| 1 | Mon Nov 6 | vs TBD | W91-58 | 1-0 | 1.000 | - | | CFSB Center · Murray, KY |
| 2 | Fri Nov 10 | vsTennessee Tech | W78-72 | 2-0 | 1.000 | - | | CFSB Center · Murray, KY |
| 3 | Tue Nov 14 | vsWestern KY | L81-86 | 2-1 | .667 | - | | CFSB Center · Murray, KY |
| 4 | Mon Nov 20 | atUNC Wilmington | L81-83 (OT) | 2-2 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 5 | Wed Nov 22 | vsAppalachian St | L57-67 | 2-3 | .400 | - | | CFSB Center · Murray, KY |
| 6 | Wed Nov 29 | vsBradley | W79-72 | 3-3 | .500 | - | | CFSB Center · Murray, KY |
| 7 | Sun Dec 3 | atIllinois St | L72-76 | 3-4 | .429 | - | | Redbird Arena · Normal, IL |
| 8 | Sat Dec 9 | atAustin Peay | L49-53 | 3-5 | .375 | - | | Winfield Dunn Center · Clarksville, TN |
| 9 | Wed Dec 13 | atMississippi St | L81-85 | 3-6 | .333 | - | | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 16 | vsSE Louisiana | L55-61 | 3-7 | .300 | - | | CFSB Center · Murray, KY |
| 11 | Mon Dec 18 | atLittle Rock | L66-80 | 3-8 | .273 | - | | Jack Stephens Center · Little Rock, AR |
| 12 | Fri Dec 22 | vsSMU | L65-92 | 3-9 | .250 | - | CBS | CFSB Center · Murray, KY |
| 13 | Sat Dec 30 | vsMTSU | W75-54 | 4-9 | .308 | - | | CFSB Center · Murray, KY |
| 14 | Tue Jan 2 | vsUIC | W85-73 | 5-9 | .357 | - | | CFSB Center · Murray, KY |
| 15 | Sat Jan 6 | atEvansville | W81-59 | 6-9 | .400 | - | | Ford Center · Evansville, IN |
| 16 | Wed Jan 10 | atMissouri St | W77-53 | 7-9 | .438 | - | | Great Southern Bank Arena · Springfield, MO |
| 17 | Sun Jan 14 | vsNorthern Iowa | L60-70 | 7-10 | .412 | - | | CFSB Center · Murray, KY |
| 18 | Wed Jan 17 | atUIC | W73-58 | 8-10 | .444 | - | | Credit Union 1 Arena · Chicago, IL |
| 19 | Sun Jan 21 | vsIndiana St | L63-72 | 8-11 | .421 | - | ESPN2 | CFSB Center · Murray, KY |
| 20 | Wed Jan 24 | atBradley | L63-71 | 8-12 | .400 | - | CBS | Carver Arena · Peoria, IL |
| 21 | Sat Jan 27 | vsS Illinois | L58-60 | 8-13 | .381 | - | | CFSB Center · Murray, KY |
| 22 | Tue Jan 30 | vsIllinois St | L59-61 | 8-14 | .364 | - | | CFSB Center · Murray, KY |
| 23 | Sat Feb 3 | atNorthern Iowa | W71-43 | 9-14 | .391 | - | CBS | McLeod Center · Cedar Falls, IA |
| 24 | Wed Feb 7 | atBelmont | L64-69 | 9-15 | .375 | - | | Curb Event Center Arena · Nashville, TN |
| 25 | Sat Feb 10 | vsEvansville | W73-70 | 10-15 | .400 | - | | CFSB Center · Murray, KY |
| 26 | Wed Feb 14 | vsMissouri St | W82-72 | 11-15 | .423 | - | | CFSB Center · Murray, KY |
| 27 | Sun Feb 18 | atDrake | L72-95 | 11-16 | .407 | - | | The Knapp Center · Des Moines, IA |
| 28 | Wed Feb 21 | atS Illinois | L68-72 | 11-17 | .393 | - | | Banterra Center · Carbondale, IL |
| 29 | Sat Feb 24 | vsValparaiso | W80-68 | 12-17 | .414 | - | | CFSB Center · Murray, KY |
| 30 | Wed Feb 28 | vsBelmont | L61-83 | 12-18 | .400 | - | | CFSB Center · Murray, KY |
| 31 | Sun Mar 3 | atIndiana St | L77-89 | 12-19 | .387 | - | | Hulman Center · Terre Haute, IN |
| 32 | Thu Mar 7 | vsMissouri St | L35-60 | 12-20 | .375 | - | | CFSB Center · Murray, KY |
