| 1 | Fri Nov 27 | at Louisville | L70-71 | +5½ | 0-1 | .000 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 2 | Mon Nov 30 | vsIona | W86-64 | -20 | 1-1 | .500 | - | FS1 | Prudential Center · Newark, NJ |
| 3 | Wed Dec 2 | atRhode Island | L63-76 | -1½ | 1-2 | .333 | - | CBS Sports Network | Ryan Center · Kingston, RI |
| 4 | Fri Dec 4 | at21Oregon | L70-83 | +4 | 1-3 | .250 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 5 | Sun Dec 6 | atPenn State | W98-92 (OT) | +2½ | 2-3 | .400 | - | Big Ten Network | Bryce Jordan Center · University Park, PA |
| 6 | Tue Dec 8 | vsWagner | W78-45 | -21 | 3-3 | .500 | - | FS1 | Prudential Center · Newark, NJ |
| 7 | Fri Dec 11 | vsSt John's | W77-68 | -5½ | 4-3 | .571 | - | | Prudential Center · Newark, NJ |
| 8 | Tue Dec 15 | atXavier | PPD | - | 14-13 | .519 | - | FS1 | Cintas Center · Cincinnati, OH |
| 9 | Thu Dec 17 | atMarquette | W70-63 | +3 | 5-3 | .625 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 10 | Sun Dec 20 | vsProvidence | L77-80 (OT) | -3½ | 5-4 | .556 | - | FS1 | Prudential Center · Newark, NJ |
| 11 | Wed Dec 23 | vsGeorgetown | W78-67 | -9½ | 6-4 | .600 | - | FS1 | Prudential Center · Newark, NJ |
| 12 | Wed Dec 30 | atXavier | W85-68 | +3 | 7-4 | .636 | - | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Sat Jan 2 | vsButler | W68-60 | -8½ | 8-4 | .667 | - | FS1 | Prudential Center · Newark, NJ |
| 14 | Wed Jan 6 | at7Creighton | L53-89 | +6 | 8-5 | .615 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 15 | Sat Jan 9 | atDePaul | W76-68 | -4 | 9-5 | .643 | - | FS1 | Wintrust Arena · Chicago, IL |
| 17 | Tue Jan 19 | at3Villanova | L74-76 | +9 | 9-6 | .600 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 18 | Fri Jan 22 | atButler | PPD | -2½ | 14-13 | .519 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Wed Jan 27 | vs17Creighton | L81-85 | +1½ | 9-7 | .563 | - | FS1 | Prudential Center · Newark, NJ |
| 20 | Sat Jan 30 | vs3Villanova | L72-80 | +5½ | 9-8 | .529 | - | FOX | Prudential Center · Newark, NJ |
| 21 | Wed Feb 3 | atProvidence | W60-43 | -2½ | 10-8 | .556 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 22 | Sat Feb 6 | atUConn | W80-73 | -1½ | 11-8 | .579 | - | FOX | Gampel Pavilion · Storrs, CT |
| 23 | Sun Feb 14 | vsMarquette | W57-51 | -7 | 12-8 | .600 | - | FS1 | Prudential Center · Newark, NJ |
| 24 | Wed Feb 17 | vsDePaul | W60-52 | -13½ | 13-8 | .619 | - | FS1 | Prudential Center · Newark, NJ |
| 25 | Sat Feb 20 | atGeorgetown | L75-81 | -4½ | 13-9 | .591 | - | CBS Sports Network | Capital One Arena · Washington, D.C. |
| 26 | Wed Feb 24 | atButler | L52-61 | -7½ | 13-10 | .565 | - | CBS Sports Network | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Wed Mar 3 | vsUConn | L58-69 | +1½ | 13-11 | .542 | - | FS1 | Prudential Center · Newark, NJ |
| 28 | Sat Mar 6 | atSt John's | L71-81 | -2½ | 13-12 | .520 | - | FS1 | Carnesecca Arena · Queens, NY |
| 29 | Thu Mar 11 | atSt John's | W77-69 (OT) | -3 | 14-12 | .538 | - | FS1 | Carnesecca Arena · Queens, NY |
| 30 | Fri Mar 12 | vsGeorgetown | L58-66 | -3½ | 14-13 | .519 | - | FS1 | Prudential Center · Newark, NJ |
