| 1 | Tue Nov 7 | vs TBD | W87-49 | 1-0 | 1.000 | - | | Holmes Convocation Center · Boone, NC |
| 2 | Sat Nov 11 | at N Illinois | L78-91 | 1-1 | .500 | - | | NIU Convocation Center · Dekalb, IL |
| 3 | Tue Nov 14 | at Oregon St | L71-81 (OT) | 1-2 | .333 | - | | Gill Coliseum · Corvallis, OR |
| 4 | Tue Nov 21 | vs UNC Wilmington | W86-56 | 2-2 | .500 | - | | Holmes Convocation Center · Boone, NC |
| 5 | Wed Nov 22 | at Murray St | W67-57 | 3-2 | .600 | - | | CFSB Center · Murray, KY |
| 6 | Sun Nov 26 | vs Austin Peay | W78-58 | 4-2 | .667 | - | | Holmes Convocation Center · Boone, NC |
| 7 | Wed Nov 29 | vs ETSU | W72-61 | 5-2 | .714 | - | | Holmes Convocation Center · Boone, NC |
| 8 | Sun Dec 3 | vs Auburn | W69-64 | 6-2 | .750 | - | ESPN2 | Holmes Convocation Center · Boone, NC |
| 9 | Tue Dec 5 | vsTBD | W111-35 | 7-2 | .778 | - | | Holmes Convocation Center · Boone, NC |
| 10 | Wed Dec 13 | at Queens | W93-81 | 8-2 | .800 | - | | Curry Arena · Charlotte, NC |
| 11 | Sat Dec 16 | vs Gardner-Webb | W80-59 | 9-2 | .818 | - | | Holmes Convocation Center · Boone, NC |
| 12 | Thu Dec 21 | vs UNC Asheville | L63-76 | 9-3 | .750 | - | | Holmes Convocation Center · Boone, NC |
| 13 | Sat Dec 30 | vs UL Monroe | W67-55 | 10-3 | .769 | - | | Holmes Convocation Center · Boone, NC |
| 14 | Thu Jan 4 | at South Alabama | W91-84 (OT) | 11-3 | .786 | - | | Mitchell Center · Mobile, AL |
| 15 | Sat Jan 6 | at Troy | L62-66 | 11-4 | .733 | - | | Trojan Arena · Troy, AL |
| 16 | Thu Jan 11 | at Coast Car | W70-45 | 12-4 | .750 | - | | The HTC Center · Conway, SC |
| 17 | Sat Jan 13 | at JMU | W59-55 | 13-4 | .765 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 18 | Wed Jan 17 | vs Georgia St | W76-68 | 14-4 | .778 | - | | Holmes Convocation Center · Boone, NC |
| 19 | Sat Jan 20 | vsCoast Car | W88-59 | 15-4 | .789 | - | | Holmes Convocation Center · Boone, NC |
| 20 | Thu Jan 25 | vs Georgia So | W84-74 | 16-4 | .800 | - | | Holmes Convocation Center · Boone, NC |
| 21 | Sat Jan 27 | vsJMU | W82-76 | 17-4 | .810 | - | ESPNEWS | Holmes Convocation Center · Boone, NC |
| 22 | Thu Feb 1 | atGeorgia St | W81-71 | 18-4 | .818 | - | | GSU Convocation Center · Atlanta, GA |
| 23 | Sat Feb 3 | atGeorgia So | W85-84 (OT) | 19-4 | .826 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 24 | Wed Feb 7 | at Texas St | L56-63 | 19-5 | .792 | - | | Strahan Arena at the University Events Center · San Marcos, TX |
| 25 | Sat Feb 10 | vs Toledo | W109-104 (2OT) | 20-5 | .800 | - | | Holmes Convocation Center · Boone, NC |
| 26 | Thu Feb 15 | vs Marshall | W73-58 | 21-5 | .808 | - | | Holmes Convocation Center · Boone, NC |
| 27 | Sat Feb 17 | vs Louisiana | W85-73 | 22-5 | .815 | - | | Holmes Convocation Center · Boone, NC |
| 28 | Thu Feb 22 | at Old Dominion | W82-67 | 23-5 | .821 | - | | Chartway Arena · Norfolk, VA |
| 29 | Sat Feb 24 | atMarshall | W65-58 | 24-5 | .828 | - | ESPN2 | Cam Henderson Center · Huntington, WV |
| 30 | Wed Feb 28 | vsOld Dominion | W89-64 | 25-5 | .833 | - | | Holmes Convocation Center · Boone, NC |
| 31 | Fri Mar 1 | vs Arkansas St | W80-57 | 26-5 | .839 | - | | Holmes Convocation Center · Boone, NC |
| 32 | Sat Mar 9 | vsGeorgia So | W85-80 (OT) | 27-5 | .844 | - | | Holmes Convocation Center · Boone, NC |
| 33 | Sun Mar 10 | vsArkansas St | L65-67 | 27-6 | .818 | - | | Holmes Convocation Center · Boone, NC |
| 34 | Wed Mar 20 | at Wake Forest | L76-87 | 27-7 | .794 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
