| 1 | Thu Apr 7 | vs Mets | L1-5 | 0-1 | .000 | Nationals Park · Washington, D.C. |
| 2 | Fri Apr 8 | vs Mets | L3-7 | 0-2 | .000 | Nationals Park · Washington, D.C. |
| 3 | Sat Apr 9 | vs Mets | L0-5 | 0-3 | .000 | Nationals Park · Washington, D.C. |
| 4 | Sun Apr 10 | vs Mets | W4-2 | 1-3 | .250 | Nationals Park · Washington, D.C. |
| 5 | Mon Apr 11 | at Braves | W11-2 | 2-3 | .400 | Truist Park · Cumberland, GA |
| 6 | Tue Apr 12 | at Braves | L4-16 | 2-4 | .333 | Truist Park · Cumberland, GA |
| 7 | Wed Apr 13 | at Braves | W3-1 | 3-4 | .429 | Truist Park · Cumberland, GA |
| 8 | Thu Apr 14 | at Pirates | L4-9 | 3-5 | .375 | PNC Park · Pittsburgh, PA |
| 9 | Fri Apr 15 | at Pirates | W7-2 | 4-5 | .444 | PNC Park · Pittsburgh, PA |
| 10 | Sat Apr 16 | at Pirates | L4-6 | 4-6 | .400 | PNC Park · Pittsburgh, PA |
| 11 | Sun Apr 17 | at Pirates | L3-5 | 4-7 | .364 | PNC Park · Pittsburgh, PA |
| 12 | Tue Apr 19 | vs D-backs | W6-1 | 5-7 | .417 | Nationals Park · Washington, D.C. |
| 13 | Tue Apr 19 | vs D-backs | W1-0 | 6-7 | .462 | Nationals Park · Washington, D.C. |
| 14 | Wed Apr 20 | vs D-backs | L2-11 | 6-8 | .429 | Nationals Park · Washington, D.C. |
| 15 | Thu Apr 21 | vs D-backs | L3-4 | 6-9 | .400 | Nationals Park · Washington, D.C. |
| 16 | Fri Apr 22 | vs Giants | L1-7 | 6-10 | .375 | Nationals Park · Washington, D.C. |
| 17 | Sat Apr 23 | vs Giants | L2-5 | 6-11 | .353 | Nationals Park · Washington, D.C. |
| 18 | Sun Apr 24 | vs Giants | L3-12 | 6-12 | .333 | Nationals Park · Washington, D.C. |
| 19 | Tue Apr 26 | vs Marlins | L2-5 | 6-13 | .316 | Nationals Park · Washington, D.C. |
| 20 | Wed Apr 27 | vs Marlins | L1-2 | 6-14 | .300 | Nationals Park · Washington, D.C. |
| 21 | Thu Apr 28 | vs Marlins | L2-3 | 6-15 | .286 | Nationals Park · Washington, D.C. |
| 22 | Fri Apr 29 | at Giants | W14-4 | 7-15 | .318 | Oracle Park · San Francisco, CA |
| 23 | Sat Apr 30 | at Giants | L3-9 | 7-16 | .304 | Oracle Park · San Francisco, CA |
| 24 | Sun May 1 | at Giants | W11-5 | 8-16 | .333 | Oracle Park · San Francisco, CA |
| 25 | Tue May 3 | at Rockies | W10-2 | 9-16 | .360 | Coors Field · Denver, CO |
| 26 | Wed May 4 | at Rockies | L2-5 | 9-17 | .346 | Coors Field · Denver, CO |
| 27 | Thu May 5 | at Rockies | L7-9 | 9-18 | .333 | Coors Field · Denver, CO |
| 28 | Fri May 6 | at Angels | L0-3 | 9-19 | .321 | Angel Stadium · Anaheim, CA |
| 29 | Sat May 7 | at Angels | W7-3 | 10-19 | .345 | Angel Stadium · Anaheim, CA |
| 30 | Sun May 8 | at Angels | L4-5 | 10-20 | .333 | Angel Stadium · Anaheim, CA |
| 31 | Tue May 10 | vs Mets | L2-4 | 10-21 | .323 | Nationals Park · Washington, D.C. |
| 32 | Wed May 11 | vs Mets | W8-3 | 11-21 | .344 | Nationals Park · Washington, D.C. |
| 33 | Thu May 12 | vs Mets | L1-4 | 11-22 | .333 | Nationals Park · Washington, D.C. |
| 34 | Fri May 13 | vs Astros | L1-6 | 11-23 | .324 | Nationals Park · Washington, D.C. |
| 35 | Sat May 14 | vs Astros | W13-6 | 12-23 | .343 | Nationals Park · Washington, D.C. |
| 36 | Sun May 15 | vs Astros | L0-8 | 12-24 | .333 | Nationals Park · Washington, D.C. |
| 37 | Mon May 16 | at Marlins | L2-8 | 12-25 | .324 | LoanDepot Park · Miami, FL |
| 38 | Tue May 17 | at Marlins | L1-5 | 12-26 | .316 | LoanDepot Park · Miami, FL |
| 39 | Wed May 18 | at Marlins | W5-4 (10) | 13-26 | .333 | LoanDepot Park · Miami, FL |
| 40 | Fri May 20 | at Brewers | L0-7 | 13-27 | .325 | American Family Field · Milwaukee, WI |
| 41 | Sat May 21 | at Brewers | L1-5 | 13-28 | .317 | American Family Field · Milwaukee, WI |
| 42 | Sun May 22 | at Brewers | W8-2 | 14-28 | .333 | American Family Field · Milwaukee, WI |
| 43 | Mon May 23 | vs Dodgers | L1-10 | 14-29 | .326 | Nationals Park · Washington, D.C. |
| 44 | Tue May 24 | vs Dodgers | L4-9 | 14-30 | .318 | Nationals Park · Washington, D.C. |
| 45 | Wed May 25 | vs Dodgers | W1-0 | 15-30 | .333 | Nationals Park · Washington, D.C. |
| 46 | Thu May 26 | vs Rockies | W7-3 | 16-30 | .348 | Nationals Park · Washington, D.C. |
| 47 | Sat May 28 | vs Rockies | W13-7 | 17-30 | .362 | Nationals Park · Washington, D.C. |
| 48 | Sat May 28 | vs Rockies | L2-3 | 17-31 | .354 | Nationals Park · Washington, D.C. |
| 49 | Sun May 29 | vs Rockies | W6-5 | 18-31 | .367 | Nationals Park · Washington, D.C. |
| 50 | Mon May 30 | at Mets | L5-13 | 18-32 | .360 | Citi Field · Queens, NY |
| 51 | Tue May 31 | at Mets | L0-10 | 18-33 | .353 | Citi Field · Queens, NY |
| 52 | Wed Jun 1 | at Mets | L0-5 | 18-34 | .346 | Citi Field · Queens, NY |
| 53 | Thu Jun 2 | at Reds | L1-8 | 18-35 | .340 | Great American Ball Park · Cincinnati, OH |
| 54 | Fri Jun 3 | at Reds | W8-5 | 19-35 | .352 | Great American Ball Park · Cincinnati, OH |
| 55 | Sat Jun 4 | at Reds | W10-8 | 20-35 | .364 | Great American Ball Park · Cincinnati, OH |
| 56 | Sun Jun 5 | at Reds | W5-4 | 21-35 | .375 | Great American Ball Park · Cincinnati, OH |
| 57 | Tue Jun 7 | at Marlins | L2-12 | 21-36 | .368 | LoanDepot Park · Miami, FL |
| 58 | Wed Jun 8 | at Marlins | L1-2 (10) | 21-37 | .362 | LoanDepot Park · Miami, FL |
| 59 | Thu Jun 9 | at Marlins | L4-7 | 21-38 | .356 | LoanDepot Park · Miami, FL |
| 60 | Fri Jun 10 | vs Brewers | W11-5 | 22-38 | .367 | Nationals Park · Washington, D.C. |
| 61 | Sat Jun 11 | vs Brewers | W8-6 | 23-38 | .377 | Nationals Park · Washington, D.C. |
| 62 | Sun Jun 12 | vs Brewers | L1-4 | 23-39 | .371 | Nationals Park · Washington, D.C. |
| 63 | Mon Jun 13 | vs Braves | L5-9 | 23-40 | .365 | Nationals Park · Washington, D.C. |
| 64 | Tue Jun 14 | vs Braves | L4-10 | 23-41 | .359 | Nationals Park · Washington, D.C. |
| 65 | Wed Jun 15 | vs Braves | L2-8 | 23-42 | .354 | Nationals Park · Washington, D.C. |
| 66 | Thu Jun 16 | vs Phillies | L1-10 | 23-43 | .348 | Nationals Park · Washington, D.C. |
| 67 | Fri Jun 17 | vs Phillies | L3-5 | 23-44 | .343 | Nationals Park · Washington, D.C. |
| 68 | Fri Jun 17 | vs Phillies | L7-8 (10) | 23-45 | .338 | Nationals Park · Washington, D.C. |
| 69 | Sat Jun 18 | vs Phillies | L1-2 (10) | 23-46 | .333 | Nationals Park · Washington, D.C. |
| 70 | Sun Jun 19 | vs Phillies | W9-3 | 24-46 | .343 | Nationals Park · Washington, D.C. |
| 71 | Tue Jun 21 | at Orioles | W3-0 | 25-46 | .352 | Camden Yards · Baltimore, MD |
| 72 | Wed Jun 22 | at Orioles | L0-7 | 25-47 | .347 | Camden Yards · Baltimore, MD |
| 73 | Fri Jun 24 | at Rangers | W2-1 | 26-47 | .356 | Globe Life Field · Arlington, TX |
| 74 | Sat Jun 25 | at Rangers | L2-3 | 26-48 | .351 | Globe Life Field · Arlington, TX |
| 75 | Sun Jun 26 | at Rangers | W6-4 | 27-48 | .360 | Globe Life Field · Arlington, TX |
| 76 | Mon Jun 27 | vs Pirates | W3-2 | 28-48 | .368 | Nationals Park · Washington, D.C. |
| 77 | Tue Jun 28 | vs Pirates | W3-1 | 29-48 | .377 | Nationals Park · Washington, D.C. |
| 78 | Wed Jun 29 | vs Pirates | L7-8 | 29-49 | .372 | Nationals Park · Washington, D.C. |
| 79 | Fri Jul 1 | vs Marlins | L3-6 | 29-50 | .367 | Nationals Park · Washington, D.C. |
| 80 | Sat Jul 2 | vs Marlins | L3-5 | 29-51 | .362 | Nationals Park · Washington, D.C. |
| 81 | Sun Jul 3 | vs Marlins | L4-7 (10) | 29-52 | .358 | Nationals Park · Washington, D.C. |
| 82 | Mon Jul 4 | vs Marlins | L2-3 (10) | 29-53 | .354 | Nationals Park · Washington, D.C. |
| 83 | Tue Jul 5 | at Phillies | L0-11 | 29-54 | .349 | Citizens Bank Park · Philadelphi, PA |
| 84 | Wed Jul 6 | at Phillies | W3-2 | 30-54 | .357 | Citizens Bank Park · Philadelphi, PA |
| 85 | Thu Jul 7 | at Phillies | L3-5 | 30-55 | .353 | Citizens Bank Park · Philadelphi, PA |
| 86 | Fri Jul 8 | at Braves | L2-12 | 30-56 | .349 | Truist Park · Cumberland, GA |
| 87 | Sat Jul 9 | at Braves | L3-4 | 30-57 | .345 | Truist Park · Cumberland, GA |
| 88 | Sun Jul 10 | at Braves | L3-4 (12) | 30-58 | .341 | Truist Park · Cumberland, GA |
| 89 | Wed Jul 13 | vs Mariners | L4-6 | 30-59 | .337 | Nationals Park · Washington, D.C. |
| 90 | Wed Jul 13 | vs Mariners | L1-2 | 30-60 | .333 | Nationals Park · Washington, D.C. |
| 91 | Thu Jul 14 | vs Braves | L4-5 | 30-61 | .330 | Nationals Park · Washington, D.C. |
| 92 | Fri Jul 15 | vs Braves | L4-8 | 30-62 | .326 | Nationals Park · Washington, D.C. |
| 93 | Sat Jul 16 | vs Braves | L3-6 | 30-63 | .323 | Nationals Park · Washington, D.C. |
| 94 | Sun Jul 17 | vs Braves | W7-3 | 31-63 | .330 | Nationals Park · Washington, D.C. |
| 95 | Fri Jul 22 | at D-backs | L1-10 | 31-64 | .326 | Chase Field · Phoenix, AZ |
| 96 | Sat Jul 23 | at D-backs | L2-7 | 31-65 | .323 | Chase Field · Phoenix, AZ |
| 97 | Sun Jul 24 | at D-backs | W4-3 | 32-65 | .330 | Chase Field · Phoenix, AZ |
| 98 | Mon Jul 25 | at Dodgers | W4-1 | 33-65 | .337 | Dodger Stadium · Los Angeles, CA |
| 99 | Tue Jul 26 | at Dodgers | W8-3 | 34-65 | .343 | Dodger Stadium · Los Angeles, CA |
| 100 | Wed Jul 27 | at Dodgers | L1-7 | 34-66 | .340 | Dodger Stadium · Los Angeles, CA |
| 101 | Fri Jul 29 | vs Cardinals | L2-6 | 34-67 | .337 | Nationals Park · Washington, D.C. |
| 102 | Sat Jul 30 | vs Cardinals | W7-6 | 35-67 | .343 | Nationals Park · Washington, D.C. |
| 103 | Sun Jul 31 | vs Cardinals | L0-5 | 35-68 | .340 | Nationals Park · Washington, D.C. |
| 104 | Mon Aug 1 | vs Mets | L3-7 | 35-69 | .337 | Nationals Park · Washington, D.C. |
| 105 | Tue Aug 2 | vs Mets | W5-1 | 36-69 | .343 | Nationals Park · Washington, D.C. |
| 106 | Wed Aug 3 | vs Mets | L5-9 | 36-70 | .340 | Nationals Park · Washington, D.C. |
| 107 | Thu Aug 4 | at Phillies | L4-5 | 36-71 | .336 | Citizens Bank Park · Philadelphi, PA |
| 108 | Fri Aug 5 | at Phillies | L2-7 | 36-72 | .333 | Citizens Bank Park · Philadelphi, PA |
| 109 | Sat Aug 6 | at Phillies | L5-11 | 36-73 | .330 | Citizens Bank Park · Philadelphi, PA |
| 110 | Sun Aug 7 | at Phillies | L1-13 | 36-74 | .327 | Citizens Bank Park · Philadelphi, PA |
| 111 | Mon Aug 8 | at Cubs | L3-6 | 36-75 | .324 | Wrigley Field · Chicago, IL |
| 112 | Tue Aug 9 | at Cubs | W6-5 | 37-75 | .330 | Wrigley Field · Chicago, IL |
| 113 | Wed Aug 10 | at Cubs | L2-4 | 37-76 | .327 | Wrigley Field · Chicago, IL |
| 114 | Fri Aug 12 | vs Padres | L5-10 | 37-77 | .325 | Nationals Park · Washington, D.C. |
| 115 | Sat Aug 13 | vs Padres | W4-3 | 38-77 | .330 | Nationals Park · Washington, D.C. |
| 116 | Sun Aug 14 | vs Padres | L0-6 | 38-78 | .328 | Nationals Park · Washington, D.C. |
| 117 | Mon Aug 15 | vs Cubs | W5-4 | 39-78 | .333 | Nationals Park · Washington, D.C. |
| 118 | Tue Aug 16 | vs Cubs | L5-7 (11) | 39-79 | .331 | Nationals Park · Washington, D.C. |
| 119 | Wed Aug 17 | vs Cubs | L2-3 | 39-80 | .328 | Nationals Park · Washington, D.C. |
| 120 | Thu Aug 18 | at Padres | W3-1 | 40-80 | .333 | Petco Park · San Diego, CA |
| 121 | Fri Aug 19 | at Padres | W6-3 | 41-80 | .339 | Petco Park · San Diego, CA |
| 122 | Sat Aug 20 | at Padres | L1-2 | 41-81 | .336 | Petco Park · San Diego, CA |
| 123 | Sun Aug 21 | at Padres | L1-2 | 41-82 | .333 | Petco Park · San Diego, CA |
| 124 | Tue Aug 23 | at Mariners | L2-4 | 41-83 | .331 | T-Mobile Park · Seattle, WA |
| 125 | Wed Aug 24 | at Mariners | W3-1 | 42-83 | .336 | T-Mobile Park · Seattle, WA |
| 126 | Fri Aug 26 | vs Reds | L3-7 | 42-84 | .333 | Nationals Park · Washington, D.C. |
| 127 | Sat Aug 27 | vs Reds | L2-6 | 42-85 | .331 | Nationals Park · Washington, D.C. |
| 128 | Sun Aug 28 | vs Reds | W3-2 | 43-85 | .336 | Nationals Park · Washington, D.C. |
| 129 | Tue Aug 30 | vs Athletics | L6-10 | 43-86 | .333 | Nationals Park · Washington, D.C. |
| 130 | Wed Aug 31 | vs Athletics | W5-1 | 44-86 | .338 | Nationals Park · Washington, D.C. |
| 131 | Thu Sep 1 | vs Athletics | W7-5 (10) | 45-86 | .344 | Nationals Park · Washington, D.C. |
| 132 | Fri Sep 2 | at Mets | L3-7 | 45-87 | .341 | Citi Field · Queens, NY |
| 133 | Sat Sep 3 | at Mets | W7-1 | 46-87 | .346 | Citi Field · Queens, NY |
| 134 | Sun Sep 4 | at Mets | W7-1 | 47-87 | .351 | Citi Field · Queens, NY |
| 135 | Mon Sep 5 | at Cardinals | W6-0 | 48-87 | .356 | Busch Stadium · St. Louis, MO |
| 136 | Tue Sep 6 | at Cardinals | L1-4 | 48-88 | .353 | Busch Stadium · St. Louis, MO |
| 137 | Wed Sep 7 | at Cardinals | L5-6 | 48-89 | .350 | Busch Stadium · St. Louis, MO |
| 138 | Thu Sep 8 | at Cardinals | W11-6 | 49-89 | .355 | Busch Stadium · St. Louis, MO |
| 139 | Fri Sep 9 | at Phillies | L3-5 | 49-90 | .353 | Citizens Bank Park · Philadelphi, PA |
| 140 | Sat Sep 10 | at Phillies | L5-8 | 49-91 | .350 | Citizens Bank Park · Philadelphi, PA |
| 141 | Sun Sep 11 | at Phillies | L5-7 | 49-92 | .348 | Citizens Bank Park · Philadelphi, PA |
| 142 | Tue Sep 13 | vs Orioles | L3-4 | 49-93 | .345 | Nationals Park · Washington, D.C. |
| 143 | Wed Sep 14 | vs Orioles | L2-6 | 49-94 | .343 | Nationals Park · Washington, D.C. |
| 144 | Fri Sep 16 | vs Marlins | W5-4 | 50-94 | .347 | Nationals Park · Washington, D.C. |
| 145 | Sat Sep 17 | vs Marlins | W5-3 | 51-94 | .352 | Nationals Park · Washington, D.C. |
| 146 | Sun Sep 18 | vs Marlins | L1-3 | 51-95 | .349 | Nationals Park · Washington, D.C. |
| 147 | Mon Sep 19 | at Braves | L2-5 | 51-96 | .347 | Truist Park · Cumberland, GA |
| 148 | Tue Sep 20 | at Braves | L2-3 | 51-97 | .345 | Truist Park · Cumberland, GA |
| 149 | Wed Sep 21 | at Braves | W3-2 | 52-97 | .349 | Truist Park · Cumberland, GA |
| 150 | Fri Sep 23 | at Marlins | L2-5 | 52-98 | .347 | LoanDepot Park · Miami, FL |
| 151 | Sat Sep 24 | at Marlins | L1-4 | 52-99 | .344 | LoanDepot Park · Miami, FL |
| 152 | Sun Sep 25 | at Marlins | W6-1 | 53-99 | .349 | LoanDepot Park · Miami, FL |
| 153 | Mon Sep 26 | vs Braves | L0-8 | 53-100 | .346 | Nationals Park · Washington, D.C. |
| 154 | Tue Sep 27 | vs Braves | L2-8 | 53-101 | .344 | Nationals Park · Washington, D.C. |
| 155 | Wed Sep 28 | vs Braves | W3-2 (10) | 54-101 | .348 | Nationals Park · Washington, D.C. |
| 156 | Fri Sep 30 | vs Phillies | L1-5 | 54-102 | .346 | Nationals Park · Washington, D.C. |
| 157 | Sat Oct 1 | vs Phillies | W13-4 | 55-102 | .350 | Nationals Park · Washington, D.C. |
| 158 | Sat Oct 1 | vs Phillies | L2-8 | 55-103 | .348 | Nationals Park · Washington, D.C. |
| 159 | Sun Oct 2 | vs Phillies | L1-8 | 55-104 | .346 | Nationals Park · Washington, D.C. |
| 160 | Tue Oct 4 | at Mets | L2-4 | 55-105 | .344 | Citi Field · Queens, NY |
| 161 | Tue Oct 4 | at Mets | L0-8 | 55-106 | .342 | Citi Field · Queens, NY |
| 162 | Wed Oct 5 | at Mets | L2-9 | 55-107 | .340 | Citi Field · Queens, NY |