| 1 | Thu Apr 1 | vs Blue Jays | L2-3 (10) | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Apr 3 | vs Blue Jays | W5-3 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Apr 4 | vs Blue Jays | L1-3 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 5 | vs Orioles | W7-0 | 2-2 | .500 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 6 | vs Orioles | W7-2 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 6 | Wed Apr 7 | vs Orioles | L3-4 (11) | 3-3 | .500 | Yankee Stadium · The Bronx, NY |
| 7 | Fri Apr 9 | at Rays | L5-10 | 3-4 | .429 | Tropicana Field · St. Petersburg, FL |
| 8 | Sat Apr 10 | at Rays | L0-4 | 3-5 | .375 | Tropicana Field · St. Petersburg, FL |
| 9 | Sun Apr 11 | at Rays | W8-4 (10) | 4-5 | .444 | Tropicana Field · St. Petersburg, FL |
| 10 | Mon Apr 12 | at Blue Jays | W3-1 | 5-5 | .500 | Rogers Centre · Toronto, ON |
| 11 | Tue Apr 13 | at Blue Jays | L3-7 | 5-6 | .455 | Rogers Centre · Toronto, ON |
| 12 | Wed Apr 14 | at Blue Jays | L4-5 | 5-7 | .417 | Rogers Centre · Toronto, ON |
| 13 | Fri Apr 16 | vs Rays | L2-8 | 5-8 | .385 | Yankee Stadium · The Bronx, NY |
| 14 | Sat Apr 17 | vs Rays | L3-6 | 5-9 | .357 | Yankee Stadium · The Bronx, NY |
| 15 | Sun Apr 18 | vs Rays | L2-4 | 5-10 | .333 | Yankee Stadium · The Bronx, NY |
| 16 | Tue Apr 20 | vs Braves | W3-1 | 6-10 | .375 | Yankee Stadium · The Bronx, NY |
| 17 | Wed Apr 21 | vs Braves | L1-4 | 6-11 | .353 | Yankee Stadium · The Bronx, NY |
| 18 | Thu Apr 22 | at Guardians | W6-3 | 7-11 | .389 | Progressive Field · Cleveland, OH |
| 19 | Fri Apr 23 | at Guardians | W5-3 | 8-11 | .421 | Progressive Field · Cleveland, OH |
| 20 | Sat Apr 24 | at Guardians | W2-1 | 9-11 | .450 | Progressive Field · Cleveland, OH |
| 21 | Sun Apr 25 | at Guardians | L3-7 | 9-12 | .429 | Progressive Field · Cleveland, OH |
| 22 | Mon Apr 26 | at Orioles | L2-4 | 9-13 | .409 | Camden Yards · Baltimore, MD |
| 23 | Tue Apr 27 | at Orioles | W5-1 | 10-13 | .435 | Camden Yards · Baltimore, MD |
| 24 | Wed Apr 28 | at Orioles | W7-0 | 11-13 | .458 | Camden Yards · Baltimore, MD |
| 25 | Thu Apr 29 | at Orioles | L3-4 (10) | 11-14 | .440 | Camden Yards · Baltimore, MD |
| 26 | Fri Apr 30 | vs Tigers | W10-0 | 12-14 | .462 | Yankee Stadium · The Bronx, NY |
| 27 | Sat May 1 | vs Tigers | W6-4 | 13-14 | .481 | Yankee Stadium · The Bronx, NY |
| 28 | Sun May 2 | vs Tigers | W2-0 | 14-14 | .500 | Yankee Stadium · The Bronx, NY |
| 29 | Tue May 4 | vs Astros | W7-3 | 15-14 | .517 | Yankee Stadium · The Bronx, NY |
| 30 | Wed May 5 | vs Astros | W6-3 | 16-14 | .533 | Yankee Stadium · The Bronx, NY |
| 31 | Thu May 6 | vs Astros | L4-7 | 16-15 | .516 | Yankee Stadium · The Bronx, NY |
| 32 | Fri May 7 | vs Nationals | L4-11 | 16-16 | .500 | Yankee Stadium · The Bronx, NY |
| 33 | Sat May 8 | vs Nationals | W4-3 (11) | 17-16 | .515 | Yankee Stadium · The Bronx, NY |
| 34 | Sun May 9 | vs Nationals | W3-2 | 18-16 | .529 | Yankee Stadium · The Bronx, NY |
| 35 | Tue May 11 | at Rays | W3-1 | 19-16 | .543 | Tropicana Field · St. Petersburg, FL |
| 36 | Wed May 12 | at Rays | W1-0 | 20-16 | .556 | Tropicana Field · St. Petersburg, FL |
| 37 | Thu May 13 | at Rays | L1-9 | 20-17 | .541 | Tropicana Field · St. Petersburg, FL |
| 38 | Fri May 14 | at Orioles | W5-4 | 21-17 | .553 | Camden Yards · Baltimore, MD |
| 39 | Sat May 15 | at Orioles | W8-2 | 22-17 | .564 | Camden Yards · Baltimore, MD |
| 40 | Sun May 16 | at Orioles | L6-10 | 22-18 | .550 | Camden Yards · Baltimore, MD |
| 41 | Mon May 17 | at Rangers | L2-5 | 22-19 | .537 | Globe Life Field · Arlington, TX |
| 42 | Tue May 18 | at Rangers | W7-4 | 23-19 | .548 | Globe Life Field · Arlington, TX |
| 43 | Wed May 19 | at Rangers | W2-0 | 24-19 | .558 | Globe Life Field · Arlington, TX |
| 44 | Thu May 20 | at Rangers | W2-0 | 25-19 | .568 | Globe Life Field · Arlington, TX |
| 45 | Fri May 21 | vs White Sox | W2-1 | 26-19 | .578 | Yankee Stadium · The Bronx, NY |
| 46 | Sat May 22 | vs White Sox | W7-0 | 27-19 | .587 | Yankee Stadium · The Bronx, NY |
| 47 | Sun May 23 | vs White Sox | W5-4 | 28-19 | .596 | Yankee Stadium · The Bronx, NY |
| 48 | Tue May 25 | vs Blue Jays | L2-6 | 28-20 | .583 | Yankee Stadium · The Bronx, NY |
| 49 | Thu May 27 | vs Blue Jays | L0-2 | 28-21 | .571 | Yankee Stadium · The Bronx, NY |
| 50 | Thu May 27 | vs Blue Jays | W5-3 | 29-21 | .580 | Yankee Stadium · The Bronx, NY |
| 51 | Fri May 28 | at Tigers | L2-3 (10) | 29-22 | .569 | Comerica Park · Detroit, MI |
| 52 | Sat May 29 | at Tigers | L1-6 | 29-23 | .558 | Comerica Park · Detroit, MI |
| 53 | Sun May 30 | at Tigers | L2-6 | 29-24 | .547 | Comerica Park · Detroit, MI |
| 54 | Mon May 31 | vs Rays | L1-3 | 29-25 | .537 | Yankee Stadium · The Bronx, NY |
| 55 | Tue Jun 1 | vs Rays | W5-3 (11) | 30-25 | .545 | Yankee Stadium · The Bronx, NY |
| 56 | Wed Jun 2 | vs Rays | W4-3 | 31-25 | .554 | Yankee Stadium · The Bronx, NY |
| 57 | Thu Jun 3 | vs Rays | L2-9 | 31-26 | .544 | Yankee Stadium · The Bronx, NY |
| 58 | Fri Jun 4 | vs Red Sox | L2-5 | 31-27 | .534 | Yankee Stadium · The Bronx, NY |
| 59 | Sat Jun 5 | vs Red Sox | L3-7 | 31-28 | .525 | Yankee Stadium · The Bronx, NY |
| 60 | Sun Jun 6 | vs Red Sox | L5-6 (10) | 31-29 | .517 | Yankee Stadium · The Bronx, NY |
| 61 | Tue Jun 8 | at Twins | W8-4 | 32-29 | .525 | Target Field · Minneapolis, MN |
| 62 | Wed Jun 9 | at Twins | W9-6 | 33-29 | .532 | Target Field · Minneapolis, MN |
| 63 | Thu Jun 10 | at Twins | L5-7 | 33-30 | .524 | Target Field · Minneapolis, MN |
| 64 | Sat Jun 12 | at Phillies | L7-8 (10) | 33-31 | .516 | Citizens Bank Park · Philadelphi, PA |
| 65 | Sun Jun 13 | at Phillies | L0-7 | 33-32 | .508 | Citizens Bank Park · Philadelphi, PA |
| 66 | Tue Jun 15 | at Blue Jays | W6-5 | 34-32 | .515 | Rogers Centre · Toronto, ON |
| 67 | Wed Jun 16 | at Blue Jays | W3-2 | 35-32 | .522 | Rogers Centre · Toronto, ON |
| 68 | Thu Jun 17 | at Blue Jays | W8-4 | 36-32 | .529 | Rogers Centre · Toronto, ON |
| 69 | Fri Jun 18 | vs Athletics | L3-5 | 36-33 | .522 | Yankee Stadium · The Bronx, NY |
| 70 | Sat Jun 19 | vs Athletics | W7-5 | 37-33 | .529 | Yankee Stadium · The Bronx, NY |
| 71 | Sun Jun 20 | vs Athletics | W2-1 | 38-33 | .535 | Yankee Stadium · The Bronx, NY |
| 72 | Tue Jun 22 | vs Royals | L5-6 | 38-34 | .528 | Yankee Stadium · The Bronx, NY |
| 73 | Wed Jun 23 | vs Royals | W6-5 | 39-34 | .534 | Yankee Stadium · The Bronx, NY |
| 74 | Thu Jun 24 | vs Royals | W8-1 | 40-34 | .541 | Yankee Stadium · The Bronx, NY |
| 75 | Fri Jun 25 | at Red Sox | L3-5 | 40-35 | .533 | Fenway Park · Boston, MA |
| 76 | Sat Jun 26 | at Red Sox | L2-4 | 40-36 | .526 | Fenway Park · Boston, MA |
| 77 | Sun Jun 27 | at Red Sox | L2-9 | 40-37 | .519 | Fenway Park · Boston, MA |
| 78 | Mon Jun 28 | vs Angels | L3-5 | 40-38 | .513 | Yankee Stadium · The Bronx, NY |
| 79 | Tue Jun 29 | vs Angels | W11-5 | 41-38 | .519 | Yankee Stadium · The Bronx, NY |
| 80 | Wed Jun 30 | vs Angels | L8-11 | 41-39 | .512 | Yankee Stadium · The Bronx, NY |
| 81 | Sat Jul 3 | vs Mets | L3-8 | 41-40 | .506 | Yankee Stadium · The Bronx, NY |
| 82 | Sun Jul 4 | vs Mets | L5-10 | 41-41 | .500 | Yankee Stadium · The Bronx, NY |
| 83 | Sun Jul 4 | vs Mets | W4-2 | 42-41 | .506 | Yankee Stadium · The Bronx, NY |
| 84 | Tue Jul 6 | at Mariners | W12-1 | 43-41 | .512 | T-Mobile Park · Seattle, WA |
| 85 | Wed Jul 7 | at Mariners | W5-4 | 44-41 | .518 | T-Mobile Park · Seattle, WA |
| 86 | Thu Jul 8 | at Mariners | L0-4 | 44-42 | .512 | T-Mobile Park · Seattle, WA |
| 87 | Fri Jul 9 | at Astros | W4-0 | 45-42 | .517 | Minute Maid Park · Houston, TX |
| 88 | Sat Jul 10 | at Astros | W1-0 | 46-42 | .523 | Minute Maid Park · Houston, TX |
| 89 | Sun Jul 11 | at Astros | L7-8 | 46-43 | .517 | Minute Maid Park · Houston, TX |
| 90 | Fri Jul 16 | vs Red Sox | L0-4 | 46-44 | .511 | Yankee Stadium · The Bronx, NY |
| 91 | Sat Jul 17 | vs Red Sox | W3-1 | 47-44 | .516 | Yankee Stadium · The Bronx, NY |
| 92 | Sun Jul 18 | vs Red Sox | W9-1 | 48-44 | .522 | Yankee Stadium · The Bronx, NY |
| 93 | Tue Jul 20 | vs Phillies | W6-4 | 49-44 | .527 | Yankee Stadium · The Bronx, NY |
| 94 | Wed Jul 21 | vs Phillies | W6-5 (10) | 50-44 | .532 | Yankee Stadium · The Bronx, NY |
| 95 | Thu Jul 22 | at Red Sox | L4-5 (10) | 50-45 | .526 | Fenway Park · Boston, MA |
| 96 | Fri Jul 23 | at Red Sox | L2-6 | 50-46 | .521 | Fenway Park · Boston, MA |
| 97 | Sat Jul 24 | at Red Sox | W4-3 | 51-46 | .526 | Fenway Park · Boston, MA |
| 98 | Sun Jul 25 | at Red Sox | L4-5 | 51-47 | .520 | Fenway Park · Boston, MA |
| 99 | Tue Jul 27 | at Rays | W4-3 | 52-47 | .525 | Tropicana Field · St. Petersburg, FL |
| 100 | Wed Jul 28 | at Rays | W3-1 (10) | 53-47 | .530 | Tropicana Field · St. Petersburg, FL |
| 101 | Thu Jul 29 | at Rays | L0-14 | 53-48 | .525 | Tropicana Field · St. Petersburg, FL |
| 102 | Fri Jul 30 | at Marlins | W3-1 | 54-48 | .529 | LoanDepot Park · Miami, FL |
| 103 | Sat Jul 31 | at Marlins | W4-2 | 55-48 | .534 | LoanDepot Park · Miami, FL |
| 104 | Sun Aug 1 | at Marlins | W3-1 | 56-48 | .538 | LoanDepot Park · Miami, FL |
| 105 | Mon Aug 2 | vs Orioles | L1-7 | 56-49 | .533 | Yankee Stadium · The Bronx, NY |
| 106 | Tue Aug 3 | vs Orioles | W13-1 | 57-49 | .538 | Yankee Stadium · The Bronx, NY |
| 107 | Wed Aug 4 | vs Orioles | W10-3 | 58-49 | .542 | Yankee Stadium · The Bronx, NY |
| 108 | Thu Aug 5 | vs Mariners | W5-3 | 59-49 | .546 | Yankee Stadium · The Bronx, NY |
| 109 | Fri Aug 6 | vs Mariners | W3-2 (11) | 60-49 | .550 | Yankee Stadium · The Bronx, NY |
| 110 | Sat Aug 7 | vs Mariners | W5-4 | 61-49 | .555 | Yankee Stadium · The Bronx, NY |
| 111 | Sun Aug 8 | vs Mariners | L0-2 | 61-50 | .550 | Yankee Stadium · The Bronx, NY |
| 112 | Mon Aug 9 | at Royals | W8-6 (11) | 62-50 | .554 | Kauffman Stadium · Kansas City, MO |
| 113 | Tue Aug 10 | at Royals | L4-8 | 62-51 | .549 | Kauffman Stadium · Kansas City, MO |
| 114 | Wed Aug 11 | at Royals | W5-2 | 63-51 | .553 | Kauffman Stadium · Kansas City, MO |
| 115 | Thu Aug 12 | at White Sox | L8-9 | 63-52 | .548 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sat Aug 14 | at White Sox | W7-5 (10) | 64-52 | .552 | Guaranteed Rate Field · Chicago, IL |
| 117 | Sun Aug 15 | at White Sox | W5-3 | 65-52 | .556 | Guaranteed Rate Field · Chicago, IL |
| 118 | Mon Aug 16 | vs Angels | W2-1 | 66-52 | .559 | Yankee Stadium · The Bronx, NY |
| 119 | Tue Aug 17 | vs Red Sox | W5-3 | 67-52 | .563 | Yankee Stadium · The Bronx, NY |
| 120 | Tue Aug 17 | vs Red Sox | W2-0 | 68-52 | .567 | Yankee Stadium · The Bronx, NY |
| 121 | Wed Aug 18 | vs Red Sox | W5-2 | 69-52 | .570 | Yankee Stadium · The Bronx, NY |
| 122 | Thu Aug 19 | vs Twins | W7-5 | 70-52 | .574 | Yankee Stadium · The Bronx, NY |
| 123 | Fri Aug 20 | vs Twins | W10-2 | 71-52 | .577 | Yankee Stadium · The Bronx, NY |
| 124 | Sat Aug 21 | vs Twins | W7-1 | 72-52 | .581 | Yankee Stadium · The Bronx, NY |
| 125 | Mon Aug 23 | at Braves | W5-1 | 73-52 | .584 | Truist Park · Cumberland, GA |
| 126 | Tue Aug 24 | at Braves | W5-4 | 74-52 | .587 | Truist Park · Cumberland, GA |
| 127 | Thu Aug 26 | at Athletics | W7-6 | 75-52 | .591 | RingCentral Coliseum · Oakland, CA |
| 128 | Fri Aug 27 | at Athletics | W8-2 | 76-52 | .594 | RingCentral Coliseum · Oakland, CA |
| 129 | Sat Aug 28 | at Athletics | L2-3 | 76-53 | .589 | RingCentral Coliseum · Oakland, CA |
| 130 | Sun Aug 29 | at Athletics | L1-3 | 76-54 | .585 | RingCentral Coliseum · Oakland, CA |
| 131 | Mon Aug 30 | at Angels | L7-8 | 76-55 | .580 | Angel Stadium · Anaheim, CA |
| 132 | Tue Aug 31 | at Angels | L4-6 | 76-56 | .576 | Angel Stadium · Anaheim, CA |
| 133 | Wed Sep 1 | at Angels | W4-1 | 77-56 | .579 | Angel Stadium · Anaheim, CA |
| 134 | Fri Sep 3 | vs Orioles | W4-3 (11) | 78-56 | .582 | Yankee Stadium · The Bronx, NY |
| 135 | Sat Sep 4 | vs Orioles | L3-4 | 78-57 | .578 | Yankee Stadium · The Bronx, NY |
| 136 | Sun Sep 5 | vs Orioles | L7-8 | 78-58 | .574 | Yankee Stadium · The Bronx, NY |
| 137 | Mon Sep 6 | vs Blue Jays | L0-8 | 78-59 | .569 | Yankee Stadium · The Bronx, NY |
| 138 | Tue Sep 7 | vs Blue Jays | L1-5 | 78-60 | .565 | Yankee Stadium · The Bronx, NY |
| 139 | Wed Sep 8 | vs Blue Jays | L3-6 | 78-61 | .561 | Yankee Stadium · The Bronx, NY |
| 140 | Thu Sep 9 | vs Blue Jays | L4-6 | 78-62 | .557 | Yankee Stadium · The Bronx, NY |
| 141 | Fri Sep 10 | at Mets | L3-10 | 78-63 | .553 | Citi Field · Queens, NY |
| 142 | Sat Sep 11 | at Mets | W8-7 | 79-63 | .556 | Citi Field · Queens, NY |
| 143 | Sun Sep 12 | at Mets | L6-7 | 79-64 | .552 | Citi Field · Queens, NY |
| 144 | Mon Sep 13 | vs Twins | W6-5 (10) | 80-64 | .556 | Yankee Stadium · The Bronx, NY |
| 145 | Tue Sep 14 | at Orioles | W7-2 | 81-64 | .559 | Camden Yards · Baltimore, MD |
| 146 | Wed Sep 15 | at Orioles | W4-3 | 82-64 | .562 | Camden Yards · Baltimore, MD |
| 147 | Thu Sep 16 | at Orioles | L2-3 (10) | 82-65 | .558 | Camden Yards · Baltimore, MD |
| 148 | Fri Sep 17 | vs Guardians | W8-0 | 83-65 | .561 | Yankee Stadium · The Bronx, NY |
| 149 | Sat Sep 18 | vs Guardians | L3-11 | 83-66 | .557 | Yankee Stadium · The Bronx, NY |
| 150 | Sun Sep 19 | vs Guardians | L1-11 | 83-67 | .553 | Yankee Stadium · The Bronx, NY |
| 151 | Mon Sep 20 | vs Rangers | W4-3 | 84-67 | .556 | Yankee Stadium · The Bronx, NY |
| 152 | Tue Sep 21 | vs Rangers | W7-1 | 85-67 | .559 | Yankee Stadium · The Bronx, NY |
| 153 | Wed Sep 22 | vs Rangers | W7-3 | 86-67 | .562 | Yankee Stadium · The Bronx, NY |
| 154 | Fri Sep 24 | at Red Sox | W8-3 | 87-67 | .565 | Fenway Park · Boston, MA |
| 155 | Sat Sep 25 | at Red Sox | W5-3 | 88-67 | .568 | Fenway Park · Boston, MA |
| 156 | Sun Sep 26 | at Red Sox | W6-3 | 89-67 | .571 | Fenway Park · Boston, MA |
| 157 | Tue Sep 28 | at Blue Jays | W7-2 | 90-67 | .573 | Rogers Centre · Toronto, ON |
| 158 | Wed Sep 29 | at Blue Jays | L5-6 | 90-68 | .570 | Rogers Centre · Toronto, ON |
| 159 | Thu Sep 30 | at Blue Jays | W6-2 | 91-68 | .572 | Rogers Centre · Toronto, ON |
| 160 | Fri Oct 1 | vs Rays | L3-4 | 91-69 | .569 | Yankee Stadium · The Bronx, NY |
| 161 | Sat Oct 2 | vs Rays | L2-12 | 91-70 | .565 | Yankee Stadium · The Bronx, NY |
| 162 | Sun Oct 3 | vs Rays | W1-0 | 92-70 | .568 | Yankee Stadium · The Bronx, NY |
| 163 | Tue Oct 5 | at Red Sox | L2-6 | 0-1 | .000 | Fenway Park · Boston, MA |