| 1 | Mon Nov 7 | at Missouri | L91-97 | 0-1 | .000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Sun Nov 13 | vsS Illinois | W71-53 | 1-1 | .500 | - | | Screaming Eagles Arena · Evansville, IN |
| 3 | Wed Nov 16 | atNotre Dame | L70-82 | 1-2 | .333 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 4 | Fri Nov 18 | vsTBD | W87-55 | 2-2 | .500 | - | | Screaming Eagles Arena · Evansville, IN |
| 5 | Tue Nov 22 | atSt Bonaventure | L66-80 | 2-3 | .400 | - | | Reilly Center · Saint Bonaventure, NY |
| 6 | Sat Nov 26 | atBowling Green | W69-57 | 3-3 | .500 | - | | Stroh Center · Bowling Green, OH |
| 7 | Wed Nov 30 | atW Illinois | L78-86 | 3-4 | .429 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 8 | Sun Dec 4 | atChicago St | L61-78 | 3-5 | .375 | - | | Jones Convocation Center · Chicago, IL |
| 9 | Wed Dec 7 | vsTBD | W78-47 | 4-5 | .444 | - | | Screaming Eagles Arena · Evansville, IN |
| 10 | Sun Dec 11 | vsIndiana St | W88-85 (OT) | 5-5 | .500 | - | | Screaming Eagles Arena · Evansville, IN |
| 11 | Thu Dec 15 | vsTBD | W84-42 | 6-5 | .545 | - | | Screaming Eagles Arena · Evansville, IN |
| 12 | Mon Dec 19 | atIU Indy | W87-74 | 7-5 | .583 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Tue Dec 20 | atPurdue FW | L59-83 | 7-6 | .538 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 14 | Thu Dec 29 | vsSE Missouri St | W86-81 | 8-6 | .571 | - | | Screaming Eagles Arena · Evansville, IN |
| 15 | Sat Dec 31 | atE Illinois | L80-91 | 8-7 | .533 | - | | Lantz Arena · Charleston, IL |
| 16 | Thu Jan 5 | atMorehead St | L80-84 | 8-8 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 7 | vsSIUE | L62-69 | 8-9 | .471 | - | | Screaming Eagles Arena · Evansville, IN |
| 18 | Thu Jan 12 | vsLittle Rock | W74-67 | 9-9 | .500 | - | ESPNU | Screaming Eagles Arena · Evansville, IN |
| 19 | Sat Jan 14 | vsUT Martin | W80-66 | 10-9 | .526 | - | | Screaming Eagles Arena · Evansville, IN |
| 20 | Thu Jan 19 | atLindenwood | W81-65 | 11-9 | .550 | - | | placeholder · sf, ca |
| 21 | Sat Jan 21 | atSIUE | W82-72 | 12-9 | .571 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Jan 26 | vsE Illinois | W78-74 | 13-9 | .591 | - | | Screaming Eagles Arena · Evansville, IN |
| 23 | Sat Jan 28 | atUT Martin | L83-86 (OT) | 13-10 | .565 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Thu Feb 2 | vsTennessee St | L76-80 | 13-11 | .542 | - | | Screaming Eagles Arena · Evansville, IN |
| 25 | Sat Feb 4 | vsMorehead St | L66-71 (OT) | 13-12 | .520 | - | | Screaming Eagles Arena · Evansville, IN |
| 26 | Thu Feb 9 | atTennessee Tech | L69-84 | 13-13 | .500 | - | ESPNU | Hooper Eblen Center · Cookeville, TN |
| 27 | Sat Feb 11 | vsLindenwood | W74-64 | 14-13 | .519 | - | | Screaming Eagles Arena · Evansville, IN |
| 28 | Thu Feb 16 | atLittle Rock | W82-81 | 15-13 | .536 | - | | Jack Stephens Center · Little Rock, AR |
| 29 | Sat Feb 18 | atSE Missouri St | L80-85 | 15-14 | .517 | - | | Show Me Center · Cape Girardeau, MO |
| 30 | Thu Feb 23 | vsTennessee Tech | L79-82 | 15-15 | .500 | - | | Screaming Eagles Arena · Evansville, IN |
| 31 | Sat Feb 25 | atTennessee St | W93-81 | 16-15 | .516 | - | | Gentry Center · Nashville, TN |
| 32 | Wed Mar 1 | atSIUE | L54-68 | 16-16 | .500 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 33 | Sat Mar 18 | vsSan Jose St | L52-77 | 16-17 | .485 | - | | Screaming Eagles Arena · Evansville, IN |
