| 1 | Mon Apr 3 | vs Marlins | W4-2 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Wed Apr 5 | vs Marlins | W6-4 | 2-0 | 1.000 | Nationals Park · Washington, D.C. |
| 3 | Thu Apr 6 | vs Marlins | L3-4 (10) | 2-1 | .667 | Nationals Park · Washington, D.C. |
| 4 | Fri Apr 7 | at Phillies | W7-6 | 3-1 | .750 | Citizens Bank Park · Philadelphi, PA |
| 5 | Sat Apr 8 | at Phillies | L3-17 | 3-2 | .600 | Citizens Bank Park · Philadelphi, PA |
| 6 | Sun Apr 9 | at Phillies | L3-4 | 3-3 | .500 | Citizens Bank Park · Philadelphi, PA |
| 7 | Mon Apr 10 | vs Cardinals | W14-6 | 4-3 | .571 | Nationals Park · Washington, D.C. |
| 8 | Tue Apr 11 | vs Cardinals | W8-3 | 5-3 | .625 | Nationals Park · Washington, D.C. |
| 9 | Wed Apr 12 | vs Cardinals | L1-6 | 5-4 | .556 | Nationals Park · Washington, D.C. |
| 10 | Fri Apr 14 | vs Phillies | W3-2 (10) | 6-4 | .600 | Nationals Park · Washington, D.C. |
| 11 | Sat Apr 15 | vs Phillies | L2-4 | 6-5 | .545 | Nationals Park · Washington, D.C. |
| 12 | Sun Apr 16 | vs Phillies | W6-4 | 7-5 | .583 | Nationals Park · Washington, D.C. |
| 13 | Tue Apr 18 | at Braves | W3-1 | 8-5 | .615 | Truist Park · Cumberland, GA |
| 14 | Wed Apr 19 | at Braves | W14-4 | 9-5 | .643 | Truist Park · Cumberland, GA |
| 15 | Thu Apr 20 | at Braves | W3-2 | 10-5 | .667 | Truist Park · Cumberland, GA |
| 16 | Fri Apr 21 | at Mets | W4-3 (11) | 11-5 | .688 | Citi Field · Queens, NY |
| 17 | Sat Apr 22 | at Mets | W3-1 | 12-5 | .706 | Citi Field · Queens, NY |
| 18 | Sun Apr 23 | at Mets | W6-3 | 13-5 | .722 | Citi Field · Queens, NY |
| 19 | Mon Apr 24 | at Rockies | L4-8 | 13-6 | .684 | Coors Field · Denver, CO |
| 20 | Tue Apr 25 | at Rockies | W15-12 | 14-6 | .700 | Coors Field · Denver, CO |
| 21 | Wed Apr 26 | at Rockies | W11-4 | 15-6 | .714 | Coors Field · Denver, CO |
| 22 | Thu Apr 27 | at Rockies | W16-5 | 16-6 | .727 | Coors Field · Denver, CO |
| 23 | Fri Apr 28 | vs Mets | L5-7 | 16-7 | .696 | Nationals Park · Washington, D.C. |
| 24 | Sat Apr 29 | vs Mets | L3-5 | 16-8 | .667 | Nationals Park · Washington, D.C. |
| 25 | Sun Apr 30 | vs Mets | W23-5 | 17-8 | .680 | Nationals Park · Washington, D.C. |
| 26 | Tue May 2 | vs D-backs | L3-6 | 17-9 | .654 | Nationals Park · Washington, D.C. |
| 27 | Wed May 3 | vs D-backs | W2-1 | 18-9 | .667 | Nationals Park · Washington, D.C. |
| 28 | Thu May 4 | vs D-backs | W4-2 | 19-9 | .679 | Nationals Park · Washington, D.C. |
| 29 | Fri May 5 | at Phillies | W4-2 | 20-9 | .690 | Citizens Bank Park · Philadelphi, PA |
| 30 | Sat May 6 | at Phillies | W6-2 | 21-9 | .700 | Citizens Bank Park · Philadelphi, PA |
| 31 | Sun May 7 | at Phillies | L5-6 (10) | 21-10 | .677 | Citizens Bank Park · Philadelphi, PA |
| 32 | Mon May 8 | at Orioles | L4-6 | 21-11 | .656 | Camden Yards · Baltimore, MD |
| 33 | Tue May 9 | at Orioles | L4-5 (12) | 21-12 | .636 | Camden Yards · Baltimore, MD |
| 34 | Wed May 10 | vs Orioles | W7-6 | 22-12 | .647 | Nationals Park · Washington, D.C. |
| 35 | Sat May 13 | vs Phillies | W6-4 | 23-12 | .657 | Nationals Park · Washington, D.C. |
| 36 | Sun May 14 | vs Phillies | L3-4 | 23-13 | .639 | Nationals Park · Washington, D.C. |
| 37 | Sun May 14 | vs Phillies | W6-5 | 24-13 | .649 | Nationals Park · Washington, D.C. |
| 38 | Tue May 16 | at Pirates | W8-4 | 25-13 | .658 | PNC Park · Pittsburgh, PA |
| 39 | Wed May 17 | at Pirates | L1-6 | 25-14 | .641 | PNC Park · Pittsburgh, PA |
| 40 | Thu May 18 | at Pirates | L4-10 | 25-15 | .625 | PNC Park · Pittsburgh, PA |
| 41 | Fri May 19 | at Braves | L4-7 | 25-16 | .610 | Truist Park · Cumberland, GA |
| 42 | Sat May 20 | at Braves | L2-5 | 25-17 | .595 | Truist Park · Cumberland, GA |
| 43 | Sun May 21 | at Braves | W3-2 | 26-17 | .605 | Truist Park · Cumberland, GA |
| 44 | Tue May 23 | vs Mariners | W10-1 | 27-17 | .614 | Nationals Park · Washington, D.C. |
| 45 | Wed May 24 | vs Mariners | W5-1 | 28-17 | .622 | Nationals Park · Washington, D.C. |
| 46 | Thu May 25 | vs Mariners | L2-4 | 28-18 | .609 | Nationals Park · Washington, D.C. |
| 47 | Fri May 26 | vs Padres | W5-1 | 29-18 | .617 | Nationals Park · Washington, D.C. |
| 48 | Sat May 27 | vs Padres | W3-0 | 30-18 | .625 | Nationals Park · Washington, D.C. |
| 49 | Sun May 28 | vs Padres | L3-5 | 30-19 | .612 | Nationals Park · Washington, D.C. |
| 50 | Mon May 29 | at Giants | W3-0 | 31-19 | .620 | Oracle Park · San Francisco, CA |
| 51 | Tue May 30 | at Giants | W6-3 | 32-19 | .627 | Oracle Park · San Francisco, CA |
| 52 | Wed May 31 | at Giants | W3-1 | 33-19 | .635 | Oracle Park · San Francisco, CA |
| 53 | Fri Jun 2 | at Athletics | W13-3 | 34-19 | .642 | RingCentral Coliseum · Oakland, CA |
| 54 | Sat Jun 3 | at Athletics | L4-10 | 34-20 | .630 | RingCentral Coliseum · Oakland, CA |
| 55 | Sun Jun 4 | at Athletics | W11-10 | 35-20 | .636 | RingCentral Coliseum · Oakland, CA |
| 56 | Mon Jun 5 | at Dodgers | W4-2 | 36-20 | .643 | Dodger Stadium · Los Angeles, CA |
| 57 | Tue Jun 6 | at Dodgers | W2-1 | 37-20 | .649 | Dodger Stadium · Los Angeles, CA |
| 58 | Wed Jun 7 | at Dodgers | L1-2 | 37-21 | .638 | Dodger Stadium · Los Angeles, CA |
| 59 | Thu Jun 8 | vs Orioles | W6-1 | 38-21 | .644 | Nationals Park · Washington, D.C. |
| 60 | Fri Jun 9 | vs Rangers | L2-5 | 38-22 | .633 | Nationals Park · Washington, D.C. |
| 61 | Sat Jun 10 | vs Rangers | L3-6 (11) | 38-23 | .623 | Nationals Park · Washington, D.C. |
| 62 | Sun Jun 11 | vs Rangers | L1-5 | 38-24 | .613 | Nationals Park · Washington, D.C. |
| 63 | Mon Jun 12 | vs Braves | L10-11 | 38-25 | .603 | Nationals Park · Washington, D.C. |
| 64 | Tue Jun 13 | vs Braves | W10-5 | 39-25 | .609 | Nationals Park · Washington, D.C. |
| 65 | Wed Jun 14 | vs Braves | L2-13 | 39-26 | .600 | Nationals Park · Washington, D.C. |
| 66 | Thu Jun 15 | at Mets | W8-3 | 40-26 | .606 | Citi Field · Queens, NY |
| 67 | Fri Jun 16 | at Mets | W7-2 | 41-26 | .612 | Citi Field · Queens, NY |
| 68 | Sat Jun 17 | at Mets | W7-4 | 42-26 | .618 | Citi Field · Queens, NY |
| 69 | Sun Jun 18 | at Mets | L1-5 | 42-27 | .609 | Citi Field · Queens, NY |
| 70 | Mon Jun 19 | at Marlins | L7-8 | 42-28 | .600 | LoanDepot Park · Miami, FL |
| 71 | Tue Jun 20 | at Marlins | W12-3 | 43-28 | .606 | LoanDepot Park · Miami, FL |
| 72 | Wed Jun 21 | at Marlins | L1-2 | 43-29 | .597 | LoanDepot Park · Miami, FL |
| 73 | Fri Jun 23 | vs Reds | W6-5 (10) | 44-29 | .603 | Nationals Park · Washington, D.C. |
| 74 | Sat Jun 24 | vs Reds | W18-3 | 45-29 | .608 | Nationals Park · Washington, D.C. |
| 75 | Sun Jun 25 | vs Reds | L2-6 | 45-30 | .600 | Nationals Park · Washington, D.C. |
| 76 | Mon Jun 26 | vs Cubs | L4-5 | 45-31 | .592 | Nationals Park · Washington, D.C. |
| 77 | Tue Jun 27 | vs Cubs | W6-1 | 46-31 | .597 | Nationals Park · Washington, D.C. |
| 78 | Wed Jun 28 | vs Cubs | W8-4 | 47-31 | .603 | Nationals Park · Washington, D.C. |
| 79 | Thu Jun 29 | vs Cubs | L4-5 | 47-32 | .595 | Nationals Park · Washington, D.C. |
| 80 | Fri Jun 30 | at Cardinals | L1-8 | 47-33 | .588 | Busch Stadium · St. Louis, MO |
| 81 | Sat Jul 1 | at Cardinals | L1-2 | 47-34 | .580 | Busch Stadium · St. Louis, MO |
| 82 | Sun Jul 2 | at Cardinals | W7-2 | 48-34 | .585 | Busch Stadium · St. Louis, MO |
| 83 | Mon Jul 3 | vs Mets | W3-2 | 49-34 | .590 | Nationals Park · Washington, D.C. |
| 84 | Tue Jul 4 | vs Mets | W11-4 | 50-34 | .595 | Nationals Park · Washington, D.C. |
| 85 | Thu Jul 6 | vs Braves | L2-5 | 50-35 | .588 | Nationals Park · Washington, D.C. |
| 86 | Fri Jul 7 | vs Braves | W5-4 (10) | 51-35 | .593 | Nationals Park · Washington, D.C. |
| 87 | Sat Jul 8 | vs Braves | L0-13 | 51-36 | .586 | Nationals Park · Washington, D.C. |
| 88 | Sun Jul 9 | vs Braves | W10-5 | 52-36 | .591 | Nationals Park · Washington, D.C. |
| 89 | Fri Jul 14 | at Reds | W5-0 | 53-36 | .596 | Great American Ball Park · Cincinnati, OH |
| 90 | Sat Jul 15 | at Reds | W10-7 | 54-36 | .600 | Great American Ball Park · Cincinnati, OH |
| 91 | Sun Jul 16 | at Reds | W14-4 | 55-36 | .604 | Great American Ball Park · Cincinnati, OH |
| 92 | Mon Jul 17 | at Reds | W6-1 | 56-36 | .609 | Great American Ball Park · Cincinnati, OH |
| 93 | Tue Jul 18 | at Angels | W4-3 | 57-36 | .613 | Angel Stadium · Anaheim, CA |
| 94 | Wed Jul 19 | at Angels | L0-7 | 57-37 | .606 | Angel Stadium · Anaheim, CA |
| 95 | Fri Jul 21 | at D-backs | L5-6 | 57-38 | .600 | Chase Field · Phoenix, AZ |
| 96 | Sat Jul 22 | at D-backs | W4-3 | 58-38 | .604 | Chase Field · Phoenix, AZ |
| 97 | Sun Jul 23 | at D-backs | W6-2 | 59-38 | .608 | Chase Field · Phoenix, AZ |
| 98 | Tue Jul 25 | vs Brewers | L0-8 | 59-39 | .602 | Nationals Park · Washington, D.C. |
| 99 | Wed Jul 26 | vs Brewers | W8-5 | 60-39 | .606 | Nationals Park · Washington, D.C. |
| 100 | Thu Jul 27 | vs Brewers | W15-2 | 61-39 | .610 | Nationals Park · Washington, D.C. |
| 101 | Sat Jul 29 | vs Rockies | L2-4 | 61-40 | .604 | Nationals Park · Washington, D.C. |
| 102 | Sun Jul 30 | vs Rockies | L6-10 | 61-41 | .598 | Nationals Park · Washington, D.C. |
| 103 | Sun Jul 30 | vs Rockies | W3-1 | 62-41 | .602 | Nationals Park · Washington, D.C. |
| 104 | Mon Jul 31 | at Marlins | W1-0 | 63-41 | .606 | LoanDepot Park · Miami, FL |
| 105 | Tue Aug 1 | at Marlins | L6-7 | 63-42 | .600 | LoanDepot Park · Miami, FL |
| 106 | Wed Aug 2 | at Marlins | L0-7 | 63-43 | .594 | LoanDepot Park · Miami, FL |
| 107 | Fri Aug 4 | at Cubs | W4-2 | 64-43 | .598 | Wrigley Field · Chicago, IL |
| 108 | Sat Aug 5 | at Cubs | L4-7 | 64-44 | .593 | Wrigley Field · Chicago, IL |
| 109 | Sun Aug 6 | at Cubs | W9-4 | 65-44 | .596 | Wrigley Field · Chicago, IL |
| 110 | Mon Aug 7 | vs Marlins | W3-2 | 66-44 | .600 | Nationals Park · Washington, D.C. |
| 111 | Tue Aug 8 | vs Marlins | L3-7 | 66-45 | .595 | Nationals Park · Washington, D.C. |
| 112 | Wed Aug 9 | vs Marlins | W10-1 | 67-45 | .598 | Nationals Park · Washington, D.C. |
| 113 | Thu Aug 10 | vs Marlins | W3-2 | 68-45 | .602 | Nationals Park · Washington, D.C. |
| 114 | Sat Aug 12 | vs Giants | W3-1 | 69-45 | .605 | Nationals Park · Washington, D.C. |
| 115 | Sun Aug 13 | vs Giants | L2-4 | 69-46 | .600 | Nationals Park · Washington, D.C. |
| 116 | Sun Aug 13 | vs Giants | W6-2 (11) | 70-46 | .603 | Nationals Park · Washington, D.C. |
| 117 | Tue Aug 15 | vs Angels | W3-1 | 71-46 | .607 | Nationals Park · Washington, D.C. |
| 118 | Wed Aug 16 | vs Angels | L2-3 | 71-47 | .602 | Nationals Park · Washington, D.C. |
| 119 | Thu Aug 17 | at Padres | W2-1 | 72-47 | .605 | Petco Park · San Diego, CA |
| 120 | Fri Aug 18 | at Padres | W7-1 | 73-47 | .608 | Petco Park · San Diego, CA |
| 121 | Sat Aug 19 | at Padres | L1-3 | 73-48 | .603 | Petco Park · San Diego, CA |
| 122 | Sun Aug 20 | at Padres | W4-1 | 74-48 | .607 | Petco Park · San Diego, CA |
| 123 | Tue Aug 22 | at Astros | W4-3 | 75-48 | .610 | Minute Maid Park · Houston, TX |
| 124 | Wed Aug 23 | at Astros | L1-6 | 75-49 | .605 | Minute Maid Park · Houston, TX |
| 125 | Thu Aug 24 | at Astros | W5-4 (11) | 76-49 | .608 | Minute Maid Park · Houston, TX |
| 126 | Fri Aug 25 | vs Mets | L2-4 | 76-50 | .603 | Nationals Park · Washington, D.C. |
| 127 | Sat Aug 26 | vs Mets | W9-4 | 77-50 | .606 | Nationals Park · Washington, D.C. |
| 128 | Sun Aug 27 | vs Mets | L5-6 | 77-51 | .602 | Nationals Park · Washington, D.C. |
| 129 | Sun Aug 27 | vs Mets | W5-4 | 78-51 | .605 | Nationals Park · Washington, D.C. |
| 130 | Mon Aug 28 | vs Marlins | W11-2 | 79-51 | .608 | Nationals Park · Washington, D.C. |
| 131 | Tue Aug 29 | vs Marlins | W8-3 | 80-51 | .611 | Nationals Park · Washington, D.C. |
| 132 | Wed Aug 30 | vs Marlins | W4-0 | 81-51 | .614 | Nationals Park · Washington, D.C. |
| 133 | Thu Aug 31 | at Brewers | L3-6 | 81-52 | .609 | American Family Field · Milwaukee, WI |
| 134 | Fri Sep 1 | at Brewers | L0-1 | 81-53 | .604 | American Family Field · Milwaukee, WI |
| 135 | Sat Sep 2 | at Brewers | W3-2 | 82-53 | .607 | American Family Field · Milwaukee, WI |
| 136 | Sun Sep 3 | at Brewers | L2-7 | 82-54 | .603 | American Family Field · Milwaukee, WI |
| 137 | Mon Sep 4 | at Marlins | W7-2 | 83-54 | .606 | LoanDepot Park · Miami, FL |
| 138 | Tue Sep 5 | at Marlins | W2-1 | 84-54 | .609 | LoanDepot Park · Miami, FL |
| 139 | Wed Sep 6 | at Marlins | W8-1 | 85-54 | .612 | LoanDepot Park · Miami, FL |
| 140 | Thu Sep 7 | vs Phillies | W4-3 | 86-54 | .614 | Nationals Park · Washington, D.C. |
| 141 | Fri Sep 8 | vs Phillies | W11-10 | 87-54 | .617 | Nationals Park · Washington, D.C. |
| 142 | Sat Sep 9 | vs Phillies | L4-5 | 87-55 | .613 | Nationals Park · Washington, D.C. |
| 143 | Sun Sep 10 | vs Phillies | W3-2 | 88-55 | .615 | Nationals Park · Washington, D.C. |
| 144 | Tue Sep 12 | vs Braves | L0-8 | 88-56 | .611 | Nationals Park · Washington, D.C. |
| 145 | Wed Sep 13 | vs Braves | L2-8 | 88-57 | .607 | Nationals Park · Washington, D.C. |
| 146 | Thu Sep 14 | vs Braves | W5-2 | 89-57 | .610 | Nationals Park · Washington, D.C. |
| 147 | Fri Sep 15 | vs Dodgers | L0-7 | 89-58 | .605 | Nationals Park · Washington, D.C. |
| 148 | Sat Sep 16 | vs Dodgers | L2-3 | 89-59 | .601 | Nationals Park · Washington, D.C. |
| 149 | Sun Sep 17 | vs Dodgers | W7-1 | 90-59 | .604 | Nationals Park · Washington, D.C. |
| 150 | Tue Sep 19 | at Braves | W4-2 | 91-59 | .607 | Truist Park · Cumberland, GA |
| 151 | Wed Sep 20 | at Braves | W7-3 | 92-59 | .609 | Truist Park · Cumberland, GA |
| 152 | Thu Sep 21 | at Braves | L2-3 | 92-60 | .605 | Truist Park · Cumberland, GA |
| 153 | Fri Sep 22 | at Mets | L6-7 | 92-61 | .601 | Citi Field · Queens, NY |
| 154 | Sat Sep 23 | at Mets | W4-3 (10) | 93-61 | .604 | Citi Field · Queens, NY |
| 155 | Sun Sep 24 | at Mets | W3-2 | 94-61 | .606 | Citi Field · Queens, NY |
| 156 | Mon Sep 25 | at Phillies | W3-1 | 95-61 | .609 | Citizens Bank Park · Philadelphi, PA |
| 157 | Tue Sep 26 | at Phillies | L1-4 | 95-62 | .605 | Citizens Bank Park · Philadelphi, PA |
| 158 | Wed Sep 27 | at Phillies | L5-7 | 95-63 | .601 | Citizens Bank Park · Philadelphi, PA |
| 159 | Thu Sep 28 | vs Pirates | W5-4 | 96-63 | .604 | Nationals Park · Washington, D.C. |
| 160 | Fri Sep 29 | vs Pirates | W6-1 | 97-63 | .606 | Nationals Park · Washington, D.C. |
| 161 | Sat Sep 30 | vs Pirates | L1-4 | 97-64 | .602 | Nationals Park · Washington, D.C. |
| 162 | Sun Oct 1 | vs Pirates | L8-11 | 97-65 | .599 | Nationals Park · Washington, D.C. |
| 163 | Fri Oct 6 | vs Cubs | L0-3 | 0-1 | .000 | Nationals Park · Washington, D.C. |
| 164 | Sat Oct 7 | vs Cubs | W6-3 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 165 | Mon Oct 9 | at Cubs | L1-2 | 1-2 | .333 | Wrigley Field · Chicago, IL |
| 166 | Wed Oct 11 | at Cubs | W5-0 | 2-2 | .500 | Wrigley Field · Chicago, IL |
| 167 | Thu Oct 12 | vs Cubs | L8-9 | 2-3 | .400 | Nationals Park · Washington, D.C. |