| 1 | Thu Mar 26 | at Dodgers | L2-8 | 0-1 | .000 | Dodger Stadium · Los Angeles, CA |
| 2 | Fri Mar 27 | at Dodgers | L4-5 | 0-2 | .000 | Dodger Stadium · Los Angeles, CA |
| 3 | Sat Mar 28 | at Dodgers | L2-3 | 0-3 | .000 | Dodger Stadium · Los Angeles, CA |
| 4 | Mon Mar 30 | vs Tigers | W9-6 | 1-3 | .250 | Chase Field · Phoenix, AZ |
| 5 | Tue Mar 31 | vs Tigers | W7-5 | 2-3 | .400 | Chase Field · Phoenix, AZ |
| 6 | Wed Apr 1 | vs Tigers | W1-0 | 3-3 | .500 | Chase Field · Phoenix, AZ |
| 7 | Thu Apr 2 | vs Braves | L2-17 | 3-4 | .429 | Chase Field · Phoenix, AZ |
| 8 | Fri Apr 3 | vs Braves | L0-2 | 3-5 | .375 | Chase Field · Phoenix, AZ |
| 9 | Sat Apr 4 | vs Braves | W2-1 | 4-5 | .444 | Chase Field · Phoenix, AZ |
| 10 | Sun Apr 5 | vs Braves | W6-5 (10) | 5-5 | .500 | Chase Field · Phoenix, AZ |
| 11 | Tue Apr 7 | at Mets | L3-4 (10) | 5-6 | .455 | Citi Field · Queens, NY |
| 12 | Wed Apr 8 | at Mets | W7-2 | 6-6 | .500 | Citi Field · Queens, NY |
| 13 | Thu Apr 9 | at Mets | W7-1 | 7-6 | .538 | Citi Field · Queens, NY |
| 14 | Fri Apr 10 | at Phillies | W5-4 | 8-6 | .571 | Citizens Bank Park · Philadelphi, PA |
| 15 | Sat Apr 11 | at Phillies | L3-4 | 8-7 | .533 | Citizens Bank Park · Philadelphi, PA |
| 16 | Sun Apr 12 | at Phillies | W4-3 | 9-7 | .563 | Citizens Bank Park · Philadelphi, PA |
| 17 | Mon Apr 13 | at Orioles | L7-9 | 9-8 | .529 | Camden Yards · Baltimore, MD |
| 18 | Tue Apr 14 | at Orioles | W4-3 | 10-8 | .556 | Camden Yards · Baltimore, MD |
| 19 | Wed Apr 15 | at Orioles | W8-5 (10) | 11-8 | .579 | Camden Yards · Baltimore, MD |
| 20 | Fri Apr 17 | vs Blue Jays | W6-3 | 12-8 | .600 | Chase Field · Phoenix, AZ |
| 21 | Sat Apr 18 | vs Blue Jays | W6-2 | 13-8 | .619 | Chase Field · Phoenix, AZ |
| 22 | Sun Apr 19 | vs Blue Jays | L4-10 | 13-9 | .591 | Chase Field · Phoenix, AZ |
| 23 | Tue Apr 21 | vs White Sox | L5-11 | 13-10 | .565 | Chase Field · Phoenix, AZ |
| 24 | Wed Apr 22 | vs White Sox | W11-7 | 14-10 | .583 | Chase Field · Phoenix, AZ |
| 25 | Thu Apr 23 | vs White Sox | L1-4 | 14-11 | .560 | Chase Field · Phoenix, AZ |
| 26 | Sat Apr 25 | vs Padres | L4-6 | 14-12 | .538 | Estadio Alfredo Harp Helu · Mexico City, CDMX |
| 27 | Sun Apr 26 | vs Padres | W12-7 | 15-12 | .556 | Estadio Alfredo Harp Helu · Mexico City, CDMX |
| 28 | Tue Apr 28 | at Brewers | L2-13 | 15-13 | .536 | American Family Field · Milwaukee, WI |
| 29 | Wed Apr 29 | at Brewers | W6-2 | 16-13 | .552 | American Family Field · Milwaukee, WI |
| 30 | Thu Apr 30 | at Brewers | L1-13 | 16-14 | .533 | American Family Field · Milwaukee, WI |
| 31 | Fri May 1 | at Cubs | L5-6 | 16-15 | .516 | Wrigley Field · Chicago, IL |
| 32 | Sat May 2 | at Cubs | L0-2 | 16-16 | .500 | Wrigley Field · Chicago, IL |
| 33 | Sun May 3 | at Cubs | L4-8 | 16-17 | .485 | Wrigley Field · Chicago, IL |
| 34 | Tue May 5 | vs Pirates | W9-0 | 17-17 | .500 | Chase Field · Phoenix, AZ |
| 35 | Wed May 6 | vs Pirates | L0-1 | 17-18 | .486 | Chase Field · Phoenix, AZ |
| 36 | Thu May 7 | vs Pirates | L2-4 | 17-19 | .472 | Chase Field · Phoenix, AZ |
| 37 | Fri May 8 | vs Mets | L1-3 (10) | 17-20 | .459 | Chase Field · Phoenix, AZ |
| 38 | Sat May 9 | vs Mets | W2-1 | 18-20 | .474 | Chase Field · Phoenix, AZ |
| 39 | Sun May 10 | vs Mets | W5-1 | 19-20 | .487 | Chase Field · Phoenix, AZ |
| 40 | Mon May 11 | at Rangers | W1-0 | 20-20 | .500 | Globe Life Field · Arlington, TX |
| 41 | Tue May 12 | at Rangers | L4-7 | 20-21 | .488 | Globe Life Field · Arlington, TX |
| 42 | Wed May 13 | at Rangers | L5-6 | 20-22 | .476 | Globe Life Field · Arlington, TX |
| 43 | Fri May 15 | at Rockies | W9-1 | 21-22 | .488 | Coors Field · Denver, CO |
| 44 | Sat May 16 | at Rockies | L2-4 | 21-23 | .477 | Coors Field · Denver, CO |
| 45 | Sun May 17 | at Rockies | W8-6 | 22-23 | .489 | Coors Field · Denver, CO |
| 46 | Mon May 18 | vs Giants | W12-2 | 23-23 | .500 | Chase Field · Phoenix, AZ |
| 47 | Tue May 19 | vs Giants | W5-3 | 24-23 | .511 | Chase Field · Phoenix, AZ |
| 48 | Wed May 20 | vs Giants | W6-3 | 25-23 | .521 | Chase Field · Phoenix, AZ |
| 49 | Thu May 21 | vs Rockies | W2-1 | 26-23 | .531 | Chase Field · Phoenix, AZ |
| 50 | Fri May 22 | vs Rockies | L2-3 | 26-24 | .520 | Chase Field · Phoenix, AZ |
| 51 | Sat May 23 | vs Rockies | W5-4 | 27-24 | .529 | Chase Field · Phoenix, AZ |
| 52 | Sun May 24 | vs Rockies | W9-1 | 28-24 | .538 | Chase Field · Phoenix, AZ |
| 53 | Mon May 25 | at Giants | W6-2 | 29-24 | .547 | Oracle Park · San Francisco, CA |
| 54 | Tue May 26 | at Giants | W7-5 | 30-24 | .556 | Oracle Park · San Francisco, CA |
| 55 | Wed May 27 | at Giants | W3-2 | 31-24 | .564 | Oracle Park · San Francisco, CA |
| 56 | Fri May 29 | at Mariners | L6-7 (10) | 31-25 | .554 | T-Mobile Park · Seattle, WA |
| 57 | Sat May 30 | at Mariners | L1-5 | 31-26 | .544 | T-Mobile Park · Seattle, WA |
| 58 | Sun May 31 | at Mariners | L2-3 (10) | 31-27 | .534 | T-Mobile Park · Seattle, WA |
| 59 | Mon Jun 1 | vs Dodgers | W4-1 | 32-27 | .542 | Chase Field · Phoenix, AZ |
| 60 | Tue Jun 2 | vs Dodgers | L5-6 | 32-28 | .533 | Chase Field · Phoenix, AZ |
| 61 | Wed Jun 3 | vs Dodgers | L0-7 | 32-29 | .525 | Chase Field · Phoenix, AZ |
| 62 | Thu Jun 4 | vs Dodgers | W3-2 | 33-29 | .532 | Chase Field · Phoenix, AZ |
| 63 | Fri Jun 5 | vs Nationals | L1-14 | 33-30 | .524 | Chase Field · Phoenix, AZ |
| 64 | Sat Jun 6 | vs Nationals | L1-6 | 33-31 | .516 | Chase Field · Phoenix, AZ |
| 65 | Sun Jun 7 | vs Nationals | W5-1 | 34-31 | .523 | Chase Field · Phoenix, AZ |
| 66 | Tue Jun 9 | at Marlins | L6-10 | 34-32 | .515 | LoanDepot Park · Miami, FL |
| 67 | Wed Jun 10 | at Marlins | L0-8 | 34-33 | .507 | LoanDepot Park · Miami, FL |
| 68 | Thu Jun 11 | at Marlins | L0-2 | 34-34 | .500 | LoanDepot Park · Miami, FL |
| 69 | Fri Jun 12 | at Reds | W5-2 | 35-34 | .507 | Great American Ball Park · Cincinnati, OH |
| 70 | Sat Jun 13 | at Reds | L1-2 | 35-35 | .500 | Great American Ball Park · Cincinnati, OH |
| 71 | Sun Jun 14 | at Reds | W5-3 | 36-35 | .507 | Great American Ball Park · Cincinnati, OH |
| 72 | Mon Jun 15 | vs Angels | W4-3 | 37-35 | .514 | Chase Field · Phoenix, AZ |
| 73 | Tue Jun 16 | vs Angels | L0-7 | 37-36 | .507 | Chase Field · Phoenix, AZ |
| 74 | Wed Jun 17 | vs Angels | W8-1 | 38-36 | .514 | Chase Field · Phoenix, AZ |
| 75 | Fri Jun 19 | vs Twins | W9-5 | 39-36 | .520 | Chase Field · Phoenix, AZ |
| 76 | Sat Jun 20 | vs Twins | L8-16 | 39-37 | .513 | Chase Field · Phoenix, AZ |
| 77 | Sun Jun 21 | vs Twins | L2-4 | 39-38 | .506 | Chase Field · Phoenix, AZ |
| 78 | Mon Jun 22 | at Cardinals | L2-3 | 39-39 | .500 | Busch Stadium · St. Louis, MO |
| 79 | Tue Jun 23 | at Cardinals | W4-3 | 40-39 | .506 | Busch Stadium · St. Louis, MO |
| 80 | Wed Jun 24 | at Cardinals | W9-4 | 41-39 | .512 | Busch Stadium · St. Louis, MO |
| 81 | Fri Jun 26 | at Rays | L1-6 | 41-40 | .506 | Tropicana Field · St. Petersburg, FL |
| 82 | Sat Jun 27 | at Rays | L2-4 | 41-41 | .500 | Tropicana Field · St. Petersburg, FL |
| 83 | Sun Jun 28 | at Rays | L1-5 | 41-42 | .494 | Tropicana Field · St. Petersburg, FL |
| 84 | Mon Jun 29 | vs Giants | W5-4 | 42-42 | .500 | Chase Field · Phoenix, AZ |
| 85 | Tue Jun 30 | vs Giants | W8-2 | 43-42 | .506 | Chase Field · Phoenix, AZ |
| 86 | Wed Jul 1 | vs Giants | L4-6 | 43-43 | .500 | Chase Field · Phoenix, AZ |
| 87 | Fri Jul 3 | vs Brewers | L4-7 (11) | 43-44 | .494 | Chase Field · Phoenix, AZ |
| 88 | Sat Jul 4 | vs Brewers | W4-3 | 44-44 | .500 | Chase Field · Phoenix, AZ |
| 89 | Sun Jul 5 | vs Brewers | L2-3 | 44-45 | .494 | Chase Field · Phoenix, AZ |
| 90 | Mon Jul 6 | at Padres | W8-0 | 45-45 | .500 | Petco Park · San Diego, CA |
| 91 | Tue Jul 7 | at Padres | L1-4 | 45-46 | .495 | Petco Park · San Diego, CA |
| 92 | Wed Jul 8 | at Padres | L4-10 | 45-47 | .489 | Petco Park · San Diego, CA |
| 93 | Thu Jul 9 | at Padres | W3-1 | 46-47 | .495 | Petco Park · San Diego, CA |
| 94 | Fri Jul 10 | at Dodgers | W9-3 | 47-47 | .500 | Dodger Stadium · Los Angeles, CA |
| 95 | Sat Jul 11 | at Dodgers | W9-2 | 48-47 | .505 | Dodger Stadium · Los Angeles, CA |
| 96 | Sun Jul 12 | at Dodgers | W5-3 | 49-47 | .510 | Dodger Stadium · Los Angeles, CA |