| 1 | Tue Apr 6 | vs Braves | W6-5 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Wed Apr 7 | vs Braves | L6-7 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 3 | Wed Apr 7 | vs Braves | L0-2 | 1-2 | .333 | Nationals Park · Washington, D.C. |
| 4 | Fri Apr 9 | at Dodgers | L0-1 | 1-3 | .250 | Dodger Stadium · Los Angeles, CA |
| 5 | Sat Apr 10 | at Dodgers | L5-9 | 1-4 | .200 | Dodger Stadium · Los Angeles, CA |
| 6 | Sun Apr 11 | at Dodgers | L0-3 | 1-5 | .167 | Dodger Stadium · Los Angeles, CA |
| 7 | Mon Apr 12 | at Cardinals | W5-2 | 2-5 | .286 | Busch Stadium · St. Louis, MO |
| 8 | Tue Apr 13 | at Cardinals | L3-14 | 2-6 | .250 | Busch Stadium · St. Louis, MO |
| 9 | Wed Apr 14 | at Cardinals | W6-0 | 3-6 | .333 | Busch Stadium · St. Louis, MO |
| 10 | Thu Apr 15 | vs D-backs | L6-11 | 3-7 | .300 | Nationals Park · Washington, D.C. |
| 11 | Fri Apr 16 | vs D-backs | W1-0 | 4-7 | .364 | Nationals Park · Washington, D.C. |
| 12 | Sat Apr 17 | vs D-backs | W6-2 | 5-7 | .417 | Nationals Park · Washington, D.C. |
| 13 | Sun Apr 18 | vs D-backs | L2-5 | 5-8 | .385 | Nationals Park · Washington, D.C. |
| 14 | Mon Apr 19 | vs Cardinals | L5-12 | 5-9 | .357 | Nationals Park · Washington, D.C. |
| 15 | Tue Apr 20 | vs Cardinals | W3-2 | 6-9 | .400 | Nationals Park · Washington, D.C. |
| 16 | Wed Apr 21 | vs Cardinals | W1-0 | 7-9 | .438 | Nationals Park · Washington, D.C. |
| 17 | Fri Apr 23 | at Mets | L0-6 | 7-10 | .412 | Citi Field · Queens, NY |
| 18 | Sat Apr 24 | at Mets | W7-1 | 8-10 | .444 | Citi Field · Queens, NY |
| 19 | Sun Apr 25 | at Mets | L0-4 | 8-11 | .421 | Citi Field · Queens, NY |
| 20 | Tue Apr 27 | at Blue Jays | L5-9 | 8-12 | .400 | Rogers Centre · Toronto, ON |
| 21 | Wed Apr 28 | at Blue Jays | W8-2 | 9-12 | .429 | Rogers Centre · Toronto, ON |
| 22 | Fri Apr 30 | vs Marlins | W2-1 (10) | 10-12 | .455 | Nationals Park · Washington, D.C. |
| 23 | Sat May 1 | vs Marlins | W7-2 | 11-12 | .478 | Nationals Park · Washington, D.C. |
| 24 | Sun May 2 | vs Marlins | W3-1 | 12-12 | .500 | Nationals Park · Washington, D.C. |
| 25 | Tue May 4 | vs Braves | L1-6 | 12-13 | .480 | Nationals Park · Washington, D.C. |
| 26 | Wed May 5 | vs Braves | L3-5 | 12-14 | .462 | Nationals Park · Washington, D.C. |
| 27 | Thu May 6 | vs Braves | L2-3 | 12-15 | .444 | Nationals Park · Washington, D.C. |
| 28 | Fri May 7 | at Yankees | W11-4 | 13-15 | .464 | Yankee Stadium · The Bronx, NY |
| 29 | Sat May 8 | at Yankees | L3-4 (11) | 13-16 | .448 | Yankee Stadium · The Bronx, NY |
| 30 | Sun May 9 | at Yankees | L2-3 | 13-17 | .433 | Yankee Stadium · The Bronx, NY |
| 31 | Tue May 11 | vs Phillies | L2-6 | 13-18 | .419 | Nationals Park · Washington, D.C. |
| 32 | Wed May 12 | vs Phillies | L2-5 (10) | 13-19 | .406 | Nationals Park · Washington, D.C. |
| 33 | Thu May 13 | vs Phillies | W5-1 | 14-19 | .424 | Nationals Park · Washington, D.C. |
| 34 | Fri May 14 | at D-backs | W17-2 | 15-19 | .441 | Chase Field · Phoenix, AZ |
| 35 | Sat May 15 | at D-backs | L4-11 | 15-20 | .429 | Chase Field · Phoenix, AZ |
| 36 | Sun May 16 | at D-backs | W3-0 | 16-20 | .444 | Chase Field · Phoenix, AZ |
| 37 | Mon May 17 | at Cubs | L3-7 | 16-21 | .432 | Wrigley Field · Chicago, IL |
| 38 | Tue May 18 | at Cubs | L3-6 | 16-22 | .421 | Wrigley Field · Chicago, IL |
| 39 | Wed May 19 | at Cubs | W4-3 | 17-22 | .436 | Wrigley Field · Chicago, IL |
| 40 | Thu May 20 | at Cubs | L2-5 | 17-23 | .425 | Wrigley Field · Chicago, IL |
| 41 | Fri May 21 | vs Orioles | W4-2 | 18-23 | .439 | Nationals Park · Washington, D.C. |
| 42 | Sat May 22 | vs Orioles | W12-9 | 19-23 | .452 | Nationals Park · Washington, D.C. |
| 43 | Sun May 23 | vs Orioles | W6-5 | 20-23 | .465 | Nationals Park · Washington, D.C. |
| 44 | Tue May 25 | vs Reds | L1-2 | 20-24 | .455 | Nationals Park · Washington, D.C. |
| 45 | Thu May 27 | vs Reds | W5-3 | 21-24 | .467 | Nationals Park · Washington, D.C. |
| 46 | Thu May 27 | vs Reds | L0-3 | 21-25 | .457 | Nationals Park · Washington, D.C. |
| 47 | Sat May 29 | vs Brewers | L1-4 | 21-26 | .447 | Nationals Park · Washington, D.C. |
| 48 | Sat May 29 | vs Brewers | L2-6 | 21-27 | .438 | Nationals Park · Washington, D.C. |
| 49 | Sun May 30 | vs Brewers | L0-3 | 21-28 | .429 | Nationals Park · Washington, D.C. |
| 50 | Mon May 31 | at Braves | L3-5 | 21-29 | .420 | Truist Park · Cumberland, GA |
| 51 | Tue Jun 1 | at Braves | W11-6 | 22-29 | .431 | Truist Park · Cumberland, GA |
| 52 | Wed Jun 2 | at Braves | W5-3 | 23-29 | .442 | Truist Park · Cumberland, GA |
| 53 | Thu Jun 3 | at Braves | L1-5 | 23-30 | .434 | Truist Park · Cumberland, GA |
| 54 | Fri Jun 4 | at Phillies | W2-1 | 24-30 | .444 | Citizens Bank Park · Philadelphi, PA |
| 55 | Sat Jun 5 | at Phillies | L2-5 | 24-31 | .436 | Citizens Bank Park · Philadelphi, PA |
| 56 | Sun Jun 6 | at Phillies | L6-12 | 24-32 | .429 | Citizens Bank Park · Philadelphi, PA |
| 57 | Tue Jun 8 | at Rays | L1-3 | 24-33 | .421 | Tropicana Field · St. Petersburg, FL |
| 58 | Wed Jun 9 | at Rays | W9-7 (11) | 25-33 | .431 | Tropicana Field · St. Petersburg, FL |
| 59 | Fri Jun 11 | vs Giants | L0-1 | 25-34 | .424 | Nationals Park · Washington, D.C. |
| 60 | Sat Jun 12 | vs Giants | W2-0 | 26-34 | .433 | Nationals Park · Washington, D.C. |
| 61 | Sat Jun 12 | vs Giants | L1-2 (8) | 26-35 | .426 | Nationals Park · Washington, D.C. |
| 62 | Sun Jun 13 | vs Giants | W5-0 | 27-35 | .435 | Nationals Park · Washington, D.C. |
| 63 | Mon Jun 14 | vs Pirates | W3-2 | 28-35 | .444 | Nationals Park · Washington, D.C. |
| 64 | Tue Jun 15 | vs Pirates | W8-1 | 29-35 | .453 | Nationals Park · Washington, D.C. |
| 65 | Wed Jun 16 | vs Pirates | W3-1 | 30-35 | .462 | Nationals Park · Washington, D.C. |
| 66 | Fri Jun 18 | vs Mets | W1-0 | 31-35 | .470 | Nationals Park · Washington, D.C. |
| 67 | Sat Jun 19 | vs Mets | L1-5 | 31-36 | .463 | Nationals Park · Washington, D.C. |
| 68 | Sat Jun 19 | vs Mets | W6-2 | 32-36 | .471 | Nationals Park · Washington, D.C. |
| 69 | Sun Jun 20 | vs Mets | W5-2 | 33-36 | .478 | Nationals Park · Washington, D.C. |
| 70 | Tue Jun 22 | at Phillies | W3-2 | 34-36 | .486 | Citizens Bank Park · Philadelphi, PA |
| 71 | Wed Jun 23 | at Phillies | W13-12 | 35-36 | .493 | Citizens Bank Park · Philadelphi, PA |
| 72 | Thu Jun 24 | at Marlins | W7-3 | 36-36 | .500 | LoanDepot Park · Miami, FL |
| 73 | Fri Jun 25 | at Marlins | L2-11 | 36-37 | .493 | LoanDepot Park · Miami, FL |
| 74 | Sat Jun 26 | at Marlins | L2-3 | 36-38 | .486 | LoanDepot Park · Miami, FL |
| 75 | Sun Jun 27 | at Marlins | W5-1 | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 76 | Mon Jun 28 | vs Mets | W8-4 | 38-38 | .500 | Nationals Park · Washington, D.C. |
| 77 | Tue Jun 29 | vs Rays | W4-3 | 39-38 | .506 | Nationals Park · Washington, D.C. |
| 78 | Wed Jun 30 | vs Rays | W15-6 | 40-38 | .513 | Nationals Park · Washington, D.C. |
| 79 | Thu Jul 1 | vs Dodgers | L2-6 | 40-39 | .506 | Nationals Park · Washington, D.C. |
| 80 | Fri Jul 2 | vs Dodgers | L5-10 | 40-40 | .500 | Nationals Park · Washington, D.C. |
| 81 | Sat Jul 3 | vs Dodgers | L3-5 | 40-41 | .494 | Nationals Park · Washington, D.C. |
| 82 | Sun Jul 4 | vs Dodgers | L1-5 | 40-42 | .488 | Nationals Park · Washington, D.C. |
| 83 | Mon Jul 5 | at Padres | W7-5 | 41-42 | .494 | Petco Park · San Diego, CA |
| 84 | Tue Jul 6 | at Padres | L4-7 | 41-43 | .488 | Petco Park · San Diego, CA |
| 85 | Wed Jul 7 | at Padres | W15-5 | 42-43 | .494 | Petco Park · San Diego, CA |
| 86 | Thu Jul 8 | at Padres | L8-9 | 42-44 | .488 | Petco Park · San Diego, CA |
| 87 | Fri Jul 9 | at Giants | L3-5 | 42-45 | .483 | Oracle Park · San Francisco, CA |
| 88 | Sat Jul 10 | at Giants | L4-10 | 42-46 | .477 | Oracle Park · San Francisco, CA |
| 89 | Sun Jul 11 | at Giants | L1-3 | 42-47 | .472 | Oracle Park · San Francisco, CA |
| 90 | Fri Jul 16 | vs Padres | L8-24 | 42-48 | .467 | Nationals Park · Washington, D.C. |
| 91 | Sun Jul 18 | vs Padres | L4-10 | 42-49 | .462 | Nationals Park · Washington, D.C. |
| 92 | Sun Jul 18 | vs Padres | W8-7 | 43-49 | .467 | Nationals Park · Washington, D.C. |
| 93 | Mon Jul 19 | vs Marlins | W18-1 | 44-49 | .473 | Nationals Park · Washington, D.C. |
| 94 | Tue Jul 20 | vs Marlins | W6-3 | 45-49 | .479 | Nationals Park · Washington, D.C. |
| 95 | Wed Jul 21 | vs Marlins | L1-3 (10) | 45-50 | .474 | Nationals Park · Washington, D.C. |
| 96 | Fri Jul 23 | at Orioles | L1-6 | 45-51 | .469 | Camden Yards · Baltimore, MD |
| 97 | Sat Jul 24 | at Orioles | L3-5 | 45-52 | .464 | Camden Yards · Baltimore, MD |
| 98 | Sun Jul 25 | at Orioles | L4-5 | 45-53 | .459 | Camden Yards · Baltimore, MD |
| 99 | Mon Jul 26 | at Phillies | L5-6 | 45-54 | .455 | Citizens Bank Park · Philadelphi, PA |
| 100 | Tue Jul 27 | at Phillies | W6-4 | 46-54 | .460 | Citizens Bank Park · Philadelphi, PA |
| 101 | Thu Jul 29 | at Phillies | W3-1 | 47-54 | .465 | Citizens Bank Park · Philadelphi, PA |
| 102 | Thu Jul 29 | at Phillies | L8-11 (8) | 47-55 | .461 | Citizens Bank Park · Philadelphi, PA |
| 103 | Fri Jul 30 | vs Cubs | W4-3 | 48-55 | .466 | Nationals Park · Washington, D.C. |
| 104 | Sat Jul 31 | vs Cubs | L3-6 | 48-56 | .462 | Nationals Park · Washington, D.C. |
| 105 | Sun Aug 1 | vs Cubs | W6-5 | 49-56 | .467 | Nationals Park · Washington, D.C. |
| 106 | Mon Aug 2 | vs Phillies | L5-7 | 49-57 | .462 | Nationals Park · Washington, D.C. |
| 107 | Tue Aug 3 | vs Phillies | L4-5 | 49-58 | .458 | Nationals Park · Washington, D.C. |
| 108 | Wed Aug 4 | vs Phillies | L5-9 | 49-59 | .454 | Nationals Park · Washington, D.C. |
| 109 | Thu Aug 5 | vs Phillies | L6-7 | 49-60 | .450 | Nationals Park · Washington, D.C. |
| 110 | Fri Aug 6 | at Braves | L4-8 | 49-61 | .445 | Truist Park · Cumberland, GA |
| 111 | Sat Aug 7 | at Braves | W3-2 | 50-61 | .450 | Truist Park · Cumberland, GA |
| 112 | Sun Aug 8 | at Braves | L4-5 | 50-62 | .446 | Truist Park · Cumberland, GA |
| 113 | Wed Aug 11 | at Mets | L7-8 | 50-63 | .442 | Citi Field · Queens, NY |
| 114 | Thu Aug 12 | at Mets | L1-4 | 50-64 | .439 | Citi Field · Queens, NY |
| 115 | Thu Aug 12 | at Mets | L4-5 | 50-65 | .435 | Citi Field · Queens, NY |
| 116 | Fri Aug 13 | vs Braves | L2-4 | 50-66 | .431 | Nationals Park · Washington, D.C. |
| 117 | Sat Aug 14 | vs Braves | L2-12 | 50-67 | .427 | Nationals Park · Washington, D.C. |
| 118 | Sun Aug 15 | vs Braves | L5-6 | 50-68 | .424 | Nationals Park · Washington, D.C. |
| 119 | Tue Aug 17 | vs Blue Jays | W12-6 | 51-68 | .429 | Nationals Park · Washington, D.C. |
| 120 | Wed Aug 18 | vs Blue Jays | W8-5 | 52-68 | .433 | Nationals Park · Washington, D.C. |
| 121 | Fri Aug 20 | at Brewers | W4-1 | 53-68 | .438 | American Family Field · Milwaukee, WI |
| 122 | Sat Aug 21 | at Brewers | L6-9 | 53-69 | .434 | American Family Field · Milwaukee, WI |
| 123 | Sun Aug 22 | at Brewers | L3-7 | 53-70 | .431 | American Family Field · Milwaukee, WI |
| 124 | Tue Aug 24 | at Marlins | W5-1 | 54-70 | .435 | LoanDepot Park · Miami, FL |
| 125 | Wed Aug 25 | at Marlins | L3-4 (10) | 54-71 | .432 | LoanDepot Park · Miami, FL |
| 126 | Thu Aug 26 | at Marlins | L5-7 | 54-72 | .429 | LoanDepot Park · Miami, FL |
| 127 | Fri Aug 27 | at Mets | W2-1 | 55-72 | .433 | Citi Field · Queens, NY |
| 128 | Sat Aug 28 | at Mets | L3-5 | 55-73 | .430 | Citi Field · Queens, NY |
| 129 | Sun Aug 29 | at Mets | L4-9 | 55-74 | .426 | Citi Field · Queens, NY |
| 130 | Mon Aug 30 | vs Phillies | L4-7 | 55-75 | .423 | Nationals Park · Washington, D.C. |
| 131 | Tue Aug 31 | vs Phillies | L6-12 | 55-76 | .420 | Nationals Park · Washington, D.C. |
| 132 | Thu Sep 2 | vs Phillies | L6-7 | 55-77 | .417 | Nationals Park · Washington, D.C. |
| 133 | Fri Sep 3 | vs Mets | L2-6 (10) | 55-78 | .414 | Nationals Park · Washington, D.C. |
| 134 | Sat Sep 4 | vs Mets | L9-11 (9) | 55-79 | .410 | Nationals Park · Washington, D.C. |
| 135 | Sat Sep 4 | vs Mets | W4-3 | 56-79 | .415 | Nationals Park · Washington, D.C. |
| 136 | Sun Sep 5 | vs Mets | L6-13 | 56-80 | .412 | Nationals Park · Washington, D.C. |
| 137 | Mon Sep 6 | vs Mets | W4-3 | 57-80 | .416 | Nationals Park · Washington, D.C. |
| 138 | Tue Sep 7 | at Braves | L5-8 | 57-81 | .413 | Truist Park · Cumberland, GA |
| 139 | Wed Sep 8 | at Braves | W4-2 | 58-81 | .417 | Truist Park · Cumberland, GA |
| 140 | Thu Sep 9 | at Braves | L6-7 (10) | 58-82 | .414 | Truist Park · Cumberland, GA |
| 141 | Fri Sep 10 | at Pirates | L3-4 | 58-83 | .411 | PNC Park · Pittsburgh, PA |
| 142 | Sat Sep 11 | at Pirates | L7-10 | 58-84 | .408 | PNC Park · Pittsburgh, PA |
| 143 | Sun Sep 12 | at Pirates | W6-2 | 59-84 | .413 | PNC Park · Pittsburgh, PA |
| 144 | Mon Sep 13 | vs Marlins | L0-3 | 59-85 | .410 | Nationals Park · Washington, D.C. |
| 145 | Tue Sep 14 | vs Marlins | W8-2 | 60-85 | .414 | Nationals Park · Washington, D.C. |
| 146 | Wed Sep 15 | vs Marlins | L6-8 | 60-86 | .411 | Nationals Park · Washington, D.C. |
| 147 | Fri Sep 17 | vs Rockies | L8-9 | 60-87 | .408 | Nationals Park · Washington, D.C. |
| 148 | Sat Sep 18 | vs Rockies | L0-6 | 60-88 | .405 | Nationals Park · Washington, D.C. |
| 149 | Sun Sep 19 | vs Rockies | W3-0 | 61-88 | .409 | Nationals Park · Washington, D.C. |
| 150 | Mon Sep 20 | at Marlins | L7-8 (10) | 61-89 | .407 | LoanDepot Park · Miami, FL |
| 151 | Tue Sep 21 | at Marlins | W7-1 | 62-89 | .411 | LoanDepot Park · Miami, FL |
| 152 | Wed Sep 22 | at Marlins | W7-5 | 63-89 | .414 | LoanDepot Park · Miami, FL |
| 153 | Thu Sep 23 | at Reds | W3-2 | 64-89 | .418 | Great American Ball Park · Cincinnati, OH |
| 154 | Fri Sep 24 | at Reds | L7-8 (11) | 64-90 | .416 | Great American Ball Park · Cincinnati, OH |
| 155 | Sat Sep 25 | at Reds | L6-7 | 64-91 | .413 | Great American Ball Park · Cincinnati, OH |
| 156 | Sun Sep 26 | at Reds | L2-9 | 64-92 | .410 | Great American Ball Park · Cincinnati, OH |
| 157 | Mon Sep 27 | at Rockies | W5-4 | 65-92 | .414 | Coors Field · Denver, CO |
| 158 | Tue Sep 28 | at Rockies | L1-3 | 65-93 | .411 | Coors Field · Denver, CO |
| 159 | Wed Sep 29 | at Rockies | L5-10 | 65-94 | .409 | Coors Field · Denver, CO |
| 160 | Fri Oct 1 | vs Red Sox | L2-4 | 65-95 | .406 | Nationals Park · Washington, D.C. |
| 161 | Sat Oct 2 | vs Red Sox | L3-5 | 65-96 | .404 | Nationals Park · Washington, D.C. |
| 162 | Sun Oct 3 | vs Red Sox | L5-7 | 65-97 | .401 | Nationals Park · Washington, D.C. |