| 1 | Thu Mar 28 | at Athletics | W8-0 | 1-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 2 | Fri Mar 29 | at Athletics | W6-4 | 2-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 3 | Sat Mar 30 | at Athletics | W12-3 | 3-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 4 | Sun Mar 31 | at Athletics | L3-4 | 3-1 | .750 | RingCentral Coliseum · Oakland, CA |
| 5 | Mon Apr 1 | at Mariners | L4-5 | 3-2 | .600 | T-Mobile Park · Seattle, WA |
| 6 | Tue Apr 2 | at Mariners | W5-2 | 4-2 | .667 | T-Mobile Park · Seattle, WA |
| 7 | Wed Apr 3 | at Mariners | W8-0 | 5-2 | .714 | T-Mobile Park · Seattle, WA |
| 8 | Thu Apr 4 | at Twins | W4-2 | 6-2 | .750 | Target Field · Minneapolis, MN |
| 9 | Sat Apr 6 | at Twins | W3-1 | 7-2 | .778 | Target Field · Minneapolis, MN |
| 10 | Mon Apr 8 | vs White Sox | W4-0 | 8-2 | .800 | Progressive Field · Cleveland, OH |
| 11 | Tue Apr 9 | vs White Sox | L5-7 | 8-3 | .727 | Progressive Field · Cleveland, OH |
| 12 | Wed Apr 10 | vs White Sox | W7-6 (10) | 9-3 | .750 | Progressive Field · Cleveland, OH |
| 13 | Sat Apr 13 | vs Yankees | L2-3 | 9-4 | .692 | Progressive Field · Cleveland, OH |
| 14 | Sat Apr 13 | vs Yankees | L2-8 | 9-5 | .643 | Progressive Field · Cleveland, OH |
| 15 | Sun Apr 14 | vs Yankees | W8-7 (10) | 10-5 | .667 | Progressive Field · Cleveland, OH |
| 16 | Mon Apr 15 | at Red Sox | W6-0 | 11-5 | .688 | Fenway Park · Boston, MA |
| 17 | Tue Apr 16 | at Red Sox | W10-7 (11) | 12-5 | .706 | Fenway Park · Boston, MA |
| 18 | Wed Apr 17 | at Red Sox | L0-2 | 12-6 | .667 | Fenway Park · Boston, MA |
| 19 | Thu Apr 18 | at Red Sox | W5-4 | 13-6 | .684 | Fenway Park · Boston, MA |
| 20 | Fri Apr 19 | vs Athletics | W10-2 | 14-6 | .700 | Progressive Field · Cleveland, OH |
| 21 | Sat Apr 20 | vs Athletics | W6-3 | 15-6 | .714 | Progressive Field · Cleveland, OH |
| 22 | Sun Apr 21 | vs Athletics | W6-2 | 16-6 | .727 | Progressive Field · Cleveland, OH |
| 23 | Tue Apr 23 | vs Red Sox | W4-1 | 17-6 | .739 | Progressive Field · Cleveland, OH |
| 24 | Wed Apr 24 | vs Red Sox | L0-8 | 17-7 | .708 | Progressive Field · Cleveland, OH |
| 25 | Thu Apr 25 | vs Red Sox | W6-4 | 18-7 | .720 | Progressive Field · Cleveland, OH |
| 26 | Fri Apr 26 | at Braves | L2-6 | 18-8 | .692 | Truist Park · Cumberland, GA |
| 27 | Sat Apr 27 | at Braves | W4-2 (11) | 19-8 | .704 | Truist Park · Cumberland, GA |
| 28 | Sun Apr 28 | at Braves | L3-4 (10) | 19-9 | .679 | Truist Park · Cumberland, GA |
| 29 | Tue Apr 30 | at Astros | L9-10 (10) | 19-10 | .655 | Minute Maid Park · Houston, TX |
| 30 | Wed May 1 | at Astros | W3-2 (10) | 20-10 | .667 | Minute Maid Park · Houston, TX |
| 31 | Thu May 2 | at Astros | L2-8 | 20-11 | .645 | Minute Maid Park · Houston, TX |
| 32 | Fri May 3 | vs Angels | L0-6 | 20-12 | .625 | Progressive Field · Cleveland, OH |
| 33 | Sat May 4 | vs Angels | W7-1 | 21-12 | .636 | Progressive Field · Cleveland, OH |
| 34 | Sun May 5 | vs Angels | W4-1 | 22-12 | .647 | Progressive Field · Cleveland, OH |
| 35 | Mon May 6 | vs Tigers | W2-1 | 23-12 | .657 | Progressive Field · Cleveland, OH |
| 36 | Tue May 7 | vs Tigers | L7-11 | 23-13 | .639 | Progressive Field · Cleveland, OH |
| 37 | Wed May 8 | vs Tigers | W5-4 (10) | 24-13 | .649 | Progressive Field · Cleveland, OH |
| 38 | Thu May 9 | at White Sox | L2-3 | 24-14 | .632 | Guaranteed Rate Field · Chicago, IL |
| 39 | Fri May 10 | at White Sox | L3-6 | 24-15 | .615 | Guaranteed Rate Field · Chicago, IL |
| 40 | Sat May 11 | at White Sox | L1-3 | 24-16 | .600 | Guaranteed Rate Field · Chicago, IL |
| 41 | Sun May 12 | at White Sox | W7-0 | 25-16 | .610 | Guaranteed Rate Field · Chicago, IL |
| 42 | Mon May 13 | at Rangers | W7-0 | 26-16 | .619 | Globe Life Field · Arlington, TX |
| 43 | Tue May 14 | at Rangers | W7-4 | 27-16 | .628 | Globe Life Field · Arlington, TX |
| 44 | Wed May 15 | at Rangers | L0-4 | 27-17 | .614 | Globe Life Field · Arlington, TX |
| 45 | Fri May 17 | vs Twins | W3-2 | 28-17 | .622 | Progressive Field · Cleveland, OH |
| 46 | Sat May 18 | vs Twins | W11-4 | 29-17 | .630 | Progressive Field · Cleveland, OH |
| 47 | Sun May 19 | vs Twins | W5-2 | 30-17 | .638 | Progressive Field · Cleveland, OH |
| 48 | Mon May 20 | vs Mets | W3-1 | 31-17 | .646 | Progressive Field · Cleveland, OH |
| 49 | Tue May 21 | vs Mets | W7-6 | 32-17 | .653 | Progressive Field · Cleveland, OH |
| 50 | Wed May 22 | vs Mets | W6-3 | 33-17 | .660 | Progressive Field · Cleveland, OH |
| 51 | Fri May 24 | at Angels | W10-4 | 34-17 | .667 | Angel Stadium · Anaheim, CA |
| 52 | Sat May 25 | at Angels | W4-3 | 35-17 | .673 | Angel Stadium · Anaheim, CA |
| 53 | Sun May 26 | at Angels | W5-4 | 36-17 | .679 | Angel Stadium · Anaheim, CA |
| 54 | Mon May 27 | at Rockies | L6-8 | 36-18 | .667 | Coors Field · Denver, CO |
| 55 | Tue May 28 | at Rockies | W13-7 | 37-18 | .673 | Coors Field · Denver, CO |
| 56 | Wed May 29 | at Rockies | L4-7 | 37-19 | .661 | Coors Field · Denver, CO |
| 57 | Fri May 31 | vs Nationals | W7-1 | 38-19 | .667 | Progressive Field · Cleveland, OH |
| 58 | Sat Jun 1 | vs Nationals | W3-2 | 39-19 | .672 | Progressive Field · Cleveland, OH |
| 59 | Sun Jun 2 | vs Nationals | L2-5 | 39-20 | .661 | Progressive Field · Cleveland, OH |
| 60 | Tue Jun 4 | vs Royals | W8-5 | 40-20 | .667 | Progressive Field · Cleveland, OH |
| 61 | Thu Jun 6 | vs Royals | L3-4 | 40-21 | .656 | Progressive Field · Cleveland, OH |
| 62 | Fri Jun 7 | at Marlins | L2-3 | 40-22 | .645 | LoanDepot Park · Miami, FL |
| 63 | Sat Jun 8 | at Marlins | W8-0 | 41-22 | .651 | LoanDepot Park · Miami, FL |
| 64 | Sun Jun 9 | at Marlins | W6-3 | 42-22 | .656 | LoanDepot Park · Miami, FL |
| 65 | Tue Jun 11 | at Reds | W5-3 | 43-22 | .662 | Great American Ball Park · Cincinnati, OH |
| 66 | Wed Jun 12 | at Reds | L2-4 | 43-23 | .652 | Great American Ball Park · Cincinnati, OH |
| 67 | Fri Jun 14 | at Blue Jays | W3-1 | 44-23 | .657 | Rogers Centre · Toronto, ON |
| 68 | Sat Jun 15 | at Blue Jays | L0-5 | 44-24 | .647 | Rogers Centre · Toronto, ON |
| 69 | Sun Jun 16 | at Blue Jays | L6-7 | 44-25 | .638 | Rogers Centre · Toronto, ON |
| 70 | Tue Jun 18 | vs Mariners | L5-8 | 44-26 | .629 | Progressive Field · Cleveland, OH |
| 71 | Wed Jun 19 | vs Mariners | W8-0 | 45-26 | .634 | Progressive Field · Cleveland, OH |
| 72 | Thu Jun 20 | vs Mariners | W6-3 | 46-26 | .639 | Progressive Field · Cleveland, OH |
| 73 | Fri Jun 21 | vs Blue Jays | W7-1 | 47-26 | .644 | Progressive Field · Cleveland, OH |
| 74 | Sat Jun 22 | vs Blue Jays | W6-3 | 48-26 | .649 | Progressive Field · Cleveland, OH |
| 75 | Sun Jun 23 | vs Blue Jays | W6-5 | 49-26 | .653 | Progressive Field · Cleveland, OH |
| 76 | Mon Jun 24 | at Orioles | W3-2 | 50-26 | .658 | Camden Yards · Baltimore, MD |
| 77 | Tue Jun 25 | at Orioles | W10-8 | 51-26 | .662 | Camden Yards · Baltimore, MD |
| 78 | Wed Jun 26 | at Orioles | L2-4 | 51-27 | .654 | Camden Yards · Baltimore, MD |
| 79 | Thu Jun 27 | at Royals | L1-2 | 51-28 | .646 | Kauffman Stadium · Kansas City, MO |
| 80 | Fri Jun 28 | at Royals | L3-10 | 51-29 | .637 | Kauffman Stadium · Kansas City, MO |
| 81 | Sat Jun 29 | at Royals | W7-2 | 52-29 | .642 | Kauffman Stadium · Kansas City, MO |
| 82 | Sun Jun 30 | at Royals | L2-6 | 52-30 | .634 | Kauffman Stadium · Kansas City, MO |
| 83 | Tue Jul 2 | vs White Sox | W7-6 | 53-30 | .639 | Progressive Field · Cleveland, OH |
| 84 | Wed Jul 3 | vs White Sox | L2-8 | 53-31 | .631 | Progressive Field · Cleveland, OH |
| 85 | Thu Jul 4 | vs White Sox | W8-4 | 54-31 | .635 | Progressive Field · Cleveland, OH |
| 86 | Fri Jul 5 | vs Giants | L2-4 | 54-32 | .628 | Progressive Field · Cleveland, OH |
| 87 | Sat Jul 6 | vs Giants | W5-4 | 55-32 | .632 | Progressive Field · Cleveland, OH |
| 88 | Sun Jul 7 | vs Giants | W5-4 | 56-32 | .636 | Progressive Field · Cleveland, OH |
| 89 | Mon Jul 8 | at Tigers | L0-1 | 56-33 | .629 | Comerica Park · Detroit, MI |
| 90 | Tue Jul 9 | at Tigers | W9-8 (10) | 57-33 | .633 | Comerica Park · Detroit, MI |
| 91 | Wed Jul 10 | at Tigers | L4-5 | 57-34 | .626 | Comerica Park · Detroit, MI |
| 92 | Thu Jul 11 | at Tigers | L1-10 | 57-35 | .620 | Comerica Park · Detroit, MI |
| 93 | Fri Jul 12 | at Rays | L0-2 | 57-36 | .613 | Tropicana Field · St. Petersburg, FL |
| 94 | Sat Jul 13 | at Rays | W4-2 | 58-36 | .617 | Tropicana Field · St. Petersburg, FL |
| 95 | Sun Jul 14 | at Rays | L0-2 | 58-37 | .611 | Tropicana Field · St. Petersburg, FL |
| 96 | Fri Jul 19 | vs Padres | W7-0 | 59-37 | .615 | Progressive Field · Cleveland, OH |
| 97 | Sat Jul 20 | vs Padres | L0-7 | 59-38 | .608 | Progressive Field · Cleveland, OH |
| 98 | Sun Jul 21 | vs Padres | L1-2 | 59-39 | .602 | Progressive Field · Cleveland, OH |
| 99 | Mon Jul 22 | vs Tigers | L2-8 | 59-40 | .596 | Progressive Field · Cleveland, OH |
| 100 | Tue Jul 23 | vs Tigers | W5-4 | 60-40 | .600 | Progressive Field · Cleveland, OH |
| 101 | Wed Jul 24 | vs Tigers | W2-1 | 61-40 | .604 | Progressive Field · Cleveland, OH |
| 102 | Thu Jul 25 | vs Tigers | L0-3 | 61-41 | .598 | Progressive Field · Cleveland, OH |
| 103 | Fri Jul 26 | at Phillies | W3-1 | 62-41 | .602 | Citizens Bank Park · Philadelphi, PA |
| 104 | Sat Jul 27 | at Phillies | L0-8 | 62-42 | .596 | Citizens Bank Park · Philadelphi, PA |
| 105 | Sun Jul 28 | at Phillies | W4-3 | 63-42 | .600 | Citizens Bank Park · Philadelphi, PA |
| 106 | Mon Jul 29 | at Tigers | W8-4 | 64-42 | .604 | Comerica Park · Detroit, MI |
| 107 | Tue Jul 30 | at Tigers | W5-0 | 65-42 | .607 | Comerica Park · Detroit, MI |
| 108 | Thu Aug 1 | vs Orioles | W10-3 | 66-42 | .611 | Progressive Field · Cleveland, OH |
| 109 | Fri Aug 2 | vs Orioles | W8-4 | 67-42 | .615 | Progressive Field · Cleveland, OH |
| 110 | Sat Aug 3 | vs Orioles | L4-7 | 67-43 | .609 | Progressive Field · Cleveland, OH |
| 111 | Sun Aug 4 | vs Orioles | L5-9 | 67-44 | .604 | Progressive Field · Cleveland, OH |
| 112 | Mon Aug 5 | vs D-backs | L6-7 (10) | 67-45 | .598 | Progressive Field · Cleveland, OH |
| 113 | Wed Aug 7 | vs D-backs | L3-7 | 67-46 | .593 | Progressive Field · Cleveland, OH |
| 114 | Wed Aug 7 | vs D-backs | L3-5 | 67-47 | .588 | Progressive Field · Cleveland, OH |
| 115 | Fri Aug 9 | at Twins | L2-4 | 67-48 | .583 | Target Field · Minneapolis, MN |
| 116 | Fri Aug 9 | at Twins | L3-6 | 67-49 | .578 | Target Field · Minneapolis, MN |
| 117 | Sat Aug 10 | at Twins | W2-1 | 68-49 | .581 | Target Field · Minneapolis, MN |
| 118 | Sun Aug 11 | at Twins | W5-3 | 69-49 | .585 | Target Field · Minneapolis, MN |
| 119 | Mon Aug 12 | vs Cubs | W9-8 | 70-49 | .588 | Progressive Field · Cleveland, OH |
| 120 | Tue Aug 13 | vs Cubs | W2-1 | 71-49 | .592 | Progressive Field · Cleveland, OH |
| 121 | Wed Aug 14 | vs Cubs | W6-1 | 72-49 | .595 | Progressive Field · Cleveland, OH |
| 122 | Fri Aug 16 | at Brewers | L3-5 | 72-50 | .590 | American Family Field · Milwaukee, WI |
| 123 | Sat Aug 17 | at Brewers | L1-2 | 72-51 | .585 | American Family Field · Milwaukee, WI |
| 124 | Sun Aug 18 | at Brewers | L0-2 | 72-52 | .581 | American Family Field · Milwaukee, WI |
| 125 | Tue Aug 20 | at Yankees | W9-5 (12) | 73-52 | .584 | Yankee Stadium · The Bronx, NY |
| 126 | Wed Aug 21 | at Yankees | L1-8 | 73-53 | .579 | Yankee Stadium · The Bronx, NY |
| 127 | Thu Aug 22 | at Yankees | L0-6 | 73-54 | .575 | Yankee Stadium · The Bronx, NY |
| 128 | Fri Aug 23 | vs Rangers | L3-5 | 73-55 | .570 | Progressive Field · Cleveland, OH |
| 129 | Sat Aug 24 | vs Rangers | W13-5 | 74-55 | .574 | Progressive Field · Cleveland, OH |
| 130 | Sun Aug 25 | vs Rangers | W4-2 | 75-55 | .577 | Progressive Field · Cleveland, OH |
| 131 | Mon Aug 26 | vs Royals | L3-4 | 75-56 | .573 | Progressive Field · Cleveland, OH |
| 132 | Mon Aug 26 | vs Royals | L4-9 | 75-57 | .568 | Progressive Field · Cleveland, OH |
| 133 | Tue Aug 27 | vs Royals | L1-6 | 75-58 | .564 | Progressive Field · Cleveland, OH |
| 134 | Wed Aug 28 | vs Royals | W7-5 | 76-58 | .567 | Progressive Field · Cleveland, OH |
| 135 | Fri Aug 30 | vs Pirates | W10-8 | 77-58 | .570 | Progressive Field · Cleveland, OH |
| 136 | Sat Aug 31 | vs Pirates | L0-3 | 77-59 | .566 | Progressive Field · Cleveland, OH |
| 137 | Sun Sep 1 | vs Pirates | W6-1 | 78-59 | .569 | Progressive Field · Cleveland, OH |
| 138 | Mon Sep 2 | at Royals | W4-2 | 79-59 | .572 | Kauffman Stadium · Kansas City, MO |
| 139 | Tue Sep 3 | at Royals | W7-1 | 80-59 | .576 | Kauffman Stadium · Kansas City, MO |
| 140 | Wed Sep 4 | at Royals | L1-4 | 80-60 | .571 | Kauffman Stadium · Kansas City, MO |
| 141 | Fri Sep 6 | at Dodgers | W3-1 | 81-60 | .574 | Dodger Stadium · Los Angeles, CA |
| 142 | Sat Sep 7 | at Dodgers | L2-7 | 81-61 | .570 | Dodger Stadium · Los Angeles, CA |
| 143 | Sun Sep 8 | at Dodgers | L0-4 | 81-62 | .566 | Dodger Stadium · Los Angeles, CA |
| 144 | Mon Sep 9 | at White Sox | W5-3 | 82-62 | .569 | Guaranteed Rate Field · Chicago, IL |
| 145 | Tue Sep 10 | at White Sox | W5-0 | 83-62 | .572 | Guaranteed Rate Field · Chicago, IL |
| 146 | Wed Sep 11 | at White Sox | W6-4 | 84-62 | .575 | Guaranteed Rate Field · Chicago, IL |
| 147 | Thu Sep 12 | vs Rays | L2-5 | 84-63 | .571 | Progressive Field · Cleveland, OH |
| 148 | Fri Sep 13 | vs Rays | L1-3 | 84-64 | .568 | Progressive Field · Cleveland, OH |
| 149 | Sat Sep 14 | vs Rays | W6-1 | 85-64 | .570 | Progressive Field · Cleveland, OH |
| 150 | Sun Sep 15 | vs Rays | W2-0 | 86-64 | .573 | Progressive Field · Cleveland, OH |
| 151 | Mon Sep 16 | vs Twins | W4-3 | 87-64 | .576 | Progressive Field · Cleveland, OH |
| 152 | Tue Sep 17 | vs Twins | L1-4 | 87-65 | .572 | Progressive Field · Cleveland, OH |
| 153 | Wed Sep 18 | vs Twins | W5-4 (10) | 88-65 | .575 | Progressive Field · Cleveland, OH |
| 154 | Thu Sep 19 | vs Twins | W3-2 (10) | 89-65 | .578 | Progressive Field · Cleveland, OH |
| 155 | Fri Sep 20 | at Cardinals | W5-1 | 90-65 | .581 | Busch Stadium · St. Louis, MO |
| 156 | Sat Sep 21 | at Cardinals | L5-6 | 90-66 | .577 | Busch Stadium · St. Louis, MO |
| 157 | Sun Sep 22 | at Cardinals | L1-2 | 90-67 | .573 | Busch Stadium · St. Louis, MO |
| 158 | Tue Sep 24 | vs Reds | W6-1 | 91-67 | .576 | Progressive Field · Cleveland, OH |
| 159 | Wed Sep 25 | vs Reds | W5-2 | 92-67 | .579 | Progressive Field · Cleveland, OH |
| 160 | Fri Sep 27 | vs Astros | L2-5 | 92-68 | .575 | Progressive Field · Cleveland, OH |
| 161 | Sat Sep 28 | vs Astros | L3-4 | 92-69 | .571 | Progressive Field · Cleveland, OH |
| 163 | Sat Oct 5 | vs Tigers | W7-0 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 164 | Mon Oct 7 | vs Tigers | L0-3 | 1-1 | .500 | Progressive Field · Cleveland, OH |
| 165 | Wed Oct 9 | at Tigers | L0-3 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 166 | Thu Oct 10 | at Tigers | W5-4 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 167 | Sat Oct 12 | vs Tigers | W7-3 | 3-2 | .600 | Progressive Field · Cleveland, OH |
| 168 | Mon Oct 14 | at Yankees | L2-5 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 169 | Tue Oct 15 | at Yankees | L3-6 | 0-2 | .000 | Yankee Stadium · The Bronx, NY |
| 170 | Thu Oct 17 | vs Yankees | W7-5 (10) | 1-2 | .333 | Progressive Field · Cleveland, OH |
| 171 | Fri Oct 18 | vs Yankees | L6-8 | 1-3 | .250 | Progressive Field · Cleveland, OH |
| 172 | Sat Oct 19 | vs Yankees | L2-5 (10) | 1-4 | .200 | Progressive Field · Cleveland, OH |