| 1 | Mon Nov 4 | vs TBD | W113-37 | 1-0 | 1.000 | - | ESPN+ | CFSB Center · Murray, KY |
| 2 | Fri Nov 8 | atPitt | L68-83 | 1-1 | .500 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 3 | Sat Nov 16 | atMTSU | W88-67 | 2-1 | .667 | - | ESPN+ | Murphy Center · Murfreesboro, TN |
| 4 | Wed Nov 20 | vsMD-Eastern | W79-61 | 3-1 | .750 | - | ESPN+ | CFSB Center · Murray, KY |
| 5 | Fri Nov 22 | vsUtah Valley | L75-77 | 3-2 | .600 | - | ESPN+ | CFSB Center · Murray, KY |
| 6 | Tue Nov 26 | vsUT Arlington | W79-66 | 4-2 | .667 | - | | CFSB Center · Murray, KY |
| 7 | Tue Dec 3 | vsEvansville | W63-61 | 5-2 | .714 | - | ESPN+ | CFSB Center · Murray, KY |
| 8 | Sun Dec 8 | vsSE Missouri St | W73-53 | 6-2 | .750 | - | ESPN+ | CFSB Center · Murray, KY |
| 9 | Sat Dec 14 | atWestern KY | L76-81 (OT) | 6-3 | .667 | - | ESPN+ | E. A. Diddle Arena · Bowling Green, KY |
| 10 | Wed Dec 18 | atIndiana St | L74-84 | 6-4 | .600 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 11 | Sun Dec 22 | vsNebraska | L49-66 | 6-5 | .545 | - | ESPN | Stan Sheriff Center · Honolulu, HI |
| 12 | Tue Dec 24 | atCharlotte | L90-94 (2OT) | 6-6 | .500 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | vsLoyola Chicago | W71-68 | 7-6 | .538 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 14 | Thu Jan 2 | vsIllinois St | L68-74 | 7-7 | .500 | - | ESPN+ | CFSB Center · Murray, KY |
| 15 | Sun Jan 5 | atDrake | W66-59 | 8-7 | .533 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 16 | Wed Jan 8 | atNorthern Iowa | W71-68 | 9-7 | .563 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 17 | Sat Jan 11 | vsValparaiso | W58-47 | 10-7 | .588 | - | ESPN+ | CFSB Center · Murray, KY |
| 18 | Wed Jan 15 | atUIC | L93-97 (2OT) | 10-8 | .556 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 19 | Sat Jan 18 | vsBradley | L61-74 | 10-9 | .526 | - | ESPN+ | CFSB Center · Murray, KY |
| 20 | Wed Jan 22 | atS Illinois | W74-64 | 11-9 | .550 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 21 | Sat Jan 25 | vsBelmont | L77-95 | 11-10 | .524 | - | ESPN+ | CFSB Center · Murray, KY |
| 22 | Wed Jan 29 | atEvansville | L74-78 | 11-11 | .500 | - | ESPN+ | Ford Center · Evansville, IN |
| 23 | Sat Feb 1 | atMissouri St | L56-77 | 11-12 | .478 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 24 | Tue Feb 4 | vsDrake | L45-55 | 11-13 | .458 | - | ESPN2 | CFSB Center · Murray, KY |
| 25 | Sat Feb 8 | atValparaiso | W74-56 | 12-13 | .480 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 26 | Tue Feb 11 | vsUIC | W63-53 | 13-13 | .500 | - | ESPN+ | CFSB Center · Murray, KY |
| 27 | Sun Feb 16 | vsNorthern Iowa | PPD | 16-17 | .485 | - | | CFSB Center · Murray, KY |
| 28 | Mon Feb 17 | vsNorthern Iowa | L67-74 | 13-14 | .481 | - | | Curb Event Center Arena · Nashville, TN |
| 29 | Wed Feb 19 | vsS Illinois | W62-60 | 14-14 | .500 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 30 | Sat Feb 22 | atBradley | L83-85 (OT) | 14-15 | .483 | - | ESPNU | Carver Arena · Peoria, IL |
| 31 | Tue Feb 25 | vsIndiana St | W85-75 | 15-15 | .500 | - | ESPN+ | CFSB Center · Murray, KY |
| 32 | Sun Mar 2 | atBelmont | L60-70 | 15-16 | .484 | - | CBS | Curb Event Center Arena · Nashville, TN |
| 33 | Thu Mar 6 | vsEvansville | W74-53 | 16-16 | .500 | - | ESPN+ | CFSB Center · Murray, KY |
| 34 | Fri Mar 7 | atBradley | L62-70 | 16-17 | .485 | - | ESPN+ | Carver Arena · Peoria, IL |
