| 1 | Thu Mar 28 | at Reds | L2-8 | 0-1 | .000 | Great American Ball Park · Cincinnati, OH |
| 2 | Sat Mar 30 | at Reds | W7-6 | 1-1 | .500 | Great American Ball Park · Cincinnati, OH |
| 3 | Sun Mar 31 | at Reds | L5-6 | 1-2 | .333 | Great American Ball Park · Cincinnati, OH |
| 4 | Mon Apr 1 | vs Pirates | L4-8 | 1-3 | .250 | Nationals Park · Washington, D.C. |
| 5 | Wed Apr 3 | vs Pirates | W5-3 | 2-3 | .400 | Nationals Park · Washington, D.C. |
| 6 | Thu Apr 4 | vs Pirates | L4-7 | 2-4 | .333 | Nationals Park · Washington, D.C. |
| 7 | Fri Apr 5 | vs Phillies | L0-4 | 2-5 | .286 | Nationals Park · Washington, D.C. |
| 8 | Sat Apr 6 | vs Phillies | L2-5 | 2-6 | .250 | Nationals Park · Washington, D.C. |
| 9 | Sun Apr 7 | vs Phillies | W3-2 | 3-6 | .333 | Nationals Park · Washington, D.C. |
| 10 | Mon Apr 8 | at Giants | W8-1 | 4-6 | .400 | Oracle Park · San Francisco, CA |
| 11 | Tue Apr 9 | at Giants | W5-3 | 5-6 | .455 | Oracle Park · San Francisco, CA |
| 12 | Wed Apr 10 | at Giants | L1-7 | 5-7 | .417 | Oracle Park · San Francisco, CA |
| 13 | Fri Apr 12 | at Athletics | L1-2 (10) | 5-8 | .385 | RingCentral Coliseum · Oakland, CA |
| 14 | Sat Apr 13 | at Athletics | W3-1 | 6-8 | .429 | RingCentral Coliseum · Oakland, CA |
| 15 | Sun Apr 14 | at Athletics | L6-7 | 6-9 | .400 | RingCentral Coliseum · Oakland, CA |
| 16 | Mon Apr 15 | at Dodgers | W6-4 | 7-9 | .438 | Dodger Stadium · Los Angeles, CA |
| 17 | Tue Apr 16 | at Dodgers | L2-6 | 7-10 | .412 | Dodger Stadium · Los Angeles, CA |
| 18 | Wed Apr 17 | at Dodgers | W2-0 | 8-10 | .444 | Dodger Stadium · Los Angeles, CA |
| 19 | Fri Apr 19 | vs Astros | L3-5 | 8-11 | .421 | Nationals Park · Washington, D.C. |
| 20 | Sat Apr 20 | vs Astros | W5-4 (10) | 9-11 | .450 | Nationals Park · Washington, D.C. |
| 21 | Sun Apr 21 | vs Astros | W6-0 | 10-11 | .476 | Nationals Park · Washington, D.C. |
| 22 | Tue Apr 23 | vs Dodgers | L1-4 | 10-12 | .455 | Nationals Park · Washington, D.C. |
| 23 | Wed Apr 24 | vs Dodgers | L2-11 | 10-13 | .435 | Nationals Park · Washington, D.C. |
| 24 | Thu Apr 25 | vs Dodgers | L1-2 | 10-14 | .417 | Nationals Park · Washington, D.C. |
| 25 | Fri Apr 26 | at Marlins | W3-1 | 11-14 | .440 | LoanDepot Park · Miami, FL |
| 26 | Sat Apr 27 | at Marlins | W11-4 | 12-14 | .462 | LoanDepot Park · Miami, FL |
| 27 | Sun Apr 28 | at Marlins | W12-9 | 13-14 | .481 | LoanDepot Park · Miami, FL |
| 28 | Mon Apr 29 | at Marlins | W7-2 | 14-14 | .500 | LoanDepot Park · Miami, FL |
| 29 | Tue Apr 30 | at Rangers | L1-7 | 14-15 | .483 | Globe Life Field · Arlington, TX |
| 30 | Wed May 1 | at Rangers | W1-0 | 15-15 | .500 | Globe Life Field · Arlington, TX |
| 31 | Thu May 2 | at Rangers | L0-6 | 15-16 | .484 | Globe Life Field · Arlington, TX |
| 32 | Fri May 3 | vs Blue Jays | W9-3 | 16-16 | .500 | Nationals Park · Washington, D.C. |
| 33 | Sat May 4 | vs Blue Jays | L3-6 | 16-17 | .485 | Nationals Park · Washington, D.C. |
| 34 | Sun May 5 | vs Blue Jays | W11-8 | 17-17 | .500 | Nationals Park · Washington, D.C. |
| 35 | Tue May 7 | vs Orioles | W3-0 | 18-17 | .514 | Nationals Park · Washington, D.C. |
| 36 | Wed May 8 | vs Orioles | L6-7 (12) | 18-18 | .500 | Nationals Park · Washington, D.C. |
| 37 | Fri May 10 | at Red Sox | W5-1 | 19-18 | .514 | Fenway Park · Boston, MA |
| 38 | Sat May 11 | at Red Sox | L2-4 | 19-19 | .500 | Fenway Park · Boston, MA |
| 39 | Sun May 12 | at Red Sox | L2-3 | 19-20 | .487 | Fenway Park · Boston, MA |
| 40 | Tue May 14 | at White Sox | W6-3 | 20-20 | .500 | Guaranteed Rate Field · Chicago, IL |
| 41 | Tue May 14 | at White Sox | L0-4 | 20-21 | .488 | Guaranteed Rate Field · Chicago, IL |
| 42 | Wed May 15 | at White Sox | L0-2 | 20-22 | .476 | Guaranteed Rate Field · Chicago, IL |
| 43 | Fri May 17 | at Phillies | L2-4 | 20-23 | .465 | Citizens Bank Park · Philadelphi, PA |
| 44 | Sat May 18 | at Phillies | L3-4 (10) | 20-24 | .455 | Citizens Bank Park · Philadelphi, PA |
| 45 | Sun May 19 | at Phillies | L5-11 | 20-25 | .444 | Citizens Bank Park · Philadelphi, PA |
| 46 | Mon May 20 | vs Twins | W12-3 | 21-25 | .457 | Nationals Park · Washington, D.C. |
| 47 | Tue May 21 | vs Twins | L0-10 | 21-26 | .447 | Nationals Park · Washington, D.C. |
| 48 | Wed May 22 | vs Twins | L2-3 | 21-27 | .438 | Nationals Park · Washington, D.C. |
| 49 | Fri May 24 | vs Mariners | W6-1 | 22-27 | .449 | Nationals Park · Washington, D.C. |
| 50 | Sat May 25 | vs Mariners | W3-1 | 23-27 | .460 | Nationals Park · Washington, D.C. |
| 51 | Sun May 26 | vs Mariners | L5-9 | 23-28 | .451 | Nationals Park · Washington, D.C. |
| 52 | Mon May 27 | at Braves | W8-4 | 24-28 | .462 | Truist Park · Cumberland, GA |
| 53 | Tue May 28 | at Braves | L0-2 | 24-29 | .453 | Truist Park · Cumberland, GA |
| 54 | Wed May 29 | at Braves | W7-2 | 25-29 | .463 | Truist Park · Cumberland, GA |
| 55 | Thu May 30 | at Braves | W3-1 | 26-29 | .473 | Truist Park · Cumberland, GA |
| 56 | Fri May 31 | at Guardians | L1-7 | 26-30 | .464 | Progressive Field · Cleveland, OH |
| 57 | Sat Jun 1 | at Guardians | L2-3 | 26-31 | .456 | Progressive Field · Cleveland, OH |
| 58 | Sun Jun 2 | at Guardians | W5-2 | 27-31 | .466 | Progressive Field · Cleveland, OH |
| 59 | Mon Jun 3 | vs Mets | L7-8 | 27-32 | .458 | Nationals Park · Washington, D.C. |
| 60 | Tue Jun 4 | vs Mets | L3-6 | 27-33 | .450 | Nationals Park · Washington, D.C. |
| 61 | Wed Jun 5 | vs Mets | L1-9 | 27-34 | .443 | Nationals Park · Washington, D.C. |
| 62 | Thu Jun 6 | vs Braves | L2-5 | 27-35 | .435 | Nationals Park · Washington, D.C. |
| 63 | Fri Jun 7 | vs Braves | W2-1 | 28-35 | .444 | Nationals Park · Washington, D.C. |
| 64 | Sat Jun 8 | vs Braves | W7-3 | 29-35 | .453 | Nationals Park · Washington, D.C. |
| 65 | Sun Jun 9 | vs Braves | W8-5 | 30-35 | .462 | Nationals Park · Washington, D.C. |
| 66 | Tue Jun 11 | at Tigers | W5-4 (10) | 31-35 | .470 | Comerica Park · Detroit, MI |
| 67 | Wed Jun 12 | at Tigers | W7-5 | 32-35 | .478 | Comerica Park · Detroit, MI |
| 68 | Thu Jun 13 | at Tigers | L2-7 | 32-36 | .471 | Comerica Park · Detroit, MI |
| 69 | Fri Jun 14 | vs Marlins | W8-1 | 33-36 | .478 | Nationals Park · Washington, D.C. |
| 70 | Sat Jun 15 | vs Marlins | W4-0 | 34-36 | .486 | Nationals Park · Washington, D.C. |
| 71 | Sun Jun 16 | vs Marlins | W3-1 | 35-36 | .493 | Nationals Park · Washington, D.C. |
| 72 | Tue Jun 18 | vs D-backs | L0-5 | 35-37 | .486 | Nationals Park · Washington, D.C. |
| 73 | Wed Jun 19 | vs D-backs | W3-1 | 36-37 | .493 | Nationals Park · Washington, D.C. |
| 74 | Thu Jun 20 | vs D-backs | L2-5 | 36-38 | .486 | Nationals Park · Washington, D.C. |
| 75 | Fri Jun 21 | at Rockies | W11-5 | 37-38 | .493 | Coors Field · Denver, CO |
| 76 | Sat Jun 22 | at Rockies | L7-8 | 37-39 | .487 | Coors Field · Denver, CO |
| 77 | Sun Jun 23 | at Rockies | W2-1 | 38-39 | .494 | Coors Field · Denver, CO |
| 78 | Mon Jun 24 | at Padres | L6-7 (10) | 38-40 | .487 | Petco Park · San Diego, CA |
| 79 | Tue Jun 25 | at Padres | L7-9 | 38-41 | .481 | Petco Park · San Diego, CA |
| 80 | Wed Jun 26 | at Padres | L5-8 | 38-42 | .475 | Petco Park · San Diego, CA |
| 81 | Fri Jun 28 | at Rays | L1-3 | 38-43 | .469 | Tropicana Field · St. Petersburg, FL |
| 82 | Sat Jun 29 | at Rays | W8-1 | 39-43 | .476 | Tropicana Field · St. Petersburg, FL |
| 83 | Sun Jun 30 | at Rays | L0-5 | 39-44 | .470 | Tropicana Field · St. Petersburg, FL |
| 84 | Mon Jul 1 | vs Mets | L7-9 (10) | 39-45 | .464 | Nationals Park · Washington, D.C. |
| 85 | Tue Jul 2 | vs Mets | L2-7 (10) | 39-46 | .459 | Nationals Park · Washington, D.C. |
| 86 | Wed Jul 3 | vs Mets | W7-5 | 40-46 | .465 | Nationals Park · Washington, D.C. |
| 87 | Thu Jul 4 | vs Mets | W1-0 | 41-46 | .471 | Nationals Park · Washington, D.C. |
| 88 | Fri Jul 5 | vs Cardinals | L6-7 (11) | 41-47 | .466 | Nationals Park · Washington, D.C. |
| 89 | Sat Jul 6 | vs Cardinals | W14-6 | 42-47 | .472 | Nationals Park · Washington, D.C. |
| 90 | Sun Jul 7 | vs Cardinals | L3-8 | 42-48 | .467 | Nationals Park · Washington, D.C. |
| 91 | Mon Jul 8 | vs Cardinals | L0-6 | 42-49 | .462 | Nationals Park · Washington, D.C. |
| 92 | Tue Jul 9 | at Mets | L5-7 | 42-50 | .457 | Citi Field · Queens, NY |
| 93 | Wed Jul 10 | at Mets | L2-6 | 42-51 | .452 | Citi Field · Queens, NY |
| 94 | Thu Jul 11 | at Mets | L0-7 | 42-52 | .447 | Citi Field · Queens, NY |
| 95 | Fri Jul 12 | at Brewers | W5-2 | 43-52 | .453 | American Family Field · Milwaukee, WI |
| 96 | Sat Jul 13 | at Brewers | W6-5 | 44-52 | .458 | American Family Field · Milwaukee, WI |
| 97 | Sun Jul 14 | at Brewers | L3-9 | 44-53 | .454 | American Family Field · Milwaukee, WI |
| 98 | Fri Jul 19 | vs Reds | W8-5 | 45-53 | .459 | Nationals Park · Washington, D.C. |
| 99 | Sat Jul 20 | vs Reds | W5-4 | 46-53 | .465 | Nationals Park · Washington, D.C. |
| 100 | Sun Jul 21 | vs Reds | W5-2 | 47-53 | .470 | Nationals Park · Washington, D.C. |
| 101 | Tue Jul 23 | vs Padres | L0-4 | 47-54 | .465 | Nationals Park · Washington, D.C. |
| 102 | Wed Jul 24 | vs Padres | L3-12 | 47-55 | .461 | Nationals Park · Washington, D.C. |
| 103 | Thu Jul 25 | vs Padres | L0-3 | 47-56 | .456 | Nationals Park · Washington, D.C. |
| 104 | Fri Jul 26 | at Cardinals | W10-8 (10) | 48-56 | .462 | Busch Stadium · St. Louis, MO |
| 105 | Sat Jul 27 | at Cardinals | W14-3 | 49-56 | .467 | Busch Stadium · St. Louis, MO |
| 106 | Sun Jul 28 | at Cardinals | L3-4 | 49-57 | .462 | Busch Stadium · St. Louis, MO |
| 107 | Mon Jul 29 | at D-backs | L8-9 | 49-58 | .458 | Chase Field · Phoenix, AZ |
| 108 | Tue Jul 30 | at D-backs | L0-17 | 49-59 | .454 | Chase Field · Phoenix, AZ |
| 109 | Wed Jul 31 | at D-backs | L4-5 | 49-60 | .450 | Chase Field · Phoenix, AZ |
| 110 | Fri Aug 2 | vs Brewers | L3-8 | 49-61 | .445 | Nationals Park · Washington, D.C. |
| 111 | Sat Aug 3 | vs Brewers | W6-4 | 50-61 | .450 | Nationals Park · Washington, D.C. |
| 112 | Sun Aug 4 | vs Brewers | W4-3 | 51-61 | .455 | Nationals Park · Washington, D.C. |
| 113 | Mon Aug 5 | vs Giants | L1-4 | 51-62 | .451 | Nationals Park · Washington, D.C. |
| 114 | Tue Aug 6 | vs Giants | W11-5 | 52-62 | .456 | Nationals Park · Washington, D.C. |
| 115 | Wed Aug 7 | vs Giants | L4-7 | 52-63 | .452 | Nationals Park · Washington, D.C. |
| 116 | Thu Aug 8 | vs Giants | L5-9 (10) | 52-64 | .448 | Nationals Park · Washington, D.C. |
| 117 | Fri Aug 9 | vs Angels | W3-2 (10) | 53-64 | .453 | Nationals Park · Washington, D.C. |
| 118 | Sat Aug 10 | vs Angels | W5-4 (10) | 54-64 | .458 | Nationals Park · Washington, D.C. |
| 119 | Sun Aug 11 | vs Angels | L4-6 | 54-65 | .454 | Nationals Park · Washington, D.C. |
| 120 | Tue Aug 13 | at Orioles | W9-3 | 55-65 | .458 | Camden Yards · Baltimore, MD |
| 121 | Wed Aug 14 | at Orioles | L1-4 | 55-66 | .455 | Camden Yards · Baltimore, MD |
| 122 | Thu Aug 15 | at Phillies | L3-13 | 55-67 | .451 | Citizens Bank Park · Philadelphi, PA |
| 123 | Fri Aug 16 | at Phillies | L2-3 | 55-68 | .447 | Citizens Bank Park · Philadelphi, PA |
| 124 | Sat Aug 17 | at Phillies | L1-5 | 55-69 | .444 | Citizens Bank Park · Philadelphi, PA |
| 125 | Sun Aug 18 | at Phillies | W6-4 | 56-69 | .448 | Citizens Bank Park · Philadelphi, PA |
| 126 | Tue Aug 20 | vs Rockies | L1-3 | 56-70 | .444 | Nationals Park · Washington, D.C. |
| 127 | Wed Aug 21 | vs Rockies | W6-1 | 57-70 | .449 | Nationals Park · Washington, D.C. |
| 128 | Thu Aug 22 | vs Rockies | W8-3 | 58-70 | .453 | Nationals Park · Washington, D.C. |
| 129 | Fri Aug 23 | at Braves | L2-3 (10) | 58-71 | .450 | Truist Park · Cumberland, GA |
| 130 | Sat Aug 24 | at Braves | L2-4 | 58-72 | .446 | Truist Park · Cumberland, GA |
| 131 | Sun Aug 25 | at Braves | W5-1 | 59-72 | .450 | Truist Park · Cumberland, GA |
| 132 | Mon Aug 26 | vs Yankees | L2-5 | 59-73 | .447 | Nationals Park · Washington, D.C. |
| 133 | Tue Aug 27 | vs Yankees | W4-2 | 60-73 | .451 | Nationals Park · Washington, D.C. |
| 134 | Wed Aug 28 | vs Yankees | W5-2 | 61-73 | .455 | Nationals Park · Washington, D.C. |
| 135 | Fri Aug 30 | vs Cubs | L6-7 | 61-74 | .452 | Nationals Park · Washington, D.C. |
| 136 | Sat Aug 31 | vs Cubs | L3-5 | 61-75 | .449 | Nationals Park · Washington, D.C. |
| 137 | Sun Sep 1 | vs Cubs | L1-14 | 61-76 | .445 | Nationals Park · Washington, D.C. |
| 138 | Tue Sep 3 | at Marlins | W6-2 | 62-76 | .449 | LoanDepot Park · Miami, FL |
| 139 | Wed Sep 4 | at Marlins | L3-4 (10) | 62-77 | .446 | LoanDepot Park · Miami, FL |
| 140 | Thu Sep 5 | at Pirates | L4-9 | 62-78 | .443 | PNC Park · Pittsburgh, PA |
| 141 | Sat Sep 7 | at Pirates | W5-3 | 63-78 | .447 | PNC Park · Pittsburgh, PA |
| 142 | Sat Sep 7 | at Pirates | W8-6 | 64-78 | .451 | PNC Park · Pittsburgh, PA |
| 143 | Sun Sep 8 | at Pirates | L3-7 | 64-79 | .448 | PNC Park · Pittsburgh, PA |
| 144 | Tue Sep 10 | vs Braves | L0-12 | 64-80 | .444 | Nationals Park · Washington, D.C. |
| 145 | Wed Sep 11 | vs Braves | W5-1 | 65-80 | .448 | Nationals Park · Washington, D.C. |
| 146 | Thu Sep 12 | vs Marlins | L3-6 | 65-81 | .445 | Nationals Park · Washington, D.C. |
| 147 | Fri Sep 13 | vs Marlins | W4-1 | 66-81 | .449 | Nationals Park · Washington, D.C. |
| 148 | Sat Sep 14 | vs Marlins | W4-1 | 67-81 | .453 | Nationals Park · Washington, D.C. |
| 149 | Sun Sep 15 | vs Marlins | W4-3 | 68-81 | .456 | Nationals Park · Washington, D.C. |
| 150 | Mon Sep 16 | at Mets | L1-2 (10) | 68-82 | .453 | Citi Field · Queens, NY |
| 151 | Tue Sep 17 | at Mets | L1-10 | 68-83 | .450 | Citi Field · Queens, NY |
| 152 | Wed Sep 18 | at Mets | L0-10 | 68-84 | .447 | Citi Field · Queens, NY |
| 153 | Thu Sep 19 | at Cubs | L6-7 | 68-85 | .444 | Wrigley Field · Chicago, IL |
| 154 | Fri Sep 20 | at Cubs | L1-3 | 68-86 | .442 | Wrigley Field · Chicago, IL |
| 155 | Sat Sep 21 | at Cubs | W5-1 | 69-86 | .445 | Wrigley Field · Chicago, IL |
| 156 | Sun Sep 22 | at Cubs | L0-5 | 69-87 | .442 | Wrigley Field · Chicago, IL |
| 157 | Tue Sep 24 | vs Royals | L0-1 (10) | 69-88 | .439 | Nationals Park · Washington, D.C. |
| 158 | Wed Sep 25 | vs Royals | L0-3 | 69-89 | .437 | Nationals Park · Washington, D.C. |
| 159 | Thu Sep 26 | vs Royals | L4-7 | 69-90 | .434 | Nationals Park · Washington, D.C. |
| 160 | Fri Sep 27 | vs Phillies | W9-1 | 70-90 | .438 | Nationals Park · Washington, D.C. |
| 161 | Sat Sep 28 | vs Phillies | W6-3 | 71-90 | .441 | Nationals Park · Washington, D.C. |
| 162 | Sun Sep 29 | vs Phillies | L3-6 | 71-91 | .438 | Nationals Park · Washington, D.C. |