| 1 | Fri Mar 27 | vs Athletics | W3-2 | 1-0 | 1.000 | Rogers Centre · Toronto, ON |
| 2 | Sat Mar 28 | vs Athletics | W8-7 (11) | 2-0 | 1.000 | Rogers Centre · Toronto, ON |
| 3 | Sun Mar 29 | vs Athletics | W5-2 | 3-0 | 1.000 | Rogers Centre · Toronto, ON |
| 4 | Mon Mar 30 | vs Rockies | L5-14 | 3-1 | .750 | Rogers Centre · Toronto, ON |
| 5 | Tue Mar 31 | vs Rockies | W5-1 | 4-1 | .800 | Rogers Centre · Toronto, ON |
| 6 | Wed Apr 1 | vs Rockies | L1-2 (10) | 4-2 | .667 | Rogers Centre · Toronto, ON |
| 7 | Fri Apr 3 | at White Sox | L4-5 (10) | 4-3 | .571 | Guaranteed Rate Field · Chicago, IL |
| 8 | Sat Apr 4 | at White Sox | L3-6 | 4-4 | .500 | Guaranteed Rate Field · Chicago, IL |
| 9 | Sun Apr 5 | at White Sox | L0-3 | 4-5 | .444 | Guaranteed Rate Field · Chicago, IL |
| 10 | Mon Apr 6 | vs Dodgers | L2-14 | 4-6 | .400 | Rogers Centre · Toronto, ON |
| 11 | Tue Apr 7 | vs Dodgers | L1-4 | 4-7 | .364 | Rogers Centre · Toronto, ON |
| 12 | Wed Apr 8 | vs Dodgers | W4-3 | 5-7 | .417 | Rogers Centre · Toronto, ON |
| 13 | Fri Apr 10 | vs Twins | W10-4 | 6-7 | .462 | Rogers Centre · Toronto, ON |
| 14 | Sat Apr 11 | vs Twins | L4-7 | 6-8 | .429 | Rogers Centre · Toronto, ON |
| 15 | Sun Apr 12 | vs Twins | L2-8 | 6-9 | .400 | Rogers Centre · Toronto, ON |
| 16 | Tue Apr 14 | at Brewers | W9-7 (10) | 7-9 | .438 | American Family Field · Milwaukee, WI |
| 17 | Wed Apr 15 | at Brewers | L1-2 | 7-10 | .412 | American Family Field · Milwaukee, WI |
| 18 | Thu Apr 16 | at Brewers | L1-2 | 7-11 | .389 | American Family Field · Milwaukee, WI |
| 19 | Fri Apr 17 | at D-backs | L3-6 | 7-12 | .368 | Chase Field · Phoenix, AZ |
| 20 | Sat Apr 18 | at D-backs | L2-6 | 7-13 | .350 | Chase Field · Phoenix, AZ |
| 21 | Sun Apr 19 | at D-backs | W10-4 | 8-13 | .381 | Chase Field · Phoenix, AZ |
| 22 | Mon Apr 20 | at Angels | W5-2 | 9-13 | .409 | Angel Stadium · Anaheim, CA |
| 23 | Tue Apr 21 | at Angels | W4-2 | 10-13 | .435 | Angel Stadium · Anaheim, CA |
| 24 | Wed Apr 22 | at Angels | L3-7 | 10-14 | .417 | Angel Stadium · Anaheim, CA |
| 25 | Fri Apr 24 | vs Guardians | L6-8 | 10-15 | .400 | Rogers Centre · Toronto, ON |
| 26 | Sat Apr 25 | vs Guardians | W5-3 | 11-15 | .423 | Rogers Centre · Toronto, ON |
| 27 | Sun Apr 26 | vs Guardians | W4-2 | 12-15 | .444 | Rogers Centre · Toronto, ON |
| 28 | Mon Apr 27 | vs Red Sox | L0-5 | 12-16 | .429 | Rogers Centre · Toronto, ON |
| 29 | Tue Apr 28 | vs Red Sox | W3-0 | 13-16 | .448 | Rogers Centre · Toronto, ON |
| 30 | Wed Apr 29 | vs Red Sox | W8-1 | 14-16 | .467 | Rogers Centre · Toronto, ON |
| 31 | Thu Apr 30 | at Twins | L1-7 | 14-17 | .452 | Target Field · Minneapolis, MN |
| 32 | Fri May 1 | at Twins | W7-3 | 15-17 | .469 | Target Field · Minneapolis, MN |
| 33 | Sat May 2 | at Twins | W11-4 | 16-17 | .485 | Target Field · Minneapolis, MN |
| 34 | Sun May 3 | at Twins | L3-4 | 16-18 | .471 | Target Field · Minneapolis, MN |
| 35 | Mon May 4 | at Rays | L1-5 | 16-19 | .457 | Tropicana Field · St. Petersburg, FL |
| 36 | Tue May 5 | at Rays | L3-4 | 16-20 | .444 | Tropicana Field · St. Petersburg, FL |
| 37 | Wed May 6 | at Rays | L0-3 | 16-21 | .432 | Tropicana Field · St. Petersburg, FL |
| 38 | Fri May 8 | vs Angels | W2-0 | 17-21 | .447 | Rogers Centre · Toronto, ON |
| 39 | Sat May 9 | vs Angels | W14-1 | 18-21 | .462 | Rogers Centre · Toronto, ON |
| 40 | Sun May 10 | vs Angels | L1-6 | 18-22 | .450 | Rogers Centre · Toronto, ON |
| 41 | Mon May 11 | vs Rays | L5-8 | 18-23 | .439 | Rogers Centre · Toronto, ON |
| 42 | Tue May 12 | vs Rays | L6-7 (10) | 18-24 | .429 | Rogers Centre · Toronto, ON |
| 43 | Wed May 13 | vs Rays | W5-3 (10) | 19-24 | .442 | Rogers Centre · Toronto, ON |
| 44 | Fri May 15 | at Tigers | L2-3 | 19-25 | .432 | Comerica Park · Detroit, MI |
| 45 | Sat May 16 | at Tigers | W2-1 (10) | 20-25 | .444 | Comerica Park · Detroit, MI |
| 46 | Sun May 17 | at Tigers | W4-1 | 21-25 | .457 | Comerica Park · Detroit, MI |
| 47 | Mon May 18 | at Yankees | L6-7 | 21-26 | .447 | Yankee Stadium · The Bronx, NY |
| 48 | Tue May 19 | at Yankees | L4-5 | 21-27 | .438 | Yankee Stadium · The Bronx, NY |
| 49 | Wed May 20 | at Yankees | W2-1 | 22-27 | .449 | Yankee Stadium · The Bronx, NY |
| 50 | Thu May 21 | at Yankees | W2-0 | 23-27 | .460 | Yankee Stadium · The Bronx, NY |
| 51 | Fri May 22 | vs Pirates | W6-2 | 24-27 | .471 | Rogers Centre · Toronto, ON |
| 52 | Sat May 23 | vs Pirates | W5-2 | 25-27 | .481 | Rogers Centre · Toronto, ON |
| 53 | Sun May 24 | vs Pirates | L1-4 | 25-28 | .472 | Rogers Centre · Toronto, ON |
| 54 | Mon May 25 | vs Marlins | L2-8 | 25-29 | .463 | Rogers Centre · Toronto, ON |
| 55 | Tue May 26 | vs Marlins | W8-1 | 26-29 | .473 | Rogers Centre · Toronto, ON |
| 56 | Wed May 27 | vs Marlins | W2-1 | 27-29 | .482 | Rogers Centre · Toronto, ON |
| 57 | Thu May 28 | at Orioles | W2-1 | 28-29 | .491 | Camden Yards · Baltimore, MD |
| 58 | Fri May 29 | at Orioles | W6-5 | 29-29 | .500 | Camden Yards · Baltimore, MD |
| 59 | Sat May 30 | at Orioles | L5-6 | 29-30 | .492 | Camden Yards · Baltimore, MD |
| 60 | Sun May 31 | at Orioles | L5-9 | 29-31 | .483 | Camden Yards · Baltimore, MD |
| 61 | Tue Jun 2 | at Braves | L3-4 | 29-32 | .475 | Truist Park · Cumberland, GA |
| 62 | Wed Jun 3 | at Braves | L3-7 | 29-33 | .468 | Truist Park · Cumberland, GA |
| 63 | Thu Jun 4 | at Braves | W7-2 | 30-33 | .476 | Truist Park · Cumberland, GA |
| 64 | Fri Jun 5 | vs Orioles | L3-13 | 30-34 | .469 | Rogers Centre · Toronto, ON |
| 65 | Sat Jun 6 | vs Orioles | W6-4 | 31-34 | .477 | Rogers Centre · Toronto, ON |
| 66 | Sun Jun 7 | vs Orioles | W6-4 | 32-34 | .485 | Rogers Centre · Toronto, ON |
| 67 | Mon Jun 8 | vs Phillies | L2-5 | 32-35 | .478 | Rogers Centre · Toronto, ON |
| 68 | Tue Jun 9 | vs Phillies | W3-2 | 33-35 | .485 | Rogers Centre · Toronto, ON |
| 69 | Wed Jun 10 | vs Phillies | L4-7 | 33-36 | .478 | Rogers Centre · Toronto, ON |
| 70 | Fri Jun 12 | vs Yankees | W8-5 | 34-36 | .486 | Rogers Centre · Toronto, ON |
| 71 | Sat Jun 13 | vs Yankees | L1-3 | 34-37 | .479 | Rogers Centre · Toronto, ON |
| 72 | Sun Jun 14 | vs Yankees | L3-8 | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 73 | Tue Jun 16 | at Red Sox | W6-1 | 35-38 | .479 | Fenway Park · Boston, MA |
| 74 | Wed Jun 17 | at Red Sox | W3-0 | 36-38 | .486 | Fenway Park · Boston, MA |
| 75 | Thu Jun 18 | at Red Sox | W4-3 | 37-38 | .493 | Fenway Park · Boston, MA |
| 76 | Fri Jun 19 | at Cubs | L2-16 | 37-39 | .487 | Wrigley Field · Chicago, IL |
| 77 | Sat Jun 20 | at Cubs | W8-6 | 38-39 | .494 | Wrigley Field · Chicago, IL |
| 78 | Mon Jun 22 | vs Astros | W4-2 | 39-39 | .500 | Rogers Centre · Toronto, ON |
| 79 | Tue Jun 23 | vs Astros | L7-9 (11) | 39-40 | .494 | Rogers Centre · Toronto, ON |
| 80 | Wed Jun 24 | vs Astros | L1-3 | 39-41 | .487 | Rogers Centre · Toronto, ON |
| 81 | Thu Jun 25 | vs Rangers | L5-6 | 39-42 | .481 | Rogers Centre · Toronto, ON |
| 82 | Fri Jun 26 | vs Rangers | L4-5 | 39-43 | .476 | Rogers Centre · Toronto, ON |
| 83 | Sat Jun 27 | vs Rangers | L4-7 | 39-44 | .470 | Rogers Centre · Toronto, ON |
| 84 | Sun Jun 28 | vs Rangers | L2-3 | 39-45 | .464 | Rogers Centre · Toronto, ON |
| 85 | Mon Jun 29 | vs Mets | W2-1 | 40-45 | .471 | Rogers Centre · Toronto, ON |
| 86 | Tue Jun 30 | vs Mets | L0-3 | 40-46 | .465 | Rogers Centre · Toronto, ON |
| 87 | Wed Jul 1 | vs Mets | W9-3 | 41-46 | .471 | Rogers Centre · Toronto, ON |
| 88 | Fri Jul 3 | at Mariners | W2-0 | 42-46 | .477 | T-Mobile Park · Seattle, WA |
| 89 | Sat Jul 4 | at Mariners | L0-11 | 42-47 | .472 | T-Mobile Park · Seattle, WA |
| 90 | Sun Jul 5 | at Mariners | L0-4 | 42-48 | .467 | T-Mobile Park · Seattle, WA |
| 91 | Mon Jul 6 | at Giants | L1-10 | 42-49 | .462 | Oracle Park · San Francisco, CA |
| 92 | Tue Jul 7 | at Giants | W9-3 | 43-49 | .467 | Oracle Park · San Francisco, CA |
| 93 | Wed Jul 8 | at Giants | W10-0 | 44-49 | .473 | Oracle Park · San Francisco, CA |
| 94 | Fri Jul 10 | at Padres | W5-3 | 45-49 | .479 | Petco Park · San Diego, CA |
| 95 | Sat Jul 11 | at Padres | L7-8 | 45-50 | .474 | Petco Park · San Diego, CA |
| 96 | Sun Jul 12 | at Padres | L4-5 | 45-51 | .469 | Petco Park · San Diego, CA |