| 1 | Thu Mar 26 | at Mariners | W6-4 | 1-0 | 1.000 | T-Mobile Park · Seattle, WA |
| 2 | Fri Mar 27 | at Mariners | L1-5 | 1-1 | .500 | T-Mobile Park · Seattle, WA |
| 3 | Sat Mar 28 | at Mariners | W6-5 (10) | 2-1 | .667 | T-Mobile Park · Seattle, WA |
| 4 | Sun Mar 29 | at Mariners | L0-8 | 2-2 | .500 | T-Mobile Park · Seattle, WA |
| 5 | Mon Mar 30 | at Dodgers | W4-2 | 3-2 | .600 | Dodger Stadium · Los Angeles, CA |
| 6 | Tue Mar 31 | at Dodgers | L1-4 | 3-3 | .500 | Dodger Stadium · Los Angeles, CA |
| 7 | Wed Apr 1 | at Dodgers | W4-1 | 4-3 | .571 | Dodger Stadium · Los Angeles, CA |
| 8 | Fri Apr 3 | vs Cubs | W4-1 | 5-3 | .625 | Progressive Field · Cleveland, OH |
| 9 | Sun Apr 5 | vs Cubs | L0-1 | 5-4 | .556 | Progressive Field · Cleveland, OH |
| 10 | Sun Apr 5 | vs Cubs | W6-5 | 6-4 | .600 | Progressive Field · Cleveland, OH |
| 11 | Mon Apr 6 | vs Royals | L2-4 | 6-5 | .545 | Progressive Field · Cleveland, OH |
| 12 | Tue Apr 7 | vs Royals | W2-1 | 7-5 | .583 | Progressive Field · Cleveland, OH |
| 13 | Wed Apr 8 | vs Royals | W10-2 | 8-5 | .615 | Progressive Field · Cleveland, OH |
| 14 | Fri Apr 10 | at Braves | L5-11 | 8-6 | .571 | Truist Park · Cumberland, GA |
| 15 | Sat Apr 11 | at Braves | W6-0 | 9-6 | .600 | Truist Park · Cumberland, GA |
| 16 | Sun Apr 12 | at Braves | L1-13 | 9-7 | .563 | Truist Park · Cumberland, GA |
| 17 | Mon Apr 13 | at Cardinals | W9-3 | 10-7 | .588 | Busch Stadium · St. Louis, MO |
| 18 | Tue Apr 14 | at Cardinals | L5-6 (10) | 10-8 | .556 | Busch Stadium · St. Louis, MO |
| 19 | Wed Apr 15 | at Cardinals | L3-5 | 10-9 | .526 | Busch Stadium · St. Louis, MO |
| 20 | Thu Apr 16 | vs Orioles | W4-2 | 11-9 | .550 | Progressive Field · Cleveland, OH |
| 21 | Fri Apr 17 | vs Orioles | L4-6 | 11-10 | .524 | Progressive Field · Cleveland, OH |
| 22 | Sat Apr 18 | vs Orioles | W4-2 | 12-10 | .545 | Progressive Field · Cleveland, OH |
| 23 | Sun Apr 19 | vs Orioles | W8-4 | 13-10 | .565 | Progressive Field · Cleveland, OH |
| 24 | Mon Apr 20 | vs Astros | L2-9 | 13-11 | .542 | Progressive Field · Cleveland, OH |
| 25 | Tue Apr 21 | vs Astros | W8-5 | 14-11 | .560 | Progressive Field · Cleveland, OH |
| 26 | Wed Apr 22 | vs Astros | L0-2 | 14-12 | .538 | Progressive Field · Cleveland, OH |
| 27 | Fri Apr 24 | at Blue Jays | W8-6 | 15-12 | .556 | Rogers Centre · Toronto, ON |
| 28 | Sat Apr 25 | at Blue Jays | L3-5 | 15-13 | .536 | Rogers Centre · Toronto, ON |
| 29 | Sun Apr 26 | at Blue Jays | L2-4 | 15-14 | .517 | Rogers Centre · Toronto, ON |
| 30 | Mon Apr 27 | vs Rays | L2-3 | 15-15 | .500 | Progressive Field · Cleveland, OH |
| 31 | Tue Apr 28 | vs Rays | L0-1 | 15-16 | .484 | Progressive Field · Cleveland, OH |
| 32 | Wed Apr 29 | vs Rays | W3-1 | 16-16 | .500 | Progressive Field · Cleveland, OH |
| 33 | Fri May 1 | at Athletics | W8-5 | 17-16 | .515 | Sutter Health Park · West Sacramento, CA |
| 34 | Sat May 2 | at Athletics | W14-6 | 18-16 | .529 | Sutter Health Park · West Sacramento, CA |
| 35 | Sun May 3 | at Athletics | L1-7 | 18-17 | .514 | Sutter Health Park · West Sacramento, CA |
| 36 | Mon May 4 | at Royals | L2-6 | 18-18 | .500 | Kauffman Stadium · Kansas City, MO |
| 37 | Tue May 5 | at Royals | L3-5 | 18-19 | .486 | Kauffman Stadium · Kansas City, MO |
| 38 | Wed May 6 | at Royals | W3-1 | 19-19 | .500 | Kauffman Stadium · Kansas City, MO |
| 39 | Thu May 7 | at Royals | W8-5 | 20-19 | .513 | Kauffman Stadium · Kansas City, MO |
| 40 | Fri May 8 | vs Twins | W6-4 | 21-19 | .525 | Progressive Field · Cleveland, OH |
| 41 | Sat May 9 | vs Twins | L1-2 (11) | 21-20 | .512 | Progressive Field · Cleveland, OH |
| 42 | Sun May 10 | vs Twins | L4-5 | 21-21 | .500 | Progressive Field · Cleveland, OH |
| 43 | Mon May 11 | vs Angels | W7-2 | 22-21 | .512 | Progressive Field · Cleveland, OH |
| 44 | Tue May 12 | vs Angels | W3-2 | 23-21 | .523 | Progressive Field · Cleveland, OH |
| 45 | Wed May 13 | vs Angels | W4-2 | 24-21 | .533 | Progressive Field · Cleveland, OH |
| 46 | Fri May 15 | vs Reds | L6-7 | 24-22 | .522 | Progressive Field · Cleveland, OH |
| 47 | Sat May 16 | vs Reds | W7-4 | 25-22 | .532 | Progressive Field · Cleveland, OH |
| 48 | Sun May 17 | vs Reds | W10-3 | 26-22 | .542 | Progressive Field · Cleveland, OH |
| 49 | Mon May 18 | at Tigers | W8-2 | 27-22 | .551 | Comerica Park · Detroit, MI |
| 50 | Tue May 19 | at Tigers | W4-3 | 28-22 | .560 | Comerica Park · Detroit, MI |
| 51 | Wed May 20 | at Tigers | W3-2 (10) | 29-22 | .569 | Comerica Park · Detroit, MI |
| 52 | Thu May 21 | at Tigers | W3-1 | 30-22 | .577 | Comerica Park · Detroit, MI |
| 53 | Fri May 22 | at Phillies | W1-0 | 31-22 | .585 | Citizens Bank Park · Philadelphi, PA |
| 54 | Sat May 23 | at Phillies | L0-3 | 31-23 | .574 | Citizens Bank Park · Philadelphi, PA |
| 55 | Sun May 24 | at Phillies | W3-1 | 32-23 | .582 | Citizens Bank Park · Philadelphi, PA |
| 56 | Mon May 25 | vs Nationals | L2-10 | 32-24 | .571 | Progressive Field · Cleveland, OH |
| 57 | Tue May 26 | vs Nationals | L3-6 | 32-25 | .561 | Progressive Field · Cleveland, OH |
| 58 | Wed May 27 | vs Nationals | W3-2 | 33-25 | .569 | Progressive Field · Cleveland, OH |
| 59 | Fri May 29 | vs Red Sox | W4-3 | 34-25 | .576 | Progressive Field · Cleveland, OH |
| 60 | Sat May 30 | vs Red Sox | L1-9 | 34-26 | .567 | Progressive Field · Cleveland, OH |
| 61 | Sun May 31 | vs Red Sox | L4-9 | 34-27 | .557 | Progressive Field · Cleveland, OH |
| 62 | Tue Jun 2 | at Yankees | W9-4 | 35-27 | .565 | Yankee Stadium · The Bronx, NY |
| 63 | Wed Jun 3 | at Yankees | W5-4 | 36-27 | .571 | Yankee Stadium · The Bronx, NY |
| 64 | Thu Jun 4 | at Yankees | L1-2 | 36-28 | .563 | Yankee Stadium · The Bronx, NY |
| 65 | Fri Jun 5 | at Rangers | L2-3 | 36-29 | .554 | Globe Life Field · Arlington, TX |
| 66 | Sat Jun 6 | at Rangers | W6-0 | 37-29 | .561 | Globe Life Field · Arlington, TX |
| 67 | Sun Jun 7 | at Rangers | L0-10 | 37-30 | .552 | Globe Life Field · Arlington, TX |
| 68 | Mon Jun 8 | vs Yankees | L5-7 (10) | 37-31 | .544 | Progressive Field · Cleveland, OH |
| 69 | Tue Jun 9 | vs Yankees | L2-3 | 37-32 | .536 | Progressive Field · Cleveland, OH |
| 70 | Wed Jun 10 | vs Yankees | L4-8 | 37-33 | .529 | Progressive Field · Cleveland, OH |
| 71 | Fri Jun 12 | vs Tigers | W3-2 | 38-33 | .535 | Progressive Field · Cleveland, OH |
| 72 | Sat Jun 13 | vs Tigers | W3-1 | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 73 | Tue Jun 16 | at Brewers | L1-2 | 39-34 | .534 | American Family Field · Milwaukee, WI |
| 74 | Wed Jun 17 | at Brewers | L4-9 | 39-35 | .527 | American Family Field · Milwaukee, WI |
| 75 | Thu Jun 18 | at Brewers | W4-2 | 40-35 | .533 | American Family Field · Milwaukee, WI |
| 76 | Fri Jun 19 | at Astros | L3-9 | 40-36 | .526 | Minute Maid Park · Houston, TX |
| 77 | Sat Jun 20 | at Astros | W8-1 | 41-36 | .532 | Minute Maid Park · Houston, TX |
| 78 | Sun Jun 21 | at Astros | L1-2 | 41-37 | .526 | Minute Maid Park · Houston, TX |
| 79 | Mon Jun 22 | at White Sox | L5-6 | 41-38 | .519 | Guaranteed Rate Field · Chicago, IL |
| 80 | Tue Jun 23 | at White Sox | L1-2 | 41-39 | .512 | Guaranteed Rate Field · Chicago, IL |
| 81 | Wed Jun 24 | at White Sox | W4-3 (10) | 42-39 | .519 | Guaranteed Rate Field · Chicago, IL |
| 82 | Fri Jun 26 | vs Mariners | L1-3 | 42-40 | .512 | Progressive Field · Cleveland, OH |
| 83 | Sat Jun 27 | vs Mariners | W4-3 | 43-40 | .518 | Progressive Field · Cleveland, OH |
| 84 | Sun Jun 28 | vs Mariners | W6-5 | 44-40 | .524 | Progressive Field · Cleveland, OH |
| 85 | Mon Jun 29 | vs Rangers | L3-6 | 44-41 | .518 | Progressive Field · Cleveland, OH |
| 86 | Tue Jun 30 | vs Rangers | L2-4 | 44-42 | .512 | Progressive Field · Cleveland, OH |
| 87 | Wed Jul 1 | vs Rangers | W9-4 | 45-42 | .517 | Progressive Field · Cleveland, OH |
| 88 | Thu Jul 2 | vs White Sox | W6-5 | 46-42 | .523 | Progressive Field · Cleveland, OH |
| 89 | Fri Jul 3 | vs White Sox | W4-3 (10) | 47-42 | .528 | Progressive Field · Cleveland, OH |
| 90 | Sat Jul 4 | vs White Sox | L1-3 | 47-43 | .522 | Progressive Field · Cleveland, OH |
| 91 | Sun Jul 5 | vs White Sox | L6-7 | 47-44 | .516 | Progressive Field · Cleveland, OH |
| 92 | Tue Jul 7 | at Twins | L1-3 | 47-45 | .511 | Target Field · Minneapolis, MN |
| 93 | Wed Jul 8 | at Twins | L5-6 | 47-46 | .505 | Target Field · Minneapolis, MN |
| 94 | Thu Jul 9 | at Twins | W5-2 | 48-46 | .511 | Target Field · Minneapolis, MN |
| 95 | Fri Jul 10 | at Marlins | W3-2 | 49-46 | .516 | LoanDepot Park · Miami, FL |
| 96 | Sat Jul 11 | at Marlins | W4-1 | 50-46 | .521 | LoanDepot Park · Miami, FL |
| 97 | Sun Jul 12 | at Marlins | W5-2 | 51-46 | .526 | LoanDepot Park · Miami, FL |