| 1 | Thu Mar 31 | vs Tigers | W6-3 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Apr 2 | vs Tigers | W10-6 | 2-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Apr 3 | vs Tigers | L7-10 | 2-1 | .667 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 4 | vs Twins | W4-3 | 3-1 | .750 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 5 | vs Twins | L4-5 (10) | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 6 | Thu Apr 7 | vs Twins | W4-3 | 4-2 | .667 | Yankee Stadium · The Bronx, NY |
| 7 | Fri Apr 8 | at Red Sox | L6-9 | 4-3 | .571 | Fenway Park · Boston, MA |
| 8 | Sat Apr 9 | at Red Sox | W9-4 | 5-3 | .625 | Fenway Park · Boston, MA |
| 9 | Sun Apr 10 | at Red Sox | L0-4 | 5-4 | .556 | Fenway Park · Boston, MA |
| 10 | Wed Apr 13 | vs Orioles | W7-4 | 6-4 | .600 | Yankee Stadium · The Bronx, NY |
| 11 | Thu Apr 14 | vs Orioles | W6-5 (10) | 7-4 | .636 | Yankee Stadium · The Bronx, NY |
| 12 | Fri Apr 15 | vs Rangers | L3-5 | 7-5 | .583 | Yankee Stadium · The Bronx, NY |
| 13 | Sat Apr 16 | vs Rangers | W5-2 | 8-5 | .615 | Yankee Stadium · The Bronx, NY |
| 14 | Sun Apr 17 | vs Rangers | W6-5 | 9-5 | .643 | Yankee Stadium · The Bronx, NY |
| 15 | Tue Apr 19 | at Blue Jays | L5-6 (10) | 9-6 | .600 | Rogers Centre · Toronto, ON |
| 16 | Wed Apr 20 | at Blue Jays | W6-2 | 10-6 | .625 | Rogers Centre · Toronto, ON |
| 17 | Sat Apr 23 | at Orioles | W15-3 | 11-6 | .647 | Camden Yards · Baltimore, MD |
| 18 | Sun Apr 24 | at Orioles | W6-3 (11) | 12-6 | .667 | Camden Yards · Baltimore, MD |
| 19 | Mon Apr 25 | vs White Sox | L0-2 | 12-7 | .632 | Yankee Stadium · The Bronx, NY |
| 20 | Tue Apr 26 | vs White Sox | L2-3 | 12-8 | .600 | Yankee Stadium · The Bronx, NY |
| 21 | Wed Apr 27 | vs White Sox | W3-1 | 13-8 | .619 | Yankee Stadium · The Bronx, NY |
| 22 | Thu Apr 28 | vs White Sox | W12-3 | 14-8 | .636 | Yankee Stadium · The Bronx, NY |
| 23 | Fri Apr 29 | vs Blue Jays | L3-5 | 14-9 | .609 | Yankee Stadium · The Bronx, NY |
| 24 | Sat Apr 30 | vs Blue Jays | W5-4 | 15-9 | .625 | Yankee Stadium · The Bronx, NY |
| 25 | Sun May 1 | vs Blue Jays | W5-2 | 16-9 | .640 | Yankee Stadium · The Bronx, NY |
| 26 | Mon May 2 | at Tigers | W5-3 | 17-9 | .654 | Comerica Park · Detroit, MI |
| 27 | Tue May 3 | at Tigers | L2-4 | 17-10 | .630 | Comerica Park · Detroit, MI |
| 28 | Wed May 4 | at Tigers | L0-4 | 17-11 | .607 | Comerica Park · Detroit, MI |
| 29 | Thu May 5 | at Tigers | L3-6 | 17-12 | .586 | Comerica Park · Detroit, MI |
| 30 | Fri May 6 | at Rangers | W4-1 | 18-12 | .600 | Globe Life Field · Arlington, TX |
| 31 | Sat May 7 | at Rangers | L5-7 | 18-13 | .581 | Globe Life Field · Arlington, TX |
| 32 | Sun May 8 | at Rangers | W12-5 | 19-13 | .594 | Globe Life Field · Arlington, TX |
| 33 | Tue May 10 | vs Royals | W3-1 | 20-13 | .606 | Yankee Stadium · The Bronx, NY |
| 34 | Wed May 11 | vs Royals | L3-4 (11) | 20-14 | .588 | Yankee Stadium · The Bronx, NY |
| 35 | Thu May 12 | vs Royals | L5-11 | 20-15 | .571 | Yankee Stadium · The Bronx, NY |
| 36 | Fri May 13 | vs Red Sox | L4-5 | 20-16 | .556 | Yankee Stadium · The Bronx, NY |
| 37 | Sat May 14 | vs Red Sox | L0-6 | 20-17 | .541 | Yankee Stadium · The Bronx, NY |
| 38 | Sun May 15 | vs Red Sox | L5-7 | 20-18 | .526 | Yankee Stadium · The Bronx, NY |
| 39 | Mon May 16 | at Rays | L5-6 | 20-19 | .513 | Tropicana Field · St. Petersburg, FL |
| 40 | Tue May 17 | at Rays | W6-2 | 21-19 | .525 | Tropicana Field · St. Petersburg, FL |
| 41 | Wed May 18 | at Orioles | W4-1 (15) | 22-19 | .537 | Camden Yards · Baltimore, MD |
| 42 | Thu May 19 | at Orioles | W13-2 | 23-19 | .548 | Camden Yards · Baltimore, MD |
| 43 | Fri May 20 | vs Mets | L1-2 | 23-20 | .535 | Yankee Stadium · The Bronx, NY |
| 44 | Sat May 21 | vs Mets | W7-3 | 24-20 | .545 | Yankee Stadium · The Bronx, NY |
| 45 | Sun May 22 | vs Mets | W9-3 | 25-20 | .556 | Yankee Stadium · The Bronx, NY |
| 46 | Mon May 23 | vs Blue Jays | L3-7 | 25-21 | .543 | Yankee Stadium · The Bronx, NY |
| 47 | Tue May 24 | vs Blue Jays | W5-4 | 26-21 | .553 | Yankee Stadium · The Bronx, NY |
| 48 | Wed May 25 | vs Blue Jays | W7-3 | 27-21 | .563 | Yankee Stadium · The Bronx, NY |
| 49 | Fri May 27 | at Mariners | L3-4 | 27-22 | .551 | T-Mobile Park · Seattle, WA |
| 50 | Sat May 28 | at Mariners | L4-5 (12) | 27-23 | .540 | T-Mobile Park · Seattle, WA |
| 51 | Sun May 29 | at Mariners | W7-1 | 28-23 | .549 | T-Mobile Park · Seattle, WA |
| 52 | Mon May 30 | at Athletics | W5-0 | 29-23 | .558 | RingCentral Coliseum · Oakland, CA |
| 53 | Tue May 31 | at Athletics | W10-3 | 30-23 | .566 | RingCentral Coliseum · Oakland, CA |
| 54 | Wed Jun 1 | at Athletics | W4-2 | 31-23 | .574 | RingCentral Coliseum · Oakland, CA |
| 55 | Fri Jun 3 | at Angels | L2-3 | 31-24 | .564 | Angel Stadium · Anaheim, CA |
| 56 | Sat Jun 4 | at Angels | W3-2 | 32-24 | .571 | Angel Stadium · Anaheim, CA |
| 57 | Sun Jun 5 | at Angels | W5-3 | 33-24 | .579 | Angel Stadium · Anaheim, CA |
| 58 | Tue Jun 7 | vs Red Sox | L4-6 | 33-25 | .569 | Yankee Stadium · The Bronx, NY |
| 59 | Wed Jun 8 | vs Red Sox | L6-11 | 33-26 | .559 | Yankee Stadium · The Bronx, NY |
| 60 | Thu Jun 9 | vs Red Sox | L3-8 | 33-27 | .550 | Yankee Stadium · The Bronx, NY |
| 61 | Fri Jun 10 | vs Guardians | W11-7 | 34-27 | .557 | Yankee Stadium · The Bronx, NY |
| 62 | Sat Jun 11 | vs Guardians | W4-0 | 35-27 | .565 | Yankee Stadium · The Bronx, NY |
| 63 | Sun Jun 12 | vs Guardians | W9-1 | 36-27 | .571 | Yankee Stadium · The Bronx, NY |
| 64 | Mon Jun 13 | vs Guardians | L0-1 | 36-28 | .563 | Yankee Stadium · The Bronx, NY |
| 65 | Tue Jun 14 | vs Rangers | W12-4 | 37-28 | .569 | Yankee Stadium · The Bronx, NY |
| 66 | Wed Jun 15 | vs Rangers | W12-4 | 38-28 | .576 | Yankee Stadium · The Bronx, NY |
| 67 | Thu Jun 16 | vs Rangers | W3-2 (12) | 39-28 | .582 | Yankee Stadium · The Bronx, NY |
| 68 | Fri Jun 17 | at Cubs | L1-3 | 39-29 | .574 | Wrigley Field · Chicago, IL |
| 69 | Sat Jun 18 | at Cubs | W4-3 | 40-29 | .580 | Wrigley Field · Chicago, IL |
| 70 | Sun Jun 19 | at Cubs | W10-4 | 41-29 | .586 | Wrigley Field · Chicago, IL |
| 71 | Mon Jun 20 | at Reds | W5-3 | 42-29 | .592 | Great American Ball Park · Cincinnati, OH |
| 72 | Wed Jun 22 | at Reds | W4-2 | 43-29 | .597 | Great American Ball Park · Cincinnati, OH |
| 73 | Wed Jun 22 | at Reds | L2-10 | 43-30 | .589 | Great American Ball Park · Cincinnati, OH |
| 74 | Fri Jun 24 | vs Rockies | L2-4 | 43-31 | .581 | Yankee Stadium · The Bronx, NY |
| 75 | Sat Jun 25 | vs Rockies | W8-3 | 44-31 | .587 | Yankee Stadium · The Bronx, NY |
| 76 | Sun Jun 26 | vs Rockies | W6-4 | 45-31 | .592 | Yankee Stadium · The Bronx, NY |
| 77 | Tue Jun 28 | vs Brewers | W12-2 | 46-31 | .597 | Yankee Stadium · The Bronx, NY |
| 78 | Wed Jun 29 | vs Brewers | W5-2 | 47-31 | .603 | Yankee Stadium · The Bronx, NY |
| 79 | Thu Jun 30 | vs Brewers | W5-0 | 48-31 | .608 | Yankee Stadium · The Bronx, NY |
| 80 | Fri Jul 1 | at Mets | W5-1 | 49-31 | .613 | Citi Field · Queens, NY |
| 81 | Sat Jul 2 | at Mets | W5-2 | 50-31 | .617 | Citi Field · Queens, NY |
| 82 | Sun Jul 3 | at Mets | L2-3 (10) | 50-32 | .610 | Citi Field · Queens, NY |
| 83 | Mon Jul 4 | at Guardians | L3-6 | 50-33 | .602 | Progressive Field · Cleveland, OH |
| 84 | Tue Jul 5 | at Guardians | W9-2 | 51-33 | .607 | Progressive Field · Cleveland, OH |
| 85 | Wed Jul 6 | at Guardians | L3-5 | 51-34 | .600 | Progressive Field · Cleveland, OH |
| 86 | Thu Jul 7 | vs Rays | L1-5 | 51-35 | .593 | Yankee Stadium · The Bronx, NY |
| 87 | Sat Jul 9 | vs Rays | W5-4 | 52-35 | .598 | Yankee Stadium · The Bronx, NY |
| 88 | Sun Jul 10 | vs Rays | W1-0 | 53-35 | .602 | Yankee Stadium · The Bronx, NY |
| 89 | Thu Jul 14 | at Blue Jays | L7-16 | 53-36 | .596 | Rogers Centre · Toronto, ON |
| 90 | Fri Jul 15 | at Blue Jays | L1-7 | 53-37 | .589 | Rogers Centre · Toronto, ON |
| 91 | Sat Jul 16 | at Blue Jays | W4-1 | 54-37 | .593 | Rogers Centre · Toronto, ON |
| 92 | Sun Jul 17 | at Blue Jays | W7-2 | 55-37 | .598 | Rogers Centre · Toronto, ON |
| 93 | Mon Jul 18 | at Rays | W5-4 | 56-37 | .602 | Tropicana Field · St. Petersburg, FL |
| 94 | Tue Jul 19 | at Rays | L2-3 | 56-38 | .596 | Tropicana Field · St. Petersburg, FL |
| 95 | Wed Jul 20 | at Rays | W4-0 | 57-38 | .600 | Tropicana Field · St. Petersburg, FL |
| 96 | Thu Jul 21 | at Rays | L1-2 | 57-39 | .594 | Tropicana Field · St. Petersburg, FL |
| 97 | Fri Jul 22 | vs Athletics | W17-7 | 58-39 | .598 | Yankee Stadium · The Bronx, NY |
| 98 | Sat Jul 23 | vs Athletics | L3-4 | 58-40 | .592 | Yankee Stadium · The Bronx, NY |
| 99 | Sun Jul 24 | vs Athletics | W7-5 | 59-40 | .596 | Yankee Stadium · The Bronx, NY |
| 100 | Mon Jul 25 | vs Mariners | W10-3 | 60-40 | .600 | Yankee Stadium · The Bronx, NY |
| 101 | Tue Jul 26 | vs Mariners | W4-1 | 61-40 | .604 | Yankee Stadium · The Bronx, NY |
| 102 | Wed Jul 27 | vs Mariners | L2-9 | 61-41 | .598 | Yankee Stadium · The Bronx, NY |
| 103 | Fri Jul 29 | vs Orioles | L2-4 | 61-42 | .592 | Yankee Stadium · The Bronx, NY |
| 104 | Sat Jul 30 | vs Orioles | W8-3 | 62-42 | .596 | Yankee Stadium · The Bronx, NY |
| 105 | Sat Jul 30 | vs Orioles | W17-3 | 63-42 | .600 | Yankee Stadium · The Bronx, NY |
| 106 | Sun Jul 31 | vs Orioles | W4-2 | 64-42 | .604 | Yankee Stadium · The Bronx, NY |
| 107 | Mon Aug 1 | at White Sox | W3-2 | 65-42 | .607 | Guaranteed Rate Field · Chicago, IL |
| 108 | Tue Aug 2 | at White Sox | W6-0 | 66-42 | .611 | Guaranteed Rate Field · Chicago, IL |
| 109 | Wed Aug 3 | at White Sox | W18-7 | 67-42 | .615 | Guaranteed Rate Field · Chicago, IL |
| 110 | Thu Aug 4 | at White Sox | W7-2 | 68-42 | .618 | Guaranteed Rate Field · Chicago, IL |
| 111 | Fri Aug 5 | at Red Sox | W3-2 | 69-42 | .622 | Fenway Park · Boston, MA |
| 112 | Sat Aug 6 | at Red Sox | L4-10 | 69-43 | .616 | Fenway Park · Boston, MA |
| 113 | Sun Aug 7 | at Red Sox | L2-3 (10) | 69-44 | .611 | Fenway Park · Boston, MA |
| 114 | Tue Aug 9 | vs Angels | L4-6 | 69-45 | .605 | Yankee Stadium · The Bronx, NY |
| 115 | Wed Aug 10 | vs Angels | W9-3 | 70-45 | .609 | Yankee Stadium · The Bronx, NY |
| 116 | Thu Aug 11 | vs Angels | W6-5 | 71-45 | .612 | Yankee Stadium · The Bronx, NY |
| 117 | Fri Aug 12 | vs Rays | L1-5 | 71-46 | .607 | Yankee Stadium · The Bronx, NY |
| 118 | Sat Aug 13 | vs Rays | W9-2 | 72-46 | .610 | Yankee Stadium · The Bronx, NY |
| 119 | Mon Aug 15 | at Royals | W7-4 | 73-46 | .613 | Kauffman Stadium · Kansas City, MO |
| 120 | Tue Aug 16 | at Royals | W9-7 | 74-46 | .617 | Kauffman Stadium · Kansas City, MO |
| 121 | Wed Aug 17 | at Royals | L4-5 | 74-47 | .612 | Kauffman Stadium · Kansas City, MO |
| 122 | Thu Aug 18 | at Twins | W8-4 | 75-47 | .615 | Target Field · Minneapolis, MN |
| 123 | Fri Aug 19 | at Twins | W8-1 | 76-47 | .618 | Target Field · Minneapolis, MN |
| 124 | Sat Aug 20 | at Twins | L4-9 | 76-48 | .613 | Target Field · Minneapolis, MN |
| 125 | Sun Aug 21 | at Twins | W3-0 | 77-48 | .616 | Target Field · Minneapolis, MN |
| 126 | Tue Aug 23 | vs Athletics | L5-6 | 77-49 | .611 | Yankee Stadium · The Bronx, NY |
| 127 | Wed Aug 24 | vs Athletics | L4-6 (10) | 77-50 | .606 | Yankee Stadium · The Bronx, NY |
| 128 | Thu Aug 25 | vs Athletics | W22-9 | 78-50 | .609 | Yankee Stadium · The Bronx, NY |
| 129 | Fri Aug 26 | at Orioles | L5-12 | 78-51 | .605 | Camden Yards · Baltimore, MD |
| 130 | Sun Aug 28 | at Orioles | L0-2 | 78-52 | .600 | Camden Yards · Baltimore, MD |
| 131 | Sun Aug 28 | at Orioles | W8-3 | 79-52 | .603 | Camden Yards · Baltimore, MD |
| 132 | Mon Aug 29 | at Orioles | W3-2 | 80-52 | .606 | Camden Yards · Baltimore, MD |
| 133 | Tue Aug 30 | at Red Sox | W5-2 | 81-52 | .609 | Fenway Park · Boston, MA |
| 134 | Wed Aug 31 | at Red Sox | L5-9 | 81-53 | .604 | Fenway Park · Boston, MA |
| 135 | Thu Sep 1 | at Red Sox | W4-2 | 82-53 | .607 | Fenway Park · Boston, MA |
| 136 | Fri Sep 2 | vs Blue Jays | W3-2 | 83-53 | .610 | Yankee Stadium · The Bronx, NY |
| 137 | Sat Sep 3 | vs Blue Jays | W6-4 | 84-53 | .613 | Yankee Stadium · The Bronx, NY |
| 138 | Sun Sep 4 | vs Blue Jays | W9-3 | 85-53 | .616 | Yankee Stadium · The Bronx, NY |
| 139 | Mon Sep 5 | vs Orioles | W11-10 | 86-53 | .619 | Yankee Stadium · The Bronx, NY |
| 140 | Tue Sep 6 | vs Orioles | W5-3 | 87-53 | .621 | Yankee Stadium · The Bronx, NY |
| 141 | Wed Sep 7 | vs Orioles | L4-5 (11) | 87-54 | .617 | Yankee Stadium · The Bronx, NY |
| 142 | Thu Sep 8 | at Orioles | L4-5 (10) | 87-55 | .613 | Camden Yards · Baltimore, MD |
| 143 | Fri Sep 9 | at Angels | L1-2 | 87-56 | .608 | Angel Stadium · Anaheim, CA |
| 144 | Sat Sep 10 | at Angels | L0-6 | 87-57 | .604 | Angel Stadium · Anaheim, CA |
| 145 | Sun Sep 11 | at Angels | W6-5 | 88-57 | .607 | Angel Stadium · Anaheim, CA |
| 146 | Mon Sep 12 | at Mariners | W9-3 | 89-57 | .610 | T-Mobile Park · Seattle, WA |
| 147 | Tue Sep 13 | at Mariners | W3-2 | 90-57 | .612 | T-Mobile Park · Seattle, WA |
| 148 | Wed Sep 14 | at Mariners | L1-2 (12) | 90-58 | .608 | T-Mobile Park · Seattle, WA |
| 149 | Fri Sep 16 | at Blue Jays | L4-5 | 90-59 | .604 | Rogers Centre · Toronto, ON |
| 150 | Sat Sep 17 | at Blue Jays | W7-6 | 91-59 | .607 | Rogers Centre · Toronto, ON |
| 151 | Sun Sep 18 | at Blue Jays | L0-3 | 91-60 | .603 | Rogers Centre · Toronto, ON |
| 152 | Mon Sep 19 | vs Twins | W6-4 | 92-60 | .605 | Yankee Stadium · The Bronx, NY |
| 153 | Tue Sep 20 | vs Rays | W5-0 | 93-60 | .608 | Yankee Stadium · The Bronx, NY |
| 154 | Wed Sep 21 | vs Rays | W4-2 | 94-60 | .610 | Yankee Stadium · The Bronx, NY |
| 155 | Wed Sep 21 | vs Rays | W4-2 | 95-60 | .613 | Yankee Stadium · The Bronx, NY |
| 156 | Thu Sep 22 | vs Rays | L8-15 | 95-61 | .609 | Yankee Stadium · The Bronx, NY |
| 157 | Sat Sep 24 | vs Red Sox | W9-1 | 96-61 | .611 | Yankee Stadium · The Bronx, NY |
| 158 | Sun Sep 25 | vs Red Sox | W6-2 | 97-61 | .614 | Yankee Stadium · The Bronx, NY |
| 159 | Sun Sep 25 | vs Red Sox | L4-7 (14) | 97-62 | .610 | Yankee Stadium · The Bronx, NY |
| 160 | Mon Sep 26 | at Rays | L2-5 | 97-63 | .606 | Tropicana Field · St. Petersburg, FL |
| 161 | Tue Sep 27 | at Rays | L3-5 | 97-64 | .602 | Tropicana Field · St. Petersburg, FL |
| 162 | Wed Sep 28 | at Rays | L7-8 (12) | 97-65 | .599 | Tropicana Field · St. Petersburg, FL |
| 163 | Sat Oct 1 | vs Tigers | W9-3 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Sun Oct 2 | vs Tigers | L3-5 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 165 | Mon Oct 3 | at Tigers | L4-5 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 166 | Tue Oct 4 | at Tigers | W10-1 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 167 | Thu Oct 6 | vs Tigers | L2-3 | 2-3 | .400 | Yankee Stadium · The Bronx, NY |