| 1 | Fri Apr 1 | vs White Sox | L10-15 | 0-1 | .000 | Progressive Field · Cleveland, OH |
| 2 | Sat Apr 2 | vs White Sox | L3-8 | 0-2 | .000 | Progressive Field · Cleveland, OH |
| 3 | Sun Apr 3 | vs White Sox | W7-1 | 1-2 | .333 | Progressive Field · Cleveland, OH |
| 4 | Tue Apr 5 | vs Red Sox | W3-1 | 2-2 | .500 | Progressive Field · Cleveland, OH |
| 5 | Wed Apr 6 | vs Red Sox | W8-4 | 3-2 | .600 | Progressive Field · Cleveland, OH |
| 6 | Thu Apr 7 | vs Red Sox | W1-0 | 4-2 | .667 | Progressive Field · Cleveland, OH |
| 7 | Fri Apr 8 | at Mariners | W12-3 | 5-2 | .714 | T-Mobile Park · Seattle, WA |
| 8 | Sat Apr 9 | at Mariners | W2-1 | 6-2 | .750 | T-Mobile Park · Seattle, WA |
| 9 | Sun Apr 10 | at Mariners | W6-4 | 7-2 | .778 | T-Mobile Park · Seattle, WA |
| 10 | Mon Apr 11 | at Angels | W4-0 | 8-2 | .800 | Angel Stadium · Anaheim, CA |
| 11 | Tue Apr 12 | at Angels | L0-2 | 8-3 | .727 | Angel Stadium · Anaheim, CA |
| 12 | Wed Apr 13 | at Angels | L3-4 (12) | 8-4 | .667 | Angel Stadium · Anaheim, CA |
| 13 | Fri Apr 15 | vs Orioles | W8-2 | 9-4 | .692 | Progressive Field · Cleveland, OH |
| 14 | Sat Apr 16 | vs Orioles | W8-3 | 10-4 | .714 | Progressive Field · Cleveland, OH |
| 15 | Sun Apr 17 | vs Orioles | W4-2 | 11-4 | .733 | Progressive Field · Cleveland, OH |
| 16 | Mon Apr 18 | at Royals | W7-3 (10) | 12-4 | .750 | Kauffman Stadium · Kansas City, MO |
| 17 | Tue Apr 19 | at Royals | L4-5 | 12-5 | .706 | Kauffman Stadium · Kansas City, MO |
| 18 | Wed Apr 20 | at Royals | W7-5 | 13-5 | .722 | Kauffman Stadium · Kansas City, MO |
| 19 | Thu Apr 21 | at Royals | L2-3 | 13-6 | .684 | Kauffman Stadium · Kansas City, MO |
| 20 | Sat Apr 23 | at Twins | L3-10 | 13-7 | .650 | Target Field · Minneapolis, MN |
| 21 | Sun Apr 24 | at Twins | L3-4 | 13-8 | .619 | Target Field · Minneapolis, MN |
| 22 | Tue Apr 26 | vs Royals | W9-4 | 14-8 | .636 | Progressive Field · Cleveland, OH |
| 23 | Wed Apr 27 | vs Royals | W7-2 | 15-8 | .652 | Progressive Field · Cleveland, OH |
| 24 | Thu Apr 28 | vs Royals | W8-2 | 16-8 | .667 | Progressive Field · Cleveland, OH |
| 25 | Fri Apr 29 | vs Tigers | W9-5 | 17-8 | .680 | Progressive Field · Cleveland, OH |
| 26 | Sat Apr 30 | vs Tigers | W3-2 (13) | 18-8 | .692 | Progressive Field · Cleveland, OH |
| 27 | Sun May 1 | vs Tigers | W5-4 | 19-8 | .704 | Progressive Field · Cleveland, OH |
| 28 | Tue May 3 | at Athletics | W4-1 | 20-8 | .714 | RingCentral Coliseum · Oakland, CA |
| 29 | Wed May 4 | at Athletics | L1-3 | 20-9 | .690 | RingCentral Coliseum · Oakland, CA |
| 30 | Thu May 5 | at Athletics | W4-3 (12) | 21-9 | .700 | RingCentral Coliseum · Oakland, CA |
| 31 | Fri May 6 | at Angels | L1-2 (11) | 21-10 | .677 | Angel Stadium · Anaheim, CA |
| 32 | Sat May 7 | at Angels | W4-3 | 22-10 | .688 | Angel Stadium · Anaheim, CA |
| 33 | Sun May 8 | at Angels | L5-6 | 22-11 | .667 | Angel Stadium · Anaheim, CA |
| 34 | Tue May 10 | vs Rays | W5-4 | 23-11 | .676 | Progressive Field · Cleveland, OH |
| 35 | Wed May 11 | vs Rays | L2-8 | 23-12 | .657 | Progressive Field · Cleveland, OH |
| 36 | Thu May 12 | vs Rays | L4-7 | 23-13 | .639 | Progressive Field · Cleveland, OH |
| 37 | Fri May 13 | vs Mariners | W5-4 | 24-13 | .649 | Progressive Field · Cleveland, OH |
| 38 | Mon May 16 | at Royals | W19-1 | 25-13 | .658 | Kauffman Stadium · Kansas City, MO |
| 39 | Tue May 17 | at Royals | W7-3 | 26-13 | .667 | Kauffman Stadium · Kansas City, MO |
| 40 | Wed May 18 | at White Sox | L0-1 | 26-14 | .650 | Guaranteed Rate Field · Chicago, IL |
| 41 | Thu May 19 | at White Sox | L2-8 | 26-15 | .634 | Guaranteed Rate Field · Chicago, IL |
| 42 | Fri May 20 | vs Reds | W5-4 | 27-15 | .643 | Progressive Field · Cleveland, OH |
| 43 | Sat May 21 | vs Reds | W2-1 | 28-15 | .651 | Progressive Field · Cleveland, OH |
| 44 | Sun May 22 | vs Reds | W12-4 | 29-15 | .659 | Progressive Field · Cleveland, OH |
| 45 | Mon May 23 | vs Red Sox | W3-2 | 30-15 | .667 | Progressive Field · Cleveland, OH |
| 46 | Tue May 24 | vs Red Sox | L2-4 | 30-16 | .652 | Progressive Field · Cleveland, OH |
| 47 | Wed May 25 | vs Red Sox | L2-14 | 30-17 | .638 | Progressive Field · Cleveland, OH |
| 48 | Fri May 27 | at Rays | L0-5 | 30-18 | .625 | Tropicana Field · St. Petersburg, FL |
| 49 | Sat May 28 | at Rays | W7-3 | 31-18 | .633 | Tropicana Field · St. Petersburg, FL |
| 50 | Sun May 29 | at Rays | L0-7 | 31-19 | .620 | Tropicana Field · St. Petersburg, FL |
| 51 | Mon May 30 | at Blue Jays | L1-11 | 31-20 | .608 | Rogers Centre · Toronto, ON |
| 52 | Tue May 31 | at Blue Jays | W6-3 | 32-20 | .615 | Rogers Centre · Toronto, ON |
| 53 | Wed Jun 1 | at Blue Jays | W13-9 | 33-20 | .623 | Rogers Centre · Toronto, ON |
| 54 | Thu Jun 2 | vs Rangers | L4-7 | 33-21 | .611 | Progressive Field · Cleveland, OH |
| 55 | Fri Jun 3 | vs Rangers | L2-11 | 33-22 | .600 | Progressive Field · Cleveland, OH |
| 56 | Sat Jun 4 | vs Rangers | L0-4 | 33-23 | .589 | Progressive Field · Cleveland, OH |
| 57 | Sun Jun 5 | vs Rangers | L0-2 | 33-24 | .579 | Progressive Field · Cleveland, OH |
| 58 | Mon Jun 6 | vs Twins | L4-6 | 33-25 | .569 | Progressive Field · Cleveland, OH |
| 59 | Tue Jun 7 | vs Twins | W1-0 | 34-25 | .576 | Progressive Field · Cleveland, OH |
| 60 | Wed Jun 8 | vs Twins | L2-3 (10) | 34-26 | .567 | Progressive Field · Cleveland, OH |
| 61 | Fri Jun 10 | at Yankees | L7-11 | 34-27 | .557 | Yankee Stadium · The Bronx, NY |
| 62 | Sat Jun 11 | at Yankees | L0-4 | 34-28 | .548 | Yankee Stadium · The Bronx, NY |
| 63 | Sun Jun 12 | at Yankees | L1-9 | 34-29 | .540 | Yankee Stadium · The Bronx, NY |
| 64 | Mon Jun 13 | at Yankees | W1-0 | 35-29 | .547 | Yankee Stadium · The Bronx, NY |
| 65 | Tue Jun 14 | at Tigers | L0-4 | 35-30 | .538 | Comerica Park · Detroit, MI |
| 66 | Wed Jun 15 | at Tigers | W6-4 | 36-30 | .545 | Comerica Park · Detroit, MI |
| 67 | Thu Jun 16 | at Tigers | L2-6 | 36-31 | .537 | Comerica Park · Detroit, MI |
| 68 | Fri Jun 17 | vs Pirates | W5-1 | 37-31 | .544 | Progressive Field · Cleveland, OH |
| 69 | Sat Jun 18 | vs Pirates | W5-1 | 38-31 | .551 | Progressive Field · Cleveland, OH |
| 70 | Sun Jun 19 | vs Pirates | W5-2 (11) | 39-31 | .557 | Progressive Field · Cleveland, OH |
| 71 | Mon Jun 20 | vs Rockies | L7-8 | 39-32 | .549 | Progressive Field · Cleveland, OH |
| 72 | Tue Jun 21 | vs Rockies | L3-4 | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 73 | Wed Jun 22 | vs Rockies | W4-3 | 40-33 | .548 | Progressive Field · Cleveland, OH |
| 74 | Fri Jun 24 | at Giants | L3-4 | 40-34 | .541 | Oracle Park · San Francisco, CA |
| 75 | Sat Jun 25 | at Giants | L0-1 | 40-35 | .533 | Oracle Park · San Francisco, CA |
| 76 | Sun Jun 26 | at Giants | L1-3 | 40-36 | .526 | Oracle Park · San Francisco, CA |
| 77 | Mon Jun 27 | at D-backs | W5-4 | 41-36 | .532 | Chase Field · Phoenix, AZ |
| 78 | Tue Jun 28 | at D-backs | L4-6 | 41-37 | .526 | Chase Field · Phoenix, AZ |
| 79 | Wed Jun 29 | at D-backs | W6-2 | 42-37 | .532 | Chase Field · Phoenix, AZ |
| 80 | Fri Jul 1 | at Reds | W8-2 | 43-37 | .537 | Great American Ball Park · Cincinnati, OH |
| 81 | Sat Jul 2 | at Reds | W3-1 | 44-37 | .543 | Great American Ball Park · Cincinnati, OH |
| 82 | Sun Jul 3 | at Reds | L5-7 | 44-38 | .537 | Great American Ball Park · Cincinnati, OH |
| 83 | Mon Jul 4 | vs Yankees | W6-3 | 45-38 | .542 | Progressive Field · Cleveland, OH |
| 84 | Tue Jul 5 | vs Yankees | L2-9 | 45-39 | .536 | Progressive Field · Cleveland, OH |
| 85 | Wed Jul 6 | vs Yankees | W5-3 | 46-39 | .541 | Progressive Field · Cleveland, OH |
| 86 | Thu Jul 7 | vs Blue Jays | W5-4 | 47-39 | .547 | Progressive Field · Cleveland, OH |
| 87 | Fri Jul 8 | vs Blue Jays | L7-11 | 47-40 | .540 | Progressive Field · Cleveland, OH |
| 88 | Sat Jul 9 | vs Blue Jays | L4-5 (10) | 47-41 | .534 | Progressive Field · Cleveland, OH |
| 89 | Sun Jul 10 | vs Blue Jays | L1-7 | 47-42 | .528 | Progressive Field · Cleveland, OH |
| 90 | Thu Jul 14 | at Orioles | W8-4 | 48-42 | .533 | Camden Yards · Baltimore, MD |
| 91 | Fri Jul 15 | at Orioles | W6-5 | 49-42 | .538 | Camden Yards · Baltimore, MD |
| 92 | Sat Jul 16 | at Orioles | L5-6 | 49-43 | .533 | Camden Yards · Baltimore, MD |
| 93 | Sun Jul 17 | at Orioles | L3-8 | 49-44 | .527 | Camden Yards · Baltimore, MD |
| 94 | Mon Jul 18 | at Twins | W5-2 | 50-44 | .532 | Target Field · Minneapolis, MN |
| 95 | Mon Jul 18 | at Twins | W6-3 | 51-44 | .537 | Target Field · Minneapolis, MN |
| 96 | Tue Jul 19 | at Twins | L1-2 | 51-45 | .531 | Target Field · Minneapolis, MN |
| 97 | Wed Jul 20 | at Twins | L5-7 | 51-46 | .526 | Target Field · Minneapolis, MN |
| 98 | Fri Jul 22 | vs White Sox | L0-3 | 51-47 | .520 | Progressive Field · Cleveland, OH |
| 99 | Sun Jul 24 | vs White Sox | L2-4 | 51-48 | .515 | Progressive Field · Cleveland, OH |
| 100 | Mon Jul 25 | vs Angels | W3-2 | 52-48 | .520 | Progressive Field · Cleveland, OH |
| 101 | Tue Jul 26 | vs Angels | L1-2 | 52-49 | .515 | Progressive Field · Cleveland, OH |
| 102 | Wed Jul 27 | vs Angels | L1-3 | 52-50 | .510 | Progressive Field · Cleveland, OH |
| 103 | Fri Jul 29 | vs Royals | L0-12 | 52-51 | .505 | Progressive Field · Cleveland, OH |
| 104 | Sat Jul 30 | vs Royals | W5-2 | 53-51 | .510 | Progressive Field · Cleveland, OH |
| 105 | Sun Jul 31 | vs Royals | L3-5 | 53-52 | .505 | Progressive Field · Cleveland, OH |
| 106 | Mon Aug 1 | at Red Sox | W9-6 | 54-52 | .509 | Fenway Park · Boston, MA |
| 107 | Tue Aug 2 | at Red Sox | L2-3 | 54-53 | .505 | Fenway Park · Boston, MA |
| 108 | Wed Aug 3 | at Red Sox | L3-4 | 54-54 | .500 | Fenway Park · Boston, MA |
| 109 | Thu Aug 4 | at Red Sox | W7-3 | 55-54 | .505 | Fenway Park · Boston, MA |
| 110 | Fri Aug 5 | at Rangers | L7-8 (11) | 55-55 | .500 | Globe Life Field · Arlington, TX |
| 111 | Sat Aug 6 | at Rangers | W7-5 | 56-55 | .505 | Globe Life Field · Arlington, TX |
| 112 | Sun Aug 7 | at Rangers | L3-5 | 56-56 | .500 | Globe Life Field · Arlington, TX |
| 113 | Tue Aug 9 | vs Tigers | W3-2 (14) | 57-56 | .504 | Progressive Field · Cleveland, OH |
| 114 | Wed Aug 10 | vs Tigers | W10-3 | 58-56 | .509 | Progressive Field · Cleveland, OH |
| 115 | Thu Aug 11 | vs Tigers | L3-4 | 58-57 | .504 | Progressive Field · Cleveland, OH |
| 116 | Fri Aug 12 | vs Twins | W3-2 | 59-57 | .509 | Progressive Field · Cleveland, OH |
| 117 | Sat Aug 13 | vs Twins | W3-1 | 60-57 | .513 | Progressive Field · Cleveland, OH |
| 118 | Tue Aug 16 | at White Sox | L7-8 (14) | 60-58 | .508 | Guaranteed Rate Field · Chicago, IL |
| 119 | Wed Aug 17 | at White Sox | W4-1 | 61-58 | .513 | Guaranteed Rate Field · Chicago, IL |
| 120 | Thu Aug 18 | at White Sox | W4-2 | 62-58 | .517 | Guaranteed Rate Field · Chicago, IL |
| 121 | Fri Aug 19 | at Tigers | L1-4 | 62-59 | .512 | Comerica Park · Detroit, MI |
| 122 | Sat Aug 20 | at Tigers | L1-10 | 62-60 | .508 | Comerica Park · Detroit, MI |
| 123 | Sun Aug 21 | at Tigers | L7-8 | 62-61 | .504 | Comerica Park · Detroit, MI |
| 124 | Mon Aug 22 | vs Mariners | L2-3 | 62-62 | .500 | Progressive Field · Cleveland, OH |
| 125 | Tue Aug 23 | vs Mariners | W7-5 | 63-62 | .504 | Progressive Field · Cleveland, OH |
| 126 | Tue Aug 23 | vs Mariners | L7-12 | 63-63 | .500 | Progressive Field · Cleveland, OH |
| 127 | Wed Aug 24 | vs Mariners | L2-9 | 63-64 | .496 | Progressive Field · Cleveland, OH |
| 128 | Fri Aug 26 | vs Royals | W2-1 | 64-64 | .500 | Progressive Field · Cleveland, OH |
| 129 | Sat Aug 27 | vs Royals | W8-7 | 65-64 | .504 | Progressive Field · Cleveland, OH |
| 130 | Sun Aug 28 | vs Royals | L1-2 | 65-65 | .500 | Progressive Field · Cleveland, OH |
| 131 | Mon Aug 29 | vs Athletics | W2-1 | 66-65 | .504 | Progressive Field · Cleveland, OH |
| 132 | Tue Aug 30 | vs Athletics | W6-2 | 67-65 | .508 | Progressive Field · Cleveland, OH |
| 133 | Wed Aug 31 | vs Athletics | W4-3 (16) | 68-65 | .511 | Progressive Field · Cleveland, OH |
| 134 | Thu Sep 1 | vs Athletics | L0-7 | 68-66 | .507 | Progressive Field · Cleveland, OH |
| 135 | Fri Sep 2 | at Royals | W5-4 | 69-66 | .511 | Kauffman Stadium · Kansas City, MO |
| 136 | Sat Sep 3 | at Royals | L1-5 | 69-67 | .507 | Kauffman Stadium · Kansas City, MO |
| 137 | Sun Sep 4 | at Royals | W9-6 | 70-67 | .511 | Kauffman Stadium · Kansas City, MO |
| 138 | Mon Sep 5 | vs Tigers | L2-4 | 70-68 | .507 | Progressive Field · Cleveland, OH |
| 139 | Tue Sep 6 | vs Tigers | L1-10 | 70-69 | .504 | Progressive Field · Cleveland, OH |
| 140 | Wed Sep 7 | vs Tigers | L6-8 | 70-70 | .500 | Progressive Field · Cleveland, OH |
| 141 | Thu Sep 8 | at White Sox | L1-8 | 70-71 | .496 | Guaranteed Rate Field · Chicago, IL |
| 142 | Fri Sep 9 | at White Sox | W8-4 | 71-71 | .500 | Guaranteed Rate Field · Chicago, IL |
| 143 | Sat Sep 10 | at White Sox | L3-7 (10) | 71-72 | .497 | Guaranteed Rate Field · Chicago, IL |
| 144 | Sun Sep 11 | at White Sox | W7-3 | 72-72 | .500 | Guaranteed Rate Field · Chicago, IL |
| 145 | Tue Sep 13 | at Rangers | L4-10 | 72-73 | .497 | Globe Life Field · Arlington, TX |
| 146 | Wed Sep 14 | at Rangers | L1-9 | 72-74 | .493 | Globe Life Field · Arlington, TX |
| 147 | Thu Sep 15 | at Rangers | L4-7 | 72-75 | .490 | Globe Life Field · Arlington, TX |
| 148 | Fri Sep 16 | at Twins | W7-6 | 73-75 | .493 | Target Field · Minneapolis, MN |
| 149 | Sat Sep 17 | at Twins | W10-4 | 74-75 | .497 | Target Field · Minneapolis, MN |
| 150 | Sun Sep 18 | at Twins | W6-5 | 75-75 | .500 | Target Field · Minneapolis, MN |
| 151 | Mon Sep 19 | vs Mariners | L6-12 | 75-76 | .497 | Progressive Field · Cleveland, OH |
| 152 | Tue Sep 20 | vs White Sox | W4-3 | 76-76 | .500 | Progressive Field · Cleveland, OH |
| 153 | Tue Sep 20 | vs White Sox | L4-5 | 76-77 | .497 | Progressive Field · Cleveland, OH |
| 154 | Wed Sep 21 | vs White Sox | L4-8 | 76-78 | .494 | Progressive Field · Cleveland, OH |
| 155 | Thu Sep 22 | vs White Sox | W11-2 | 77-78 | .497 | Progressive Field · Cleveland, OH |
| 156 | Fri Sep 23 | vs Twins | W6-5 | 78-78 | .500 | Progressive Field · Cleveland, OH |
| 157 | Sat Sep 24 | vs Twins | W8-2 | 79-78 | .503 | Progressive Field · Cleveland, OH |
| 158 | Sat Sep 24 | vs Twins | W7-6 | 80-78 | .506 | Progressive Field · Cleveland, OH |
| 159 | Sun Sep 25 | vs Twins | L4-6 (10) | 80-79 | .503 | Progressive Field · Cleveland, OH |
| 160 | Mon Sep 26 | at Tigers | L0-14 | 80-80 | .500 | Comerica Park · Detroit, MI |
| 161 | Tue Sep 27 | at Tigers | L6-9 | 80-81 | .497 | Comerica Park · Detroit, MI |
| 162 | Wed Sep 28 | at Tigers | L4-5 | 80-82 | .494 | Comerica Park · Detroit, MI |