| 1 | Thu Mar 26 | at Cubs | W10-4 | 1-0 | 1.000 | Wrigley Field · Chicago, IL |
| 2 | Sat Mar 28 | at Cubs | L2-10 | 1-1 | .500 | Wrigley Field · Chicago, IL |
| 3 | Sun Mar 29 | at Cubs | W6-3 | 2-1 | .667 | Wrigley Field · Chicago, IL |
| 4 | Mon Mar 30 | at Phillies | W13-2 | 3-1 | .750 | Citizens Bank Park · Philadelphi, PA |
| 5 | Tue Mar 31 | at Phillies | L2-3 | 3-2 | .600 | Citizens Bank Park · Philadelphi, PA |
| 6 | Wed Apr 1 | at Phillies | L5-6 (10) | 3-3 | .500 | Citizens Bank Park · Philadelphi, PA |
| 7 | Fri Apr 3 | vs Dodgers | L6-13 | 3-4 | .429 | Nationals Park · Washington, D.C. |
| 8 | Sat Apr 4 | vs Dodgers | L5-10 | 3-5 | .375 | Nationals Park · Washington, D.C. |
| 9 | Sun Apr 5 | vs Dodgers | L6-8 | 3-6 | .333 | Nationals Park · Washington, D.C. |
| 10 | Mon Apr 6 | vs Cardinals | W9-6 | 4-6 | .400 | Nationals Park · Washington, D.C. |
| 11 | Tue Apr 7 | vs Cardinals | L6-7 (10) | 4-7 | .364 | Nationals Park · Washington, D.C. |
| 12 | Wed Apr 8 | vs Cardinals | L1-6 | 4-8 | .333 | Nationals Park · Washington, D.C. |
| 13 | Fri Apr 10 | at Brewers | W7-3 | 5-8 | .385 | American Family Field · Milwaukee, WI |
| 14 | Sat Apr 11 | at Brewers | W3-1 | 6-8 | .429 | American Family Field · Milwaukee, WI |
| 15 | Sun Apr 12 | at Brewers | W8-6 | 7-8 | .467 | American Family Field · Milwaukee, WI |
| 16 | Mon Apr 13 | at Pirates | L5-16 | 7-9 | .438 | PNC Park · Pittsburgh, PA |
| 17 | Tue Apr 14 | at Pirates | W5-4 | 8-9 | .471 | PNC Park · Pittsburgh, PA |
| 18 | Wed Apr 15 | at Pirates | L0-2 | 8-10 | .444 | PNC Park · Pittsburgh, PA |
| 19 | Thu Apr 16 | at Pirates | W8-7 (10) | 9-10 | .474 | PNC Park · Pittsburgh, PA |
| 20 | Fri Apr 17 | vs Giants | L5-10 | 9-11 | .450 | Nationals Park · Washington, D.C. |
| 21 | Sat Apr 18 | vs Giants | L6-7 (12) | 9-12 | .429 | Nationals Park · Washington, D.C. |
| 22 | Sun Apr 19 | vs Giants | W3-0 | 10-12 | .455 | Nationals Park · Washington, D.C. |
| 23 | Mon Apr 20 | vs Braves | L4-9 | 10-13 | .435 | Nationals Park · Washington, D.C. |
| 24 | Tue Apr 21 | vs Braves | W11-4 | 11-13 | .458 | Nationals Park · Washington, D.C. |
| 25 | Wed Apr 22 | vs Braves | L6-8 | 11-14 | .440 | Nationals Park · Washington, D.C. |
| 26 | Thu Apr 23 | vs Braves | L2-7 | 11-15 | .423 | Nationals Park · Washington, D.C. |
| 27 | Fri Apr 24 | at White Sox | L4-5 | 11-16 | .407 | Guaranteed Rate Field · Chicago, IL |
| 28 | Sat Apr 25 | at White Sox | W6-3 (10) | 12-16 | .429 | Guaranteed Rate Field · Chicago, IL |
| 29 | Sun Apr 26 | at White Sox | W2-1 (10) | 13-16 | .448 | Guaranteed Rate Field · Chicago, IL |
| 30 | Tue Apr 28 | at Mets | L0-8 | 13-17 | .433 | Citi Field · Queens, NY |
| 31 | Wed Apr 29 | at Mets | W14-2 | 14-17 | .452 | Citi Field · Queens, NY |
| 32 | Thu Apr 30 | at Mets | W5-4 | 15-17 | .469 | Citi Field · Queens, NY |
| 33 | Fri May 1 | vs Brewers | L1-6 | 15-18 | .455 | Nationals Park · Washington, D.C. |
| 34 | Sat May 2 | vs Brewers | L1-4 | 15-19 | .441 | Nationals Park · Washington, D.C. |
| 35 | Sun May 3 | vs Brewers | W3-2 | 16-19 | .457 | Nationals Park · Washington, D.C. |
| 36 | Tue May 5 | vs Twins | L3-11 | 16-20 | .444 | Nationals Park · Washington, D.C. |
| 37 | Wed May 6 | vs Twins | W15-2 | 17-20 | .459 | Nationals Park · Washington, D.C. |
| 38 | Thu May 7 | vs Twins | W7-5 | 18-20 | .474 | Nationals Park · Washington, D.C. |
| 39 | Fri May 8 | at Marlins | W3-2 | 19-20 | .487 | LoanDepot Park · Miami, FL |
| 40 | Sat May 9 | at Marlins | L7-8 | 19-21 | .475 | LoanDepot Park · Miami, FL |
| 41 | Sun May 10 | at Marlins | L2-5 | 19-22 | .463 | LoanDepot Park · Miami, FL |
| 42 | Tue May 12 | at Reds | W10-4 | 20-22 | .476 | Great American Ball Park · Cincinnati, OH |
| 43 | Wed May 13 | at Reds | W8-7 (10) | 21-22 | .488 | Great American Ball Park · Cincinnati, OH |
| 44 | Thu May 14 | at Reds | L1-15 | 21-23 | .477 | Great American Ball Park · Cincinnati, OH |
| 45 | Fri May 15 | vs Orioles | W3-2 | 22-23 | .489 | Nationals Park · Washington, D.C. |
| 46 | Sat May 16 | vs Orioles | W13-3 | 23-23 | .500 | Nationals Park · Washington, D.C. |
| 47 | Sun May 17 | vs Orioles | L3-7 | 23-24 | .489 | Nationals Park · Washington, D.C. |
| 48 | Mon May 18 | vs Mets | L7-16 (12) | 23-25 | .479 | Nationals Park · Washington, D.C. |
| 49 | Tue May 19 | vs Mets | W9-6 | 24-25 | .490 | Nationals Park · Washington, D.C. |
| 50 | Wed May 20 | vs Mets | W8-4 | 25-25 | .500 | Nationals Park · Washington, D.C. |
| 51 | Thu May 21 | vs Mets | L1-2 | 25-26 | .490 | Nationals Park · Washington, D.C. |
| 52 | Fri May 22 | at Braves | L4-5 (11) | 25-27 | .481 | Truist Park · Cumberland, GA |
| 53 | Sat May 23 | at Braves | W2-0 | 26-27 | .491 | Truist Park · Cumberland, GA |
| 54 | Sun May 24 | at Braves | W2-1 | 27-27 | .500 | Truist Park · Cumberland, GA |
| 55 | Mon May 25 | at Guardians | W10-2 | 28-27 | .509 | Progressive Field · Cleveland, OH |
| 56 | Tue May 26 | at Guardians | W6-3 | 29-27 | .518 | Progressive Field · Cleveland, OH |
| 57 | Wed May 27 | at Guardians | L2-3 | 29-28 | .509 | Progressive Field · Cleveland, OH |
| 58 | Fri May 29 | vs Padres | L5-7 | 29-29 | .500 | Nationals Park · Washington, D.C. |
| 59 | Sat May 30 | vs Padres | W9-4 | 30-29 | .508 | Nationals Park · Washington, D.C. |
| 60 | Sun May 31 | vs Padres | W4-2 | 31-29 | .517 | Nationals Park · Washington, D.C. |
| 61 | Mon Jun 1 | vs Marlins | L3-7 | 31-30 | .508 | Nationals Park · Washington, D.C. |
| 62 | Tue Jun 2 | vs Marlins | L3-7 | 31-31 | .500 | Nationals Park · Washington, D.C. |
| 63 | Wed Jun 3 | vs Marlins | L1-4 | 31-32 | .492 | Nationals Park · Washington, D.C. |
| 64 | Fri Jun 5 | at D-backs | W14-1 | 32-32 | .500 | Chase Field · Phoenix, AZ |
| 65 | Sat Jun 6 | at D-backs | W6-1 | 33-32 | .508 | Chase Field · Phoenix, AZ |
| 66 | Sun Jun 7 | at D-backs | L1-5 | 33-33 | .500 | Chase Field · Phoenix, AZ |
| 67 | Mon Jun 8 | at Giants | W4-3 | 34-33 | .507 | Oracle Park · San Francisco, CA |
| 68 | Tue Jun 9 | at Giants | W6-3 | 35-33 | .515 | Oracle Park · San Francisco, CA |
| 69 | Wed Jun 10 | at Giants | L10-11 | 35-34 | .507 | Oracle Park · San Francisco, CA |
| 70 | Fri Jun 12 | vs Mariners | L2-10 | 35-35 | .500 | Nationals Park · Washington, D.C. |
| 71 | Sat Jun 13 | vs Mariners | W8-3 | 36-35 | .507 | Nationals Park · Washington, D.C. |
| 72 | Sun Jun 14 | vs Mariners | W10-1 | 37-35 | .514 | Nationals Park · Washington, D.C. |
| 73 | Mon Jun 15 | vs Royals | W7-3 | 38-35 | .521 | Nationals Park · Washington, D.C. |
| 74 | Tue Jun 16 | vs Royals | W6-4 | 39-35 | .527 | Nationals Park · Washington, D.C. |
| 75 | Wed Jun 17 | vs Royals | L2-6 | 39-36 | .520 | Nationals Park · Washington, D.C. |
| 76 | Fri Jun 19 | at Rays | L2-5 | 39-37 | .513 | Tropicana Field · St. Petersburg, FL |
| 77 | Sat Jun 20 | at Rays | W4-3 | 40-37 | .519 | Tropicana Field · St. Petersburg, FL |
| 78 | Sun Jun 21 | at Rays | L3-4 | 40-38 | .513 | Tropicana Field · St. Petersburg, FL |
| 79 | Mon Jun 22 | vs Phillies | W4-1 | 41-38 | .519 | Nationals Park · Washington, D.C. |
| 80 | Tue Jun 23 | vs Phillies | L9-14 | 41-39 | .512 | Nationals Park · Washington, D.C. |
| 81 | Wed Jun 24 | vs Phillies | L4-5 | 41-40 | .506 | Nationals Park · Washington, D.C. |
| 82 | Thu Jun 25 | vs Phillies | L5-10 | 41-41 | .500 | Nationals Park · Washington, D.C. |
| 83 | Fri Jun 26 | at Orioles | L1-3 | 41-42 | .494 | Camden Yards · Baltimore, MD |
| 84 | Sat Jun 27 | at Orioles | W4-3 (10) | 42-42 | .500 | Camden Yards · Baltimore, MD |
| 85 | Sun Jun 28 | at Orioles | W6-4 | 43-42 | .506 | Camden Yards · Baltimore, MD |
| 86 | Mon Jun 29 | at Red Sox | L3-6 | 43-43 | .500 | Fenway Park · Boston, MA |
| 87 | Tue Jun 30 | at Red Sox | W8-1 | 44-43 | .506 | Fenway Park · Boston, MA |
| 88 | Wed Jul 1 | at Red Sox | W10-2 | 45-43 | .511 | Fenway Park · Boston, MA |
| 89 | Fri Jul 3 | vs Pirates | W9-5 | 46-43 | .517 | Nationals Park · Washington, D.C. |
| 90 | Sat Jul 4 | vs Pirates | L1-7 | 46-44 | .511 | Nationals Park · Washington, D.C. |
| 91 | Sun Jul 5 | vs Pirates | L5-11 | 46-45 | .505 | Nationals Park · Washington, D.C. |
| 92 | Mon Jul 6 | vs Astros | W12-11 | 47-45 | .511 | Nationals Park · Washington, D.C. |
| 93 | Tue Jul 7 | vs Astros | L3-6 | 47-46 | .505 | Nationals Park · Washington, D.C. |
| 94 | Wed Jul 8 | vs Astros | W8-2 | 48-46 | .511 | Nationals Park · Washington, D.C. |
| 95 | Fri Jul 10 | vs Yankees | L3-5 | 48-47 | .505 | Nationals Park · Washington, D.C. |
| 96 | Sat Jul 11 | vs Yankees | L2-4 | 48-48 | .500 | Nationals Park · Washington, D.C. |
| 97 | Sun Jul 12 | vs Yankees | L3-5 | 48-49 | .495 | Nationals Park · Washington, D.C. |