| 1 | Fri Apr 8 | vs Red Sox | W6-5 (11) | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Apr 9 | vs Red Sox | W4-2 | 2-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Apr 10 | vs Red Sox | L3-4 | 2-1 | .667 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 11 | vs Blue Jays | L0-3 | 2-2 | .500 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 12 | vs Blue Jays | W4-0 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 6 | Wed Apr 13 | vs Blue Jays | L4-6 | 3-3 | .500 | Yankee Stadium · The Bronx, NY |
| 7 | Thu Apr 14 | vs Blue Jays | W3-0 | 4-3 | .571 | Yankee Stadium · The Bronx, NY |
| 8 | Fri Apr 15 | at Orioles | L1-2 (11) | 4-4 | .500 | Camden Yards · Baltimore, MD |
| 9 | Sat Apr 16 | at Orioles | W5-2 | 5-4 | .556 | Camden Yards · Baltimore, MD |
| 10 | Sun Apr 17 | at Orioles | L0-5 | 5-5 | .500 | Camden Yards · Baltimore, MD |
| 11 | Tue Apr 19 | at Tigers | W4-2 | 6-5 | .545 | Comerica Park · Detroit, MI |
| 12 | Wed Apr 20 | at Tigers | W5-3 | 7-5 | .583 | Comerica Park · Detroit, MI |
| 13 | Thu Apr 21 | at Tigers | L0-3 | 7-6 | .538 | Comerica Park · Detroit, MI |
| 14 | Fri Apr 22 | vs Guardians | W4-1 | 8-6 | .571 | Yankee Stadium · The Bronx, NY |
| 15 | Sat Apr 23 | vs Guardians | W5-4 | 9-6 | .600 | Yankee Stadium · The Bronx, NY |
| 16 | Sun Apr 24 | vs Guardians | W10-2 | 10-6 | .625 | Yankee Stadium · The Bronx, NY |
| 17 | Tue Apr 26 | vs Orioles | W12-8 | 11-6 | .647 | Yankee Stadium · The Bronx, NY |
| 18 | Wed Apr 27 | vs Orioles | W5-2 | 12-6 | .667 | Yankee Stadium · The Bronx, NY |
| 19 | Thu Apr 28 | vs Orioles | W10-5 | 13-6 | .684 | Yankee Stadium · The Bronx, NY |
| 20 | Fri Apr 29 | at Royals | W12-2 | 14-6 | .700 | Kauffman Stadium · Kansas City, MO |
| 21 | Sat Apr 30 | at Royals | W3-0 | 15-6 | .714 | Kauffman Stadium · Kansas City, MO |
| 22 | Sun May 1 | at Royals | W6-4 | 16-6 | .727 | Kauffman Stadium · Kansas City, MO |
| 23 | Mon May 2 | at Blue Jays | W3-2 | 17-6 | .739 | Rogers Centre · Toronto, ON |
| 24 | Tue May 3 | at Blue Jays | W9-1 | 18-6 | .750 | Rogers Centre · Toronto, ON |
| 25 | Wed May 4 | at Blue Jays | L1-2 | 18-7 | .720 | Rogers Centre · Toronto, ON |
| 26 | Sun May 8 | vs Rangers | W2-1 | 19-7 | .731 | Yankee Stadium · The Bronx, NY |
| 27 | Sun May 8 | vs Rangers | L2-4 | 19-8 | .704 | Yankee Stadium · The Bronx, NY |
| 28 | Mon May 9 | vs Rangers | W1-0 | 20-8 | .714 | Yankee Stadium · The Bronx, NY |
| 29 | Tue May 10 | vs Blue Jays | W6-5 | 21-8 | .724 | Yankee Stadium · The Bronx, NY |
| 30 | Wed May 11 | vs Blue Jays | W5-3 | 22-8 | .733 | Yankee Stadium · The Bronx, NY |
| 31 | Thu May 12 | at White Sox | W15-7 | 23-8 | .742 | Guaranteed Rate Field · Chicago, IL |
| 32 | Fri May 13 | at White Sox | W10-4 | 24-8 | .750 | Guaranteed Rate Field · Chicago, IL |
| 33 | Sat May 14 | at White Sox | L2-3 | 24-9 | .727 | Guaranteed Rate Field · Chicago, IL |
| 34 | Sun May 15 | at White Sox | W5-1 | 25-9 | .735 | Guaranteed Rate Field · Chicago, IL |
| 35 | Mon May 16 | at Orioles | W6-2 | 26-9 | .743 | Camden Yards · Baltimore, MD |
| 36 | Tue May 17 | at Orioles | W5-4 | 27-9 | .750 | Camden Yards · Baltimore, MD |
| 37 | Wed May 18 | at Orioles | W3-2 | 28-9 | .757 | Camden Yards · Baltimore, MD |
| 38 | Thu May 19 | at Orioles | L6-9 | 28-10 | .737 | Camden Yards · Baltimore, MD |
| 39 | Sat May 21 | vs White Sox | W7-5 | 29-10 | .744 | Yankee Stadium · The Bronx, NY |
| 40 | Sun May 22 | vs White Sox | L1-3 | 29-11 | .725 | Yankee Stadium · The Bronx, NY |
| 41 | Sun May 22 | vs White Sox | L0-5 | 29-12 | .707 | Yankee Stadium · The Bronx, NY |
| 42 | Mon May 23 | vs Orioles | L4-6 | 29-13 | .690 | Yankee Stadium · The Bronx, NY |
| 43 | Tue May 24 | vs Orioles | W7-6 (11) | 30-13 | .698 | Yankee Stadium · The Bronx, NY |
| 44 | Wed May 25 | vs Orioles | W2-0 | 31-13 | .705 | Yankee Stadium · The Bronx, NY |
| 45 | Thu May 26 | at Rays | W7-2 | 32-13 | .711 | Tropicana Field · St. Petersburg, FL |
| 46 | Fri May 27 | at Rays | W2-0 | 33-13 | .717 | Tropicana Field · St. Petersburg, FL |
| 47 | Sat May 28 | at Rays | L1-3 | 33-14 | .702 | Tropicana Field · St. Petersburg, FL |
| 48 | Sun May 29 | at Rays | L2-4 | 33-15 | .688 | Tropicana Field · St. Petersburg, FL |
| 49 | Tue May 31 | vs Angels | W9-1 | 34-15 | .694 | Yankee Stadium · The Bronx, NY |
| 50 | Thu Jun 2 | vs Angels | W6-1 | 35-15 | .700 | Yankee Stadium · The Bronx, NY |
| 51 | Thu Jun 2 | vs Angels | W2-1 | 36-15 | .706 | Yankee Stadium · The Bronx, NY |
| 52 | Fri Jun 3 | vs Tigers | W13-0 | 37-15 | .712 | Yankee Stadium · The Bronx, NY |
| 53 | Sat Jun 4 | vs Tigers | W3-0 | 38-15 | .717 | Yankee Stadium · The Bronx, NY |
| 54 | Sun Jun 5 | vs Tigers | W5-4 (10) | 39-15 | .722 | Yankee Stadium · The Bronx, NY |
| 55 | Tue Jun 7 | at Twins | W10-4 | 40-15 | .727 | Target Field · Minneapolis, MN |
| 56 | Wed Jun 8 | at Twins | L1-8 | 40-16 | .714 | Target Field · Minneapolis, MN |
| 57 | Thu Jun 9 | at Twins | W10-7 | 41-16 | .719 | Target Field · Minneapolis, MN |
| 58 | Fri Jun 10 | vs Cubs | W2-1 (13) | 42-16 | .724 | Yankee Stadium · The Bronx, NY |
| 59 | Sat Jun 11 | vs Cubs | W8-0 | 43-16 | .729 | Yankee Stadium · The Bronx, NY |
| 60 | Sun Jun 12 | vs Cubs | W18-4 | 44-16 | .733 | Yankee Stadium · The Bronx, NY |
| 61 | Tue Jun 14 | vs Rays | W2-0 | 45-16 | .738 | Yankee Stadium · The Bronx, NY |
| 62 | Wed Jun 15 | vs Rays | W4-3 | 46-16 | .742 | Yankee Stadium · The Bronx, NY |
| 63 | Thu Jun 16 | vs Rays | W2-1 | 47-16 | .746 | Yankee Stadium · The Bronx, NY |
| 64 | Fri Jun 17 | at Blue Jays | W12-3 | 48-16 | .750 | Rogers Centre · Toronto, ON |
| 65 | Sat Jun 18 | at Blue Jays | W4-0 | 49-16 | .754 | Rogers Centre · Toronto, ON |
| 66 | Sun Jun 19 | at Blue Jays | L9-10 | 49-17 | .742 | Rogers Centre · Toronto, ON |
| 67 | Mon Jun 20 | at Rays | W4-2 | 50-17 | .746 | Tropicana Field · St. Petersburg, FL |
| 68 | Tue Jun 21 | at Rays | L4-5 | 50-18 | .735 | Tropicana Field · St. Petersburg, FL |
| 69 | Wed Jun 22 | at Rays | W5-4 | 51-18 | .739 | Tropicana Field · St. Petersburg, FL |
| 70 | Thu Jun 23 | vs Astros | W7-6 | 52-18 | .743 | Yankee Stadium · The Bronx, NY |
| 71 | Fri Jun 24 | vs Astros | L1-3 | 52-19 | .732 | Yankee Stadium · The Bronx, NY |
| 72 | Sat Jun 25 | vs Astros | L0-3 | 52-20 | .722 | Yankee Stadium · The Bronx, NY |
| 73 | Sun Jun 26 | vs Astros | W6-3 (10) | 53-20 | .726 | Yankee Stadium · The Bronx, NY |
| 74 | Mon Jun 27 | vs Athletics | W9-5 | 54-20 | .730 | Yankee Stadium · The Bronx, NY |
| 75 | Tue Jun 28 | vs Athletics | W2-1 | 55-20 | .733 | Yankee Stadium · The Bronx, NY |
| 76 | Wed Jun 29 | vs Athletics | W5-3 | 56-20 | .737 | Yankee Stadium · The Bronx, NY |
| 77 | Thu Jun 30 | at Astros | L1-2 | 56-21 | .727 | Minute Maid Park · Houston, TX |
| 78 | Sat Jul 2 | at Guardians | W13-4 | 57-21 | .731 | Progressive Field · Cleveland, OH |
| 79 | Sat Jul 2 | at Guardians | W6-1 | 58-21 | .734 | Progressive Field · Cleveland, OH |
| 80 | Sun Jul 3 | at Guardians | L0-2 | 58-22 | .725 | Progressive Field · Cleveland, OH |
| 81 | Tue Jul 5 | at Pirates | L2-5 | 58-23 | .716 | PNC Park · Pittsburgh, PA |
| 82 | Wed Jul 6 | at Pirates | W16-0 | 59-23 | .720 | PNC Park · Pittsburgh, PA |
| 83 | Thu Jul 7 | at Red Sox | W6-5 | 60-23 | .723 | Fenway Park · Boston, MA |
| 84 | Fri Jul 8 | at Red Sox | W12-5 | 61-23 | .726 | Fenway Park · Boston, MA |
| 85 | Sat Jul 9 | at Red Sox | L5-6 (10) | 61-24 | .718 | Fenway Park · Boston, MA |
| 86 | Sun Jul 10 | at Red Sox | L6-11 | 61-25 | .709 | Fenway Park · Boston, MA |
| 87 | Tue Jul 12 | vs Reds | L3-4 | 61-26 | .701 | Yankee Stadium · The Bronx, NY |
| 88 | Wed Jul 13 | vs Reds | W7-6 (10) | 62-26 | .705 | Yankee Stadium · The Bronx, NY |
| 89 | Thu Jul 14 | vs Reds | L6-7 (10) | 62-27 | .697 | Yankee Stadium · The Bronx, NY |
| 90 | Fri Jul 15 | vs Red Sox | L4-5 (11) | 62-28 | .689 | Yankee Stadium · The Bronx, NY |
| 91 | Sat Jul 16 | vs Red Sox | W14-1 | 63-28 | .692 | Yankee Stadium · The Bronx, NY |
| 92 | Sun Jul 17 | vs Red Sox | W13-2 | 64-28 | .696 | Yankee Stadium · The Bronx, NY |
| 93 | Thu Jul 21 | at Astros | L2-3 | 64-29 | .688 | Minute Maid Park · Houston, TX |
| 94 | Thu Jul 21 | at Astros | L5-7 | 64-30 | .681 | Minute Maid Park · Houston, TX |
| 95 | Fri Jul 22 | at Orioles | W7-6 | 65-30 | .684 | Camden Yards · Baltimore, MD |
| 96 | Sat Jul 23 | at Orioles | L3-6 | 65-31 | .677 | Camden Yards · Baltimore, MD |
| 97 | Sun Jul 24 | at Orioles | W6-0 | 66-31 | .680 | Camden Yards · Baltimore, MD |
| 98 | Tue Jul 26 | at Mets | L3-6 | 66-32 | .673 | Citi Field · Queens, NY |
| 99 | Wed Jul 27 | at Mets | L2-3 | 66-33 | .667 | Citi Field · Queens, NY |
| 100 | Thu Jul 28 | vs Royals | W1-0 | 67-33 | .670 | Yankee Stadium · The Bronx, NY |
| 101 | Fri Jul 29 | vs Royals | W11-5 | 68-33 | .673 | Yankee Stadium · The Bronx, NY |
| 102 | Sat Jul 30 | vs Royals | W8-2 | 69-33 | .676 | Yankee Stadium · The Bronx, NY |
| 103 | Sun Jul 31 | vs Royals | L6-8 | 69-34 | .670 | Yankee Stadium · The Bronx, NY |
| 104 | Mon Aug 1 | vs Mariners | W7-2 | 70-34 | .673 | Yankee Stadium · The Bronx, NY |
| 105 | Tue Aug 2 | vs Mariners | L6-8 | 70-35 | .667 | Yankee Stadium · The Bronx, NY |
| 106 | Wed Aug 3 | vs Mariners | L3-7 | 70-36 | .660 | Yankee Stadium · The Bronx, NY |
| 107 | Fri Aug 5 | at Cardinals | L3-4 | 70-37 | .654 | Busch Stadium · St. Louis, MO |
| 108 | Sat Aug 6 | at Cardinals | L0-1 | 70-38 | .648 | Busch Stadium · St. Louis, MO |
| 109 | Sun Aug 7 | at Cardinals | L9-12 | 70-39 | .642 | Busch Stadium · St. Louis, MO |
| 110 | Mon Aug 8 | at Mariners | W9-4 | 71-39 | .645 | T-Mobile Park · Seattle, WA |
| 111 | Tue Aug 9 | at Mariners | L0-1 (13) | 71-40 | .640 | T-Mobile Park · Seattle, WA |
| 112 | Wed Aug 10 | at Mariners | L3-4 | 71-41 | .634 | T-Mobile Park · Seattle, WA |
| 113 | Fri Aug 12 | at Red Sox | L2-3 (10) | 71-42 | .628 | Fenway Park · Boston, MA |
| 114 | Sat Aug 13 | at Red Sox | W3-2 | 72-42 | .632 | Fenway Park · Boston, MA |
| 115 | Sun Aug 14 | at Red Sox | L0-3 | 72-43 | .626 | Fenway Park · Boston, MA |
| 116 | Mon Aug 15 | vs Rays | L0-4 | 72-44 | .621 | Yankee Stadium · The Bronx, NY |
| 117 | Tue Aug 16 | vs Rays | L1-3 | 72-45 | .615 | Yankee Stadium · The Bronx, NY |
| 118 | Wed Aug 17 | vs Rays | W8-7 (10) | 73-45 | .619 | Yankee Stadium · The Bronx, NY |
| 119 | Thu Aug 18 | vs Blue Jays | L2-9 | 73-46 | .613 | Yankee Stadium · The Bronx, NY |
| 120 | Fri Aug 19 | vs Blue Jays | L0-4 | 73-47 | .608 | Yankee Stadium · The Bronx, NY |
| 121 | Sat Aug 20 | vs Blue Jays | L2-5 | 73-48 | .603 | Yankee Stadium · The Bronx, NY |
| 122 | Sun Aug 21 | vs Blue Jays | W4-2 | 74-48 | .607 | Yankee Stadium · The Bronx, NY |
| 123 | Mon Aug 22 | vs Mets | W4-2 | 75-48 | .610 | Yankee Stadium · The Bronx, NY |
| 124 | Tue Aug 23 | vs Mets | W4-2 | 76-48 | .613 | Yankee Stadium · The Bronx, NY |
| 125 | Thu Aug 25 | at Athletics | W13-4 | 77-48 | .616 | RingCentral Coliseum · Oakland, CA |
| 126 | Fri Aug 26 | at Athletics | W3-2 | 78-48 | .619 | RingCentral Coliseum · Oakland, CA |
| 127 | Sat Aug 27 | at Athletics | L2-3 (11) | 78-49 | .614 | RingCentral Coliseum · Oakland, CA |
| 128 | Sun Aug 28 | at Athletics | L1-4 | 78-50 | .609 | RingCentral Coliseum · Oakland, CA |
| 129 | Mon Aug 29 | at Angels | L3-4 | 78-51 | .605 | Angel Stadium · Anaheim, CA |
| 130 | Tue Aug 30 | at Angels | W7-4 | 79-51 | .608 | Angel Stadium · Anaheim, CA |
| 131 | Wed Aug 31 | at Angels | L2-3 | 79-52 | .603 | Angel Stadium · Anaheim, CA |
| 132 | Fri Sep 2 | at Rays | L0-9 | 79-53 | .598 | Tropicana Field · St. Petersburg, FL |
| 133 | Sat Sep 3 | at Rays | L1-2 | 79-54 | .594 | Tropicana Field · St. Petersburg, FL |
| 134 | Sun Sep 4 | at Rays | W2-1 | 80-54 | .597 | Tropicana Field · St. Petersburg, FL |
| 135 | Mon Sep 5 | vs Twins | W5-2 | 81-54 | .600 | Yankee Stadium · The Bronx, NY |
| 136 | Wed Sep 7 | vs Twins | W5-4 (12) | 82-54 | .603 | Yankee Stadium · The Bronx, NY |
| 137 | Wed Sep 7 | vs Twins | W7-1 | 83-54 | .606 | Yankee Stadium · The Bronx, NY |
| 138 | Thu Sep 8 | vs Twins | L3-4 | 83-55 | .601 | Yankee Stadium · The Bronx, NY |
| 139 | Fri Sep 9 | vs Rays | L2-4 | 83-56 | .597 | Yankee Stadium · The Bronx, NY |
| 140 | Sat Sep 10 | vs Rays | W10-3 | 84-56 | .600 | Yankee Stadium · The Bronx, NY |
| 141 | Sun Sep 11 | vs Rays | W10-4 | 85-56 | .603 | Yankee Stadium · The Bronx, NY |
| 142 | Tue Sep 13 | at Red Sox | W7-6 (10) | 86-56 | .606 | Fenway Park · Boston, MA |
| 143 | Wed Sep 14 | at Red Sox | W5-3 | 87-56 | .608 | Fenway Park · Boston, MA |
| 144 | Fri Sep 16 | at Brewers | L6-7 | 87-57 | .604 | American Family Field · Milwaukee, WI |
| 145 | Sat Sep 17 | at Brewers | L1-4 | 87-58 | .600 | American Family Field · Milwaukee, WI |
| 146 | Sun Sep 18 | at Brewers | W12-8 | 88-58 | .603 | American Family Field · Milwaukee, WI |
| 147 | Tue Sep 20 | vs Pirates | W9-8 | 89-58 | .605 | Yankee Stadium · The Bronx, NY |
| 148 | Wed Sep 21 | vs Pirates | W14-2 | 90-58 | .608 | Yankee Stadium · The Bronx, NY |
| 149 | Thu Sep 22 | vs Red Sox | W5-4 (10) | 91-58 | .611 | Yankee Stadium · The Bronx, NY |
| 150 | Fri Sep 23 | vs Red Sox | W5-4 | 92-58 | .613 | Yankee Stadium · The Bronx, NY |
| 151 | Sat Sep 24 | vs Red Sox | W7-5 | 93-58 | .616 | Yankee Stadium · The Bronx, NY |
| 152 | Sun Sep 25 | vs Red Sox | W2-0 | 94-58 | .618 | Yankee Stadium · The Bronx, NY |
| 153 | Mon Sep 26 | at Blue Jays | L2-3 (10) | 94-59 | .614 | Rogers Centre · Toronto, ON |
| 154 | Tue Sep 27 | at Blue Jays | W5-2 | 95-59 | .617 | Rogers Centre · Toronto, ON |
| 155 | Wed Sep 28 | at Blue Jays | W8-3 | 96-59 | .619 | Rogers Centre · Toronto, ON |
| 156 | Fri Sep 30 | vs Orioles | L1-2 | 96-60 | .615 | Yankee Stadium · The Bronx, NY |
| 157 | Sat Oct 1 | vs Orioles | W8-0 | 97-60 | .618 | Yankee Stadium · The Bronx, NY |
| 158 | Sun Oct 2 | vs Orioles | L1-3 | 97-61 | .614 | Yankee Stadium · The Bronx, NY |
| 159 | Mon Oct 3 | at Rangers | W3-1 | 98-61 | .616 | Globe Life Field · Arlington, TX |
| 160 | Tue Oct 4 | at Rangers | W5-4 | 99-61 | .619 | Globe Life Field · Arlington, TX |
| 161 | Tue Oct 4 | at Rangers | L2-3 | 99-62 | .615 | Globe Life Field · Arlington, TX |
| 162 | Wed Oct 5 | at Rangers | L2-4 | 99-63 | .611 | Globe Life Field · Arlington, TX |
| 163 | Tue Oct 11 | vs Guardians | W4-1 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Fri Oct 14 | vs Guardians | L2-4 (10) | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 165 | Sat Oct 15 | at Guardians | L5-6 | 1-2 | .333 | Progressive Field · Cleveland, OH |
| 166 | Sun Oct 16 | at Guardians | W4-2 | 2-2 | .500 | Progressive Field · Cleveland, OH |
| 167 | Tue Oct 18 | vs Guardians | W5-1 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 168 | Wed Oct 19 | at Astros | L2-4 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 169 | Thu Oct 20 | at Astros | L2-3 | 0-2 | .000 | Minute Maid Park · Houston, TX |
| 170 | Sat Oct 22 | vs Astros | L0-5 | 0-3 | .000 | Yankee Stadium · The Bronx, NY |
| 171 | Sun Oct 23 | vs Astros | L5-6 | 0-4 | .000 | Yankee Stadium · The Bronx, NY |