| 1 | Thu Jul 23 | at Nationals | W4-1 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Sat Jul 25 | atNationals | L2-9 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 3 | Sun Jul 26 | atNationals | W3-2 | 2-1 | .667 | Nationals Park · Washington, D.C. |
| 4 | Wed Jul 29 | at Orioles | W9-3 | 3-1 | .750 | Camden Yards · Baltimore, MD |
| 5 | Thu Jul 30 | atOrioles | W8-6 | 4-1 | .800 | Camden Yards · Baltimore, MD |
| 6 | Fri Jul 31 | vs Red Sox | W5-1 | 5-1 | .833 | Yankee Stadium · The Bronx, NY |
| 7 | Sat Aug 1 | vsRed Sox | W5-2 | 6-1 | .857 | Yankee Stadium · The Bronx, NY |
| 8 | Sun Aug 2 | vsRed Sox | W9-7 | 7-1 | .875 | Yankee Stadium · The Bronx, NY |
| 9 | Mon Aug 3 | vs Phillies | W6-3 | 8-1 | .889 | Yankee Stadium · The Bronx, NY |
| 10 | Wed Aug 5 | vsPhillies | L7-11 | 8-2 | .800 | Citizens Bank Park · Philadelphi, PA |
| 11 | Wed Aug 5 | atPhillies | W3-1 | 9-2 | .818 | Citizens Bank Park · Philadelphi, PA |
| 12 | Thu Aug 6 | atPhillies | L4-5 | 9-3 | .750 | Citizens Bank Park · Philadelphi, PA |
| 13 | Fri Aug 7 | at Rays | L0-1 | 9-4 | .692 | Tropicana Field · St. Petersburg, FL |
| 14 | Sat Aug 8 | atRays | W8-4 | 10-4 | .714 | Tropicana Field · St. Petersburg, FL |
| 15 | Sat Aug 8 | atRays | L3-5 | 10-5 | .667 | Tropicana Field · St. Petersburg, FL |
| 16 | Sun Aug 9 | atRays | L3-4 | 10-6 | .625 | Tropicana Field · St. Petersburg, FL |
| 17 | Tue Aug 11 | vs Braves | W9-6 | 11-6 | .647 | Yankee Stadium · The Bronx, NY |
| 18 | Wed Aug 12 | vsBraves | W6-3 | 12-6 | .667 | Yankee Stadium · The Bronx, NY |
| 19 | Fri Aug 14 | vsRed Sox | W10-3 | 13-6 | .684 | Yankee Stadium · The Bronx, NY |
| 20 | Sat Aug 15 | vsRed Sox | W11-5 | 14-6 | .700 | Yankee Stadium · The Bronx, NY |
| 21 | Sun Aug 16 | vsRed Sox | W4-2 | 15-6 | .714 | Yankee Stadium · The Bronx, NY |
| 22 | Mon Aug 17 | vsRed Sox | W6-3 | 16-6 | .727 | Yankee Stadium · The Bronx, NY |
| 23 | Tue Aug 18 | vsRays | L3-6 | 16-7 | .696 | Yankee Stadium · The Bronx, NY |
| 24 | Wed Aug 19 | vsRays | L2-4 | 16-8 | .667 | Yankee Stadium · The Bronx, NY |
| 25 | Thu Aug 20 | vsRays | L5-10 | 16-9 | .640 | Yankee Stadium · The Bronx, NY |
| 26 | Wed Aug 26 | atBraves | L1-5 | 16-10 | .615 | Truist Park · Cumberland, GA |
| 27 | Wed Aug 26 | atBraves | L1-2 | 16-11 | .593 | Truist Park · Cumberland, GA |
| 28 | Fri Aug 28 | vs Mets | L4-6 | 16-12 | .571 | Yankee Stadium · The Bronx, NY |
| 29 | Fri Aug 28 | atMets | L3-4 | 16-13 | .552 | Yankee Stadium · The Bronx, NY |
| 30 | Sat Aug 29 | vsMets | W2-1 | 17-13 | .567 | Yankee Stadium · The Bronx, NY |
| 31 | Sun Aug 30 | vsMets | W8-7 (8) | 18-13 | .581 | Yankee Stadium · The Bronx, NY |
| 32 | Sun Aug 30 | atMets | W5-2 (8) | 19-13 | .594 | Yankee Stadium · The Bronx, NY |
| 33 | Mon Aug 31 | vsRays | L3-5 | 19-14 | .576 | Yankee Stadium · The Bronx, NY |
| 34 | Tue Sep 1 | vsRays | W5-3 | 20-14 | .588 | Yankee Stadium · The Bronx, NY |
| 35 | Wed Sep 2 | vsRays | L2-5 | 20-15 | .571 | Yankee Stadium · The Bronx, NY |
| 36 | Thu Sep 3 | atMets | L7-9 (10) | 20-16 | .556 | Citi Field · Queens, NY |
| 37 | Fri Sep 4 | atOrioles | W6-5 (9) | 21-16 | .568 | Camden Yards · Baltimore, MD |
| 38 | Fri Sep 4 | atOrioles | L3-6 | 21-17 | .553 | Camden Yards · Baltimore, MD |
| 39 | Sat Sep 5 | atOrioles | L1-6 | 21-18 | .538 | Camden Yards · Baltimore, MD |
| 40 | Sun Sep 6 | atOrioles | L1-5 | 21-19 | .525 | Camden Yards · Baltimore, MD |
| 41 | Mon Sep 7 | at Blue Jays | L7-12 | 21-20 | .512 | Rogers Centre · Toronto, ON |
| 42 | Tue Sep 8 | atBlue Jays | L1-2 | 21-21 | .500 | Rogers Centre · Toronto, ON |
| 43 | Wed Sep 9 | atBlue Jays | W7-2 | 22-21 | .512 | Rogers Centre · Toronto, ON |
| 44 | Fri Sep 11 | vsOrioles | W6-0 | 23-21 | .523 | Yankee Stadium · The Bronx, NY |
| 45 | Fri Sep 11 | vsOrioles | W10-1 | 24-21 | .533 | Yankee Stadium · The Bronx, NY |
| 46 | Sat Sep 12 | vsOrioles | W2-1 (10) | 25-21 | .543 | Yankee Stadium · The Bronx, NY |
| 47 | Sun Sep 13 | vsOrioles | W3-1 | 26-21 | .553 | Yankee Stadium · The Bronx, NY |
| 48 | Tue Sep 15 | vsBlue Jays | W20-6 | 27-21 | .563 | Yankee Stadium · The Bronx, NY |
| 49 | Wed Sep 16 | vsBlue Jays | W13-2 | 28-21 | .571 | Yankee Stadium · The Bronx, NY |
| 50 | Thu Sep 17 | vsBlue Jays | W10-7 | 29-21 | .580 | Yankee Stadium · The Bronx, NY |
| 51 | Fri Sep 18 | atRed Sox | W6-5 (12) | 30-21 | .588 | Fenway Park · Boston, MA |
| 52 | Sat Sep 19 | atRed Sox | W8-0 | 31-21 | .596 | Fenway Park · Boston, MA |
| 53 | Sun Sep 20 | atRed Sox | L2-10 | 31-22 | .585 | Fenway Park · Boston, MA |
| 54 | Mon Sep 21 | atBlue Jays | L5-11 | 31-23 | .574 | Rogers Centre · Toronto, ON |
| 55 | Tue Sep 22 | atBlue Jays | W12-1 | 32-23 | .582 | Rogers Centre · Toronto, ON |
| 56 | Wed Sep 23 | atBlue Jays | L1-14 | 32-24 | .571 | Rogers Centre · Toronto, ON |
| 57 | Thu Sep 24 | atBlue Jays | L1-4 | 32-25 | .561 | Rogers Centre · Toronto, ON |
| 58 | Fri Sep 25 | vs Marlins | L3-4 (10) | 32-26 | .552 | Yankee Stadium · The Bronx, NY |
| 59 | Sat Sep 26 | vsMarlins | W11-4 | 33-26 | .559 | Yankee Stadium · The Bronx, NY |
| 60 | Sun Sep 27 | vsMarlins | L0-5 | 33-27 | .550 | Yankee Stadium · The Bronx, NY |
| 61 | Tue Sep 29 | at Guardians | W12-3 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 62 | Wed Sep 30 | atGuardians | W10-9 | 2-0 | 1.000 | Progressive Field · Cleveland, OH |
| 63 | Mon Oct 5 | atRays | W9-3 | 1-0 | 1.000 | Petco Park · San Diego, CA |
| 64 | Tue Oct 6 | atRays | L5-7 | 1-1 | .500 | Petco Park · San Diego, CA |
| 65 | Wed Oct 7 | vsRays | L4-8 | 1-2 | .333 | Petco Park · San Diego, CA |
| 66 | Thu Oct 8 | vsRays | W5-1 | 2-2 | .500 | Petco Park · San Diego, CA |
| 67 | Fri Oct 9 | atRays | L1-2 | 2-3 | .400 | Petco Park · San Diego, CA |
