| 1 | Tue Apr 1 | at Astros | L2-6 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Wed Apr 2 | at Astros | L1-3 | 0-2 | .000 | Minute Maid Park · Houston, TX |
| 3 | Thu Apr 3 | at Astros | W4-2 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 4 | Fri Apr 4 | at Blue Jays | W7-3 | 2-2 | .500 | Rogers Centre · Toronto, ON |
| 5 | Sat Apr 5 | at Blue Jays | L0-4 | 2-3 | .400 | Rogers Centre · Toronto, ON |
| 6 | Sun Apr 6 | at Blue Jays | W6-4 | 3-3 | .500 | Rogers Centre · Toronto, ON |
| 7 | Mon Apr 7 | vs Orioles | W4-2 | 4-3 | .571 | Yankee Stadium · The Bronx, NY |
| 8 | Tue Apr 8 | vs Orioles | L5-14 | 4-4 | .500 | Yankee Stadium · The Bronx, NY |
| 9 | Wed Apr 9 | vs Orioles | L4-5 | 4-5 | .444 | Yankee Stadium · The Bronx, NY |
| 10 | Thu Apr 10 | vs Red Sox | W4-1 | 5-5 | .500 | Yankee Stadium · The Bronx, NY |
| 11 | Fri Apr 11 | vs Red Sox | L2-4 | 5-6 | .455 | Yankee Stadium · The Bronx, NY |
| 12 | Sat Apr 12 | vs Red Sox | W7-4 | 6-6 | .500 | Yankee Stadium · The Bronx, NY |
| 13 | Sun Apr 13 | vs Red Sox | W3-2 | 7-6 | .538 | Yankee Stadium · The Bronx, NY |
| 14 | Wed Apr 16 | vs Cubs | W3-0 | 8-6 | .571 | Yankee Stadium · The Bronx, NY |
| 15 | Wed Apr 16 | vs Cubs | W2-0 | 9-6 | .600 | Yankee Stadium · The Bronx, NY |
| 16 | Thu Apr 17 | at Rays | W10-2 | 10-6 | .625 | Tropicana Field · St. Petersburg, FL |
| 17 | Fri Apr 18 | at Rays | L5-11 | 10-7 | .588 | Tropicana Field · St. Petersburg, FL |
| 18 | Sat Apr 19 | at Rays | L1-16 | 10-8 | .556 | Tropicana Field · St. Petersburg, FL |
| 19 | Sun Apr 20 | at Rays | W5-1 (12) | 11-8 | .579 | Tropicana Field · St. Petersburg, FL |
| 20 | Tue Apr 22 | at Red Sox | W9-3 | 12-8 | .600 | Fenway Park · Boston, MA |
| 21 | Wed Apr 23 | at Red Sox | L1-5 | 12-9 | .571 | Fenway Park · Boston, MA |
| 22 | Thu Apr 24 | at Red Sox | W14-5 | 13-9 | .591 | Fenway Park · Boston, MA |
| 23 | Fri Apr 25 | vs Angels | L1-13 | 13-10 | .565 | Yankee Stadium · The Bronx, NY |
| 24 | Sat Apr 26 | vs Angels | W4-3 | 14-10 | .583 | Yankee Stadium · The Bronx, NY |
| 25 | Sun Apr 27 | vs Angels | W3-2 | 15-10 | .600 | Yankee Stadium · The Bronx, NY |
| 26 | Tue Apr 29 | vs Mariners | L3-6 | 15-11 | .577 | Yankee Stadium · The Bronx, NY |
| 27 | Thu May 1 | vs Mariners | L2-4 | 15-12 | .556 | Yankee Stadium · The Bronx, NY |
| 28 | Fri May 2 | vs Rays | L5-10 (14) | 15-13 | .536 | Yankee Stadium · The Bronx, NY |
| 29 | Sat May 3 | vs Rays | W9-3 | 16-13 | .552 | Yankee Stadium · The Bronx, NY |
| 30 | Sun May 4 | vs Rays | L1-5 | 16-14 | .533 | Yankee Stadium · The Bronx, NY |
| 31 | Mon May 5 | at Angels | L1-4 | 16-15 | .516 | Angel Stadium · Anaheim, CA |
| 32 | Tue May 6 | at Angels | W4-3 | 17-15 | .531 | Angel Stadium · Anaheim, CA |
| 33 | Wed May 7 | at Angels | W9-2 | 18-15 | .545 | Angel Stadium · Anaheim, CA |
| 34 | Fri May 9 | at Brewers | W5-3 | 19-15 | .559 | American Family Field · Milwaukee, WI |
| 35 | Sat May 10 | at Brewers | L4-5 | 19-16 | .543 | American Family Field · Milwaukee, WI |
| 36 | Sun May 11 | at Brewers | L5-6 | 19-17 | .528 | American Family Field · Milwaukee, WI |
| 37 | Mon May 12 | vs Mets | L7-9 | 19-18 | .514 | Yankee Stadium · The Bronx, NY |
| 38 | Tue May 13 | vs Mets | L7-12 | 19-19 | .500 | Yankee Stadium · The Bronx, NY |
| 39 | Wed May 14 | at Mets | W4-0 | 20-19 | .513 | Citi Field · Queens, NY |
| 40 | Thu May 15 | at Mets | W1-0 | 21-19 | .525 | Citi Field · Queens, NY |
| 41 | Sat May 17 | vs Pirates | W7-1 | 22-19 | .537 | Yankee Stadium · The Bronx, NY |
| 42 | Sun May 18 | vs Pirates | W4-3 | 23-19 | .548 | Yankee Stadium · The Bronx, NY |
| 43 | Sun May 18 | vs Pirates | L3-5 | 23-20 | .535 | Yankee Stadium · The Bronx, NY |
| 44 | Tue May 20 | at Cubs | L1-6 | 23-21 | .523 | Wrigley Field · Chicago, IL |
| 45 | Wed May 21 | at Cubs | W4-2 (13) | 24-21 | .533 | Wrigley Field · Chicago, IL |
| 46 | Thu May 22 | at White Sox | L2-3 | 24-22 | .522 | Guaranteed Rate Field · Chicago, IL |
| 47 | Fri May 23 | at White Sox | L5-6 | 24-23 | .511 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sat May 24 | at White Sox | W4-3 (10) | 25-23 | .521 | Guaranteed Rate Field · Chicago, IL |
| 49 | Sun May 25 | at White Sox | W7-1 | 26-23 | .531 | Guaranteed Rate Field · Chicago, IL |
| 50 | Mon May 26 | at Cardinals | W6-4 (12) | 27-23 | .540 | Busch Stadium · St. Louis, MO |
| 51 | Tue May 27 | at Cardinals | L0-6 | 27-24 | .529 | Busch Stadium · St. Louis, MO |
| 52 | Wed May 28 | at Cardinals | W7-4 | 28-24 | .538 | Busch Stadium · St. Louis, MO |
| 53 | Fri May 30 | vs Twins | L1-6 | 28-25 | .528 | Yankee Stadium · The Bronx, NY |
| 54 | Sat May 31 | vs Twins | W3-1 | 29-25 | .537 | Yankee Stadium · The Bronx, NY |
| 55 | Sun Jun 1 | vs Twins | L2-7 | 29-26 | .527 | Yankee Stadium · The Bronx, NY |
| 56 | Mon Jun 2 | vs Mariners | L2-10 | 29-27 | .518 | Yankee Stadium · The Bronx, NY |
| 57 | Tue Jun 3 | vs Athletics | L2-5 (10) | 29-28 | .509 | Yankee Stadium · The Bronx, NY |
| 58 | Wed Jun 4 | vs Athletics | L4-7 | 29-29 | .500 | Yankee Stadium · The Bronx, NY |
| 59 | Thu Jun 5 | vs Athletics | W2-1 | 30-29 | .508 | Yankee Stadium · The Bronx, NY |
| 60 | Fri Jun 6 | at Royals | W4-2 | 31-29 | .517 | Kauffman Stadium · Kansas City, MO |
| 61 | Sat Jun 7 | at Royals | L4-8 | 31-30 | .508 | Kauffman Stadium · Kansas City, MO |
| 62 | Sun Jun 8 | at Royals | L1-2 | 31-31 | .500 | Kauffman Stadium · Kansas City, MO |
| 63 | Tue Jun 10 | at Mariners | W3-2 | 32-31 | .508 | T-Mobile Park · Seattle, WA |
| 64 | Wed Jun 11 | at Mariners | W4-2 | 33-31 | .516 | T-Mobile Park · Seattle, WA |
| 65 | Thu Jun 12 | at Mariners | W6-3 | 34-31 | .523 | T-Mobile Park · Seattle, WA |
| 66 | Fri Jun 13 | at Athletics | W7-0 | 35-31 | .530 | RingCentral Coliseum · Oakland, CA |
| 67 | Sat Jun 14 | at Athletics | L1-5 | 35-32 | .522 | RingCentral Coliseum · Oakland, CA |
| 68 | Sun Jun 15 | at Athletics | L5-10 | 35-33 | .515 | RingCentral Coliseum · Oakland, CA |
| 69 | Tue Jun 17 | vs Blue Jays | W3-1 | 36-33 | .522 | Yankee Stadium · The Bronx, NY |
| 70 | Wed Jun 18 | vs Blue Jays | W7-3 | 37-33 | .529 | Yankee Stadium · The Bronx, NY |
| 71 | Thu Jun 19 | vs Blue Jays | W6-4 | 38-33 | .535 | Yankee Stadium · The Bronx, NY |
| 72 | Fri Jun 20 | vs Orioles | W5-3 | 39-33 | .542 | Yankee Stadium · The Bronx, NY |
| 73 | Sat Jun 21 | vs Orioles | L1-6 | 39-34 | .534 | Yankee Stadium · The Bronx, NY |
| 74 | Sun Jun 22 | vs Orioles | L0-8 | 39-35 | .527 | Yankee Stadium · The Bronx, NY |
| 75 | Mon Jun 23 | at Blue Jays | L3-8 | 39-36 | .520 | Rogers Centre · Toronto, ON |
| 76 | Tue Jun 24 | at Blue Jays | L6-7 | 39-37 | .513 | Rogers Centre · Toronto, ON |
| 77 | Wed Jun 25 | at Blue Jays | W5-3 | 40-37 | .519 | Rogers Centre · Toronto, ON |
| 78 | Fri Jun 27 | vs Red Sox | W6-0 | 41-37 | .526 | Yankee Stadium · The Bronx, NY |
| 79 | Sat Jun 28 | vs Red Sox | L1-2 | 41-38 | .519 | Yankee Stadium · The Bronx, NY |
| 80 | Sun Jun 29 | vs Red Sox | L5-8 | 41-39 | .512 | Yankee Stadium · The Bronx, NY |
| 81 | Mon Jun 30 | vs Rays | L3-4 (12) | 41-40 | .506 | Yankee Stadium · The Bronx, NY |
| 82 | Tue Jul 1 | vs Rays | L1-2 | 41-41 | .500 | Yankee Stadium · The Bronx, NY |
| 83 | Wed Jul 2 | vs Rays | L3-6 | 41-42 | .494 | Yankee Stadium · The Bronx, NY |
| 84 | Thu Jul 3 | at Twins | W7-4 | 42-42 | .500 | Target Field · Minneapolis, MN |
| 85 | Fri Jul 4 | at Twins | W6-5 | 43-42 | .506 | Target Field · Minneapolis, MN |
| 86 | Sat Jul 5 | at Twins | L1-2 (11) | 43-43 | .500 | Target Field · Minneapolis, MN |
| 87 | Sun Jul 6 | at Twins | W9-7 | 44-43 | .506 | Target Field · Minneapolis, MN |
| 88 | Mon Jul 7 | at Guardians | W5-3 | 45-43 | .511 | Progressive Field · Cleveland, OH |
| 89 | Tue Jul 8 | at Guardians | L3-5 | 45-44 | .506 | Progressive Field · Cleveland, OH |
| 90 | Wed Jul 9 | at Guardians | W5-4 (14) | 46-44 | .511 | Progressive Field · Cleveland, OH |
| 91 | Thu Jul 10 | at Guardians | L3-9 | 46-45 | .505 | Progressive Field · Cleveland, OH |
| 92 | Fri Jul 11 | at Orioles | L2-3 (10) | 46-46 | .500 | Camden Yards · Baltimore, MD |
| 93 | Sat Jul 12 | at Orioles | W3-0 | 47-46 | .505 | Camden Yards · Baltimore, MD |
| 94 | Sun Jul 13 | at Orioles | L1-3 | 47-47 | .500 | Camden Yards · Baltimore, MD |
| 95 | Fri Jul 18 | vs Reds | W4-3 | 48-47 | .505 | Yankee Stadium · The Bronx, NY |
| 96 | Sat Jul 19 | vs Reds | W7-1 | 49-47 | .510 | Yankee Stadium · The Bronx, NY |
| 97 | Sun Jul 20 | vs Reds | W3-2 | 50-47 | .515 | Yankee Stadium · The Bronx, NY |
| 98 | Mon Jul 21 | vs Rangers | L2-4 | 50-48 | .510 | Yankee Stadium · The Bronx, NY |
| 99 | Tue Jul 22 | vs Rangers | W2-1 (14) | 51-48 | .515 | Yankee Stadium · The Bronx, NY |
| 100 | Wed Jul 23 | vs Rangers | W2-1 | 52-48 | .520 | Yankee Stadium · The Bronx, NY |
| 101 | Thu Jul 24 | vs Rangers | W4-2 | 53-48 | .525 | Yankee Stadium · The Bronx, NY |
| 102 | Fri Jul 25 | vs Blue Jays | W6-4 | 54-48 | .529 | Yankee Stadium · The Bronx, NY |
| 103 | Sat Jul 26 | vs Blue Jays | L4-6 | 54-49 | .524 | Yankee Stadium · The Bronx, NY |
| 104 | Sun Jul 27 | vs Blue Jays | L4-5 | 54-50 | .519 | Yankee Stadium · The Bronx, NY |
| 105 | Mon Jul 28 | at Rangers | L2-4 | 54-51 | .514 | Globe Life Field · Arlington, TX |
| 106 | Tue Jul 29 | at Rangers | W12-11 | 55-51 | .519 | Globe Life Field · Arlington, TX |
| 107 | Wed Jul 30 | at Rangers | L2-3 | 55-52 | .514 | Globe Life Field · Arlington, TX |
| 108 | Fri Aug 1 | at Red Sox | L3-4 | 55-53 | .509 | Fenway Park · Boston, MA |
| 109 | Sat Aug 2 | at Red Sox | W6-4 | 56-53 | .514 | Fenway Park · Boston, MA |
| 110 | Sun Aug 3 | at Red Sox | W8-7 | 57-53 | .518 | Fenway Park · Boston, MA |
| 111 | Mon Aug 4 | vs Tigers | W2-1 | 58-53 | .523 | Yankee Stadium · The Bronx, NY |
| 112 | Tue Aug 5 | vs Tigers | L3-4 (12) | 58-54 | .518 | Yankee Stadium · The Bronx, NY |
| 113 | Wed Aug 6 | vs Tigers | W5-1 | 59-54 | .522 | Yankee Stadium · The Bronx, NY |
| 114 | Thu Aug 7 | vs Tigers | W1-0 | 60-54 | .526 | Yankee Stadium · The Bronx, NY |
| 115 | Fri Aug 8 | vs Guardians | W10-6 | 61-54 | .530 | Yankee Stadium · The Bronx, NY |
| 116 | Sat Aug 9 | vs Guardians | L0-3 | 61-55 | .526 | Yankee Stadium · The Bronx, NY |
| 117 | Sun Aug 10 | vs Guardians | L1-4 | 61-56 | .521 | Yankee Stadium · The Bronx, NY |
| 118 | Mon Aug 11 | at Orioles | L3-11 | 61-57 | .517 | Camden Yards · Baltimore, MD |
| 119 | Wed Aug 13 | at Orioles | L3-5 | 61-58 | .513 | Camden Yards · Baltimore, MD |
| 120 | Fri Aug 15 | at Rays | L0-5 | 61-59 | .508 | Tropicana Field · St. Petersburg, FL |
| 121 | Sat Aug 16 | at Rays | W3-2 | 62-59 | .512 | Tropicana Field · St. Petersburg, FL |
| 122 | Sun Aug 17 | at Rays | W4-2 | 63-59 | .516 | Tropicana Field · St. Petersburg, FL |
| 123 | Tue Aug 19 | vs Astros | L4-7 | 63-60 | .512 | Yankee Stadium · The Bronx, NY |
| 124 | Wed Aug 20 | vs Astros | L2-5 | 63-61 | .508 | Yankee Stadium · The Bronx, NY |
| 125 | Thu Aug 21 | vs Astros | W3-0 | 64-61 | .512 | Yankee Stadium · The Bronx, NY |
| 126 | Fri Aug 22 | vs White Sox | W4-3 | 65-61 | .516 | Yankee Stadium · The Bronx, NY |
| 127 | Sat Aug 23 | vs White Sox | W5-3 | 66-61 | .520 | Yankee Stadium · The Bronx, NY |
| 128 | Sun Aug 24 | vs White Sox | W7-4 (10) | 67-61 | .523 | Yankee Stadium · The Bronx, NY |
| 129 | Mon Aug 25 | at Royals | W8-1 | 68-61 | .527 | Kauffman Stadium · Kansas City, MO |
| 130 | Tue Aug 26 | at Tigers | L2-5 | 68-62 | .523 | Comerica Park · Detroit, MI |
| 131 | Wed Aug 27 | at Tigers | W8-4 | 69-62 | .527 | Comerica Park · Detroit, MI |
| 132 | Thu Aug 28 | at Tigers | L2-3 | 69-63 | .523 | Comerica Park · Detroit, MI |
| 133 | Fri Aug 29 | at Blue Jays | W6-3 | 70-63 | .526 | Rogers Centre · Toronto, ON |
| 134 | Sat Aug 30 | at Blue Jays | L0-2 | 70-64 | .522 | Rogers Centre · Toronto, ON |
| 135 | Sun Aug 31 | at Blue Jays | L3-4 | 70-65 | .519 | Rogers Centre · Toronto, ON |
| 136 | Tue Sep 2 | vs Red Sox | L4-9 | 70-66 | .515 | Yankee Stadium · The Bronx, NY |
| 137 | Wed Sep 3 | vs Red Sox | W5-1 | 71-66 | .518 | Yankee Stadium · The Bronx, NY |
| 138 | Thu Sep 4 | vs Red Sox | W5-4 | 72-66 | .522 | Yankee Stadium · The Bronx, NY |
| 139 | Fri Sep 5 | vs Royals | L0-1 | 72-67 | .518 | Yankee Stadium · The Bronx, NY |
| 140 | Sat Sep 6 | vs Royals | W6-2 | 73-67 | .521 | Yankee Stadium · The Bronx, NY |
| 141 | Sun Sep 7 | vs Royals | L0-2 | 73-68 | .518 | Yankee Stadium · The Bronx, NY |
| 142 | Tue Sep 9 | vs Rays | L3-4 | 73-69 | .514 | Yankee Stadium · The Bronx, NY |
| 143 | Wed Sep 10 | vs Rays | W8-5 | 74-69 | .517 | Yankee Stadium · The Bronx, NY |
| 144 | Thu Sep 11 | vs Rays | W5-4 | 75-69 | .521 | Yankee Stadium · The Bronx, NY |
| 145 | Fri Sep 12 | at Orioles | L1-2 (11) | 75-70 | .517 | Camden Yards · Baltimore, MD |
| 146 | Fri Sep 12 | at Orioles | L0-5 | 75-71 | .514 | Camden Yards · Baltimore, MD |
| 147 | Sat Sep 13 | at Orioles | W3-2 | 76-71 | .517 | Camden Yards · Baltimore, MD |
| 148 | Sun Sep 14 | at Orioles | L2-3 | 76-72 | .514 | Camden Yards · Baltimore, MD |
| 149 | Mon Sep 15 | at Rays | L0-1 | 76-73 | .510 | Tropicana Field · St. Petersburg, FL |
| 150 | Tue Sep 16 | at Rays | L1-6 | 76-74 | .507 | Tropicana Field · St. Petersburg, FL |
| 151 | Wed Sep 17 | at Rays | W3-2 | 77-74 | .510 | Tropicana Field · St. Petersburg, FL |
| 152 | Thu Sep 18 | vs Blue Jays | W3-2 | 78-74 | .513 | Yankee Stadium · The Bronx, NY |
| 153 | Fri Sep 19 | vs Blue Jays | W5-3 | 79-74 | .516 | Yankee Stadium · The Bronx, NY |
| 154 | Sat Sep 20 | vs Blue Jays | L3-6 | 79-75 | .513 | Yankee Stadium · The Bronx, NY |
| 155 | Sun Sep 21 | vs Blue Jays | W5-2 | 80-75 | .516 | Yankee Stadium · The Bronx, NY |
| 156 | Mon Sep 22 | vs Orioles | W5-0 | 81-75 | .519 | Yankee Stadium · The Bronx, NY |
| 157 | Tue Sep 23 | vs Orioles | L4-5 | 81-76 | .516 | Yankee Stadium · The Bronx, NY |
| 158 | Wed Sep 24 | vs Orioles | L5-9 | 81-77 | .513 | Yankee Stadium · The Bronx, NY |
| 159 | Thu Sep 25 | vs Orioles | W6-5 | 82-77 | .516 | Yankee Stadium · The Bronx, NY |
| 160 | Fri Sep 26 | at Red Sox | W3-2 | 83-77 | .519 | Fenway Park · Boston, MA |
| 161 | Sat Sep 27 | at Red Sox | L4-10 | 83-78 | .516 | Fenway Park · Boston, MA |
| 162 | Sun Sep 28 | at Red Sox | W9-5 | 84-78 | .519 | Fenway Park · Boston, MA |