| 1 | Thu Mar 28 | vs Orioles | W7-2 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Mar 30 | vs Orioles | L3-5 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Mar 31 | vs Orioles | L5-7 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 1 | vs Tigers | W3-1 | 2-2 | .500 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 2 | vs Tigers | L1-3 | 2-3 | .400 | Yankee Stadium · The Bronx, NY |
| 6 | Wed Apr 3 | vs Tigers | L1-2 | 2-4 | .333 | Yankee Stadium · The Bronx, NY |
| 7 | Thu Apr 4 | at Orioles | W8-4 | 3-4 | .429 | Camden Yards · Baltimore, MD |
| 8 | Sat Apr 6 | at Orioles | W6-4 | 4-4 | .500 | Camden Yards · Baltimore, MD |
| 9 | Sun Apr 7 | at Orioles | W15-3 | 5-4 | .556 | Camden Yards · Baltimore, MD |
| 10 | Mon Apr 8 | at Astros | L3-4 | 5-5 | .500 | Minute Maid Park · Houston, TX |
| 11 | Tue Apr 9 | at Astros | L3-6 | 5-6 | .455 | Minute Maid Park · Houston, TX |
| 12 | Wed Apr 10 | at Astros | L6-8 | 5-7 | .417 | Minute Maid Park · Houston, TX |
| 13 | Fri Apr 12 | vs White Sox | L6-9 | 5-8 | .385 | Yankee Stadium · The Bronx, NY |
| 14 | Sat Apr 13 | vs White Sox | W4-0 | 6-8 | .429 | Yankee Stadium · The Bronx, NY |
| 15 | Sun Apr 14 | vs White Sox | L2-5 | 6-9 | .400 | Yankee Stadium · The Bronx, NY |
| 16 | Tue Apr 16 | vs Red Sox | W8-0 | 7-9 | .438 | Yankee Stadium · The Bronx, NY |
| 17 | Wed Apr 17 | vs Red Sox | W5-3 | 8-9 | .471 | Yankee Stadium · The Bronx, NY |
| 18 | Thu Apr 18 | vs Royals | L1-6 | 8-10 | .444 | Yankee Stadium · The Bronx, NY |
| 19 | Fri Apr 19 | vs Royals | W6-2 | 9-10 | .474 | Yankee Stadium · The Bronx, NY |
| 20 | Sat Apr 20 | vs Royals | W9-2 | 10-10 | .500 | Yankee Stadium · The Bronx, NY |
| 21 | Sun Apr 21 | vs Royals | W7-6 (10) | 11-10 | .524 | Yankee Stadium · The Bronx, NY |
| 22 | Mon Apr 22 | at Angels | W4-3 (14) | 12-10 | .545 | Angel Stadium · Anaheim, CA |
| 23 | Tue Apr 23 | at Angels | W7-5 | 13-10 | .565 | Angel Stadium · Anaheim, CA |
| 24 | Wed Apr 24 | at Angels | W6-5 | 14-10 | .583 | Angel Stadium · Anaheim, CA |
| 25 | Thu Apr 25 | at Angels | L5-11 | 14-11 | .560 | Angel Stadium · Anaheim, CA |
| 26 | Fri Apr 26 | at Giants | W7-3 | 15-11 | .577 | Oracle Park · San Francisco, CA |
| 27 | Sat Apr 27 | at Giants | W6-4 | 16-11 | .593 | Oracle Park · San Francisco, CA |
| 28 | Sun Apr 28 | at Giants | W11-5 | 17-11 | .607 | Oracle Park · San Francisco, CA |
| 29 | Tue Apr 30 | at D-backs | L1-3 | 17-12 | .586 | Chase Field · Phoenix, AZ |
| 30 | Wed May 1 | at D-backs | L2-3 | 17-13 | .567 | Chase Field · Phoenix, AZ |
| 31 | Fri May 3 | vs Twins | W6-3 | 18-13 | .581 | Yankee Stadium · The Bronx, NY |
| 32 | Sat May 4 | vs Twins | L3-7 | 18-14 | .563 | Yankee Stadium · The Bronx, NY |
| 33 | Sun May 5 | vs Twins | W4-1 | 19-14 | .576 | Yankee Stadium · The Bronx, NY |
| 34 | Mon May 6 | vs Mariners | W7-3 | 20-14 | .588 | Yankee Stadium · The Bronx, NY |
| 35 | Tue May 7 | vs Mariners | W5-4 | 21-14 | .600 | Yankee Stadium · The Bronx, NY |
| 36 | Wed May 8 | vs Mariners | L1-10 | 21-15 | .583 | Yankee Stadium · The Bronx, NY |
| 37 | Thu May 9 | vs Mariners | W3-1 | 22-15 | .595 | Yankee Stadium · The Bronx, NY |
| 38 | Fri May 10 | at Rays | W4-3 | 23-15 | .605 | Tropicana Field · St. Petersburg, FL |
| 39 | Sat May 11 | at Rays | L2-7 | 23-16 | .590 | Tropicana Field · St. Petersburg, FL |
| 40 | Sun May 12 | at Rays | W7-1 | 24-16 | .600 | Tropicana Field · St. Petersburg, FL |
| 41 | Wed May 15 | vs Orioles | W5-3 | 25-16 | .610 | Yankee Stadium · The Bronx, NY |
| 42 | Wed May 15 | vs Orioles | W3-1 | 26-16 | .619 | Yankee Stadium · The Bronx, NY |
| 43 | Fri May 17 | vs Rays | W4-3 | 27-16 | .628 | Yankee Stadium · The Bronx, NY |
| 44 | Sat May 18 | vs Rays | L1-2 (11) | 27-17 | .614 | Yankee Stadium · The Bronx, NY |
| 45 | Sun May 19 | vs Rays | W13-5 | 28-17 | .622 | Yankee Stadium · The Bronx, NY |
| 46 | Mon May 20 | at Orioles | W10-7 | 29-17 | .630 | Camden Yards · Baltimore, MD |
| 47 | Tue May 21 | at Orioles | W11-4 | 30-17 | .638 | Camden Yards · Baltimore, MD |
| 48 | Wed May 22 | at Orioles | W7-5 | 31-17 | .646 | Camden Yards · Baltimore, MD |
| 49 | Thu May 23 | at Orioles | W6-5 | 32-17 | .653 | Camden Yards · Baltimore, MD |
| 50 | Sat May 25 | at Royals | W7-3 | 33-17 | .660 | Kauffman Stadium · Kansas City, MO |
| 51 | Sat May 25 | at Royals | W6-5 | 34-17 | .667 | Kauffman Stadium · Kansas City, MO |
| 52 | Sun May 26 | at Royals | L7-8 (10) | 34-18 | .654 | Kauffman Stadium · Kansas City, MO |
| 53 | Mon May 27 | vs Padres | W5-2 | 35-18 | .660 | Yankee Stadium · The Bronx, NY |
| 54 | Tue May 28 | vs Padres | L4-5 | 35-19 | .648 | Yankee Stadium · The Bronx, NY |
| 55 | Wed May 29 | vs Padres | W7-0 | 36-19 | .655 | Yankee Stadium · The Bronx, NY |
| 56 | Fri May 31 | vs Red Sox | W4-1 | 37-19 | .661 | Yankee Stadium · The Bronx, NY |
| 57 | Sat Jun 1 | vs Red Sox | W5-3 | 38-19 | .667 | Yankee Stadium · The Bronx, NY |
| 58 | Sun Jun 2 | vs Red Sox | L5-8 | 38-20 | .655 | Yankee Stadium · The Bronx, NY |
| 59 | Tue Jun 4 | at Blue Jays | L3-4 | 38-21 | .644 | Rogers Centre · Toronto, ON |
| 60 | Wed Jun 5 | at Blue Jays | L7-11 | 38-22 | .633 | Rogers Centre · Toronto, ON |
| 61 | Thu Jun 6 | at Blue Jays | W6-2 | 39-22 | .639 | Rogers Centre · Toronto, ON |
| 62 | Fri Jun 7 | at Guardians | L2-5 | 39-23 | .629 | Progressive Field · Cleveland, OH |
| 63 | Sat Jun 8 | at Guardians | L4-8 | 39-24 | .619 | Progressive Field · Cleveland, OH |
| 64 | Sun Jun 9 | at Guardians | W7-6 (10) | 40-24 | .625 | Progressive Field · Cleveland, OH |
| 65 | Tue Jun 11 | vs Mets | W12-5 | 41-24 | .631 | Yankee Stadium · The Bronx, NY |
| 66 | Tue Jun 11 | vs Mets | L4-10 | 41-25 | .621 | Yankee Stadium · The Bronx, NY |
| 67 | Thu Jun 13 | at White Sox | L4-5 | 41-26 | .612 | Guaranteed Rate Field · Chicago, IL |
| 68 | Fri Jun 14 | at White Sox | L2-10 | 41-27 | .603 | Guaranteed Rate Field · Chicago, IL |
| 69 | Sat Jun 15 | at White Sox | W8-4 | 42-27 | .609 | Guaranteed Rate Field · Chicago, IL |
| 70 | Sun Jun 16 | at White Sox | W10-3 | 43-27 | .614 | Guaranteed Rate Field · Chicago, IL |
| 71 | Mon Jun 17 | vs Rays | W3-0 | 44-27 | .620 | Yankee Stadium · The Bronx, NY |
| 72 | Tue Jun 18 | vs Rays | W6-3 | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 73 | Wed Jun 19 | vs Rays | W12-1 | 46-27 | .630 | Yankee Stadium · The Bronx, NY |
| 74 | Thu Jun 20 | vs Astros | W10-6 | 47-27 | .635 | Yankee Stadium · The Bronx, NY |
| 75 | Fri Jun 21 | vs Astros | W4-1 | 48-27 | .640 | Yankee Stadium · The Bronx, NY |
| 76 | Sat Jun 22 | vs Astros | W7-5 | 49-27 | .645 | Yankee Stadium · The Bronx, NY |
| 77 | Sun Jun 23 | vs Astros | L4-9 | 49-28 | .636 | Yankee Stadium · The Bronx, NY |
| 78 | Mon Jun 24 | vs Blue Jays | W10-8 | 50-28 | .641 | Yankee Stadium · The Bronx, NY |
| 79 | Tue Jun 25 | vs Blue Jays | W4-3 | 51-28 | .646 | Yankee Stadium · The Bronx, NY |
| 80 | Wed Jun 26 | vs Blue Jays | W8-7 | 52-28 | .650 | Yankee Stadium · The Bronx, NY |
| 81 | Sat Jun 29 | at Red Sox | W17-13 | 53-28 | .654 | Fenway Park · Boston, MA |
| 82 | Sun Jun 30 | at Red Sox | W12-8 | 54-28 | .659 | Fenway Park · Boston, MA |
| 83 | Tue Jul 2 | at Mets | L2-4 | 54-29 | .651 | Citi Field · Queens, NY |
| 84 | Wed Jul 3 | at Mets | W5-1 | 55-29 | .655 | Citi Field · Queens, NY |
| 85 | Thu Jul 4 | at Rays | W8-4 (10) | 56-29 | .659 | Tropicana Field · St. Petersburg, FL |
| 86 | Fri Jul 5 | at Rays | W8-4 (11) | 57-29 | .663 | Tropicana Field · St. Petersburg, FL |
| 87 | Sat Jul 6 | at Rays | L3-4 | 57-30 | .655 | Tropicana Field · St. Petersburg, FL |
| 88 | Sun Jul 7 | at Rays | L1-2 | 57-31 | .648 | Tropicana Field · St. Petersburg, FL |
| 89 | Fri Jul 12 | vs Blue Jays | W4-0 | 58-31 | .652 | Yankee Stadium · The Bronx, NY |
| 90 | Sat Jul 13 | vs Blue Jays | L1-2 | 58-32 | .644 | Yankee Stadium · The Bronx, NY |
| 91 | Sun Jul 14 | vs Blue Jays | W4-2 | 59-32 | .648 | Yankee Stadium · The Bronx, NY |
| 92 | Mon Jul 15 | vs Rays | L4-5 | 59-33 | .641 | Yankee Stadium · The Bronx, NY |
| 93 | Tue Jul 16 | vs Rays | W8-3 | 60-33 | .645 | Yankee Stadium · The Bronx, NY |
| 94 | Thu Jul 18 | vs Rays | W6-2 | 61-33 | .649 | Yankee Stadium · The Bronx, NY |
| 95 | Thu Jul 18 | vs Rays | W5-1 | 62-33 | .653 | Yankee Stadium · The Bronx, NY |
| 96 | Fri Jul 19 | vs Rockies | W8-2 | 63-33 | .656 | Yankee Stadium · The Bronx, NY |
| 97 | Sat Jul 20 | vs Rockies | W11-5 | 64-33 | .660 | Yankee Stadium · The Bronx, NY |
| 98 | Sun Jul 21 | vs Rockies | L4-8 | 64-34 | .653 | Yankee Stadium · The Bronx, NY |
| 99 | Mon Jul 22 | at Twins | L6-8 | 64-35 | .646 | Target Field · Minneapolis, MN |
| 100 | Tue Jul 23 | at Twins | W14-12 (10) | 65-35 | .650 | Target Field · Minneapolis, MN |
| 101 | Wed Jul 24 | at Twins | W10-7 | 66-35 | .653 | Target Field · Minneapolis, MN |
| 102 | Thu Jul 25 | at Red Sox | L3-19 | 66-36 | .647 | Fenway Park · Boston, MA |
| 103 | Fri Jul 26 | at Red Sox | L5-10 | 66-37 | .641 | Fenway Park · Boston, MA |
| 104 | Sat Jul 27 | at Red Sox | L5-9 | 66-38 | .635 | Fenway Park · Boston, MA |
| 105 | Sun Jul 28 | at Red Sox | W9-6 | 67-38 | .638 | Fenway Park · Boston, MA |
| 106 | Tue Jul 30 | vs D-backs | L2-4 | 67-39 | .632 | Yankee Stadium · The Bronx, NY |
| 107 | Wed Jul 31 | vs D-backs | W7-5 | 68-39 | .636 | Yankee Stadium · The Bronx, NY |
| 108 | Fri Aug 2 | vs Red Sox | W4-2 | 69-39 | .639 | Yankee Stadium · The Bronx, NY |
| 109 | Sat Aug 3 | vs Red Sox | W9-2 | 70-39 | .642 | Yankee Stadium · The Bronx, NY |
| 110 | Sat Aug 3 | vs Red Sox | W6-4 | 71-39 | .645 | Yankee Stadium · The Bronx, NY |
| 111 | Sun Aug 4 | vs Red Sox | W7-4 | 72-39 | .649 | Yankee Stadium · The Bronx, NY |
| 112 | Mon Aug 5 | at Orioles | W9-6 | 73-39 | .652 | Camden Yards · Baltimore, MD |
| 113 | Tue Aug 6 | at Orioles | W9-4 | 74-39 | .655 | Camden Yards · Baltimore, MD |
| 114 | Wed Aug 7 | at Orioles | W14-2 | 75-39 | .658 | Camden Yards · Baltimore, MD |
| 115 | Thu Aug 8 | at Blue Jays | W12-6 | 76-39 | .661 | Rogers Centre · Toronto, ON |
| 116 | Fri Aug 9 | at Blue Jays | L2-8 | 76-40 | .655 | Rogers Centre · Toronto, ON |
| 117 | Sat Aug 10 | at Blue Jays | L4-5 | 76-41 | .650 | Rogers Centre · Toronto, ON |
| 118 | Sun Aug 11 | at Blue Jays | W1-0 | 77-41 | .653 | Rogers Centre · Toronto, ON |
| 119 | Mon Aug 12 | vs Orioles | W8-5 | 78-41 | .655 | Yankee Stadium · The Bronx, NY |
| 120 | Mon Aug 12 | vs Orioles | W11-8 | 79-41 | .658 | Yankee Stadium · The Bronx, NY |
| 121 | Tue Aug 13 | vs Orioles | W8-3 | 80-41 | .661 | Yankee Stadium · The Bronx, NY |
| 122 | Wed Aug 14 | vs Orioles | W6-5 | 81-41 | .664 | Yankee Stadium · The Bronx, NY |
| 123 | Thu Aug 15 | vs Guardians | L5-19 | 81-42 | .659 | Yankee Stadium · The Bronx, NY |
| 124 | Fri Aug 16 | vs Guardians | W3-2 | 82-42 | .661 | Yankee Stadium · The Bronx, NY |
| 125 | Sat Aug 17 | vs Guardians | W6-5 | 83-42 | .664 | Yankee Stadium · The Bronx, NY |
| 126 | Sun Aug 18 | vs Guardians | L4-8 | 83-43 | .659 | Yankee Stadium · The Bronx, NY |
| 127 | Tue Aug 20 | at Athletics | L2-6 | 83-44 | .654 | RingCentral Coliseum · Oakland, CA |
| 128 | Wed Aug 21 | at Athletics | L4-6 | 83-45 | .648 | RingCentral Coliseum · Oakland, CA |
| 129 | Thu Aug 22 | at Athletics | L3-5 | 83-46 | .643 | RingCentral Coliseum · Oakland, CA |
| 130 | Fri Aug 23 | at Dodgers | W10-2 | 84-46 | .646 | Dodger Stadium · Los Angeles, CA |
| 131 | Sat Aug 24 | at Dodgers | L1-2 | 84-47 | .641 | Dodger Stadium · Los Angeles, CA |
| 132 | Sun Aug 25 | at Dodgers | W5-1 | 85-47 | .644 | Dodger Stadium · Los Angeles, CA |
| 133 | Mon Aug 26 | at Mariners | W5-4 | 86-47 | .647 | T-Mobile Park · Seattle, WA |
| 134 | Tue Aug 27 | at Mariners | W7-0 | 87-47 | .649 | T-Mobile Park · Seattle, WA |
| 135 | Wed Aug 28 | at Mariners | W7-3 | 88-47 | .652 | T-Mobile Park · Seattle, WA |
| 136 | Fri Aug 30 | vs Athletics | L2-8 | 88-48 | .647 | Yankee Stadium · The Bronx, NY |
| 137 | Sat Aug 31 | vs Athletics | W4-3 (11) | 89-48 | .650 | Yankee Stadium · The Bronx, NY |
| 138 | Sun Sep 1 | vs Athletics | W5-4 | 90-48 | .652 | Yankee Stadium · The Bronx, NY |
| 139 | Mon Sep 2 | vs Rangers | L0-7 | 90-49 | .647 | Yankee Stadium · The Bronx, NY |
| 140 | Tue Sep 3 | vs Rangers | W10-1 | 91-49 | .650 | Yankee Stadium · The Bronx, NY |
| 141 | Wed Sep 4 | vs Rangers | W4-1 | 92-49 | .652 | Yankee Stadium · The Bronx, NY |
| 142 | Fri Sep 6 | at Red Sox | L1-6 | 92-50 | .648 | Fenway Park · Boston, MA |
| 143 | Sat Sep 7 | at Red Sox | W5-1 | 93-50 | .650 | Fenway Park · Boston, MA |
| 144 | Sun Sep 8 | at Red Sox | W10-5 | 94-50 | .653 | Fenway Park · Boston, MA |
| 145 | Mon Sep 9 | at Red Sox | W5-0 | 95-50 | .655 | Fenway Park · Boston, MA |
| 146 | Tue Sep 10 | at Tigers | L11-12 | 95-51 | .651 | Comerica Park · Detroit, MI |
| 147 | Thu Sep 12 | at Tigers | W10-4 | 96-51 | .653 | Comerica Park · Detroit, MI |
| 148 | Thu Sep 12 | at Tigers | W6-4 | 97-51 | .655 | Comerica Park · Detroit, MI |
| 149 | Fri Sep 13 | at Blue Jays | L5-6 (12) | 97-52 | .651 | Rogers Centre · Toronto, ON |
| 150 | Sat Sep 14 | at Blue Jays | W13-3 | 98-52 | .653 | Rogers Centre · Toronto, ON |
| 151 | Sun Sep 15 | at Blue Jays | L4-6 | 98-53 | .649 | Rogers Centre · Toronto, ON |
| 152 | Tue Sep 17 | vs Angels | W8-0 | 99-53 | .651 | Yankee Stadium · The Bronx, NY |
| 153 | Wed Sep 18 | vs Angels | L2-3 | 99-54 | .647 | Yankee Stadium · The Bronx, NY |
| 154 | Thu Sep 19 | vs Angels | W9-1 | 100-54 | .649 | Yankee Stadium · The Bronx, NY |
| 155 | Fri Sep 20 | vs Blue Jays | L3-4 | 100-55 | .645 | Yankee Stadium · The Bronx, NY |
| 156 | Sat Sep 21 | vs Blue Jays | W7-2 | 101-55 | .647 | Yankee Stadium · The Bronx, NY |
| 157 | Sun Sep 22 | vs Blue Jays | W8-3 | 102-55 | .650 | Yankee Stadium · The Bronx, NY |
| 158 | Tue Sep 24 | at Rays | L1-2 (12) | 102-56 | .646 | Tropicana Field · St. Petersburg, FL |
| 159 | Wed Sep 25 | at Rays | L0-4 | 102-57 | .642 | Tropicana Field · St. Petersburg, FL |
| 160 | Fri Sep 27 | at Rangers | W14-7 | 103-57 | .644 | Globe Life Field · Arlington, TX |
| 161 | Sat Sep 28 | at Rangers | L4-9 | 103-58 | .640 | Globe Life Field · Arlington, TX |
| 162 | Sun Sep 29 | at Rangers | L1-6 | 103-59 | .636 | Globe Life Field · Arlington, TX |
| 163 | Fri Oct 4 | vs Twins | W10-4 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Sat Oct 5 | vs Twins | W8-2 | 2-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 165 | Mon Oct 7 | at Twins | W5-1 | 3-0 | 1.000 | Target Field · Minneapolis, MN |
| 166 | Sat Oct 12 | at Astros | W7-0 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 167 | Sun Oct 13 | at Astros | L2-3 (11) | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 168 | Tue Oct 15 | vs Astros | L1-4 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 169 | Thu Oct 17 | vs Astros | L3-8 | 1-3 | .250 | Yankee Stadium · The Bronx, NY |
| 170 | Fri Oct 18 | vs Astros | W4-1 | 2-3 | .400 | Yankee Stadium · The Bronx, NY |
| 171 | Sat Oct 19 | at Astros | L4-6 | 2-4 | .333 | Minute Maid Park · Houston, TX |