maid Park · Houston, TX |
| 58 | Sat May 31 | vs Rays | L3-16 | 31-27 | .534 | Minute Maid Park · Houston, TX |
| 59 | Sun Jun 1 | vs Rays | W1-0 | 32-27 | .542 | Minute Maid Park · Houston, TX |
| 60 | Tue Jun 3 | at Pirates | W3-0 | 33-27 | .550 | PNC Park · Pittsburgh, PA |
| 61 | Wed Jun 4 | at Pirates | L0-3 | 33-28 | .541 | PNC Park · Pittsburgh, PA |
| 62 | Thu Jun 5 | at Pirates | W8-2 | 34-28 | .548 | PNC Park · Pittsburgh, PA |
| 63 | Fri Jun 6 | at Guardians | W4-2 | 35-28 | .556 | Progressive Field · Cleveland, OH |
| 64 | Sat Jun 7 | at Guardians | W5-3 (10) | 36-28 | .563 | Progressive Field · Cleveland, OH |
| 65 | Sun Jun 8 | at Guardians | L2-4 | 36-29 | .554 | Progressive Field · Cleveland, OH |
| 66 | Tue Jun 10 | vs White Sox | L2-4 | 36-30 | .545 | Minute Maid Park · Houston, TX |
| 67 | Wed Jun 11 | vs White Sox | W10-2 | 37-30 | .552 | Minute Maid Park · Houston, TX |
| 68 | Thu Jun 12 | vs White Sox | W4-3 | 38-30 | .559 | Minute Maid Park · Houston, TX |
| 69 | Fri Jun 13 | vs Twins | W10-3 | 39-30 | .565 | Minute Maid Park · Houston, TX |
| 70 | Sat Jun 14 | vs Twins | W3-2 | 40-30 | .571 | Minute Maid Park · Houston, TX |
| 71 | Sun Jun 15 | vs Twins | W2-1 (10) | 41-30 | .577 | Minute Maid Park · Houston, TX |
| 72 | Mon Jun 16 | at Athletics | L1-3 | 41-31 | .569 | Sutter Health Park · West Sacramento, CA |
| 73 | Tue Jun 17 | at Athletics | W13-3 | 42-31 | .575 | Sutter Health Park · West Sacramento, CA |
| 74 | Wed Jun 18 | at Athletics | W11-4 | 43-31 | .581 | Sutter Health Park · West Sacramento, CA |
| 75 | Thu Jun 19 | at Athletics | L4-6 (10) | 43-32 | .573 | Sutter Health Park · West Sacramento, CA |
| 76 | Fri Jun 20 | at Angels | W3-2 (10) | 44-32 | .579 | Angel Stadium · Anaheim, CA |
| 77 | Sat Jun 21 | at Angels | L1-9 | 44-33 | .571 | Angel Stadium · Anaheim, CA |
| 78 | Sun Jun 22 | at Angels | W8-7 | 45-33 | .577 | Angel Stadium · Anaheim, CA |
| 79 | Tue Jun 24 | vs Phillies | W1-0 | 46-33 | .582 | Minute Maid Park · Houston, TX |
| 80 | Wed Jun 25 | vs Phillies | W2-0 | 47-33 | .588 | Minute Maid Park · Houston, TX |
| 81 | Thu Jun 26 | vs Phillies | W2-1 | 48-33 | .593 | Minute Maid Park · Houston, TX |
| 82 | Fri Jun 27 | vs Cubs | W7-4 | 49-33 | .598 | Minute Maid Park · Houston, TX |
| 83 | Sat Jun 28 | vs Cubs | L3-12 | 49-34 | .590 | Minute Maid Park · Houston, TX |
| 84 | Sun Jun 29 | vs Cubs | W2-0 | 50-34 | .595 | Minute Maid Park · Houston, TX |
| 85 | Tue Jul 1 | at Rockies | W6-5 | 51-34 | .600 | Coors Field · Denver, CO |
| 86 | Wed Jul 2 | at Rockies | W5-3 | 52-34 | .605 | Coors Field · Denver, CO |
| 87 | Thu Jul 3 | at Rockies | L6-7 | 52-35 | .598 | Coors Field · Denver, CO |
| 88 | Fri Jul 4 | at Dodgers | W18-1 | 53-35 | .602 | Dodger Stadium · Los Angeles, CA |
| 89 | Sat Jul 5 | at Dodgers | W6-4 | 54-35 | .607 | Dodger Stadium · Los Angeles, CA |
| 90 | Sun Jul 6 | at Dodgers | W5-1 | 55-35 | .611 | Dodger Stadium · Los Angeles, CA |
| 91 | Mon Jul 7 | vs Guardians | L5-7 | 55-36 | .604 | Minute Maid Park · Houston, TX |
| 92 | Tue Jul 8 | vs Guardians | L6-10 (10) | 55-37 | .598 | Minute Maid Park · Houston, TX |
| 93 | Wed Jul 9 | vs Guardians | L2-4 | 55-38 | .591 | Minute Maid Park · Houston, TX |
| 94 | Fri Jul 11 | vs Rangers | L3-7 | 55-39 | .585 | Minute Maid Park · Houston, TX |
| 95 | Sat Jul 12 | vs Rangers | W5-4 (11) | 56-39 | .589 | Minute Maid Park · Houston, TX |
| 96 | Sun Jul 13 | vs Rangers | L1-5 | 56-40 | .583 | Minute Maid Park · Houston, TX |
| 97 | Fri Jul 18 | at Mariners | L1-6 | 56-41 | .577 | T-Mobile Park · Seattle, WA |
| 98 | Sat Jul 19 | at Mariners | L6-7 (11) | 56-42 | .571 | T-Mobile Park · Seattle, WA |
| 99 | Sun Jul 20 | at Mariners | W11-3 | 57-42 | .576 | T-Mobile Park · Seattle, WA |
| 100 | Mon Jul 21 | at D-backs | W6-3 | 58-42 | .580 | Chase Field · Phoenix, AZ |
| 101 | Tue Jul 22 | at D-backs | W3-1 | 59-42 | .584 | Chase Field · Phoenix, AZ |
| 102 | Wed Jul 23 | at D-backs | W4-3 | 60-42 | .588 | Chase Field · Phoenix, AZ |
| 103 | Thu Jul 24 | vs Athletics | L2-5 | 60-43 | .583 | Minute Maid Park · Houston, TX |
| 104 | Fri Jul 25 | vs Athletics | L3-15 | 60-44 | .577 | Minute Maid Park · Houston, TX |
| 105 | Sat Jul 26 | vs Athletics | L1-5 | 60-45 | .571 | Minute Maid Park · Houston, TX |
| 106 | Sun Jul 27 | vs Athletics | L1-7 | 60-46 | .566 | Minute Maid Park · Houston, TX |
| 107 | Mon Jul 28 | vs Nationals | L1-2 | 60-47 | .561 | Minute Maid Park · Houston, TX |
| 108 | Tue Jul 29 | vs Nationals | W7-4 | 61-47 | .565 | Minute Maid Park · Houston, TX |
| 109 | Wed Jul 30 | vs Nationals | W9-1 | 62-47 | .569 | Minute Maid Park · Houston, TX |
| 110 | Fri Aug 1 | at Red Sox | L1-2 (10) | 62-48 | .564 | Fenway Park · Boston, MA |
| 111 | Sat Aug 2 | at Red Sox | L3-7 | 62-49 | .559 | Fenway Park · Boston, MA |
| 112 | Sun Aug 3 | at Red Sox | L1-6 | 62-50 | .554 | Fenway Park · Boston, MA |
| 113 | Mon Aug 4 | at Marlins | W8-2 | 63-50 | .558 | LoanDepot Park · Miami, FL |
| 114 | Tue Aug 5 | at Marlins | W7-3 | 64-50 | .561 | LoanDepot Park · Miami, FL |
| 115 | Wed Aug 6 | at Marlins | L4-6 | 64-51 | .557 | LoanDepot Park · Miami, FL |
| 116 | Fri Aug 8 | at Yankees | W5-3 (10) | 65-51 | .560 | Yankee Stadium · The Bronx, NY |
| 117 | Sat Aug 9 | at Yankees | L4-5 | 65-52 | .556 | Yankee Stadium · The Bronx, NY |
| 118 | Sun Aug 10 | at Yankees | W7-1 | 66-52 | .559 | Yankee Stadium · The Bronx, NY |
| 119 | Mon Aug 11 | vs Red Sox | W7-6 | 67-52 | .563 | Minute Maid Park · Houston, TX |
| 120 | Tue Aug 12 | vs Red Sox | L1-14 | 67-53 | .558 | Minute Maid Park · Houston, TX |
| 121 | Wed Aug 13 | vs Red Sox | W4-1 | 68-53 | .562 | Minute Maid Park · Houston, TX |
| 122 | Fri Aug 15 | vs Orioles | L0-7 | 68-54 | .557 | Minute Maid Park · Houston, TX |
| 123 | Sat Aug 16 | vs Orioles | W5-4 (12) | 69-54 | .561 | Minute Maid Park · Houston, TX |
| 124 | Sun Aug 17 | vs Orioles | L0-12 | 69-55 | .556 | Minute Maid Park · Houston, TX |
| 125 | Mon Aug 18 | at Tigers | L0-10 | 69-56 | .552 | Comerica Park · Detroit, MI |
| 126 | Tue Aug 19 | at Tigers | L0-1 (10) | 69-57 | .548 | Comerica Park · Detroit, MI |
| 127 | Wed Aug 20 | at Tigers | L2-7 | 69-58 | .543 | Comerica Park · Detroit, MI |
| 128 | Thu Aug 21 | at Orioles | W7-2 | 70-58 | .547 | Camden Yards · Baltimore, MD |
| 129 | Fri Aug 22 | at Orioles | W10-7 | 71-58 | .550 | Camden Yards · Baltimore, MD |
| 130 | Sat Aug 23 | at Orioles | W9-8 | 72-58 | .554 | Camden Yards · Baltimore, MD |
| 131 | Sun Aug 24 | at Orioles | L2-3 | 72-59 | .550 | Camden Yards · Baltimore, MD |
| 132 | Tue Aug 26 | vs Rockies | L1-6 | 72-60 | .545 | Minute Maid Park · Houston, TX |
| 133 | Wed Aug 27 | vs Rockies | W4-0 | 73-60 | .549 | Minute Maid Park · Houston, TX |
| 134 | Thu Aug 28 | vs Rockies | W4-3 | 74-60 | .552 | Minute Maid Park · Houston, TX |
| 135 | Fri Aug 29 | vs Angels | W2-0 | 75-60 | .556 | Minute Maid Park · Houston, TX |
| 136 | Sat Aug 30 | vs Angels | L1-4 | 75-61 | .551 | Minute Maid Park · Houston, TX |
| 137 | Sun Aug 31 | vs Angels | L0-3 | 75-62 | .547 | Minute Maid Park · Houston, TX |
| 138 | Mon Sep 1 | vs Angels | W8-3 | 76-62 | .551 | Minute Maid Park · Houston, TX |
| 139 | Tue Sep 2 | vs Yankees | L1-7 | 76-63 | .547 | Minute Maid Park · Houston, TX |
| 140 | Wed Sep 3 | vs Yankees | W8-7 | 77-63 | .550 | Minute Maid Park · Houston, TX |
| 141 | Thu Sep 4 | vs Yankees | L4-8 | 77-64 | .546 | Minute Maid Park · Houston, TX |
| 142 | Fri Sep 5 | at Rangers | L3-4 (12) | 77-65 | .542 | Globe Life Field · Arlington, TX |
| 143 | Sat Sep 6 | at Rangers | W11-0 | 78-65 | .545 | Globe Life Field · Arlington, TX |
| 144 | Sun Sep 7 | at Rangers | L2-4 | 78-66 | .542 | Globe Life Field · Arlington, TX |
| 145 | Tue Sep 9 | at Blue Jays | L3-4 (10) | 78-67 | .538 | Rogers Centre · Toronto, ON |
| 146 | Wed Sep 10 | at Blue Jays | W3-2 | 79-67 | .541 | Rogers Centre · Toronto, ON |
| 147 | Thu Sep 11 | at Blue Jays | L0-6 | 79-68 | .537 | Rogers Centre · Toronto, ON |
| 148 | Fri Sep 12 | at Braves | W11-3 | 80-68 | .541 | Truist Park · Cumberland, GA |
| 149 | Sat Sep 13 | at Braves | W6-2 | 81-68 | .544 | Truist Park · Cumberland, GA |
| 150 | Sun Sep 14 | at Braves | L3-8 | 81-69 | .540 | Truist Park · Cumberland, GA |
| 151 | Mon Sep 15 | vs Rangers | W6-3 | 82-69 | .543 | Minute Maid Park · Houston, TX |
| 152 | Tue Sep 16 | vs Rangers | W6-5 | 83-69 | .546 | Minute Maid Park · Houston, TX |
| 153 | Wed Sep 17 | vs Rangers | W5-2 | 84-69 | .549 | Minute Maid Park · Houston, TX |
| 154 | Fri Sep 19 | vs Mariners | L0-4 | 84-70 | .545 | Minute Maid Park · Houston, TX |
| 155 | Sat Sep 20 | vs Mariners | L4-6 | 84-71 | .542 | Minute Maid Park · Houston, TX |
| 156 | Sun Sep 21 | vs Mariners | L3-7 | 84-72 | .538 | Minute Maid Park · Houston, TX |
| 157 | Tue Sep 23 | at Athletics | L1-5 | 84-73 | .535 | Sutter Health Park · West Sacramento, CA |
| 158 | Wed Sep 24 | at Athletics | L0-6 | 84-74 | .532 | Sutter Health Park · West Sacramento, CA |
| 159 | Thu Sep 25 | at Athletics | W11-5 | 85-74 | .535 | Sutter Health Park · West Sacramento, CA |
| 160 | Fri Sep 26 | at Angels | L3-4 | 85-75 | .531 | Angel Stadium · Anaheim, CA |
| 161 | Sat Sep 27 | at Angels | W6-1 | 86-75 | .534 | Angel Stadium · Anaheim, CA |
| 162 | Sun Sep 28 | at Angels | W6-2 | 87-75 | .537 | Angel Stadium · Anaheim, CA |