| 1 | Wed Oct 13 | vs Canucks | W3-2 (SO) | 1-0-0 | 2 PTS | Rogers Place · Edmonton, AB |
| 2 | Sat Oct 16 | vsFlames | W5-2 | 2-0-0 | 4 PTS | Rogers Place · Edmonton, AB |
| 3 | Tue Oct 19 | vsDucks | W6-5 | 3-0-0 | 6 PTS | Rogers Place · Edmonton, AB |
| 4 | Thu Oct 21 | atCoyotes | W5-1 | 4-0-0 | 8 PTS | Mullett Arena · Tempe, AZ |
| 5 | Fri Oct 22 | atKnights | W5-3 | 5-0-0 | 10 PTS | T-Mobile Arena · Las Vegas, NV |
| 6 | Wed Oct 27 | vsFlyers | L3-5 | 5-1-0 | 10 PTS | Rogers Place · Edmonton, AB |
| 7 | Sat Oct 30 | atCanucks | W2-1 | 6-1-0 | 12 PTS | Rogers Arena · Vancouver, British Columbia |
| 8 | Mon Nov 1 | vsKraken | W5-2 | 7-1-0 | 14 PTS | Rogers Place · Edmonton, AB |
| 9 | Wed Nov 3 | vsPredators | W5-2 | 8-1-0 | 16 PTS | Rogers Place · Edmonton, AB |
| 10 | Fri Nov 5 | vsRangers | W6-5 (OT) | 9-1-0 | 18 PTS | Rogers Place · Edmonton, AB |
| 11 | Tue Nov 9 | atRed Wings | L2-4 | 9-2-0 | 18 PTS | Little Caesars Arena · Detroit, MI |
| 12 | Thu Nov 11 | atBruins | W5-3 | 10-2-0 | 20 PTS | TD Garden · Boston, MA |
| 13 | Fri Nov 12 | atSabres | L2-3 | 10-3-0 | 20 PTS | KeyBank Center · Buffalo, NY |
| 14 | Sun Nov 14 | atBlues | W5-4 | 11-3-0 | 22 PTS | Enterprise Center · St. Louis, MO |
| 15 | Tue Nov 16 | atJets | L2-5 | 11-4-0 | 22 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 16 | Thu Nov 18 | vsJets | W2-1 (SO) | 12-4-0 | 24 PTS | Rogers Place · Edmonton, AB |
| 17 | Sat Nov 20 | vsBlackhawks | W5-2 | 13-4-0 | 26 PTS | Rogers Place · Edmonton, AB |
| 18 | Tue Nov 23 | atStars | L1-4 | 13-5-0 | 26 PTS | American Airlines Center · Dallas, TX |
| 19 | Wed Nov 24 | atCoyotes | W5-3 | 14-5-0 | 28 PTS | Mullett Arena · Tempe, AZ |
| 20 | Sat Nov 27 | atKnights | W3-2 | 15-5-0 | 30 PTS | T-Mobile Arena · Las Vegas, NV |
| 21 | Wed Dec 1 | vsPenguins | W5-2 | 16-5-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 22 | Fri Dec 3 | atKraken | L3-4 | 16-6-0 | 32 PTS | Climate Pledge Arena · Seattle, WA |
| 23 | Sun Dec 5 | vsKings | L1-5 | 16-7-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 24 | Tue Dec 7 | vsWild | L1-4 | 16-8-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 25 | Thu Dec 9 | vsBruins | L2-3 | 16-9-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 26 | Sat Dec 11 | vsHurricanes | L1-3 | 16-10-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 27 | Tue Dec 14 | vsMaple Leafs | L1-5 | 16-11-0 | 32 PTS | Rogers Place · Edmonton, AB |
| 28 | Thu Dec 16 | vsJackets | W5-2 | 17-11-0 | 34 PTS | Rogers Place · Edmonton, AB |
| 29 | Sat Dec 18 | atKraken | W5-3 | 18-11-0 | 36 PTS | Climate Pledge Arena · Seattle, WA |
| 30 | Wed Dec 29 | atBlues | L2-4 | 18-12-0 | 36 PTS | Enterprise Center · St. Louis, MO |
| 31 | Fri Dec 31 | atDevils | L5-6 (OT) | 18-12-1 | 37 PTS | Prudential Center · Newark, NJ |
| 32 | Sat Jan 1 | atIslanders | L2-3 (OT) | 18-12-2 | 38 PTS | UBS Arena · Elmont, NY |
| 33 | Mon Jan 3 | atRangers | L1-4 | 18-13-2 | 38 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Wed Jan 5 | atMaple Leafs | L2-4 | 18-14-2 | 38 PTS | Scotiabank Arena · Toronto, ON |
| 35 | Sat Jan 15 | vsSenators | L4-6 | 18-15-2 | 38 PTS | Rogers Place · Edmonton, AB |
| 36 | Thu Jan 20 | vsPanthers | L0-6 | 18-16-2 | 38 PTS | Rogers Place · Edmonton, AB |
| 37 | Sat Jan 22 | vsFlames | W5-3 | 19-16-2 | 40 PTS | Rogers Place · Edmonton, AB |
| 38 | Tue Jan 25 | atCanucks | W3-2 (OT) | 20-16-2 | 42 PTS | Rogers Arena · Vancouver, British Columbia |
| 39 | Thu Jan 27 | vsPredators | W3-2 (SO) | 21-16-2 | 44 PTS | Rogers Place · Edmonton, AB |
| 40 | Sat Jan 29 | atCanadiens | W7-2 | 22-16-2 | 46 PTS | Bell Centre · Montreal, QC |
| 41 | Mon Jan 31 | atSenators | L2-3 (OT) | 22-16-3 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 42 | Wed Feb 2 | atCapitals | W5-3 | 23-16-3 | 49 PTS | Capital One Arena · Washington, D.C. |
| 43 | Tue Feb 8 | vsKnights | L0-4 | 23-17-3 | 49 PTS | Rogers Place · Edmonton, AB |
| 44 | Wed Feb 9 | vsBlackhawks | L1-4 | 23-18-3 | 49 PTS | Rogers Place · Edmonton, AB |
| 45 | Fri Feb 11 | vsIslanders | W3-1 | 24-18-3 | 51 PTS | Rogers Place · Edmonton, AB |
| 46 | Mon Feb 14 | atSharks | W3-0 | 25-18-3 | 53 PTS | SAP Center · San Jose, CA |
| 47 | Tue Feb 15 | atKings | W5-2 | 26-18-3 | 55 PTS | Crypto.com Arena · Los Angeles, CA |
| 48 | Thu Feb 17 | vsDucks | W7-3 | 27-18-3 | 57 PTS | Rogers Place · Edmonton, AB |
| 49 | Sat Feb 19 | atJets | W4-2 | 28-18-3 | 59 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 50 | Sun Feb 20 | vsWild | L3-7 | 28-19-3 | 59 PTS | Rogers Place · Edmonton, AB |
| 51 | Wed Feb 23 | atLightning | L3-5 | 28-20-3 | 59 PTS | AMALIE Arena · Tampa, FL |
| 52 | Sat Feb 26 | atPanthers | W4-3 | 29-20-3 | 61 PTS | Amerant Bank Arena · Sunrise, FL |
| 53 | Sun Feb 27 | atHurricanes | L1-2 | 29-21-3 | 61 PTS | PNC Arena · Raleigh, NC |
| 54 | Tue Mar 1 | atFlyers | W3-0 | 30-21-3 | 63 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Thu Mar 3 | atBlackhawks | L3-4 (OT) | 30-21-4 | 64 PTS | United Center · Chicago, IL |
| 56 | Sat Mar 5 | vsCanadiens | L2-5 | 30-22-4 | 64 PTS | Rogers Place · Edmonton, AB |
| 57 | Mon Mar 7 | atFlames | L1-3 | 30-23-4 | 64 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 58 | Wed Mar 9 | vsCapitals | W4-3 (OT) | 31-23-4 | 66 PTS | Rogers Place · Edmonton, AB |
| 59 | Sat Mar 12 | vsLightning | W4-1 | 32-23-4 | 68 PTS | Rogers Place · Edmonton, AB |
| 60 | Tue Mar 15 | vsRed Wings | W7-5 | 33-23-4 | 70 PTS | Rogers Place · Edmonton, AB |
| 61 | Thu Mar 17 | vsSabres | W6-1 | 34-23-4 | 72 PTS | Rogers Place · Edmonton, AB |
| 62 | Sat Mar 19 | vsDevils | W6-3 | 35-23-4 | 74 PTS | Rogers Place · Edmonton, AB |
| 63 | Mon Mar 21 | atAvalanche | L2-3 (OT) | 35-23-5 | 75 PTS | Ball Arena · Denver, CO |
| 64 | Tue Mar 22 | atStars | L3-5 | 35-24-5 | 75 PTS | American Airlines Center · Dallas, TX |
| 65 | Thu Mar 24 | vsSharks | W5-2 | 36-24-5 | 77 PTS | Rogers Place · Edmonton, AB |
| 66 | Sat Mar 26 | atFlames | L5-9 | 36-25-5 | 77 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 67 | Mon Mar 28 | vsCoyotes | W6-1 | 37-25-5 | 79 PTS | Rogers Place · Edmonton, AB |
| 68 | Wed Mar 30 | vsKings | W4-3 (SO) | 38-25-5 | 81 PTS | Rogers Place · Edmonton, AB |
| 69 | Fri Apr 1 | vsBlues | W6-5 (OT) | 39-25-5 | 83 PTS | Rogers Place · Edmonton, AB |
| 70 | Sun Apr 3 | atDucks | W6-1 | 40-25-5 | 85 PTS | Honda Center · Anaheim, CA |
| 71 | Tue Apr 5 | atSharks | W2-1 (OT) | 41-25-5 | 87 PTS | SAP Center · San Jose, CA |
| 72 | Thu Apr 7 | atKings | W3-2 | 42-25-5 | 89 PTS | Crypto.com Arena · Los Angeles, CA |
| 73 | Sat Apr 9 | vsAvalanche | L1-2 (SO) | 42-25-6 | 90 PTS | Rogers Place · Edmonton, AB |
| 74 | Tue Apr 12 | atWild | L1-5 | 42-26-6 | 90 PTS | Xcel Energy Center · St. Paul, MN |
| 75 | Thu Apr 14 | atPredators | W4-0 | 43-26-6 | 92 PTS | Bridgestone Arena · Nashville, TN |
| 76 | Sat Apr 16 | vsKnights | W4-0 | 44-26-6 | 94 PTS | Rogers Place · Edmonton, AB |
| 77 | Wed Apr 20 | vsStars | W5-2 | 45-26-6 | 96 PTS | Rogers Place · Edmonton, AB |
| 78 | Fri Apr 22 | vsAvalanche | W6-3 | 46-26-6 | 98 PTS | Rogers Place · Edmonton, AB |
| 79 | Sun Apr 24 | atJackets | L2-5 | 46-27-6 | 98 PTS | Nationwide Arena · Columbus, OH |
| 80 | Tue Apr 26 | atPenguins | W5-1 | 47-27-6 | 100 PTS | PPG Paints Arena · Pittsburgh, PA |
| 81 | Thu Apr 28 | vsSharks | W5-4 (OT) | 48-27-6 | 102 PTS | Rogers Place · Edmonton, AB |
| 82 | Fri Apr 29 | vsCanucks | W3-2 (SO) | 49-27-6 | 104 PTS | Rogers Place · Edmonton, AB |
| 1 | Mon May 2 | vsKings | L3-4 | 0-1 | .000 | Rogers Place · Edmonton, AB |
| 2 | Wed May 4 | vsKings | W6-0 | 1-1 | .500 | Rogers Place · Edmonton, AB |
| 3 | Fri May 6 | atKings | W8-2 | 2-1 | .667 | Crypto.com Arena · Los Angeles, CA |
| 4 | Sun May 8 | atKings | L0-4 | 2-2 | .500 | Crypto.com Arena · Los Angeles, CA |
| 5 | Tue May 10 | vsKings | L4-5 (OT) | 2-3 | .400 | Rogers Place · Edmonton, AB |
| 6 | Thu May 12 | atKings | W4-2 | 3-3 | .500 | Crypto.com Arena · Los Angeles, CA |
| 7 | Sat May 14 | vsKings | W2-0 | 4-3 | .571 | Rogers Place · Edmonton, AB |
| 1 | Wed May 18 | atFlames | L6-9 | 0-1 | .000 | Scotiabank Saddledome · Calgary, Alberta |
| 2 | Fri May 20 | atFlames | W5-3 | 1-1 | .500 | Scotiabank Saddledome · Calgary, Alberta |
| 3 | Sun May 22 | vsFlames | W4-1 | 2-1 | .667 | Rogers Place · Edmonton, AB |
| 4 | Tue May 24 | vsFlames | W5-3 | 3-1 | .750 | Rogers Place · Edmonton, AB |
| 5 | Thu May 26 | atFlames | W5-4 (OT) | 4-1 | .800 | Scotiabank Saddledome · Calgary, Alberta |
| 1 | Tue May 31 | atAvalanche | L6-8 | 0-1 | .000 | Ball Arena · Denver, CO |
| 2 | Thu Jun 2 | atAvalanche | L0-4 | 0-2 | .000 | Ball Arena · Denver, CO |
| 3 | Sat Jun 4 | vsAvalanche | L2-4 | 0-3 | .000 | Rogers Place · Edmonton, AB |
| 4 | Mon Jun 6 | vsAvalanche | L5-6 (OT) | 0-4 | .000 | Rogers Place · Edmonton, AB |
