| 1 | Mon Apr 4 | at Braves | W4-3 (10) | 1-0 | 1.000 | Truist Park · Cumberland, GA |
| 2 | Wed Apr 6 | at Braves | W3-1 | 2-0 | 1.000 | Truist Park · Cumberland, GA |
| 3 | Thu Apr 7 | vs Marlins | L4-6 | 2-1 | .667 | Nationals Park · Washington, D.C. |
| 4 | Sun Apr 10 | vs Marlins | W4-2 | 3-1 | .750 | Nationals Park · Washington, D.C. |
| 5 | Mon Apr 11 | vs Braves | W6-4 | 4-1 | .800 | Nationals Park · Washington, D.C. |
| 6 | Tue Apr 12 | vs Braves | W2-1 | 5-1 | .833 | Nationals Park · Washington, D.C. |
| 7 | Wed Apr 13 | vs Braves | W3-0 | 6-1 | .857 | Nationals Park · Washington, D.C. |
| 8 | Thu Apr 14 | vs Braves | W6-2 | 7-1 | .875 | Nationals Park · Washington, D.C. |
| 9 | Fri Apr 15 | at Phillies | W9-1 | 8-1 | .889 | Citizens Bank Park · Philadelphi, PA |
| 10 | Sat Apr 16 | at Phillies | W8-1 | 9-1 | .900 | Citizens Bank Park · Philadelphi, PA |
| 11 | Sun Apr 17 | at Phillies | L2-3 (10) | 9-2 | .818 | Citizens Bank Park · Philadelphi, PA |
| 12 | Mon Apr 18 | at Marlins | L1-6 | 9-3 | .750 | LoanDepot Park · Miami, FL |
| 13 | Tue Apr 19 | at Marlins | W7-0 | 10-3 | .769 | LoanDepot Park · Miami, FL |
| 14 | Wed Apr 20 | at Marlins | W3-1 | 11-3 | .786 | LoanDepot Park · Miami, FL |
| 15 | Thu Apr 21 | at Marlins | L1-5 | 11-4 | .733 | LoanDepot Park · Miami, FL |
| 16 | Fri Apr 22 | vs Twins | W8-4 | 12-4 | .750 | Nationals Park · Washington, D.C. |
| 17 | Sat Apr 23 | vs Twins | W2-0 | 13-4 | .765 | Nationals Park · Washington, D.C. |
| 18 | Sun Apr 24 | vs Twins | W6-5 (16) | 14-4 | .778 | Nationals Park · Washington, D.C. |
| 19 | Tue Apr 26 | vs Phillies | L3-4 | 14-5 | .737 | Nationals Park · Washington, D.C. |
| 20 | Wed Apr 27 | vs Phillies | L0-3 | 14-6 | .700 | Nationals Park · Washington, D.C. |
| 21 | Thu Apr 28 | vs Phillies | L0-3 | 14-7 | .667 | Nationals Park · Washington, D.C. |
| 22 | Fri Apr 29 | at Cardinals | W5-4 | 15-7 | .682 | Busch Stadium · St. Louis, MO |
| 23 | Sat Apr 30 | at Cardinals | W6-1 | 16-7 | .696 | Busch Stadium · St. Louis, MO |
| 24 | Sun May 1 | at Cardinals | W6-1 | 17-7 | .708 | Busch Stadium · St. Louis, MO |
| 25 | Mon May 2 | at Royals | W2-0 | 18-7 | .720 | Kauffman Stadium · Kansas City, MO |
| 26 | Tue May 3 | at Royals | L6-7 | 18-8 | .692 | Kauffman Stadium · Kansas City, MO |
| 27 | Wed May 4 | at Royals | W13-2 | 19-8 | .704 | Kauffman Stadium · Kansas City, MO |
| 28 | Thu May 5 | at Cubs | L2-5 | 19-9 | .679 | Wrigley Field · Chicago, IL |
| 29 | Fri May 6 | at Cubs | L6-8 | 19-10 | .655 | Wrigley Field · Chicago, IL |
| 30 | Sat May 7 | at Cubs | L5-8 | 19-11 | .633 | Wrigley Field · Chicago, IL |
| 31 | Sun May 8 | at Cubs | L3-4 (13) | 19-12 | .613 | Wrigley Field · Chicago, IL |
| 32 | Mon May 9 | vs Tigers | W5-4 | 20-12 | .625 | Nationals Park · Washington, D.C. |
| 33 | Tue May 10 | vs Tigers | L4-5 | 20-13 | .606 | Nationals Park · Washington, D.C. |
| 34 | Wed May 11 | vs Tigers | W3-2 | 21-13 | .618 | Nationals Park · Washington, D.C. |
| 35 | Fri May 13 | vs Marlins | W5-3 | 22-13 | .629 | Nationals Park · Washington, D.C. |
| 36 | Sat May 14 | vs Marlins | W6-4 | 23-13 | .639 | Nationals Park · Washington, D.C. |
| 37 | Sat May 14 | vs Marlins | L1-7 | 23-14 | .622 | Nationals Park · Washington, D.C. |
| 38 | Sun May 15 | vs Marlins | L1-5 | 23-15 | .605 | Nationals Park · Washington, D.C. |
| 39 | Tue May 17 | at Mets | L0-2 | 23-16 | .590 | Citi Field · Queens, NY |
| 40 | Wed May 18 | at Mets | W7-1 | 24-16 | .600 | Citi Field · Queens, NY |
| 41 | Thu May 19 | at Mets | W9-1 | 25-16 | .610 | Citi Field · Queens, NY |
| 42 | Fri May 20 | at Marlins | W4-1 | 26-16 | .619 | LoanDepot Park · Miami, FL |
| 43 | Sat May 21 | at Marlins | L2-3 | 26-17 | .605 | LoanDepot Park · Miami, FL |
| 44 | Sun May 22 | at Marlins | W8-2 | 27-17 | .614 | LoanDepot Park · Miami, FL |
| 45 | Mon May 23 | vs Mets | L1-7 | 27-18 | .600 | Nationals Park · Washington, D.C. |
| 46 | Tue May 24 | vs Mets | W7-4 | 28-18 | .609 | Nationals Park · Washington, D.C. |
| 47 | Wed May 25 | vs Mets | L0-2 | 28-19 | .596 | Nationals Park · Washington, D.C. |
| 48 | Thu May 26 | vs Cardinals | W2-1 | 29-19 | .604 | Nationals Park · Washington, D.C. |
| 49 | Fri May 27 | vs Cardinals | L2-6 | 29-20 | .592 | Nationals Park · Washington, D.C. |
| 50 | Sat May 28 | vs Cardinals | L4-9 | 29-21 | .580 | Nationals Park · Washington, D.C. |
| 51 | Sun May 29 | vs Cardinals | W10-2 | 30-21 | .588 | Nationals Park · Washington, D.C. |
| 52 | Mon May 30 | at Phillies | W4-3 | 31-21 | .596 | Citizens Bank Park · Philadelphi, PA |
| 53 | Tue May 31 | at Phillies | W5-1 | 32-21 | .604 | Citizens Bank Park · Philadelphi, PA |
| 54 | Wed Jun 1 | at Phillies | W7-2 | 33-21 | .611 | Citizens Bank Park · Philadelphi, PA |
| 55 | Fri Jun 3 | at Reds | L2-7 | 33-22 | .600 | Great American Ball Park · Cincinnati, OH |
| 56 | Sat Jun 4 | at Reds | L3-6 | 33-23 | .589 | Great American Ball Park · Cincinnati, OH |
| 57 | Sun Jun 5 | at Reds | W10-9 | 34-23 | .596 | Great American Ball Park · Cincinnati, OH |
| 58 | Tue Jun 7 | at White Sox | W10-5 | 35-23 | .603 | Guaranteed Rate Field · Chicago, IL |
| 59 | Wed Jun 8 | at White Sox | W11-4 | 36-23 | .610 | Guaranteed Rate Field · Chicago, IL |
| 60 | Thu Jun 9 | at White Sox | L1-3 | 36-24 | .600 | Guaranteed Rate Field · Chicago, IL |
| 61 | Fri Jun 10 | vs Phillies | W9-6 | 37-24 | .607 | Nationals Park · Washington, D.C. |
| 62 | Sat Jun 11 | vs Phillies | W8-0 | 38-24 | .613 | Nationals Park · Washington, D.C. |
| 63 | Sun Jun 12 | vs Phillies | W5-4 | 39-24 | .619 | Nationals Park · Washington, D.C. |
| 64 | Mon Jun 13 | vs Cubs | W4-1 | 40-24 | .625 | Nationals Park · Washington, D.C. |
| 65 | Tue Jun 14 | vs Cubs | L3-4 | 40-25 | .615 | Nationals Park · Washington, D.C. |
| 66 | Wed Jun 15 | vs Cubs | W5-4 (12) | 41-25 | .621 | Nationals Park · Washington, D.C. |
| 67 | Thu Jun 16 | at Padres | W8-5 | 42-25 | .627 | Petco Park · San Diego, CA |
| 68 | Fri Jun 17 | at Padres | W7-5 | 43-25 | .632 | Petco Park · San Diego, CA |
| 69 | Sat Jun 18 | at Padres | L3-7 | 43-26 | .623 | Petco Park · San Diego, CA |
| 70 | Sun Jun 19 | at Padres | L3-6 | 43-27 | .614 | Petco Park · San Diego, CA |
| 71 | Mon Jun 20 | at Dodgers | L1-4 | 43-28 | .606 | Dodger Stadium · Los Angeles, CA |
| 72 | Tue Jun 21 | at Dodgers | L2-3 | 43-29 | .597 | Dodger Stadium · Los Angeles, CA |
| 73 | Wed Jun 22 | at Dodgers | L3-4 | 43-30 | .589 | Dodger Stadium · Los Angeles, CA |
| 74 | Fri Jun 24 | at Brewers | L3-5 | 43-31 | .581 | American Family Field · Milwaukee, WI |
| 75 | Sat Jun 25 | at Brewers | L5-6 | 43-32 | .573 | American Family Field · Milwaukee, WI |
| 76 | Sun Jun 26 | at Brewers | W3-2 | 44-32 | .579 | American Family Field · Milwaukee, WI |
| 77 | Mon Jun 27 | vs Mets | W11-4 | 45-32 | .584 | Nationals Park · Washington, D.C. |
| 78 | Tue Jun 28 | vs Mets | W5-0 | 46-32 | .590 | Nationals Park · Washington, D.C. |
| 79 | Wed Jun 29 | vs Mets | W4-2 | 47-32 | .595 | Nationals Park · Washington, D.C. |
| 80 | Thu Jun 30 | vs Reds | W13-4 | 48-32 | .600 | Nationals Park · Washington, D.C. |
| 81 | Fri Jul 1 | vs Reds | W3-2 (14) | 49-32 | .605 | Nationals Park · Washington, D.C. |
| 82 | Sat Jul 2 | vs Reds | L4-9 (10) | 49-33 | .598 | Nationals Park · Washington, D.C. |
| 83 | Sun Jul 3 | vs Reds | W12-1 | 50-33 | .602 | Nationals Park · Washington, D.C. |
| 84 | Mon Jul 4 | vs Brewers | L0-1 | 50-34 | .595 | Nationals Park · Washington, D.C. |
| 85 | Tue Jul 5 | vs Brewers | L2-5 | 50-35 | .588 | Nationals Park · Washington, D.C. |
| 86 | Wed Jul 6 | vs Brewers | W7-4 | 51-35 | .593 | Nationals Park · Washington, D.C. |
| 87 | Thu Jul 7 | at Mets | L7-9 | 51-36 | .586 | Citi Field · Queens, NY |
| 88 | Fri Jul 8 | at Mets | W3-1 | 52-36 | .591 | Citi Field · Queens, NY |
| 89 | Sat Jul 9 | at Mets | W6-1 | 53-36 | .596 | Citi Field · Queens, NY |
| 90 | Sun Jul 10 | at Mets | W3-2 | 54-36 | .600 | Citi Field · Queens, NY |
| 91 | Fri Jul 15 | vs Pirates | W5-1 | 55-36 | .604 | Nationals Park · Washington, D.C. |
| 92 | Sat Jul 16 | vs Pirates | W6-0 | 56-36 | .609 | Nationals Park · Washington, D.C. |
| 93 | Sun Jul 17 | vs Pirates | L1-2 (18) | 56-37 | .602 | Nationals Park · Washington, D.C. |
| 94 | Tue Jul 19 | vs Dodgers | L4-8 | 56-38 | .596 | Nationals Park · Washington, D.C. |
| 95 | Wed Jul 20 | vs Dodgers | W8-1 | 57-38 | .600 | Nationals Park · Washington, D.C. |
| 96 | Thu Jul 21 | vs Dodgers | L3-6 | 57-39 | .594 | Nationals Park · Washington, D.C. |
| 97 | Fri Jul 22 | vs Padres | L3-5 | 57-40 | .588 | Nationals Park · Washington, D.C. |
| 98 | Sat Jul 23 | vs Padres | W3-2 | 58-40 | .592 | Nationals Park · Washington, D.C. |
| 99 | Sun Jul 24 | vs Padres | L6-10 | 58-41 | .586 | Nationals Park · Washington, D.C. |
| 100 | Tue Jul 26 | at Guardians | L6-7 | 58-42 | .580 | Progressive Field · Cleveland, OH |
| 101 | Wed Jul 27 | at Guardians | W4-1 | 59-42 | .584 | Progressive Field · Cleveland, OH |
| 102 | Thu Jul 28 | at Giants | W4-2 | 60-42 | .588 | Oracle Park · San Francisco, CA |
| 103 | Fri Jul 29 | at Giants | W4-1 | 61-42 | .592 | Oracle Park · San Francisco, CA |
| 104 | Sat Jul 30 | at Giants | L3-5 | 61-43 | .587 | Oracle Park · San Francisco, CA |
| 105 | Sun Jul 31 | at Giants | L1-3 | 61-44 | .581 | Oracle Park · San Francisco, CA |
| 106 | Mon Aug 1 | at D-backs | W14-1 | 62-44 | .585 | Chase Field · Phoenix, AZ |
| 107 | Tue Aug 2 | at D-backs | W10-4 | 63-44 | .589 | Chase Field · Phoenix, AZ |
| 108 | Wed Aug 3 | at D-backs | W8-3 | 64-44 | .593 | Chase Field · Phoenix, AZ |
| 109 | Fri Aug 5 | vs Giants | W5-1 | 65-44 | .596 | Nationals Park · Washington, D.C. |
| 110 | Sat Aug 6 | vs Giants | L1-7 | 65-45 | .591 | Nationals Park · Washington, D.C. |
| 111 | Sun Aug 7 | vs Giants | W1-0 | 66-45 | .595 | Nationals Park · Washington, D.C. |
| 112 | Tue Aug 9 | vs Guardians | L1-3 | 66-46 | .589 | Nationals Park · Washington, D.C. |
| 113 | Wed Aug 10 | vs Guardians | W7-4 | 67-46 | .593 | Nationals Park · Washington, D.C. |
| 114 | Fri Aug 12 | vs Braves | L5-8 | 67-47 | .588 | Nationals Park · Washington, D.C. |
| 115 | Sat Aug 13 | vs Braves | W7-6 | 68-47 | .591 | Nationals Park · Washington, D.C. |
| 116 | Sun Aug 14 | vs Braves | W9-1 | 69-47 | .595 | Nationals Park · Washington, D.C. |
| 117 | Mon Aug 15 | at Rockies | W5-4 | 70-47 | .598 | Coors Field · Denver, CO |
| 118 | Tue Aug 16 | at Rockies | L2-6 | 70-48 | .593 | Coors Field · Denver, CO |
| 119 | Wed Aug 17 | at Rockies | L10-12 | 70-49 | .588 | Coors Field · Denver, CO |
| 120 | Thu Aug 18 | at Braves | W8-2 | 71-49 | .592 | Truist Park · Cumberland, GA |
| 121 | Fri Aug 19 | at Braves | W7-6 | 72-49 | .595 | Truist Park · Cumberland, GA |
| 122 | Sat Aug 20 | at Braves | W11-9 | 73-49 | .598 | Truist Park · Cumberland, GA |
| 123 | Sun Aug 21 | at Braves | L6-7 (10) | 73-50 | .593 | Truist Park · Cumberland, GA |
| 124 | Mon Aug 22 | at Orioles | L3-4 | 73-51 | .589 | Camden Yards · Baltimore, MD |
| 125 | Tue Aug 23 | at Orioles | L1-8 | 73-52 | .584 | Camden Yards · Baltimore, MD |
| 126 | Wed Aug 24 | vs Orioles | L8-10 | 73-53 | .579 | Nationals Park · Washington, D.C. |
| 127 | Thu Aug 25 | vs Orioles | W4-0 | 74-53 | .583 | Nationals Park · Washington, D.C. |
| 128 | Fri Aug 26 | vs Rockies | W8-5 | 75-53 | .586 | Nationals Park · Washington, D.C. |
| 129 | Sat Aug 27 | vs Rockies | L4-9 (11) | 75-54 | .581 | Nationals Park · Washington, D.C. |
| 130 | Sun Aug 28 | vs Rockies | L3-5 | 75-55 | .577 | Nationals Park · Washington, D.C. |
| 131 | Mon Aug 29 | at Phillies | W4-0 | 76-55 | .580 | Citizens Bank Park · Philadelphi, PA |
| 132 | Tue Aug 30 | at Phillies | W3-2 | 77-55 | .583 | Citizens Bank Park · Philadelphi, PA |
| 133 | Wed Aug 31 | at Phillies | W2-1 | 78-55 | .586 | Citizens Bank Park · Philadelphi, PA |
| 134 | Fri Sep 2 | at Mets | W4-1 | 79-55 | .590 | Citi Field · Queens, NY |
| 135 | Sat Sep 3 | at Mets | L1-3 | 79-56 | .585 | Citi Field · Queens, NY |
| 136 | Sun Sep 4 | at Mets | L1-5 | 79-57 | .581 | Citi Field · Queens, NY |
| 137 | Mon Sep 5 | vs Braves | W6-4 | 80-57 | .584 | Nationals Park · Washington, D.C. |
| 138 | Tue Sep 6 | vs Braves | W9-7 | 81-57 | .587 | Nationals Park · Washington, D.C. |
| 139 | Wed Sep 7 | vs Braves | W5-4 (11) | 82-57 | .590 | Nationals Park · Washington, D.C. |
| 140 | Thu Sep 8 | vs Phillies | L1-4 | 82-58 | .586 | Nationals Park · Washington, D.C. |
| 141 | Fri Sep 9 | vs Phillies | W5-4 | 83-58 | .589 | Nationals Park · Washington, D.C. |
| 142 | Sat Sep 10 | vs Phillies | W3-0 | 84-58 | .592 | Nationals Park · Washington, D.C. |
| 143 | Sun Sep 11 | vs Phillies | W3-2 | 85-58 | .594 | Nationals Park · Washington, D.C. |
| 144 | Mon Sep 12 | vs Mets | W8-1 | 86-58 | .597 | Nationals Park · Washington, D.C. |
| 145 | Tue Sep 13 | vs Mets | L3-4 (10) | 86-59 | .593 | Nationals Park · Washington, D.C. |
| 146 | Wed Sep 14 | vs Mets | W1-0 | 87-59 | .596 | Nationals Park · Washington, D.C. |
| 147 | Fri Sep 16 | at Braves | W7-2 | 88-59 | .599 | Truist Park · Cumberland, GA |
| 148 | Sat Sep 17 | at Braves | L3-7 | 88-60 | .595 | Truist Park · Cumberland, GA |
| 149 | Sun Sep 18 | at Braves | L2-6 | 88-61 | .591 | Truist Park · Cumberland, GA |
| 150 | Mon Sep 19 | at Marlins | L3-4 | 88-62 | .587 | LoanDepot Park · Miami, FL |
| 151 | Tue Sep 20 | at Marlins | L0-1 | 88-63 | .583 | LoanDepot Park · Miami, FL |
| 152 | Wed Sep 21 | at Marlins | W8-3 | 89-63 | .586 | LoanDepot Park · Miami, FL |
| 153 | Fri Sep 23 | at Pirates | L5-6 (11) | 89-64 | .582 | PNC Park · Pittsburgh, PA |
| 154 | Sat Sep 24 | at Pirates | W6-1 | 90-64 | .584 | PNC Park · Pittsburgh, PA |
| 155 | Sun Sep 25 | at Pirates | W10-7 | 91-64 | .587 | PNC Park · Pittsburgh, PA |
| 156 | Mon Sep 26 | vs D-backs | L4-14 | 91-65 | .583 | Nationals Park · Washington, D.C. |
| 157 | Tue Sep 27 | vs D-backs | W4-2 | 92-65 | .586 | Nationals Park · Washington, D.C. |
| 158 | Wed Sep 28 | vs D-backs | L0-3 | 92-66 | .582 | Nationals Park · Washington, D.C. |
| 159 | Thu Sep 29 | vs D-backs | W5-3 | 93-66 | .585 | Nationals Park · Washington, D.C. |
| 160 | Fri Sep 30 | vs Marlins | L4-7 | 93-67 | .581 | Nationals Park · Washington, D.C. |
| 161 | Sat Oct 1 | vs Marlins | W2-1 | 94-67 | .584 | Nationals Park · Washington, D.C. |
| 162 | Sun Oct 2 | vs Marlins | W10-7 | 95-67 | .586 | Nationals Park · Washington, D.C. |
| 163 | Fri Oct 7 | vs Dodgers | L3-4 | 0-1 | .000 | Nationals Park · Washington, D.C. |
| 164 | Sun Oct 9 | vs Dodgers | W5-2 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 165 | Mon Oct 10 | at Dodgers | W8-3 | 2-1 | .667 | Dodger Stadium · Los Angeles, CA |
| 166 | Tue Oct 11 | at Dodgers | L5-6 | 2-2 | .500 | Dodger Stadium · Los Angeles, CA |
| 167 | Thu Oct 13 | vs Dodgers | L3-4 | 2-3 | .400 | Nationals Park · Washington, D.C. |