| 1 | Thu Mar 29 | at Blue Jays | W6-1 | 1-0 | 1.000 | Rogers Centre · Toronto, ON |
| 2 | Fri Mar 30 | at Blue Jays | W4-2 | 2-0 | 1.000 | Rogers Centre · Toronto, ON |
| 3 | Sat Mar 31 | at Blue Jays | L3-5 | 2-1 | .667 | Rogers Centre · Toronto, ON |
| 4 | Sun Apr 1 | at Blue Jays | L4-7 | 2-2 | .500 | Rogers Centre · Toronto, ON |
| 5 | Tue Apr 3 | vs Rays | W11-4 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 6 | Wed Apr 4 | vs Rays | W7-2 | 4-2 | .667 | Yankee Stadium · The Bronx, NY |
| 7 | Thu Apr 5 | vs Orioles | L2-5 | 4-3 | .571 | Yankee Stadium · The Bronx, NY |
| 8 | Fri Apr 6 | vs Orioles | L3-7 (14) | 4-4 | .500 | Yankee Stadium · The Bronx, NY |
| 9 | Sat Apr 7 | vs Orioles | W8-3 | 5-4 | .556 | Yankee Stadium · The Bronx, NY |
| 10 | Sun Apr 8 | vs Orioles | L7-8 (12) | 5-5 | .500 | Yankee Stadium · The Bronx, NY |
| 11 | Tue Apr 10 | at Red Sox | L1-14 | 5-6 | .455 | Fenway Park · Boston, MA |
| 12 | Wed Apr 11 | at Red Sox | W10-7 | 6-6 | .500 | Fenway Park · Boston, MA |
| 13 | Thu Apr 12 | at Red Sox | L3-6 | 6-7 | .462 | Fenway Park · Boston, MA |
| 14 | Fri Apr 13 | at Tigers | W8-6 | 7-7 | .500 | Comerica Park · Detroit, MI |
| 15 | Mon Apr 16 | vs Marlins | W12-1 | 8-7 | .533 | Yankee Stadium · The Bronx, NY |
| 16 | Tue Apr 17 | vs Marlins | L1-9 | 8-8 | .500 | Yankee Stadium · The Bronx, NY |
| 17 | Thu Apr 19 | vs Blue Jays | W4-3 | 9-8 | .529 | Yankee Stadium · The Bronx, NY |
| 18 | Fri Apr 20 | vs Blue Jays | L5-8 | 9-9 | .500 | Yankee Stadium · The Bronx, NY |
| 19 | Sat Apr 21 | vs Blue Jays | W9-1 | 10-9 | .526 | Yankee Stadium · The Bronx, NY |
| 20 | Sun Apr 22 | vs Blue Jays | W5-1 | 11-9 | .550 | Yankee Stadium · The Bronx, NY |
| 21 | Mon Apr 23 | vs Twins | W14-1 | 12-9 | .571 | Yankee Stadium · The Bronx, NY |
| 22 | Tue Apr 24 | vs Twins | W8-3 | 13-9 | .591 | Yankee Stadium · The Bronx, NY |
| 23 | Wed Apr 25 | vs Twins | W7-4 | 14-9 | .609 | Yankee Stadium · The Bronx, NY |
| 24 | Thu Apr 26 | vs Twins | W4-3 | 15-9 | .625 | Yankee Stadium · The Bronx, NY |
| 25 | Fri Apr 27 | at Angels | W4-3 (10) | 16-9 | .640 | Angel Stadium · Anaheim, CA |
| 26 | Sat Apr 28 | at Angels | W11-1 | 17-9 | .654 | Angel Stadium · Anaheim, CA |
| 27 | Sun Apr 29 | at Angels | W2-1 | 18-9 | .667 | Angel Stadium · Anaheim, CA |
| 28 | Mon Apr 30 | at Astros | L1-2 | 18-10 | .643 | Minute Maid Park · Houston, TX |
| 29 | Tue May 1 | at Astros | W4-0 | 19-10 | .655 | Minute Maid Park · Houston, TX |
| 30 | Wed May 2 | at Astros | W4-0 | 20-10 | .667 | Minute Maid Park · Houston, TX |
| 31 | Thu May 3 | at Astros | W6-5 | 21-10 | .677 | Minute Maid Park · Houston, TX |
| 32 | Fri May 4 | vs Guardians | W7-6 | 22-10 | .688 | Yankee Stadium · The Bronx, NY |
| 33 | Sat May 5 | vs Guardians | W5-2 | 23-10 | .697 | Yankee Stadium · The Bronx, NY |
| 34 | Sun May 6 | vs Guardians | W7-4 | 24-10 | .706 | Yankee Stadium · The Bronx, NY |
| 35 | Tue May 8 | vs Red Sox | W3-2 | 25-10 | .714 | Yankee Stadium · The Bronx, NY |
| 36 | Wed May 9 | vs Red Sox | W9-6 | 26-10 | .722 | Yankee Stadium · The Bronx, NY |
| 37 | Thu May 10 | vs Red Sox | L4-5 | 26-11 | .703 | Yankee Stadium · The Bronx, NY |
| 38 | Fri May 11 | vs Athletics | L5-10 | 26-12 | .684 | Yankee Stadium · The Bronx, NY |
| 39 | Sat May 12 | vs Athletics | W7-6 (11) | 27-12 | .692 | Yankee Stadium · The Bronx, NY |
| 40 | Sun May 13 | vs Athletics | W6-2 | 28-12 | .700 | Yankee Stadium · The Bronx, NY |
| 41 | Fri May 18 | at Royals | L2-5 | 28-14 | .667 | Kauffman Stadium · Kansas City, MO |
| 42 | Sat May 19 | at Royals | W8-3 | 29-14 | .674 | Kauffman Stadium · Kansas City, MO |
| 43 | Sun May 20 | at Royals | W10-1 | 30-14 | .682 | Kauffman Stadium · Kansas City, MO |
| 44 | Mon May 21 | at Rangers | W10-5 | 31-14 | .689 | Globe Life Field · Arlington, TX |
| 45 | Tue May 22 | at Rangers | L4-6 | 31-15 | .674 | Globe Life Field · Arlington, TX |
| 46 | Wed May 23 | at Rangers | L10-12 | 31-16 | .660 | Globe Life Field · Arlington, TX |
| 47 | Fri May 25 | vs Angels | W2-1 | 32-16 | .667 | Yankee Stadium · The Bronx, NY |
| 48 | Sat May 26 | vs Angels | L4-11 | 32-17 | .653 | Yankee Stadium · The Bronx, NY |
| 49 | Sun May 27 | vs Angels | W3-1 | 33-17 | .660 | Yankee Stadium · The Bronx, NY |
| 50 | Mon May 28 | vs Astros | L1-5 | 33-18 | .647 | Yankee Stadium · The Bronx, NY |
| 51 | Tue May 29 | vs Astros | W6-5 (10) | 34-18 | .654 | Yankee Stadium · The Bronx, NY |
| 52 | Wed May 30 | vs Astros | W5-3 | 35-18 | .660 | Yankee Stadium · The Bronx, NY |
| 53 | Fri Jun 1 | at Orioles | W4-1 | 36-18 | .667 | Camden Yards · Baltimore, MD |
| 54 | Sat Jun 2 | at Orioles | W8-5 | 37-18 | .673 | Camden Yards · Baltimore, MD |
| 55 | Mon Jun 4 | at Tigers | W7-4 | 38-18 | .679 | Comerica Park · Detroit, MI |
| 56 | Mon Jun 4 | at Tigers | L2-4 | 38-19 | .667 | Comerica Park · Detroit, MI |
| 57 | Tue Jun 5 | at Blue Jays | W7-2 | 39-19 | .672 | Rogers Centre · Toronto, ON |
| 58 | Wed Jun 6 | at Blue Jays | W3-0 (13) | 40-19 | .678 | Rogers Centre · Toronto, ON |
| 59 | Fri Jun 8 | at Mets | W4-1 | 41-19 | .683 | Citi Field · Queens, NY |
| 60 | Sat Jun 9 | at Mets | W4-3 | 42-19 | .689 | Citi Field · Queens, NY |
| 61 | Sun Jun 10 | at Mets | L0-2 | 42-20 | .677 | Citi Field · Queens, NY |
| 62 | Tue Jun 12 | vs Nationals | W3-0 | 43-20 | .683 | Yankee Stadium · The Bronx, NY |
| 63 | Wed Jun 13 | vs Nationals | L4-5 | 43-21 | .672 | Yankee Stadium · The Bronx, NY |
| 64 | Thu Jun 14 | vs Rays | W4-3 | 44-21 | .677 | Yankee Stadium · The Bronx, NY |
| 65 | Fri Jun 15 | vs Rays | W5-0 | 45-21 | .682 | Yankee Stadium · The Bronx, NY |
| 66 | Sat Jun 16 | vs Rays | W4-1 | 46-21 | .687 | Yankee Stadium · The Bronx, NY |
| 67 | Sun Jun 17 | vs Rays | L1-3 | 46-22 | .676 | Yankee Stadium · The Bronx, NY |
| 68 | Mon Jun 18 | at Nationals | L3-5 | 28-13 | .683 | Nationals Park · Washington, D.C. |
| 69 | Mon Jun 18 | at Nationals | W4-2 | 47-22 | .681 | Nationals Park · Washington, D.C. |
| 70 | Tue Jun 19 | vs Mariners | W7-2 | 48-22 | .686 | Yankee Stadium · The Bronx, NY |
| 71 | Wed Jun 20 | vs Mariners | W7-5 | 49-22 | .690 | Yankee Stadium · The Bronx, NY |
| 72 | Thu Jun 21 | vs Mariners | W4-3 | 50-22 | .694 | Yankee Stadium · The Bronx, NY |
| 73 | Fri Jun 22 | at Rays | L1-2 | 50-23 | .685 | Tropicana Field · St. Petersburg, FL |
| 74 | Sat Jun 23 | at Rays | L0-4 | 50-24 | .676 | Tropicana Field · St. Petersburg, FL |
| 75 | Sun Jun 24 | at Rays | L6-7 (12) | 50-25 | .667 | Tropicana Field · St. Petersburg, FL |
| 76 | Mon Jun 25 | at Phillies | W4-2 | 51-25 | .671 | Citizens Bank Park · Philadelphi, PA |
| 77 | Tue Jun 26 | at Phillies | W6-0 | 52-25 | .675 | Citizens Bank Park · Philadelphi, PA |
| 78 | Wed Jun 27 | at Phillies | L0-3 | 52-26 | .667 | Citizens Bank Park · Philadelphi, PA |
| 79 | Fri Jun 29 | vs Red Sox | W8-1 | 53-26 | .671 | Yankee Stadium · The Bronx, NY |
| 80 | Sat Jun 30 | vs Red Sox | L0-11 | 53-27 | .662 | Yankee Stadium · The Bronx, NY |
| 81 | Sun Jul 1 | vs Red Sox | W11-1 | 54-27 | .667 | Yankee Stadium · The Bronx, NY |
| 82 | Mon Jul 2 | vs Braves | L3-5 (11) | 54-28 | .659 | Yankee Stadium · The Bronx, NY |
| 83 | Tue Jul 3 | vs Braves | W8-5 | 55-28 | .663 | Yankee Stadium · The Bronx, NY |
| 84 | Wed Jul 4 | vs Braves | W6-2 | 56-28 | .667 | Yankee Stadium · The Bronx, NY |
| 85 | Fri Jul 6 | at Blue Jays | L2-6 | 56-29 | .659 | Rogers Centre · Toronto, ON |
| 86 | Sat Jul 7 | at Blue Jays | W8-5 | 57-29 | .663 | Rogers Centre · Toronto, ON |
| 87 | Sun Jul 8 | at Blue Jays | W2-1 (10) | 58-29 | .667 | Rogers Centre · Toronto, ON |
| 88 | Mon Jul 9 | at Orioles | L4-5 | 58-30 | .659 | Camden Yards · Baltimore, MD |
| 89 | Mon Jul 9 | at Orioles | W10-2 | 59-30 | .663 | Camden Yards · Baltimore, MD |
| 90 | Tue Jul 10 | at Orioles | L5-6 | 59-31 | .656 | Camden Yards · Baltimore, MD |
| 91 | Wed Jul 11 | at Orioles | W9-0 | 60-31 | .659 | Camden Yards · Baltimore, MD |
| 92 | Thu Jul 12 | at Guardians | W7-4 | 61-31 | .663 | Progressive Field · Cleveland, OH |
| 93 | Fri Jul 13 | at Guardians | L5-6 | 61-32 | .656 | Progressive Field · Cleveland, OH |
| 94 | Sat Jul 14 | at Guardians | W5-4 | 62-32 | .660 | Progressive Field · Cleveland, OH |
| 95 | Sun Jul 15 | at Guardians | L2-5 | 62-33 | .653 | Progressive Field · Cleveland, OH |
| 96 | Fri Jul 20 | vs Mets | L5-7 | 62-34 | .646 | Yankee Stadium · The Bronx, NY |
| 97 | Sat Jul 21 | vs Mets | W7-6 | 63-34 | .649 | Yankee Stadium · The Bronx, NY |
| 98 | Mon Jul 23 | at Rays | L6-7 | 63-35 | .643 | Tropicana Field · St. Petersburg, FL |
| 99 | Tue Jul 24 | at Rays | W4-0 | 64-35 | .646 | Tropicana Field · St. Petersburg, FL |
| 100 | Wed Jul 25 | at Rays | L2-3 | 64-36 | .640 | Tropicana Field · St. Petersburg, FL |
| 101 | Thu Jul 26 | vs Royals | W7-2 | 65-36 | .644 | Yankee Stadium · The Bronx, NY |
| 102 | Sat Jul 28 | vs Royals | L5-10 | 65-37 | .637 | Yankee Stadium · The Bronx, NY |
| 103 | Sat Jul 28 | vs Royals | W5-4 | 66-37 | .641 | Yankee Stadium · The Bronx, NY |
| 104 | Sun Jul 29 | vs Royals | W6-3 | 67-37 | .644 | Yankee Stadium · The Bronx, NY |
| 105 | Tue Jul 31 | vs Orioles | W6-3 | 68-37 | .648 | Yankee Stadium · The Bronx, NY |
| 106 | Wed Aug 1 | vs Orioles | L5-7 | 68-38 | .642 | Yankee Stadium · The Bronx, NY |
| 107 | Thu Aug 2 | at Red Sox | L7-15 | 68-39 | .636 | Fenway Park · Boston, MA |
| 108 | Fri Aug 3 | at Red Sox | L1-4 | 68-40 | .630 | Fenway Park · Boston, MA |
| 109 | Sat Aug 4 | at Red Sox | L1-4 | 68-41 | .624 | Fenway Park · Boston, MA |
| 110 | Sun Aug 5 | at Red Sox | L4-5 (10) | 68-42 | .618 | Fenway Park · Boston, MA |
| 111 | Mon Aug 6 | at White Sox | W7-0 | 69-42 | .622 | Guaranteed Rate Field · Chicago, IL |
| 112 | Tue Aug 7 | at White Sox | W4-3 (13) | 70-42 | .625 | Guaranteed Rate Field · Chicago, IL |
| 113 | Wed Aug 8 | at White Sox | W7-3 | 71-42 | .628 | Guaranteed Rate Field · Chicago, IL |
| 114 | Thu Aug 9 | vs Rangers | W7-3 | 72-42 | .632 | Yankee Stadium · The Bronx, NY |
| 115 | Fri Aug 10 | vs Rangers | L7-12 | 72-43 | .626 | Yankee Stadium · The Bronx, NY |
| 116 | Sat Aug 11 | vs Rangers | W5-3 | 73-43 | .629 | Yankee Stadium · The Bronx, NY |
| 117 | Sun Aug 12 | vs Rangers | W7-2 | 74-43 | .632 | Yankee Stadium · The Bronx, NY |
| 118 | Mon Aug 13 | vs Mets | L5-8 | 74-44 | .627 | Yankee Stadium · The Bronx, NY |
| 119 | Tue Aug 14 | vs Rays | W4-1 | 75-44 | .630 | Yankee Stadium · The Bronx, NY |
| 120 | Wed Aug 15 | vs Rays | L1-6 | 75-45 | .625 | Yankee Stadium · The Bronx, NY |
| 121 | Thu Aug 16 | vs Rays | L1-3 | 75-46 | .620 | Yankee Stadium · The Bronx, NY |
| 122 | Fri Aug 17 | vs Blue Jays | W7-5 | 76-46 | .623 | Yankee Stadium · The Bronx, NY |
| 123 | Sat Aug 18 | vs Blue Jays | W11-6 | 77-46 | .626 | Yankee Stadium · The Bronx, NY |
| 124 | Sun Aug 19 | vs Blue Jays | W10-2 | 78-46 | .629 | Yankee Stadium · The Bronx, NY |
| 125 | Tue Aug 21 | at Marlins | W2-1 (12) | 79-46 | .632 | LoanDepot Park · Miami, FL |
| 126 | Wed Aug 22 | at Marlins | L3-9 | 79-47 | .627 | LoanDepot Park · Miami, FL |
| 127 | Fri Aug 24 | at Orioles | W7-5 (10) | 80-47 | .630 | Camden Yards · Baltimore, MD |
| 128 | Sat Aug 25 | at Orioles | W10-3 | 81-47 | .633 | Camden Yards · Baltimore, MD |
| 129 | Sat Aug 25 | at Orioles | W5-1 | 82-47 | .636 | Camden Yards · Baltimore, MD |
| 130 | Sun Aug 26 | at Orioles | W5-3 | 83-47 | .638 | Camden Yards · Baltimore, MD |
| 131 | Mon Aug 27 | vs White Sox | L2-6 | 83-48 | .634 | Yankee Stadium · The Bronx, NY |
| 132 | Tue Aug 28 | vs White Sox | W5-4 | 84-48 | .636 | Yankee Stadium · The Bronx, NY |
| 133 | Wed Aug 29 | vs White Sox | L1-4 | 84-49 | .632 | Yankee Stadium · The Bronx, NY |
| 134 | Thu Aug 30 | vs Tigers | L7-8 | 84-50 | .627 | Yankee Stadium · The Bronx, NY |
| 135 | Fri Aug 31 | vs Tigers | W7-5 | 85-50 | .630 | Yankee Stadium · The Bronx, NY |
| 136 | Sat Sep 1 | vs Tigers | W2-1 | 86-50 | .632 | Yankee Stadium · The Bronx, NY |
| 137 | Sun Sep 2 | vs Tigers | L7-11 | 86-51 | .628 | Yankee Stadium · The Bronx, NY |
| 138 | Mon Sep 3 | at Athletics | L3-6 | 86-52 | .623 | RingCentral Coliseum · Oakland, CA |
| 139 | Tue Sep 4 | at Athletics | W5-1 | 87-52 | .626 | RingCentral Coliseum · Oakland, CA |
| 140 | Wed Sep 5 | at Athletics | L2-8 | 87-53 | .621 | RingCentral Coliseum · Oakland, CA |
| 141 | Fri Sep 7 | at Mariners | W4-0 | 88-53 | .624 | T-Mobile Park · Seattle, WA |
| 142 | Sat Sep 8 | at Mariners | W4-2 | 89-53 | .627 | T-Mobile Park · Seattle, WA |
| 143 | Sun Sep 9 | at Mariners | L2-3 | 89-54 | .622 | T-Mobile Park · Seattle, WA |
| 144 | Mon Sep 10 | at Twins | W7-2 | 90-54 | .625 | Target Field · Minneapolis, MN |
| 145 | Tue Sep 11 | at Twins | L5-10 | 90-55 | .621 | Target Field · Minneapolis, MN |
| 146 | Wed Sep 12 | at Twins | L1-3 | 90-56 | .616 | Target Field · Minneapolis, MN |
| 147 | Fri Sep 14 | vs Blue Jays | W11-0 | 91-56 | .619 | Yankee Stadium · The Bronx, NY |
| 148 | Sat Sep 15 | vs Blue Jays | L7-8 | 91-57 | .615 | Yankee Stadium · The Bronx, NY |
| 149 | Sun Sep 16 | vs Blue Jays | L2-3 | 91-58 | .611 | Yankee Stadium · The Bronx, NY |
| 150 | Tue Sep 18 | vs Red Sox | W3-2 | 92-58 | .613 | Yankee Stadium · The Bronx, NY |
| 151 | Wed Sep 19 | vs Red Sox | W10-1 | 93-58 | .616 | Yankee Stadium · The Bronx, NY |
| 152 | Thu Sep 20 | vs Red Sox | L6-11 | 93-59 | .612 | Yankee Stadium · The Bronx, NY |
| 153 | Fri Sep 21 | vs Orioles | W10-8 | 94-59 | .614 | Yankee Stadium · The Bronx, NY |
| 154 | Sat Sep 22 | vs Orioles | W3-2 (11) | 95-59 | .617 | Yankee Stadium · The Bronx, NY |
| 155 | Sun Sep 23 | vs Orioles | L3-6 | 95-60 | .613 | Yankee Stadium · The Bronx, NY |
| 156 | Mon Sep 24 | at Rays | W4-1 | 96-60 | .615 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 25 | at Rays | W9-2 | 97-60 | .618 | Tropicana Field · St. Petersburg, FL |
| 158 | Wed Sep 26 | at Rays | L7-8 | 97-61 | .614 | Tropicana Field · St. Petersburg, FL |
| 159 | Thu Sep 27 | at Rays | W12-1 | 98-61 | .616 | Tropicana Field · St. Petersburg, FL |
| 160 | Fri Sep 28 | at Red Sox | W11-6 | 99-61 | .619 | Fenway Park · Boston, MA |
| 161 | Sat Sep 29 | at Red Sox | W8-5 | 100-61 | .621 | Fenway Park · Boston, MA |
| 162 | Sun Sep 30 | at Red Sox | L2-10 | 100-62 | .617 | Fenway Park · Boston, MA |
| 163 | Wed Oct 3 | vs Athletics | W7-2 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Fri Oct 5 | at Red Sox | L4-5 | 0-1 | .000 | Fenway Park · Boston, MA |
| 165 | Sat Oct 6 | at Red Sox | W6-2 | 1-1 | .500 | Fenway Park · Boston, MA |
| 166 | Mon Oct 8 | vs Red Sox | L1-16 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 167 | Tue Oct 9 | vs Red Sox | L3-4 | 1-3 | .250 | Yankee Stadium · The Bronx, NY |