| 1 | Mon Nov 6 | at Bowling Green | L41-70 | 0-1 | .000 | - | | Stroh Center · Bowling Green, OH |
| 2 | Thu Nov 9 | vsMercer | L61-66 | 0-2 | .000 | - | | Jones Convocation Center · Chicago, IL |
| 3 | Sun Nov 12 | atSo Indiana | W78-67 | 1-2 | .333 | - | | Screaming Eagles Arena · Evansville, IN |
| 4 | Tue Nov 14 | vsCSU Northridge | L64-74 | 1-3 | .250 | - | | Jones Convocation Center · Chicago, IL |
| 5 | Thu Nov 16 | atS Illinois | L55-71 | 1-4 | .200 | - | | Banterra Center · Carbondale, IL |
| 6 | Tue Nov 21 | vsN Colorado | L77-78 (OT) | 1-5 | .167 | - | | Jones Convocation Center · Chicago, IL |
| 7 | Wed Nov 22 | atMorgan St | W84-83 | 2-5 | .286 | - | | Hill Field House · Baltimore, MD |
| 8 | Sat Nov 25 | vsUT Martin | L71-94 | 2-6 | .250 | - | | Jones Convocation Center · Chicago, IL |
| 9 | Tue Nov 28 | atLoyola Chicago | L53-62 | 2-7 | .222 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Thu Nov 30 | vsDelaware St | L69-76 | 2-8 | .200 | - | | Jones Convocation Center · Chicago, IL |
| 11 | Sun Dec 3 | vsStetson | W77-54 | 3-8 | .273 | - | | Jones Convocation Center · Chicago, IL |
| 12 | Sun Dec 10 | vsSt Thomas (MN) | L50-66 | 3-9 | .250 | - | | Jones Convocation Center · Chicago, IL |
| 13 | Wed Dec 13 | at25Northwestern | W75-73 | 4-9 | .308 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 14 | Sat Dec 16 | atValparaiso | W63-62 | 5-9 | .357 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 15 | Mon Dec 18 | vsUT Rio Grande | W78-68 | 6-9 | .400 | - | | Jones Convocation Center · Chicago, IL |
| 16 | Wed Dec 20 | vsBethune | W55-54 | 7-9 | .438 | - | | Jones Convocation Center · Chicago, IL |
| 17 | Fri Dec 22 | at24Wisconsin | L53-80 | 7-10 | .412 | - | BTN | Kohl Center · Madison, WI |
| 18 | Wed Dec 27 | atCA Baptist | L62-74 | 7-11 | .389 | - | | CBU Events Center · Riverside, CA |
| 19 | Sat Dec 30 | atDePaul | L58-70 | 7-12 | .368 | - | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Tue Jan 2 | atKansas St | L55-62 | 7-13 | .350 | - | | Bramlage Coliseum · Manhattan, KS |
| 21 | Wed Jan 3 | atOklahoma St | L53-72 | 7-14 | .333 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Sun Jan 7 | atUTEP | L69-74 | 7-15 | .318 | - | | Don Haskins Center · El Paso, TX |
| 23 | Wed Jan 10 | atFairleigh | W75-74 | 8-15 | .348 | - | | Bogota Savings Bank Center · Teaneck, NJ |
| 24 | Mon Jan 15 | atStetson | W77-70 | 9-15 | .375 | - | | Edmunds Center · Deland, FL |
| 25 | Fri Jan 19 | vsTBD | W131-55 | 10-15 | .400 | - | | Jones Convocation Center · Chicago, IL |
| 26 | Sun Jan 21 | vsTBD | W108-58 | 11-15 | .423 | - | | Jones Convocation Center · Chicago, IL |
| 27 | Wed Jan 31 | atDuquesne | L60-65 | 11-16 | .407 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 28 | Sat Feb 10 | atSC State | L55-78 | 11-17 | .393 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 29 | Wed Feb 14 | atE Kentucky | L73-86 | 11-18 | .379 | - | | McBrayer Arena · Richmond, KY |
| 30 | Mon Feb 19 | vsTBD | W93-70 | 12-18 | .400 | - | | Jones Convocation Center · Chicago, IL |
| 31 | Sat Mar 23 | vsUC San Diego | W77-75 | 13-18 | .419 | - | | Jones Convocation Center · Chicago, IL |
| 32 | Mon Mar 25 | vsFairfield | L74-77 | 13-19 | .406 | - | | Jones Convocation Center · Chicago, IL |
