| 1 | Tue Nov 9 | vs TBD | W109-77 | 1-0 | 1.000 | - | | CFSB Center · Murray, KY |
| 2 | Sat Nov 13 | vsBellarmine | W78-59 | 2-0 | 1.000 | - | | CFSB Center · Murray, KY |
| 3 | Tue Nov 16 | atIllinois St | W77-65 | 3-0 | 1.000 | - | | Redbird Arena · Normal, IL |
| 4 | Mon Nov 22 | atETSU | L58-66 | 3-1 | .750 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 5 | Tue Nov 23 | vsLong Beach St | W80-43 | 4-1 | .800 | - | | CFSB Center · Murray, KY |
| 6 | Wed Nov 24 | atJMU | W74-62 | 5-1 | .833 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 7 | Mon Nov 29 | vsTBD | W98-61 | 6-1 | .857 | - | | CFSB Center · Murray, KY |
| 8 | Sat Dec 4 | vsMTSU | W93-87 | 7-1 | .875 | - | | CFSB Center · Murray, KY |
| 9 | Fri Dec 10 | atMemphis | W74-72 | 8-1 | .889 | - | | FedExForum · Memphis, TN |
| 10 | Wed Dec 15 | vsTBD | W118-48 | 9-1 | .900 | - | | CFSB Center · Murray, KY |
| 11 | Sat Dec 18 | vsChattanooga | W87-76 | 10-1 | .909 | - | | CFSB Center · Murray, KY |
| 12 | Wed Dec 22 | at#12Auburn | L58-71 | 10-2 | .833 | - | SEC Network | Neville Arena · Auburn, AL |
| 13 | Thu Dec 30 | vsSE Missouri St | W106-81 | 11-2 | .846 | - | | CFSB Center · Murray, KY |
| 14 | Sat Jan 1 | vsTennessee Tech | PPD | 31-3 | .912 | - | | CFSB Center · Murray, KY |
| 15 | Thu Jan 6 | atE Illinois | PPD | 31-3 | .912 | - | | Lantz Arena · Charleston, IL |
| 16 | Sat Jan 8 | atSIUE | W74-69 | 12-2 | .857 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 17 | Thu Jan 13 | vsTennessee St | W67-44 | 13-2 | .867 | - | | CFSB Center · Murray, KY |
| 18 | Sat Jan 15 | atBelmont | W82-60 | 14-2 | .875 | - | | Curb Event Center Arena · Nashville, TN |
| 19 | Mon Jan 17 | atE Illinois | W72-46 | 15-2 | .882 | - | | Lantz Arena · Charleston, IL |
| 20 | Thu Jan 20 | vsE Illinois | W91-51 | 16-2 | .889 | - | | CFSB Center · Murray, KY |
| 21 | Sat Jan 22 | vsUT Martin | W74-66 | 17-2 | .895 | - | | CFSB Center · Murray, KY |
| 22 | Mon Jan 24 | vsTennessee Tech | W79-53 | 18-2 | .900 | - | | CFSB Center · Murray, KY |
| 23 | Thu Jan 27 | atTennessee Tech | W80-75 | 19-2 | .905 | - | | Hooper Eblen Center · Cookeville, TN |
| 24 | Sat Jan 29 | vsMorehead St | W77-66 | 20-2 | .909 | - | | CFSB Center · Murray, KY |
| 25 | Thu Feb 3 | atAustin Peay | W65-53 | 21-2 | .913 | - | | Winfield Dunn Center · Clarksville, TN |
| 26 | Sat Feb 5 | vsSIUE | W79-59 | 22-2 | .917 | - | | CFSB Center · Murray, KY |
| 27 | Thu Feb 10 | atTennessee St | W73-62 | 23-2 | .920 | #23 | | Gentry Center · Nashville, TN |
| 28 | Sat Feb 12 | atMorehead St | W57-53 | 24-2 | .923 | #23 | | Ellis T. Johnson Arena · Morehead, KY |
| 29 | Thu Feb 17 | vsAustin Peay | W91-56 | 25-2 | .926 | #21 | ESPNU | CFSB Center · Murray, KY |
| 30 | Sat Feb 19 | atUT Martin | W62-60 | 26-2 | .929 | #21 | | Kathleen and Tom Elam Center · Martin, TN |
| 31 | Thu Feb 24 | vsBelmont | W76-43 | 27-2 | .931 | #19 | ESPNU | CFSB Center · Murray, KY |
| 32 | Sat Feb 26 | atSE Missouri St | W70-68 | 28-2 | .933 | #19 | | Show Me Center · Cape Girardeau, MO |
| 33 | Fri Mar 4 | vsSE Missouri St | W88-74 | 29-2 | .935 | - | ESPNU | Ford Center · Evansville, IN |
| 34 | Sat Mar 5 | vsMorehead St | W71-67 | 30-2 | .938 | - | ESPN2 | Ford Center · Evansville, IN |
| 35 | Thu Mar 17 | vs#10San Francisco | W92-87 (OT) | 31-2 | .939 | #7 | CBS | CFSB Center · Murray, KY |
| 36 | Sat Mar 19 | vs#15Saint Peter's | L60-70 | 31-3 | .912 | #7 | CBS | CFSB Center · Murray, KY |
