| 1 | Mon Apr 3 | at Rangers | W8-5 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 2 | Tue Apr 4 | at Rangers | W4-3 | 2-0 | 1.000 | Globe Life Field · Arlington, TX |
| 3 | Wed Apr 5 | at Rangers | W9-6 | 3-0 | 1.000 | Globe Life Field · Arlington, TX |
| 4 | Fri Apr 7 | at D-backs | L3-7 | 3-1 | .750 | Chase Field · Phoenix, AZ |
| 5 | Sat Apr 8 | at D-backs | L2-11 | 3-2 | .600 | Chase Field · Phoenix, AZ |
| 6 | Sun Apr 9 | at D-backs | L2-3 | 3-3 | .500 | Chase Field · Phoenix, AZ |
| 7 | Tue Apr 11 | vs White Sox | W2-1 (10) | 4-3 | .571 | Progressive Field · Cleveland, OH |
| 8 | Wed Apr 12 | vs White Sox | L1-2 | 4-4 | .500 | Progressive Field · Cleveland, OH |
| 9 | Thu Apr 13 | vs White Sox | L4-10 | 4-5 | .444 | Progressive Field · Cleveland, OH |
| 10 | Fri Apr 14 | vs Tigers | L6-7 | 4-6 | .400 | Progressive Field · Cleveland, OH |
| 11 | Sat Apr 15 | vs Tigers | W13-6 | 5-6 | .455 | Progressive Field · Cleveland, OH |
| 12 | Sun Apr 16 | vs Tigers | L1-4 | 5-7 | .417 | Progressive Field · Cleveland, OH |
| 13 | Mon Apr 17 | at Twins | W3-1 | 6-7 | .462 | Target Field · Minneapolis, MN |
| 14 | Tue Apr 18 | at Twins | W11-4 | 7-7 | .500 | Target Field · Minneapolis, MN |
| 15 | Thu Apr 20 | at Twins | W6-2 | 8-7 | .533 | Target Field · Minneapolis, MN |
| 16 | Fri Apr 21 | at White Sox | W3-0 | 9-7 | .563 | Guaranteed Rate Field · Chicago, IL |
| 17 | Sat Apr 22 | at White Sox | W7-0 | 10-7 | .588 | Guaranteed Rate Field · Chicago, IL |
| 18 | Sun Apr 23 | at White Sox | L2-6 | 10-8 | .556 | Guaranteed Rate Field · Chicago, IL |
| 19 | Tue Apr 25 | vs Astros | L2-4 | 10-9 | .526 | Progressive Field · Cleveland, OH |
| 20 | Wed Apr 26 | vs Astros | W7-6 | 11-9 | .550 | Progressive Field · Cleveland, OH |
| 21 | Thu Apr 27 | vs Astros | W4-3 | 12-9 | .571 | Progressive Field · Cleveland, OH |
| 22 | Fri Apr 28 | vs Mariners | L1-3 | 12-10 | .545 | Progressive Field · Cleveland, OH |
| 23 | Sat Apr 29 | vs Mariners | W4-3 | 13-10 | .565 | Progressive Field · Cleveland, OH |
| 24 | Sun Apr 30 | vs Mariners | W12-4 | 14-10 | .583 | Progressive Field · Cleveland, OH |
| 25 | Mon May 1 | at Tigers | L1-7 | 14-11 | .560 | Comerica Park · Detroit, MI |
| 26 | Tue May 2 | at Tigers | L2-5 | 14-12 | .538 | Comerica Park · Detroit, MI |
| 27 | Wed May 3 | at Tigers | W3-2 | 15-12 | .556 | Comerica Park · Detroit, MI |
| 28 | Fri May 5 | at Royals | L1-3 | 15-13 | .536 | Kauffman Stadium · Kansas City, MO |
| 29 | Sat May 6 | at Royals | W3-1 | 16-13 | .552 | Kauffman Stadium · Kansas City, MO |
| 30 | Sun May 7 | at Royals | W1-0 | 17-13 | .567 | Kauffman Stadium · Kansas City, MO |
| 31 | Mon May 8 | at Blue Jays | L2-4 | 17-14 | .548 | Rogers Centre · Toronto, ON |
| 32 | Tue May 9 | at Blue Jays | W6-0 | 18-14 | .563 | Rogers Centre · Toronto, ON |
| 33 | Wed May 10 | at Blue Jays | L7-8 | 18-15 | .545 | Rogers Centre · Toronto, ON |
| 34 | Fri May 12 | vs Twins | L0-1 | 18-16 | .529 | Progressive Field · Cleveland, OH |
| 35 | Sat May 13 | vs Twins | L1-4 | 18-17 | .514 | Progressive Field · Cleveland, OH |
| 36 | Sun May 14 | vs Twins | W8-3 | 19-17 | .528 | Progressive Field · Cleveland, OH |
| 37 | Mon May 15 | vs Rays | W8-7 | 20-17 | .541 | Progressive Field · Cleveland, OH |
| 38 | Tue May 16 | vs Rays | L4-6 | 20-18 | .526 | Progressive Field · Cleveland, OH |
| 39 | Wed May 17 | vs Rays | L4-7 | 20-19 | .513 | Progressive Field · Cleveland, OH |
| 40 | Fri May 19 | at Astros | W5-3 | 21-19 | .525 | Minute Maid Park · Houston, TX |
| 41 | Sat May 20 | at Astros | W3-0 | 22-19 | .537 | Minute Maid Park · Houston, TX |
| 42 | Sun May 21 | at Astros | W8-6 | 23-19 | .548 | Minute Maid Park · Houston, TX |
| 43 | Mon May 22 | at Reds | L1-5 | 23-20 | .535 | Great American Ball Park · Cincinnati, OH |
| 44 | Tue May 23 | at Reds | W8-7 | 24-20 | .545 | Great American Ball Park · Cincinnati, OH |
| 45 | Wed May 24 | vs Reds | L3-4 | 24-21 | .533 | Progressive Field · Cleveland, OH |
| 46 | Fri May 26 | vs Royals | L4-6 | 24-22 | .522 | Progressive Field · Cleveland, OH |
| 47 | Sat May 27 | vs Royals | L2-5 | 24-23 | .511 | Progressive Field · Cleveland, OH |
| 48 | Sun May 28 | vs Royals | W10-1 | 25-23 | .521 | Progressive Field · Cleveland, OH |
| 49 | Mon May 29 | vs Athletics | W5-3 | 26-23 | .531 | Progressive Field · Cleveland, OH |
| 50 | Tue May 30 | vs Athletics | W9-4 | 27-23 | .540 | Progressive Field · Cleveland, OH |
| 51 | Wed May 31 | vs Athletics | L1-3 | 27-24 | .529 | Progressive Field · Cleveland, OH |
| 52 | Thu Jun 1 | vs Athletics | W8-0 | 28-24 | .538 | Progressive Field · Cleveland, OH |
| 53 | Fri Jun 2 | at Royals | L0-4 | 28-25 | .528 | Kauffman Stadium · Kansas City, MO |
| 54 | Sat Jun 3 | at Royals | L5-12 | 28-26 | .519 | Kauffman Stadium · Kansas City, MO |
| 55 | Sun Jun 4 | at Royals | W8-0 | 29-26 | .527 | Kauffman Stadium · Kansas City, MO |
| 56 | Tue Jun 6 | at Rockies | L3-11 | 29-27 | .518 | Coors Field · Denver, CO |
| 57 | Wed Jun 7 | at Rockies | L1-8 | 29-28 | .509 | Coors Field · Denver, CO |
| 58 | Fri Jun 9 | vs White Sox | W7-3 | 30-28 | .517 | Progressive Field · Cleveland, OH |
| 59 | Sat Jun 10 | vs White Sox | L3-5 | 30-29 | .508 | Progressive Field · Cleveland, OH |
| 60 | Sun Jun 11 | vs White Sox | W4-2 | 31-29 | .517 | Progressive Field · Cleveland, OH |
| 61 | Tue Jun 13 | vs Dodgers | L5-7 | 31-30 | .508 | Progressive Field · Cleveland, OH |
| 62 | Wed Jun 14 | vs Dodgers | L4-6 | 31-31 | .500 | Progressive Field · Cleveland, OH |
| 63 | Thu Jun 15 | vs Dodgers | W12-5 | 32-31 | .508 | Progressive Field · Cleveland, OH |
| 64 | Fri Jun 16 | at Twins | W8-1 | 33-31 | .516 | Target Field · Minneapolis, MN |
| 65 | Sat Jun 17 | at Twins | W9-3 | 34-31 | .523 | Target Field · Minneapolis, MN |
| 66 | Sat Jun 17 | at Twins | W6-2 | 35-31 | .530 | Target Field · Minneapolis, MN |
| 67 | Sun Jun 18 | at Twins | W5-2 | 36-31 | .537 | Target Field · Minneapolis, MN |
| 68 | Mon Jun 19 | at Orioles | W12-0 | 37-31 | .544 | Camden Yards · Baltimore, MD |
| 69 | Tue Jun 20 | at Orioles | L5-6 | 37-32 | .536 | Camden Yards · Baltimore, MD |
| 70 | Wed Jun 21 | at Orioles | W5-1 | 38-32 | .543 | Camden Yards · Baltimore, MD |
| 71 | Thu Jun 22 | at Orioles | W6-3 | 39-32 | .549 | Camden Yards · Baltimore, MD |
| 72 | Fri Jun 23 | vs Twins | L0-5 | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 73 | Sat Jun 24 | vs Twins | L2-4 | 39-34 | .534 | Progressive Field · Cleveland, OH |
| 74 | Sun Jun 25 | vs Twins | L0-4 | 39-35 | .527 | Progressive Field · Cleveland, OH |
| 75 | Mon Jun 26 | vs Rangers | W15-9 | 40-35 | .533 | Progressive Field · Cleveland, OH |
| 76 | Tue Jun 27 | vs Rangers | L1-2 | 40-36 | .526 | Progressive Field · Cleveland, OH |
| 77 | Wed Jun 28 | vs Rangers | W5-3 | 41-36 | .532 | Progressive Field · Cleveland, OH |
| 78 | Thu Jun 29 | vs Rangers | W5-1 | 42-36 | .538 | Progressive Field · Cleveland, OH |
| 79 | Sat Jul 1 | at Tigers | L4-7 | 42-37 | .532 | Comerica Park · Detroit, MI |
| 80 | Sat Jul 1 | at Tigers | W4-1 | 43-37 | .537 | Comerica Park · Detroit, MI |
| 81 | Sun Jul 2 | at Tigers | W11-8 | 44-37 | .543 | Comerica Park · Detroit, MI |
| 82 | Tue Jul 4 | vs Padres | L0-1 | 44-38 | .537 | Progressive Field · Cleveland, OH |
| 83 | Wed Jul 5 | vs Padres | L2-6 | 44-39 | .530 | Progressive Field · Cleveland, OH |
| 84 | Thu Jul 6 | vs Padres | W11-2 | 45-39 | .536 | Progressive Field · Cleveland, OH |
| 85 | Fri Jul 7 | vs Tigers | W11-2 | 46-39 | .541 | Progressive Field · Cleveland, OH |
| 86 | Sat Jul 8 | vs Tigers | W4-0 | 47-39 | .547 | Progressive Field · Cleveland, OH |
| 87 | Sun Jul 9 | vs Tigers | L3-5 | 47-40 | .540 | Progressive Field · Cleveland, OH |
| 88 | Fri Jul 14 | at Athletics | L0-5 | 47-41 | .534 | RingCentral Coliseum · Oakland, CA |
| 89 | Sat Jul 15 | at Athletics | L3-5 | 47-42 | .528 | RingCentral Coliseum · Oakland, CA |
| 90 | Sun Jul 16 | at Athletics | L3-7 | 47-43 | .522 | RingCentral Coliseum · Oakland, CA |
| 91 | Mon Jul 17 | at Giants | W5-3 | 48-43 | .527 | Oracle Park · San Francisco, CA |
| 92 | Tue Jul 18 | at Giants | L1-2 (10) | 48-44 | .522 | Oracle Park · San Francisco, CA |
| 93 | Wed Jul 19 | at Giants | L4-5 | 48-45 | .516 | Oracle Park · San Francisco, CA |
| 94 | Fri Jul 21 | vs Blue Jays | W13-3 | 49-45 | .521 | Progressive Field · Cleveland, OH |
| 95 | Sat Jul 22 | vs Blue Jays | W2-1 (10) | 50-45 | .526 | Progressive Field · Cleveland, OH |
| 96 | Sun Jul 23 | vs Blue Jays | W8-1 | 51-45 | .531 | Progressive Field · Cleveland, OH |
| 97 | Mon Jul 24 | vs Reds | W6-2 | 52-45 | .536 | Progressive Field · Cleveland, OH |
| 98 | Tue Jul 25 | vs Angels | W11-7 (11) | 53-45 | .541 | Progressive Field · Cleveland, OH |
| 99 | Wed Jul 26 | vs Angels | W10-4 | 54-45 | .545 | Progressive Field · Cleveland, OH |
| 100 | Thu Jul 27 | vs Angels | W2-1 | 55-45 | .550 | Progressive Field · Cleveland, OH |
| 101 | Fri Jul 28 | at White Sox | W9-3 | 56-45 | .554 | Guaranteed Rate Field · Chicago, IL |
| 102 | Sat Jul 29 | at White Sox | W5-4 | 57-45 | .559 | Guaranteed Rate Field · Chicago, IL |
| 103 | Sun Jul 30 | at White Sox | L1-3 | 57-46 | .553 | Guaranteed Rate Field · Chicago, IL |
| 104 | Mon Jul 31 | at Red Sox | L2-6 | 57-47 | .548 | Fenway Park · Boston, MA |
| 105 | Tue Aug 1 | at Red Sox | L10-12 | 57-48 | .543 | Fenway Park · Boston, MA |
| 106 | Thu Aug 3 | vs Yankees | W5-1 | 58-48 | .547 | Progressive Field · Cleveland, OH |
| 107 | Fri Aug 4 | vs Yankees | W7-2 | 59-48 | .551 | Progressive Field · Cleveland, OH |
| 108 | Sat Aug 5 | vs Yankees | L1-2 | 59-49 | .546 | Progressive Field · Cleveland, OH |
| 109 | Sun Aug 6 | vs Yankees | L1-8 | 59-50 | .541 | Progressive Field · Cleveland, OH |
| 110 | Tue Aug 8 | vs Rockies | W4-1 | 60-50 | .545 | Progressive Field · Cleveland, OH |
| 111 | Wed Aug 9 | vs Rockies | L2-3 (12) | 60-51 | .541 | Progressive Field · Cleveland, OH |
| 112 | Thu Aug 10 | at Rays | L1-4 | 60-52 | .536 | Tropicana Field · St. Petersburg, FL |
| 113 | Fri Aug 11 | at Rays | W5-0 | 61-52 | .540 | Tropicana Field · St. Petersburg, FL |
| 114 | Sat Aug 12 | at Rays | W3-0 | 62-52 | .544 | Tropicana Field · St. Petersburg, FL |
| 115 | Sun Aug 13 | at Rays | W4-3 | 63-52 | .548 | Tropicana Field · St. Petersburg, FL |
| 116 | Mon Aug 14 | at Red Sox | W7-3 | 64-52 | .552 | Fenway Park · Boston, MA |
| 117 | Tue Aug 15 | at Twins | W8-1 | 65-52 | .556 | Target Field · Minneapolis, MN |
| 118 | Thu Aug 17 | at Twins | W9-3 | 66-52 | .559 | Target Field · Minneapolis, MN |
| 119 | Thu Aug 17 | at Twins | L2-4 | 66-53 | .555 | Target Field · Minneapolis, MN |
| 120 | Fri Aug 18 | at Royals | W10-1 | 67-53 | .558 | Kauffman Stadium · Kansas City, MO |
| 121 | Sat Aug 19 | at Royals | W5-0 | 68-53 | .562 | Kauffman Stadium · Kansas City, MO |
| 122 | Sun Aug 20 | at Royals | L4-7 | 68-54 | .557 | Kauffman Stadium · Kansas City, MO |
| 123 | Mon Aug 21 | vs Red Sox | W5-4 | 69-54 | .561 | Progressive Field · Cleveland, OH |
| 124 | Tue Aug 22 | vs Red Sox | L1-9 | 69-55 | .556 | Progressive Field · Cleveland, OH |
| 125 | Wed Aug 23 | vs Red Sox | L1-6 | 69-56 | .552 | Progressive Field · Cleveland, OH |
| 126 | Thu Aug 24 | vs Red Sox | W13-6 | 70-56 | .556 | Progressive Field · Cleveland, OH |
| 127 | Fri Aug 25 | vs Royals | W4-0 | 71-56 | .559 | Progressive Field · Cleveland, OH |
| 128 | Sat Aug 26 | vs Royals | W4-0 | 72-56 | .563 | Progressive Field · Cleveland, OH |
| 129 | Sun Aug 27 | vs Royals | W12-0 | 73-56 | .566 | Progressive Field · Cleveland, OH |
| 130 | Mon Aug 28 | at Yankees | W6-2 | 74-56 | .569 | Yankee Stadium · The Bronx, NY |
| 131 | Wed Aug 30 | at Yankees | W2-1 | 75-56 | .573 | Yankee Stadium · The Bronx, NY |
| 132 | Wed Aug 30 | at Yankees | W9-4 | 76-56 | .576 | Yankee Stadium · The Bronx, NY |
| 133 | Fri Sep 1 | at Tigers | W3-2 | 77-56 | .579 | Comerica Park · Detroit, MI |
| 134 | Fri Sep 1 | at Tigers | W10-0 | 78-56 | .582 | Comerica Park · Detroit, MI |
| 135 | Sat Sep 2 | at Tigers | W5-2 | 79-56 | .585 | Comerica Park · Detroit, MI |
| 136 | Sun Sep 3 | at Tigers | W11-1 | 80-56 | .588 | Comerica Park · Detroit, MI |
| 137 | Mon Sep 4 | at White Sox | W5-3 | 81-56 | .591 | Guaranteed Rate Field · Chicago, IL |
| 138 | Tue Sep 5 | at White Sox | W9-4 | 82-56 | .594 | Guaranteed Rate Field · Chicago, IL |
| 139 | Wed Sep 6 | at White Sox | W5-1 | 83-56 | .597 | Guaranteed Rate Field · Chicago, IL |
| 140 | Thu Sep 7 | at White Sox | W11-2 | 84-56 | .600 | Guaranteed Rate Field · Chicago, IL |
| 141 | Fri Sep 8 | vs Orioles | W5-0 | 85-56 | .603 | Progressive Field · Cleveland, OH |
| 142 | Sat Sep 9 | vs Orioles | W4-2 | 86-56 | .606 | Progressive Field · Cleveland, OH |
| 143 | Sun Sep 10 | vs Orioles | W3-2 | 87-56 | .608 | Progressive Field · Cleveland, OH |
| 144 | Mon Sep 11 | vs Tigers | W11-0 | 88-56 | .611 | Progressive Field · Cleveland, OH |
| 145 | Tue Sep 12 | vs Tigers | W2-0 | 89-56 | .614 | Progressive Field · Cleveland, OH |
| 146 | Wed Sep 13 | vs Tigers | W5-3 | 90-56 | .616 | Progressive Field · Cleveland, OH |
| 147 | Thu Sep 14 | vs Royals | W3-2 (10) | 91-56 | .619 | Progressive Field · Cleveland, OH |
| 148 | Fri Sep 15 | vs Royals | L3-4 | 91-57 | .615 | Progressive Field · Cleveland, OH |
| 149 | Sat Sep 16 | vs Royals | W8-4 | 92-57 | .617 | Progressive Field · Cleveland, OH |
| 150 | Sun Sep 17 | vs Royals | W3-2 | 93-57 | .620 | Progressive Field · Cleveland, OH |
| 151 | Tue Sep 19 | at Angels | W6-3 | 94-57 | .623 | Angel Stadium · Anaheim, CA |
| 152 | Wed Sep 20 | at Angels | W6-5 | 95-57 | .625 | Angel Stadium · Anaheim, CA |
| 153 | Thu Sep 21 | at Angels | W4-1 | 96-57 | .627 | Angel Stadium · Anaheim, CA |
| 154 | Fri Sep 22 | at Mariners | L1-3 | 96-58 | .623 | T-Mobile Park · Seattle, WA |
| 155 | Sat Sep 23 | at Mariners | W11-4 | 97-58 | .626 | T-Mobile Park · Seattle, WA |
| 156 | Sun Sep 24 | at Mariners | W4-2 | 98-58 | .628 | T-Mobile Park · Seattle, WA |
| 157 | Tue Sep 26 | vs Twins | L6-8 | 98-59 | .624 | Progressive Field · Cleveland, OH |
| 158 | Wed Sep 27 | vs Twins | W4-2 | 99-59 | .627 | Progressive Field · Cleveland, OH |
| 159 | Thu Sep 28 | vs Twins | W5-2 | 100-59 | .629 | Progressive Field · Cleveland, OH |
| 160 | Fri Sep 29 | vs White Sox | W10-1 | 101-59 | .631 | Progressive Field · Cleveland, OH |
| 161 | Sat Sep 30 | vs White Sox | L1-2 | 101-60 | .627 | Progressive Field · Cleveland, OH |
| 162 | Sun Oct 1 | vs White Sox | W3-1 | 102-60 | .630 | Progressive Field · Cleveland, OH |
| 163 | Thu Oct 5 | vs Yankees | W4-0 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 164 | Fri Oct 6 | vs Yankees | W9-8 (13) | 2-0 | 1.000 | Progressive Field · Cleveland, OH |
| 165 | Sun Oct 8 | at Yankees | L0-1 | 2-1 | .667 | Yankee Stadium · The Bronx, NY |
| 166 | Mon Oct 9 | at Yankees | L3-7 | 2-2 | .500 | Yankee Stadium · The Bronx, NY |
| 167 | Wed Oct 11 | vs Yankees | L2-5 | 2-3 | .400 | Progressive Field · Cleveland, OH |