| 1 | Sat Nov 9 | vs Southern | W69-49 | 1-0 | 1.000 | - | | CFSB Center · Murray, KY |
| 2 | Tue Nov 12 | atTennessee | L63-82 | 1-1 | .500 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 3 | Sat Nov 16 | vsTBD | W114-48 | 2-1 | .667 | - | | CFSB Center · Murray, KY |
| 4 | Tue Nov 19 | vsS Illinois | W79-66 | 3-1 | .750 | - | | CFSB Center · Murray, KY |
| 5 | Mon Nov 25 | vsLa Salle | L64-75 | 3-2 | .600 | - | | CFSB Center · Murray, KY |
| 6 | Tue Nov 26 | atWeber St | W69-68 | 4-2 | .667 | - | | Dee Events Center · Ogden, UT |
| 7 | Wed Nov 27 | atDrake | L53-63 | 4-3 | .571 | - | | The Knapp Center · Des Moines, IA |
| 8 | Tue Dec 3 | atMissouri St | L69-71 | 4-4 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 9 | Sat Dec 7 | vsMTSU | W85-52 | 5-4 | .556 | - | | CFSB Center · Murray, KY |
| 10 | Mon Dec 16 | vsKennesaw St | W74-38 | 6-4 | .600 | - | | CFSB Center · Murray, KY |
| 11 | Sat Dec 21 | atEvansville | L76-78 (OT) | 6-5 | .545 | - | | Ford Center · Evansville, IN |
| 12 | Sat Dec 28 | vsTBD | W81-46 | 7-5 | .583 | - | | CFSB Center · Murray, KY |
| 13 | Thu Jan 2 | vsUT Martin | W89-76 | 8-5 | .615 | - | | CFSB Center · Murray, KY |
| 14 | Sat Jan 4 | vsSE Missouri St | W81-59 | 9-5 | .643 | - | | CFSB Center · Murray, KY |
| 15 | Thu Jan 9 | atJ'Ville St | W72-68 | 10-5 | .667 | - | ESPNU | Pete Mathews Coliseum · Jacksonville, AL |
| 16 | Sat Jan 11 | atTennessee Tech | W81-69 | 11-5 | .688 | - | | Hooper Eblen Center · Cookeville, TN |
| 17 | Thu Jan 16 | atUT Martin | W84-62 | 12-5 | .706 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 18 | Sat Jan 18 | atSE Missouri St | W96-91 (OT) | 13-5 | .722 | - | | Show Me Center · Cape Girardeau, MO |
| 19 | Thu Jan 23 | vsBelmont | W85-75 | 14-5 | .737 | - | ESPN2 | CFSB Center · Murray, KY |
| 20 | Sat Jan 25 | vsTennessee St | W76-64 | 15-5 | .750 | - | | CFSB Center · Murray, KY |
| 21 | Thu Jan 30 | vsE Illinois | W73-70 | 16-5 | .762 | - | | CFSB Center · Murray, KY |
| 22 | Sat Feb 1 | vsSIUE | W74-55 | 17-5 | .773 | - | | CFSB Center · Murray, KY |
| 23 | Thu Feb 6 | atBelmont | L64-71 | 17-6 | .739 | - | | Curb Event Center Arena · Nashville, TN |
| 24 | Sat Feb 8 | atTennessee St | W73-65 | 18-6 | .750 | - | | Gentry Center · Nashville, TN |
| 25 | Thu Feb 13 | atAustin Peay | L68-71 | 18-7 | .720 | - | ESPNU | Winfield Dunn Center · Clarksville, TN |
| 26 | Sat Feb 15 | vsMorehead St | W85-57 | 19-7 | .731 | - | | CFSB Center · Murray, KY |
| 27 | Thu Feb 20 | atE Illinois | L60-63 | 19-8 | .704 | - | | Lantz Arena · Charleston, IL |
| 28 | Sat Feb 22 | atSIUE | W59-58 | 20-8 | .714 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 29 | Thu Feb 27 | vsE Kentucky | W74-62 | 21-8 | .724 | - | | CFSB Center · Murray, KY |
| 30 | Sat Feb 29 | vsAustin Peay | W75-61 | 22-8 | .733 | - | | CFSB Center · Murray, KY |
| 31 | Fri Mar 6 | vsAustin Peay | W73-61 | 23-8 | .742 | - | ESPNU | CFSB Center · Murray, KY |
| 32 | Sat Mar 7 | atBelmont | L75-76 | 23-9 | .719 | - | ESPN2 | Curb Event Center Arena · Nashville, TN |
