| 1 | Thu Apr 5 | vs Blue Jays | L4-7 (16) | 0-1 | .000 | Progressive Field · Cleveland, OH |
| 2 | Sat Apr 7 | vs Blue Jays | L4-7 (12) | 0-2 | .000 | Progressive Field · Cleveland, OH |
| 3 | Sun Apr 8 | vs Blue Jays | W4-3 | 1-2 | .333 | Progressive Field · Cleveland, OH |
| 4 | Mon Apr 9 | vs White Sox | L2-4 | 1-3 | .250 | Progressive Field · Cleveland, OH |
| 5 | Wed Apr 11 | vs White Sox | L6-10 | 1-4 | .200 | Progressive Field · Cleveland, OH |
| 6 | Fri Apr 13 | at Royals | W8-3 | 2-4 | .333 | Kauffman Stadium · Kansas City, MO |
| 7 | Sat Apr 14 | at Royals | W11-9 (10) | 3-4 | .429 | Kauffman Stadium · Kansas City, MO |
| 8 | Sun Apr 15 | at Royals | W13-7 | 4-4 | .500 | Kauffman Stadium · Kansas City, MO |
| 9 | Tue Apr 17 | at Mariners | W9-8 | 5-4 | .556 | T-Mobile Park · Seattle, WA |
| 10 | Wed Apr 18 | at Mariners | L1-4 | 5-5 | .500 | T-Mobile Park · Seattle, WA |
| 11 | Thu Apr 19 | at Mariners | W2-1 | 6-5 | .545 | T-Mobile Park · Seattle, WA |
| 12 | Fri Apr 20 | at Athletics | W4-3 | 7-5 | .583 | RingCentral Coliseum · Oakland, CA |
| 13 | Sat Apr 21 | at Athletics | W5-1 | 8-5 | .615 | RingCentral Coliseum · Oakland, CA |
| 14 | Sun Apr 22 | at Athletics | L1-5 | 8-6 | .571 | RingCentral Coliseum · Oakland, CA |
| 15 | Tue Apr 24 | vs Royals | W4-3 | 9-6 | .600 | Progressive Field · Cleveland, OH |
| 16 | Wed Apr 25 | vs Royals | L2-8 | 9-7 | .563 | Progressive Field · Cleveland, OH |
| 17 | Thu Apr 26 | vs Royals | L2-4 | 9-8 | .529 | Progressive Field · Cleveland, OH |
| 18 | Fri Apr 27 | vs Angels | W3-2 | 10-8 | .556 | Progressive Field · Cleveland, OH |
| 19 | Sat Apr 28 | vs Angels | L1-2 | 10-9 | .526 | Progressive Field · Cleveland, OH |
| 20 | Sun Apr 29 | vs Angels | W4-0 | 11-9 | .550 | Progressive Field · Cleveland, OH |
| 21 | Tue May 1 | at White Sox | L2-7 | 11-10 | .524 | Guaranteed Rate Field · Chicago, IL |
| 22 | Wed May 2 | at White Sox | W6-3 | 12-10 | .545 | Guaranteed Rate Field · Chicago, IL |
| 23 | Thu May 3 | at White Sox | W7-5 | 13-10 | .565 | Guaranteed Rate Field · Chicago, IL |
| 24 | Fri May 4 | vs Rangers | W6-3 | 14-10 | .583 | Progressive Field · Cleveland, OH |
| 25 | Sat May 5 | vs Rangers | L2-5 (11) | 14-11 | .560 | Progressive Field · Cleveland, OH |
| 26 | Sun May 6 | vs Rangers | W4-2 | 15-11 | .577 | Progressive Field · Cleveland, OH |
| 27 | Mon May 7 | vs White Sox | W8-6 | 16-11 | .593 | Progressive Field · Cleveland, OH |
| 28 | Mon May 7 | vs White Sox | W3-2 | 17-11 | .607 | Progressive Field · Cleveland, OH |
| 29 | Tue May 8 | vs White Sox | L3-5 (10) | 17-12 | .586 | Progressive Field · Cleveland, OH |
| 30 | Wed May 9 | vs White Sox | L1-8 | 17-13 | .567 | Progressive Field · Cleveland, OH |
| 31 | Thu May 10 | at Red Sox | W8-3 | 18-13 | .581 | Fenway Park · Boston, MA |
| 32 | Fri May 11 | at Red Sox | L5-7 | 18-14 | .563 | Fenway Park · Boston, MA |
| 33 | Sat May 12 | at Red Sox | L1-4 | 18-15 | .545 | Fenway Park · Boston, MA |
| 34 | Sun May 13 | at Red Sox | L1-12 | 18-16 | .529 | Fenway Park · Boston, MA |
| 35 | Mon May 14 | at Twins | W5-4 | 19-16 | .543 | Target Field · Minneapolis, MN |
| 36 | Tue May 15 | at Twins | W5-0 | 20-16 | .556 | Target Field · Minneapolis, MN |
| 37 | Wed May 16 | vs Mariners | W9-3 | 21-16 | .568 | Progressive Field · Cleveland, OH |
| 38 | Thu May 17 | vs Mariners | W6-5 (11) | 22-16 | .579 | Progressive Field · Cleveland, OH |
| 39 | Fri May 18 | vs Marlins | L2-3 | 22-17 | .564 | Progressive Field · Cleveland, OH |
| 40 | Sat May 19 | vs Marlins | W2-0 | 23-17 | .575 | Progressive Field · Cleveland, OH |
| 41 | Sun May 20 | vs Marlins | L3-5 | 23-18 | .561 | Progressive Field · Cleveland, OH |
| 42 | Tue May 22 | vs Tigers | W5-3 | 24-18 | .571 | Progressive Field · Cleveland, OH |
| 43 | Wed May 23 | vs Tigers | W4-2 | 25-18 | .581 | Progressive Field · Cleveland, OH |
| 44 | Thu May 24 | vs Tigers | W2-1 | 26-18 | .591 | Progressive Field · Cleveland, OH |
| 45 | Fri May 25 | at White Sox | L3-9 | 26-19 | .578 | Guaranteed Rate Field · Chicago, IL |
| 46 | Sat May 26 | at White Sox | L7-14 | 26-20 | .565 | Guaranteed Rate Field · Chicago, IL |
| 47 | Sun May 27 | at White Sox | L6-12 | 26-21 | .553 | Guaranteed Rate Field · Chicago, IL |
| 48 | Mon May 28 | vs Royals | W8-5 | 27-21 | .563 | Progressive Field · Cleveland, OH |
| 49 | Tue May 29 | vs Royals | L2-8 | 27-22 | .551 | Progressive Field · Cleveland, OH |
| 50 | Wed May 30 | vs Royals | L3-6 | 27-23 | .540 | Progressive Field · Cleveland, OH |
| 51 | Fri Jun 1 | vs Twins | W7-1 | 28-23 | .549 | Progressive Field · Cleveland, OH |
| 52 | Sat Jun 2 | vs Twins | L4-7 | 28-24 | .538 | Progressive Field · Cleveland, OH |
| 53 | Sun Jun 3 | vs Twins | L3-6 | 28-25 | .528 | Progressive Field · Cleveland, OH |
| 54 | Tue Jun 5 | at Tigers | W4-2 | 29-25 | .537 | Comerica Park · Detroit, MI |
| 55 | Wed Jun 6 | at Tigers | W9-6 | 30-25 | .545 | Comerica Park · Detroit, MI |
| 56 | Thu Jun 7 | at Tigers | L5-7 | 30-26 | .536 | Comerica Park · Detroit, MI |
| 57 | Fri Jun 8 | at Cardinals | W6-2 | 31-26 | .544 | Busch Stadium · St. Louis, MO |
| 58 | Sat Jun 9 | at Cardinals | L0-2 | 31-27 | .534 | Busch Stadium · St. Louis, MO |
| 59 | Sun Jun 10 | at Cardinals | W4-1 | 32-27 | .542 | Busch Stadium · St. Louis, MO |
| 60 | Tue Jun 12 | at Reds | L1-7 | 32-28 | .533 | Great American Ball Park · Cincinnati, OH |
| 61 | Wed Jun 13 | at Reds | L3-5 | 32-29 | .525 | Great American Ball Park · Cincinnati, OH |
| 62 | Thu Jun 14 | at Reds | L5-12 | 32-30 | .516 | Great American Ball Park · Cincinnati, OH |
| 63 | Fri Jun 15 | vs Pirates | W2-0 | 33-30 | .524 | Progressive Field · Cleveland, OH |
| 64 | Sat Jun 16 | vs Pirates | L2-9 | 33-31 | .516 | Progressive Field · Cleveland, OH |
| 65 | Sun Jun 17 | vs Pirates | L5-9 | 33-32 | .508 | Progressive Field · Cleveland, OH |
| 66 | Mon Jun 18 | vs Reds | W10-9 | 34-32 | .515 | Progressive Field · Cleveland, OH |
| 67 | Tue Jun 19 | vs Reds | W3-2 (10) | 35-32 | .522 | Progressive Field · Cleveland, OH |
| 68 | Wed Jun 20 | vs Reds | W8-1 | 36-32 | .529 | Progressive Field · Cleveland, OH |
| 69 | Fri Jun 22 | at Astros | W2-0 | 37-32 | .536 | Minute Maid Park · Houston, TX |
| 70 | Sat Jun 23 | at Astros | L1-8 | 37-33 | .529 | Minute Maid Park · Houston, TX |
| 71 | Sun Jun 24 | at Astros | L1-7 | 37-34 | .521 | Minute Maid Park · Houston, TX |
| 72 | Mon Jun 25 | at Yankees | L1-7 | 37-35 | .514 | Yankee Stadium · The Bronx, NY |
| 73 | Tue Jun 26 | at Yankees | L4-6 | 37-36 | .507 | Yankee Stadium · The Bronx, NY |
| 74 | Wed Jun 27 | at Yankees | L4-5 | 37-37 | .500 | Yankee Stadium · The Bronx, NY |
| 75 | Thu Jun 28 | at Orioles | W7-2 | 38-37 | .507 | Camden Yards · Baltimore, MD |
| 76 | Fri Jun 29 | at Orioles | L8-9 | 38-38 | .500 | Camden Yards · Baltimore, MD |
| 77 | Sat Jun 30 | at Orioles | W11-5 | 39-38 | .506 | Camden Yards · Baltimore, MD |
| 78 | Sun Jul 1 | at Orioles | W6-2 | 40-38 | .513 | Camden Yards · Baltimore, MD |
| 79 | Mon Jul 2 | vs Angels | L0-3 | 40-39 | .506 | Progressive Field · Cleveland, OH |
| 80 | Tue Jul 3 | vs Angels | W9-5 | 41-39 | .512 | Progressive Field · Cleveland, OH |
| 81 | Wed Jul 4 | vs Angels | W12-3 | 42-39 | .519 | Progressive Field · Cleveland, OH |
| 82 | Thu Jul 5 | vs Rays | W3-1 | 43-39 | .524 | Progressive Field · Cleveland, OH |
| 83 | Fri Jul 6 | vs Rays | L3-10 | 43-40 | .518 | Progressive Field · Cleveland, OH |
| 84 | Sat Jul 7 | vs Rays | W7-3 | 44-40 | .524 | Progressive Field · Cleveland, OH |
| 85 | Sun Jul 8 | vs Rays | L6-7 | 44-41 | .518 | Progressive Field · Cleveland, OH |
| 86 | Fri Jul 13 | at Blue Jays | W1-0 | 45-41 | .523 | Rogers Centre · Toronto, ON |
| 87 | Sat Jul 14 | at Blue Jays | L9-11 | 45-42 | .517 | Rogers Centre · Toronto, ON |
| 88 | Sun Jul 15 | at Blue Jays | L0-3 | 45-43 | .511 | Rogers Centre · Toronto, ON |
| 89 | Mon Jul 16 | at Rays | W3-2 | 46-43 | .517 | Tropicana Field · St. Petersburg, FL |
| 90 | Tue Jul 17 | at Rays | L2-4 | 46-44 | .511 | Tropicana Field · St. Petersburg, FL |
| 91 | Wed Jul 18 | at Rays | W10-6 | 47-44 | .516 | Tropicana Field · St. Petersburg, FL |
| 92 | Thu Jul 19 | at Rays | L0-6 | 47-45 | .511 | Tropicana Field · St. Petersburg, FL |
| 93 | Fri Jul 20 | vs Orioles | L2-10 | 47-46 | .505 | Progressive Field · Cleveland, OH |
| 94 | Sat Jul 21 | vs Orioles | L1-3 | 47-47 | .500 | Progressive Field · Cleveland, OH |
| 95 | Sun Jul 22 | vs Orioles | L3-4 | 47-48 | .495 | Progressive Field · Cleveland, OH |
| 96 | Mon Jul 23 | vs Orioles | W3-1 | 48-48 | .500 | Progressive Field · Cleveland, OH |
| 97 | Tue Jul 24 | vs Tigers | W3-2 | 49-48 | .505 | Progressive Field · Cleveland, OH |
| 98 | Wed Jul 25 | vs Tigers | L3-5 | 49-49 | .500 | Progressive Field · Cleveland, OH |
| 99 | Thu Jul 26 | vs Tigers | W5-3 | 50-49 | .505 | Progressive Field · Cleveland, OH |
| 100 | Fri Jul 27 | at Twins | L0-11 | 50-50 | .500 | Target Field · Minneapolis, MN |
| 101 | Sat Jul 28 | at Twins | L5-12 | 50-51 | .495 | Target Field · Minneapolis, MN |
| 102 | Sun Jul 29 | at Twins | L1-5 | 50-52 | .490 | Target Field · Minneapolis, MN |
| 103 | Tue Jul 31 | at Royals | L3-8 | 50-53 | .485 | Kauffman Stadium · Kansas City, MO |
| 104 | Wed Aug 1 | at Royals | L2-5 | 50-54 | .481 | Kauffman Stadium · Kansas City, MO |
| 105 | Thu Aug 2 | at Royals | L6-7 (11) | 50-55 | .476 | Kauffman Stadium · Kansas City, MO |
| 106 | Fri Aug 3 | at Tigers | L2-10 | 50-56 | .472 | Comerica Park · Detroit, MI |
| 107 | Sat Aug 4 | at Tigers | L1-6 | 50-57 | .467 | Comerica Park · Detroit, MI |
| 108 | Sun Aug 5 | at Tigers | L8-10 (10) | 50-58 | .463 | Comerica Park · Detroit, MI |
| 109 | Mon Aug 6 | vs Twins | L3-14 | 50-59 | .459 | Progressive Field · Cleveland, OH |
| 110 | Tue Aug 7 | vs Twins | L5-7 | 50-60 | .455 | Progressive Field · Cleveland, OH |
| 111 | Wed Aug 8 | vs Twins | W6-2 | 51-60 | .459 | Progressive Field · Cleveland, OH |
| 112 | Thu Aug 9 | vs Red Sox | W5-3 | 52-60 | .464 | Progressive Field · Cleveland, OH |
| 113 | Fri Aug 10 | vs Red Sox | L2-3 | 52-61 | .460 | Progressive Field · Cleveland, OH |
| 114 | Sat Aug 11 | vs Red Sox | W5-2 | 53-61 | .465 | Progressive Field · Cleveland, OH |
| 115 | Sun Aug 12 | vs Red Sox | L1-14 | 53-62 | .461 | Progressive Field · Cleveland, OH |
| 116 | Mon Aug 13 | at Angels | W6-2 | 54-62 | .466 | Angel Stadium · Anaheim, CA |
| 117 | Tue Aug 14 | at Angels | L6-9 | 54-63 | .462 | Angel Stadium · Anaheim, CA |
| 118 | Wed Aug 15 | at Angels | L4-8 | 54-64 | .458 | Angel Stadium · Anaheim, CA |
| 119 | Fri Aug 17 | at Athletics | L4-6 | 54-65 | .454 | RingCentral Coliseum · Oakland, CA |
| 120 | Sat Aug 18 | at Athletics | L5-8 | 54-66 | .450 | RingCentral Coliseum · Oakland, CA |
| 121 | Sun Aug 19 | at Athletics | L0-7 | 54-67 | .446 | RingCentral Coliseum · Oakland, CA |
| 122 | Mon Aug 20 | at Mariners | L3-5 | 54-68 | .443 | T-Mobile Park · Seattle, WA |
| 123 | Tue Aug 21 | at Mariners | L1-5 | 54-69 | .439 | T-Mobile Park · Seattle, WA |
| 124 | Wed Aug 22 | at Mariners | L1-3 | 54-70 | .435 | T-Mobile Park · Seattle, WA |
| 125 | Fri Aug 24 | vs Yankees | L1-3 | 54-71 | .432 | Progressive Field · Cleveland, OH |
| 126 | Sat Aug 25 | vs Yankees | W3-1 | 55-71 | .437 | Progressive Field · Cleveland, OH |
| 127 | Sun Aug 26 | vs Yankees | L2-4 | 55-72 | .433 | Progressive Field · Cleveland, OH |
| 128 | Mon Aug 27 | vs Athletics | L0-3 | 55-73 | .430 | Progressive Field · Cleveland, OH |
| 129 | Tue Aug 28 | vs Athletics | L0-7 | 55-74 | .426 | Progressive Field · Cleveland, OH |
| 130 | Wed Aug 29 | vs Athletics | L4-8 | 55-75 | .423 | Progressive Field · Cleveland, OH |
| 131 | Thu Aug 30 | vs Athletics | L7-12 | 55-76 | .420 | Progressive Field · Cleveland, OH |
| 132 | Fri Aug 31 | vs Rangers | L3-5 | 55-77 | .417 | Progressive Field · Cleveland, OH |
| 133 | Sat Sep 1 | vs Rangers | W4-3 | 56-77 | .421 | Progressive Field · Cleveland, OH |
| 134 | Sun Sep 2 | vs Rangers | L3-8 | 56-78 | .418 | Progressive Field · Cleveland, OH |
| 135 | Mon Sep 3 | at Tigers | W3-2 | 57-78 | .422 | Comerica Park · Detroit, MI |
| 136 | Tue Sep 4 | at Tigers | W3-2 | 58-78 | .426 | Comerica Park · Detroit, MI |
| 137 | Wed Sep 5 | at Tigers | L1-7 | 58-79 | .423 | Comerica Park · Detroit, MI |
| 138 | Fri Sep 7 | at Twins | W7-6 | 59-79 | .428 | Target Field · Minneapolis, MN |
| 139 | Sat Sep 8 | at Twins | L0-3 | 59-80 | .424 | Target Field · Minneapolis, MN |
| 140 | Sun Sep 9 | at Twins | L7-8 | 59-81 | .421 | Target Field · Minneapolis, MN |
| 141 | Mon Sep 10 | at Twins | L2-7 | 59-82 | .418 | Target Field · Minneapolis, MN |
| 142 | Tue Sep 11 | at Rangers | L4-6 | 59-83 | .415 | Globe Life Field · Arlington, TX |
| 143 | Wed Sep 12 | at Rangers | L2-5 | 59-84 | .413 | Globe Life Field · Arlington, TX |
| 144 | Thu Sep 13 | at Rangers | W5-4 | 60-84 | .417 | Globe Life Field · Arlington, TX |
| 145 | Fri Sep 14 | vs Tigers | L0-4 | 60-85 | .414 | Progressive Field · Cleveland, OH |
| 146 | Sat Sep 15 | vs Tigers | L3-5 | 60-86 | .411 | Progressive Field · Cleveland, OH |
| 147 | Sun Sep 16 | vs Tigers | W7-6 | 61-86 | .415 | Progressive Field · Cleveland, OH |
| 148 | Tue Sep 18 | vs Twins | L5-6 (12) | 61-87 | .412 | Progressive Field · Cleveland, OH |
| 149 | Wed Sep 19 | vs Twins | L4-6 | 61-88 | .409 | Progressive Field · Cleveland, OH |
| 150 | Thu Sep 20 | vs Twins | W4-3 (10) | 62-88 | .413 | Progressive Field · Cleveland, OH |
| 151 | Fri Sep 21 | at Royals | L3-6 | 62-89 | .411 | Kauffman Stadium · Kansas City, MO |
| 152 | Sat Sep 22 | at Royals | L3-5 | 62-90 | .408 | Kauffman Stadium · Kansas City, MO |
| 153 | Sun Sep 23 | at Royals | W15-4 | 63-90 | .412 | Kauffman Stadium · Kansas City, MO |
| 154 | Mon Sep 24 | at White Sox | L4-5 | 63-91 | .409 | Guaranteed Rate Field · Chicago, IL |
| 155 | Tue Sep 25 | at White Sox | W4-3 | 64-91 | .413 | Guaranteed Rate Field · Chicago, IL |
| 156 | Wed Sep 26 | at White Sox | W6-4 | 65-91 | .417 | Guaranteed Rate Field · Chicago, IL |
| 157 | Fri Sep 28 | vs Royals | W8-5 | 66-91 | .420 | Progressive Field · Cleveland, OH |
| 158 | Sat Sep 29 | vs Royals | L6-7 (14) | 66-92 | .418 | Progressive Field · Cleveland, OH |
| 159 | Sun Sep 30 | vs Royals | W15-3 | 67-92 | .421 | Progressive Field · Cleveland, OH |
| 160 | Mon Oct 1 | vs White Sox | L0-11 | 67-93 | .419 | Progressive Field · Cleveland, OH |
| 161 | Tue Oct 2 | vs White Sox | W4-3 (12) | 68-93 | .422 | Progressive Field · Cleveland, OH |
| 162 | Wed Oct 3 | vs White Sox | L0-9 | 68-94 | .420 | Progressive Field · Cleveland, OH |