| 1 | Thu Apr 5 | at Cubs | W2-1 | 1-0 | 1.000 | Wrigley Field · Chicago, IL |
| 2 | Sat Apr 7 | at Cubs | W7-4 | 2-0 | 1.000 | Wrigley Field · Chicago, IL |
| 3 | Sun Apr 8 | at Cubs | L3-4 | 2-1 | .667 | Wrigley Field · Chicago, IL |
| 4 | Mon Apr 9 | at Mets | L3-4 | 2-2 | .500 | Citi Field · Queens, NY |
| 5 | Tue Apr 10 | at Mets | W6-2 | 3-2 | .600 | Citi Field · Queens, NY |
| 6 | Wed Apr 11 | at Mets | W4-0 | 4-2 | .667 | Citi Field · Queens, NY |
| 7 | Thu Apr 12 | vs Reds | W3-2 (10) | 5-2 | .714 | Nationals Park · Washington, D.C. |
| 8 | Fri Apr 13 | vs Reds | W2-1 (13) | 6-2 | .750 | Nationals Park · Washington, D.C. |
| 9 | Sat Apr 14 | vs Reds | W4-1 | 7-2 | .778 | Nationals Park · Washington, D.C. |
| 10 | Sun Apr 15 | vs Reds | L5-8 (11) | 7-3 | .700 | Nationals Park · Washington, D.C. |
| 11 | Mon Apr 16 | vs Astros | W6-3 | 8-3 | .727 | Nationals Park · Washington, D.C. |
| 12 | Tue Apr 17 | vs Astros | W1-0 | 9-3 | .750 | Nationals Park · Washington, D.C. |
| 13 | Wed Apr 18 | vs Astros | W3-2 | 10-3 | .769 | Nationals Park · Washington, D.C. |
| 14 | Thu Apr 19 | vs Astros | L4-11 | 10-4 | .714 | Nationals Park · Washington, D.C. |
| 15 | Fri Apr 20 | vs Marlins | W2-0 | 11-4 | .733 | Nationals Park · Washington, D.C. |
| 16 | Sat Apr 21 | vs Marlins | W3-2 (10) | 12-4 | .750 | Nationals Park · Washington, D.C. |
| 17 | Tue Apr 24 | at Padres | W3-1 | 13-4 | .765 | Petco Park · San Diego, CA |
| 18 | Wed Apr 25 | at Padres | W7-2 | 14-4 | .778 | Petco Park · San Diego, CA |
| 19 | Thu Apr 26 | at Padres | L1-2 | 14-5 | .737 | Petco Park · San Diego, CA |
| 20 | Fri Apr 27 | at Dodgers | L2-3 | 14-6 | .700 | Dodger Stadium · Los Angeles, CA |
| 21 | Sat Apr 28 | at Dodgers | L3-4 (10) | 14-7 | .667 | Dodger Stadium · Los Angeles, CA |
| 22 | Sun Apr 29 | at Dodgers | L0-2 | 14-8 | .636 | Dodger Stadium · Los Angeles, CA |
| 23 | Tue May 1 | vs D-backs | L1-5 | 14-9 | .609 | Nationals Park · Washington, D.C. |
| 24 | Wed May 2 | vs D-backs | W5-4 | 15-9 | .625 | Nationals Park · Washington, D.C. |
| 25 | Thu May 3 | vs D-backs | W2-1 | 16-9 | .640 | Nationals Park · Washington, D.C. |
| 26 | Fri May 4 | vs Phillies | W4-3 (11) | 17-9 | .654 | Nationals Park · Washington, D.C. |
| 27 | Sat May 5 | vs Phillies | W7-1 | 18-9 | .667 | Nationals Park · Washington, D.C. |
| 28 | Sun May 6 | vs Phillies | L3-9 | 18-10 | .643 | Nationals Park · Washington, D.C. |
| 29 | Tue May 8 | at Pirates | L4-5 | 18-11 | .621 | PNC Park · Pittsburgh, PA |
| 30 | Wed May 9 | at Pirates | L2-4 | 18-12 | .600 | PNC Park · Pittsburgh, PA |
| 31 | Thu May 10 | at Pirates | W4-2 | 19-12 | .613 | PNC Park · Pittsburgh, PA |
| 32 | Fri May 11 | at Reds | W7-3 | 20-12 | .625 | Great American Ball Park · Cincinnati, OH |
| 33 | Sat May 12 | at Reds | W2-1 | 21-12 | .636 | Great American Ball Park · Cincinnati, OH |
| 34 | Sun May 13 | at Reds | L6-9 | 21-13 | .618 | Great American Ball Park · Cincinnati, OH |
| 35 | Mon May 14 | vs Padres | W8-5 | 22-13 | .629 | Nationals Park · Washington, D.C. |
| 36 | Tue May 15 | vs Padres | L1-6 | 22-14 | .611 | Nationals Park · Washington, D.C. |
| 37 | Wed May 16 | vs Pirates | W7-4 | 23-14 | .622 | Nationals Park · Washington, D.C. |
| 38 | Thu May 17 | vs Pirates | L3-5 | 23-15 | .605 | Nationals Park · Washington, D.C. |
| 39 | Fri May 18 | vs Orioles | L1-2 (11) | 23-16 | .590 | Nationals Park · Washington, D.C. |
| 40 | Sat May 19 | vs Orioles | L5-6 | 23-17 | .575 | Nationals Park · Washington, D.C. |
| 41 | Sun May 20 | vs Orioles | W9-3 | 24-17 | .585 | Nationals Park · Washington, D.C. |
| 42 | Mon May 21 | at Phillies | W2-1 | 25-17 | .595 | Citizens Bank Park · Philadelphi, PA |
| 43 | Tue May 22 | at Phillies | W5-2 | 26-17 | .605 | Citizens Bank Park · Philadelphi, PA |
| 44 | Wed May 23 | at Phillies | L1-4 | 26-18 | .591 | Citizens Bank Park · Philadelphi, PA |
| 45 | Fri May 25 | at Braves | W7-4 | 27-18 | .600 | Truist Park · Cumberland, GA |
| 46 | Sat May 26 | at Braves | W8-4 | 28-18 | .609 | Truist Park · Cumberland, GA |
| 47 | Sun May 27 | at Braves | W7-2 | 29-18 | .617 | Truist Park · Cumberland, GA |
| 48 | Mon May 28 | at Marlins | L3-5 | 29-19 | .604 | LoanDepot Park · Miami, FL |
| 49 | Tue May 29 | at Marlins | L1-3 | 29-20 | .592 | LoanDepot Park · Miami, FL |
| 50 | Wed May 30 | at Marlins | L3-5 | 29-21 | .580 | LoanDepot Park · Miami, FL |
| 51 | Sat Jun 2 | vs Braves | W2-0 | 30-21 | .588 | Nationals Park · Washington, D.C. |
| 52 | Sun Jun 3 | vs Braves | L2-3 | 30-22 | .577 | Nationals Park · Washington, D.C. |
| 53 | Tue Jun 5 | vs Mets | W7-6 (12) | 31-22 | .585 | Nationals Park · Washington, D.C. |
| 54 | Wed Jun 6 | vs Mets | W5-3 | 32-22 | .593 | Nationals Park · Washington, D.C. |
| 55 | Thu Jun 7 | vs Mets | L1-3 | 32-23 | .582 | Nationals Park · Washington, D.C. |
| 56 | Fri Jun 8 | at Red Sox | W7-4 | 33-23 | .589 | Fenway Park · Boston, MA |
| 57 | Sat Jun 9 | at Red Sox | W4-2 | 34-23 | .596 | Fenway Park · Boston, MA |
| 58 | Sun Jun 10 | at Red Sox | W4-3 | 35-23 | .603 | Fenway Park · Boston, MA |
| 59 | Mon Jun 11 | at Blue Jays | W6-3 | 36-23 | .610 | Rogers Centre · Toronto, ON |
| 60 | Tue Jun 12 | at Blue Jays | W4-2 | 37-23 | .617 | Rogers Centre · Toronto, ON |
| 61 | Wed Jun 13 | at Blue Jays | W6-2 | 38-23 | .623 | Rogers Centre · Toronto, ON |
| 62 | Fri Jun 15 | vs Yankees | L2-7 | 38-24 | .613 | Nationals Park · Washington, D.C. |
| 63 | Sat Jun 16 | vs Yankees | L3-5 (14) | 38-25 | .603 | Nationals Park · Washington, D.C. |
| 64 | Sun Jun 17 | vs Yankees | L1-4 | 38-26 | .594 | Nationals Park · Washington, D.C. |
| 65 | Tue Jun 19 | vs Rays | L4-5 | 38-27 | .585 | Nationals Park · Washington, D.C. |
| 66 | Wed Jun 20 | vs Rays | W3-2 | 39-27 | .591 | Nationals Park · Washington, D.C. |
| 67 | Thu Jun 21 | vs Rays | W5-2 | 40-27 | .597 | Nationals Park · Washington, D.C. |
| 68 | Fri Jun 22 | at Orioles | L1-2 | 40-28 | .588 | Camden Yards · Baltimore, MD |
| 69 | Sat Jun 23 | at Orioles | W3-1 | 41-28 | .594 | Camden Yards · Baltimore, MD |
| 70 | Sun Jun 24 | at Orioles | L1-2 | 41-29 | .586 | Camden Yards · Baltimore, MD |
| 71 | Mon Jun 25 | at Rockies | L2-4 | 41-30 | .577 | Coors Field · Denver, CO |
| 72 | Tue Jun 26 | at Rockies | W12-5 | 42-30 | .583 | Coors Field · Denver, CO |
| 73 | Wed Jun 27 | at Rockies | W11-5 | 43-30 | .589 | Coors Field · Denver, CO |
| 74 | Thu Jun 28 | at Rockies | L10-11 (11) | 43-31 | .581 | Coors Field · Denver, CO |
| 75 | Fri Jun 29 | at Braves | W5-4 | 44-31 | .587 | Truist Park · Cumberland, GA |
| 76 | Sat Jun 30 | at Braves | L5-7 | 44-32 | .579 | Truist Park · Cumberland, GA |
| 77 | Sun Jul 1 | at Braves | W8-4 | 45-32 | .584 | Truist Park · Cumberland, GA |
| 78 | Tue Jul 3 | vs Giants | W9-3 | 46-32 | .590 | Nationals Park · Washington, D.C. |
| 79 | Wed Jul 4 | vs Giants | W9-4 | 47-32 | .595 | Nationals Park · Washington, D.C. |
| 80 | Thu Jul 5 | vs Giants | W6-5 | 48-32 | .600 | Nationals Park · Washington, D.C. |
| 81 | Fri Jul 6 | vs Rockies | L1-5 | 48-33 | .593 | Nationals Park · Washington, D.C. |
| 82 | Sat Jul 7 | vs Rockies | W4-1 | 49-33 | .598 | Nationals Park · Washington, D.C. |
| 83 | Sun Jul 8 | vs Rockies | L3-4 | 49-34 | .590 | Nationals Park · Washington, D.C. |
| 84 | Fri Jul 13 | at Marlins | W5-1 | 50-34 | .595 | LoanDepot Park · Miami, FL |
| 85 | Sat Jul 14 | at Marlins | L1-2 | 50-35 | .588 | LoanDepot Park · Miami, FL |
| 86 | Sun Jul 15 | at Marlins | W4-0 | 51-35 | .593 | LoanDepot Park · Miami, FL |
| 87 | Mon Jul 16 | at Marlins | L3-5 | 51-36 | .586 | LoanDepot Park · Miami, FL |
| 88 | Tue Jul 17 | vs Mets | W5-4 (10) | 52-36 | .591 | Nationals Park · Washington, D.C. |
| 89 | Wed Jul 18 | vs Mets | W4-3 | 53-36 | .596 | Nationals Park · Washington, D.C. |
| 90 | Thu Jul 19 | vs Mets | L5-9 | 53-37 | .589 | Nationals Park · Washington, D.C. |
| 91 | Fri Jul 20 | vs Braves | L10-11 (11) | 53-38 | .582 | Nationals Park · Washington, D.C. |
| 92 | Sat Jul 21 | vs Braves | L0-4 | 53-39 | .576 | Nationals Park · Washington, D.C. |
| 93 | Sat Jul 21 | vs Braves | W5-2 | 54-39 | .581 | Nationals Park · Washington, D.C. |
| 94 | Sun Jul 22 | vs Braves | W9-2 | 55-39 | .585 | Nationals Park · Washington, D.C. |
| 95 | Mon Jul 23 | at Mets | W8-2 (10) | 56-39 | .589 | Citi Field · Queens, NY |
| 96 | Tue Jul 24 | at Mets | W5-2 | 57-39 | .594 | Citi Field · Queens, NY |
| 97 | Wed Jul 25 | at Mets | W5-2 | 58-39 | .598 | Citi Field · Queens, NY |
| 98 | Thu Jul 26 | at Brewers | W8-2 | 59-39 | .602 | American Family Field · Milwaukee, WI |
| 99 | Fri Jul 27 | at Brewers | L0-6 | 59-40 | .596 | American Family Field · Milwaukee, WI |
| 100 | Sat Jul 28 | at Brewers | W4-1 | 60-40 | .600 | American Family Field · Milwaukee, WI |
| 101 | Sun Jul 29 | at Brewers | W11-10 (11) | 61-40 | .604 | American Family Field · Milwaukee, WI |
| 102 | Tue Jul 31 | vs Phillies | L0-8 | 61-41 | .598 | Nationals Park · Washington, D.C. |
| 103 | Wed Aug 1 | vs Phillies | L2-3 | 61-42 | .592 | Nationals Park · Washington, D.C. |
| 104 | Thu Aug 2 | vs Phillies | W3-0 | 62-42 | .596 | Nationals Park · Washington, D.C. |
| 105 | Fri Aug 3 | vs Marlins | W7-4 | 63-42 | .600 | Nationals Park · Washington, D.C. |
| 106 | Fri Aug 3 | vs Marlins | L2-5 | 63-43 | .594 | Nationals Park · Washington, D.C. |
| 107 | Sat Aug 4 | vs Marlins | W10-7 | 64-43 | .598 | Nationals Park · Washington, D.C. |
| 108 | Sun Aug 5 | vs Marlins | W4-1 | 65-43 | .602 | Nationals Park · Washington, D.C. |
| 109 | Mon Aug 6 | at Astros | W5-4 (11) | 66-43 | .606 | Minute Maid Park · Houston, TX |
| 110 | Tue Aug 7 | at Astros | W3-2 (12) | 67-43 | .609 | Minute Maid Park · Houston, TX |
| 111 | Wed Aug 8 | at Astros | W4-3 | 68-43 | .613 | Minute Maid Park · Houston, TX |
| 112 | Thu Aug 9 | at Astros | W5-0 | 69-43 | .616 | Minute Maid Park · Houston, TX |
| 113 | Fri Aug 10 | at D-backs | W9-1 | 70-43 | .619 | Chase Field · Phoenix, AZ |
| 114 | Sat Aug 11 | at D-backs | W6-5 | 71-43 | .623 | Chase Field · Phoenix, AZ |
| 115 | Sun Aug 12 | at D-backs | L4-7 | 71-44 | .617 | Chase Field · Phoenix, AZ |
| 116 | Mon Aug 13 | at Giants | W14-2 | 72-44 | .621 | Oracle Park · San Francisco, CA |
| 117 | Tue Aug 14 | at Giants | L1-6 | 72-45 | .615 | Oracle Park · San Francisco, CA |
| 118 | Wed Aug 15 | at Giants | W6-4 | 73-45 | .619 | Oracle Park · San Francisco, CA |
| 119 | Fri Aug 17 | vs Mets | W6-4 | 74-45 | .622 | Nationals Park · Washington, D.C. |
| 120 | Sat Aug 18 | vs Mets | L0-2 | 74-46 | .617 | Nationals Park · Washington, D.C. |
| 121 | Sun Aug 19 | vs Mets | W5-2 | 75-46 | .620 | Nationals Park · Washington, D.C. |
| 122 | Mon Aug 20 | vs Braves | W5-4 (13) | 76-46 | .623 | Nationals Park · Washington, D.C. |
| 123 | Tue Aug 21 | vs Braves | W4-1 | 77-46 | .626 | Nationals Park · Washington, D.C. |
| 124 | Wed Aug 22 | vs Braves | L1-5 | 77-47 | .621 | Nationals Park · Washington, D.C. |
| 125 | Fri Aug 24 | at Phillies | L2-4 | 77-48 | .616 | Citizens Bank Park · Philadelphi, PA |
| 126 | Sat Aug 25 | at Phillies | L2-4 | 77-49 | .611 | Citizens Bank Park · Philadelphi, PA |
| 127 | Sun Aug 26 | at Phillies | L1-4 | 77-50 | .606 | Citizens Bank Park · Philadelphi, PA |
| 128 | Tue Aug 28 | at Marlins | L0-9 | 77-51 | .602 | LoanDepot Park · Miami, FL |
| 129 | Wed Aug 29 | at Marlins | W8-4 | 78-51 | .605 | LoanDepot Park · Miami, FL |
| 130 | Thu Aug 30 | vs Cardinals | W8-1 | 79-51 | .608 | Nationals Park · Washington, D.C. |
| 131 | Fri Aug 31 | vs Cardinals | W10-0 | 80-51 | .611 | Nationals Park · Washington, D.C. |
| 132 | Sat Sep 1 | vs Cardinals | L9-10 | 80-52 | .606 | Nationals Park · Washington, D.C. |
| 133 | Sun Sep 2 | vs Cardinals | W4-3 | 81-52 | .609 | Nationals Park · Washington, D.C. |
| 134 | Mon Sep 3 | vs Cubs | W2-1 | 82-52 | .612 | Nationals Park · Washington, D.C. |
| 135 | Tue Sep 4 | vs Cubs | W11-5 | 83-52 | .615 | Nationals Park · Washington, D.C. |
| 136 | Wed Sep 5 | vs Cubs | W9-1 | 84-52 | .618 | Nationals Park · Washington, D.C. |
| 137 | Thu Sep 6 | vs Cubs | W9-2 | 85-52 | .620 | Nationals Park · Washington, D.C. |
| 138 | Fri Sep 7 | vs Marlins | L7-9 (10) | 85-53 | .616 | Nationals Park · Washington, D.C. |
| 139 | Sat Sep 8 | vs Marlins | W7-6 (10) | 86-53 | .619 | Nationals Park · Washington, D.C. |
| 140 | Sun Sep 9 | vs Marlins | L0-8 | 86-54 | .614 | Nationals Park · Washington, D.C. |
| 141 | Mon Sep 10 | at Mets | W5-1 | 87-54 | .617 | Citi Field · Queens, NY |
| 142 | Tue Sep 11 | at Mets | W5-3 | 88-54 | .620 | Citi Field · Queens, NY |
| 143 | Wed Sep 12 | at Mets | W2-0 | 89-54 | .622 | Citi Field · Queens, NY |
| 144 | Fri Sep 14 | at Braves | L1-2 | 89-55 | .618 | Truist Park · Cumberland, GA |
| 145 | Sat Sep 15 | at Braves | L4-5 | 89-56 | .614 | Truist Park · Cumberland, GA |
| 146 | Sun Sep 16 | at Braves | L1-5 | 89-57 | .610 | Truist Park · Cumberland, GA |
| 147 | Wed Sep 19 | vs Dodgers | W3-1 | 90-57 | .612 | Nationals Park · Washington, D.C. |
| 148 | Wed Sep 19 | vs Dodgers | L6-7 | 90-58 | .608 | Nationals Park · Washington, D.C. |
| 149 | Thu Sep 20 | vs Dodgers | W4-1 | 91-58 | .611 | Nationals Park · Washington, D.C. |
| 150 | Fri Sep 21 | vs Brewers | L2-4 | 91-59 | .607 | Nationals Park · Washington, D.C. |
| 151 | Sat Sep 22 | vs Brewers | W10-4 | 92-59 | .609 | Nationals Park · Washington, D.C. |
| 152 | Sun Sep 23 | vs Brewers | L2-6 | 92-60 | .605 | Nationals Park · Washington, D.C. |
| 153 | Mon Sep 24 | vs Brewers | W12-2 | 93-60 | .608 | Nationals Park · Washington, D.C. |
| 154 | Tue Sep 25 | at Phillies | L3-6 | 93-61 | .604 | Citizens Bank Park · Philadelphi, PA |
| 155 | Wed Sep 26 | at Phillies | W8-4 | 94-61 | .606 | Citizens Bank Park · Philadelphi, PA |
| 156 | Thu Sep 27 | at Phillies | W7-3 | 95-61 | .609 | Citizens Bank Park · Philadelphi, PA |
| 157 | Fri Sep 28 | at Cardinals | L2-12 | 95-62 | .605 | Busch Stadium · St. Louis, MO |
| 158 | Sat Sep 29 | at Cardinals | W6-4 (10) | 96-62 | .608 | Busch Stadium · St. Louis, MO |
| 159 | Sun Sep 30 | at Cardinals | L4-10 | 96-63 | .604 | Busch Stadium · St. Louis, MO |
| 160 | Mon Oct 1 | vs Phillies | L0-2 | 96-64 | .600 | Nationals Park · Washington, D.C. |
| 161 | Tue Oct 2 | vs Phillies | W4-2 | 97-64 | .602 | Nationals Park · Washington, D.C. |
| 162 | Wed Oct 3 | vs Phillies | W5-1 | 98-64 | .605 | Nationals Park · Washington, D.C. |
| 163 | Sun Oct 7 | at Cardinals | W3-2 | 1-0 | 1.000 | Busch Stadium · St. Louis, MO |
| 164 | Mon Oct 8 | at Cardinals | L4-12 | 1-1 | .500 | Busch Stadium · St. Louis, MO |
| 165 | Wed Oct 10 | vs Cardinals | L0-8 | 1-2 | .333 | Nationals Park · Washington, D.C. |
| 166 | Thu Oct 11 | vs Cardinals | W2-1 | 2-2 | .500 | Nationals Park · Washington, D.C. |
| 167 | Fri Oct 12 | vs Cardinals | L7-9 | 2-3 | .400 | Nationals Park · Washington, D.C. |