| 1 | Mon Nov 3 | vs TBD | W95-48 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Wed Nov 5 | vsTBD | W94-53 | 2-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 3 | Sat Nov 8 | atWichita St | L62-105 | 2-1 | .667 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 4 | Wed Nov 12 | atOklahoma St | L67-94 | 2-2 | .500 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 17 | atMissouri | L73-91 | 2-3 | .400 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 6 | Sat Nov 22 | vsUT Martin | L68-69 | 2-4 | .333 | - | | William Nicks Building · Prairie View, TX |
| 7 | Sun Nov 23 | atNorth Florida | W85-82 | 3-4 | .429 | - | | UNF Arena · Jacksonville, FL |
| 8 | Sun Nov 30 | atNorth Texas | L69-72 | 3-5 | .375 | - | ESPN+ | The Super Pit · Denton, TX |
| 9 | Sat Dec 6 | vsTBD | W124-62 | 4-5 | .444 | - | | William Nicks Building · Prairie View, TX |
| 10 | Sat Dec 13 | atSouth Dakota | L85-97 | 4-6 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Sat Dec 20 | vsTBD | W100-64 | 5-6 | .455 | - | | William Nicks Building · Prairie View, TX |
| 12 | Mon Dec 22 | atLSU | L90-104 | 5-7 | .417 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 13 | Mon Dec 29 | atTexas A&M | L82-111 | 5-8 | .385 | - | SECN+ | Reed Arena · College Station, TX |
| 14 | Sat Jan 3 | atGrambling | L72-76 | 5-9 | .357 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 15 | Mon Jan 5 | atSouthern | W89-85 | 6-9 | .400 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 16 | Sat Jan 10 | vsMiss Valley St | W70-69 | 7-9 | .438 | - | | William Nicks Building · Prairie View, TX |
| 17 | Mon Jan 12 | vsAR-Pine Bluff | W73-61 | 8-9 | .471 | - | | William Nicks Building · Prairie View, TX |
| 18 | Sat Jan 17 | atJackson St | L78-82 | 8-10 | .444 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Mon Jan 19 | atAlcorn St | L75-76 | 8-11 | .421 | - | | Davey L. Whitney Complex · Lorman, MS |
| 20 | Sat Jan 24 | vsAlabama St | L80-95 | 8-12 | .400 | - | | William Nicks Building · Prairie View, TX |
| 21 | Mon Jan 26 | vsAlabama A&M | PPD | 18-17 | .514 | - | | William Nicks Building · Prairie View, TX |
| 22 | Tue Jan 27 | vsAlabama A&M | L60-80 | 8-13 | .381 | - | | William Nicks Building · Prairie View, TX |
| 23 | Sat Jan 31 | vsTexas So | W85-78 | 9-13 | .409 | - | | William Nicks Building · Prairie View, TX |
| 24 | Sat Feb 7 | atBethune | L76-82 | 9-14 | .391 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 25 | Mon Feb 9 | atFAMU | L96-100 | 9-15 | .375 | - | | Al Lawson Center · Tallahassee, FL |
| 26 | Sat Feb 14 | vsSouthern | L82-87 | 9-16 | .360 | - | | William Nicks Building · Prairie View, TX |
| 27 | Mon Feb 16 | vsGrambling | W68-63 | 10-16 | .385 | - | | William Nicks Building · Prairie View, TX |
| 28 | Thu Feb 19 | atMiss Valley St | W72-62 | 11-16 | .407 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 29 | Sat Feb 21 | atAR-Pine Bluff | L82-84 | 11-17 | .393 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 30 | Thu Feb 26 | vsJackson St | W85-76 (OT) | 12-17 | .414 | - | | William Nicks Building · Prairie View, TX |
| 31 | Sat Feb 28 | vsAlcorn St | W72-51 | 13-17 | .433 | - | | William Nicks Building · Prairie View, TX |
| 32 | Thu Mar 5 | atTexas So | W70-59 | 14-17 | .452 | - | | H&PE Arena · Houston, TX |
| 33 | Tue Mar 10 | vsAlcorn St | W65-56 | 15-17 | .469 | - | ESPN+ | William Nicks Building · Prairie View, TX |
| 34 | Wed Mar 11 | atBethune | W71-67 | 16-17 | .485 | - | ESPN+ | Moore Gymnasium (FL) · Daytona Beach, FL |
| 35 | Fri Mar 13 | atAlabama A&M | W74-55 | 17-17 | .500 | - | ESPN+ | T.M. Elmore Gymnasium · Normal, AL |
| 36 | Sat Mar 14 | atSouthern | W72-66 | 18-17 | .514 | - | ESPNU | F. G. Clark Activity Center · Baton Rouge, LA |
| R0 | Wed Mar 18 | at16Lehigh | W67-55 | 19-17 | .528 | #16 | truTV | UD Arena · Dayton, OH |
| R1 | Fri Mar 20 | at1Florida | L55-114 | 19-18 | .514 | #16 | TNT | Benchmark International Arena · Tampa, FL |
