| 1 | Wed Oct 11 | at Canucks | L1-8 | 0-1-0 | 0 PTS | Rogers Arena · Vancouver, British Columbia |
| 2 | Sat Oct 14 | vsCanucks | L3-4 | 0-2-0 | 0 PTS | Rogers Place · Edmonton, AB |
| 3 | Tue Oct 17 | atPredators | W6-1 | 1-2-0 | 2 PTS | Bridgestone Arena · Nashville, TN |
| 4 | Thu Oct 19 | atFlyers | L1-4 | 1-3-0 | 2 PTS | Wells Fargo Center · Philadelphia, PA |
| 5 | Sat Oct 21 | vsJets | L2-3 (OT) | 1-3-1 | 3 PTS | Rogers Place · Edmonton, AB |
| 6 | Tue Oct 24 | atWild | L4-7 | 1-4-1 | 3 PTS | Xcel Energy Center · St. Paul, MN |
| 7 | Thu Oct 26 | vsRangers | L0-3 | 1-5-1 | 3 PTS | Rogers Place · Edmonton, AB |
| 8 | Sun Oct 29 | vsFlames | W5-2 | 2-5-1 | 5 PTS | Rogers Place · Edmonton, AB |
| 9 | Thu Nov 2 | vsStars | L3-4 | 2-6-1 | 5 PTS | Rogers Place · Edmonton, AB |
| 10 | Sat Nov 4 | vsPredators | L2-5 | 2-7-1 | 5 PTS | Rogers Place · Edmonton, AB |
| 11 | Mon Nov 6 | atCanucks | L2-6 | 2-8-1 | 5 PTS | Rogers Arena · Vancouver, British Columbia |
| 12 | Thu Nov 9 | atSharks | L2-3 | 2-9-1 | 5 PTS | SAP Center · San Jose, CA |
| 13 | Sat Nov 11 | atKraken | W4-1 | 3-9-1 | 7 PTS | Climate Pledge Arena · Seattle, WA |
| 14 | Mon Nov 13 | vsIslanders | W4-1 | 4-9-1 | 9 PTS | Rogers Place · Edmonton, AB |
| 15 | Wed Nov 15 | vsKraken | W4-3 (OT) | 5-9-1 | 11 PTS | Rogers Place · Edmonton, AB |
| 16 | Sat Nov 18 | atLightning | L4-6 | 5-10-1 | 11 PTS | AMALIE Arena · Tampa, FL |
| 17 | Mon Nov 20 | atPanthers | L3-5 | 5-11-1 | 11 PTS | Amerant Bank Arena · Sunrise, FL |
| 18 | Wed Nov 22 | atHurricanes | L3-6 | 5-12-1 | 11 PTS | PNC Arena · Raleigh, NC |
| 19 | Fri Nov 24 | atCapitals | W5-0 | 6-12-1 | 13 PTS | Capital One Arena · Washington, D.C. |
| 20 | Sun Nov 26 | vsDucks | W8-2 | 7-12-1 | 15 PTS | Rogers Place · Edmonton, AB |
| 21 | Tue Nov 28 | vsKnights | W5-4 (SO) | 8-12-1 | 17 PTS | Rogers Place · Edmonton, AB |
| 22 | Thu Nov 30 | atJets | W3-1 | 9-12-1 | 19 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 23 | Wed Dec 6 | vsHurricanes | W6-1 | 10-12-1 | 21 PTS | Rogers Place · Edmonton, AB |
| 24 | Fri Dec 8 | vsWild | W4-3 | 11-12-1 | 23 PTS | Rogers Place · Edmonton, AB |
| 25 | Sun Dec 10 | vsDevils | W4-1 | 12-12-1 | 25 PTS | Rogers Place · Edmonton, AB |
| 26 | Tue Dec 12 | vsBlackhawks | W4-1 | 13-12-1 | 27 PTS | Rogers Place · Edmonton, AB |
| 27 | Thu Dec 14 | vsLightning | L4-7 | 13-13-1 | 27 PTS | Rogers Place · Edmonton, AB |
| 28 | Sat Dec 16 | vsPanthers | L1-5 | 13-14-1 | 27 PTS | Rogers Place · Edmonton, AB |
| 29 | Tue Dec 19 | atIslanders | L1-3 | 13-15-1 | 27 PTS | UBS Arena · Elmont, NY |
| 30 | Thu Dec 21 | atDevils | W6-3 | 14-15-1 | 29 PTS | Prudential Center · Newark, NJ |
| 31 | Fri Dec 22 | atRangers | W4-3 | 15-15-1 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 32 | Thu Dec 28 | atSharks | W5-0 | 16-15-1 | 33 PTS | SAP Center · San Jose, CA |
| 33 | Sat Dec 30 | atKings | W3-2 (SO) | 17-15-1 | 35 PTS | Crypto.com Arena · Los Angeles, CA |
| 34 | Sun Dec 31 | atDucks | W7-2 | 18-15-1 | 37 PTS | Honda Center · Anaheim, CA |
| 35 | Tue Jan 2 | vsFlyers | W5-2 | 19-15-1 | 39 PTS | Rogers Place · Edmonton, AB |
| 36 | Sat Jan 6 | vsSenators | W3-1 | 20-15-1 | 41 PTS | Rogers Place · Edmonton, AB |
| 37 | Tue Jan 9 | atBlackhawks | W2-1 | 21-15-1 | 43 PTS | United Center · Chicago, IL |
| 38 | Thu Jan 11 | atRed Wings | W3-2 (OT) | 22-15-1 | 45 PTS | Little Caesars Arena · Detroit, MI |
| 39 | Sat Jan 13 | atCanadiens | W2-1 (OT) | 23-15-1 | 47 PTS | Bell Centre · Montreal, QC |
| 40 | Tue Jan 16 | vsMaple Leafs | W4-2 | 24-15-1 | 49 PTS | Rogers Place · Edmonton, AB |
| 41 | Thu Jan 18 | vsKraken | W4-2 | 25-15-1 | 51 PTS | Rogers Place · Edmonton, AB |
| 42 | Sat Jan 20 | atFlames | W3-1 | 26-15-1 | 53 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 43 | Tue Jan 23 | vsJackets | W4-1 | 27-15-1 | 55 PTS | Rogers Place · Edmonton, AB |
| 44 | Thu Jan 25 | vsBlackhawks | W3-0 | 28-15-1 | 57 PTS | Rogers Place · Edmonton, AB |
| 45 | Sat Jan 27 | vsPredators | W4-1 | 29-15-1 | 59 PTS | Rogers Place · Edmonton, AB |
| 46 | Tue Feb 6 | atKnights | L1-3 | 29-16-1 | 59 PTS | T-Mobile Arena · Las Vegas, NV |
| 47 | Fri Feb 9 | atDucks | W5-3 | 30-16-1 | 61 PTS | Honda Center · Anaheim, CA |
| 48 | Sat Feb 10 | atKings | L0-4 | 30-17-1 | 61 PTS | Crypto.com Arena · Los Angeles, CA |
| 49 | Tue Feb 13 | vsRed Wings | W8-4 | 31-17-1 | 63 PTS | Rogers Place · Edmonton, AB |
| 50 | Thu Feb 15 | atBlues | L3-6 | 31-18-1 | 63 PTS | Enterprise Center · St. Louis, MO |
| 51 | Sat Feb 17 | atStars | W4-3 (OT) | 32-18-1 | 65 PTS | American Airlines Center · Dallas, TX |
| 52 | Mon Feb 19 | atCoyotes | W6-3 | 33-18-1 | 67 PTS | Mullett Arena · Tempe, AZ |
| 53 | Wed Feb 21 | vsBruins | L5-6 (OT) | 33-18-2 | 68 PTS | Rogers Place · Edmonton, AB |
| 54 | Fri Feb 23 | vsWild | L2-4 | 33-19-2 | 68 PTS | Rogers Place · Edmonton, AB |
| 55 | Sat Feb 24 | vsFlames | L3-6 | 33-20-2 | 68 PTS | Rogers Place · Edmonton, AB |
| 56 | Mon Feb 26 | vsKings | W4-2 | 34-20-2 | 70 PTS | Rogers Place · Edmonton, AB |
| 57 | Wed Feb 28 | vsBlues | W3-2 (OT) | 35-20-2 | 72 PTS | Rogers Place · Edmonton, AB |
| 58 | Sat Mar 2 | atKraken | W2-1 | 36-20-2 | 74 PTS | Climate Pledge Arena · Seattle, WA |
| 59 | Sun Mar 3 | vsPenguins | W6-1 | 37-20-2 | 76 PTS | Rogers Place · Edmonton, AB |
| 60 | Tue Mar 5 | atBruins | W2-1 (OT) | 38-20-2 | 78 PTS | TD Garden · Boston, MA |
| 61 | Thu Mar 7 | atJackets | L2-4 | 38-21-2 | 78 PTS | Nationwide Arena · Columbus, OH |
| 62 | Sat Mar 9 | atSabres | L2-3 (SO) | 38-21-3 | 79 PTS | KeyBank Center · Buffalo, NY |
| 63 | Sun Mar 10 | atPenguins | W4-0 | 39-21-3 | 81 PTS | PPG Paints Arena · Pittsburgh, PA |
| 64 | Wed Mar 13 | vsCapitals | W7-2 | 40-21-3 | 83 PTS | Rogers Place · Edmonton, AB |
| 65 | Sat Mar 16 | vsAvalanche | L2-3 (OT) | 40-21-4 | 84 PTS | Rogers Place · Edmonton, AB |
| 66 | Tue Mar 19 | vsCanadiens | W3-2 (OT) | 41-21-4 | 86 PTS | Rogers Place · Edmonton, AB |
| 67 | Thu Mar 21 | vsSabres | W8-3 | 42-21-4 | 88 PTS | Rogers Place · Edmonton, AB |
| 68 | Sat Mar 23 | atMaple Leafs | L3-6 | 42-22-4 | 88 PTS | Scotiabank Arena · Toronto, ON |
| 69 | Sun Mar 24 | atSenators | L3-5 | 42-23-4 | 88 PTS | Canadian Tire Centre · Ottawa, ON |
| 70 | Tue Mar 26 | atJets | W4-3 (OT) | 43-23-4 | 90 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 71 | Thu Mar 28 | vsKings | W4-1 | 44-23-4 | 92 PTS | Rogers Place · Edmonton, AB |
| 72 | Sat Mar 30 | vsDucks | W6-1 | 45-23-4 | 94 PTS | Rogers Place · Edmonton, AB |
| 73 | Mon Apr 1 | atBlues | L2-3 (OT) | 45-23-5 | 95 PTS | Enterprise Center · St. Louis, MO |
| 74 | Wed Apr 3 | atStars | L0-5 | 45-24-5 | 95 PTS | American Airlines Center · Dallas, TX |
| 75 | Fri Apr 5 | vsAvalanche | W6-2 | 46-24-5 | 97 PTS | Rogers Place · Edmonton, AB |
| 76 | Sat Apr 6 | atFlames | W4-2 | 47-24-5 | 99 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 77 | Wed Apr 10 | vsKnights | W5-1 | 48-24-5 | 101 PTS | Rogers Place · Edmonton, AB |
| 78 | Fri Apr 12 | vsCoyotes | L2-3 (OT) | 48-24-6 | 102 PTS | Rogers Place · Edmonton, AB |
| 79 | Sat Apr 13 | vsCanucks | L1-3 | 48-25-6 | 102 PTS | Rogers Place · Edmonton, AB |
| 80 | Mon Apr 15 | vsSharks | W9-2 | 49-25-6 | 104 PTS | Rogers Place · Edmonton, AB |
| 81 | Wed Apr 17 | atCoyotes | L2-5 | 49-26-6 | 104 PTS | Mullett Arena · Tempe, AZ |
| 82 | Thu Apr 18 | atAvalanche | L1-5 | 49-27-6 | 104 PTS | Ball Arena · Denver, CO |
| 1 | Mon Apr 22 | vsKings | W7-4 | 1-0 | 1.000 | Rogers Place · Edmonton, AB |
| 2 | Wed Apr 24 | vsKings | L4-5 (OT) | 1-1 | .500 | Rogers Place · Edmonton, AB |
| 3 | Fri Apr 26 | atKings | W6-1 | 2-1 | .667 | Crypto.com Arena · Los Angeles, CA |
| 4 | Sun Apr 28 | atKings | W1-0 | 3-1 | .750 | Crypto.com Arena · Los Angeles, CA |
| 5 | Wed May 1 | vsKings | W4-3 | 4-1 | .800 | Rogers Place · Edmonton, AB |
| 1 | Wed May 8 | atCanucks | L4-5 | 0-1 | .000 | Rogers Arena · Vancouver, British Columbia |
| 2 | Fri May 10 | atCanucks | W4-3 (OT) | 1-1 | .500 | Rogers Arena · Vancouver, British Columbia |
| 3 | Sun May 12 | vsCanucks | L3-4 | 1-2 | .333 | Rogers Place · Edmonton, AB |
| 4 | Tue May 14 | vsCanucks | W3-2 | 2-2 | .500 | Rogers Place · Edmonton, AB |
| 5 | Thu May 16 | atCanucks | L2-3 | 2-3 | .400 | Rogers Arena · Vancouver, British Columbia |
| 6 | Sat May 18 | vsCanucks | W5-1 | 3-3 | .500 | Rogers Place · Edmonton, AB |
| 7 | Mon May 20 | atCanucks | W3-2 | 4-3 | .571 | Rogers Arena · Vancouver, British Columbia |
| 1 | Thu May 23 | atStars | W3-2 (OT) | 1-0 | 1.000 | American Airlines Center · Dallas, TX |
| 2 | Sat May 25 | atStars | L1-3 | 1-1 | .500 | American Airlines Center · Dallas, TX |
| 3 | Mon May 27 | vsStars | L3-5 | 1-2 | .333 | Rogers Place · Edmonton, AB |
| 4 | Wed May 29 | vsStars | W5-2 | 2-2 | .500 | Rogers Place · Edmonton, AB |
| 5 | Fri May 31 | atStars | W3-1 | 3-2 | .600 | American Airlines Center · Dallas, TX |
| 6 | Sun Jun 2 | vsStars | W2-1 | 4-2 | .667 | Rogers Place · Edmonton, AB |
| 1 | Sat Jun 8 | atPanthers | L0-3 | 0-1 | .000 | Amerant Bank Arena · Sunrise, FL |
| 2 | Mon Jun 10 | atPanthers | L1-4 | 0-2 | .000 | Amerant Bank Arena · Sunrise, FL |
| 3 | Thu Jun 13 | vsPanthers | L3-4 | 0-3 | .000 | Rogers Place · Edmonton, AB |
| 4 | Sat Jun 15 | vsPanthers | W8-1 | 1-3 | .250 | Rogers Place · Edmonton, AB |
| 5 | Tue Jun 18 | atPanthers | W5-3 | 2-3 | .400 | Amerant Bank Arena · Sunrise, FL |
| 6 | Fri Jun 21 | vsPanthers | W5-1 | 3-3 | .500 | Rogers Place · Edmonton, AB |
| 7 | Mon Jun 24 | atPanthers | L1-2 | 3-4 | .429 | Amerant Bank Arena · Sunrise, FL |
