| 1 | Thu Mar 28 | at Twins | L0-2 | 0-1 | .000 | Target Field · Minneapolis, MN |
| 2 | Sat Mar 30 | at Twins | W2-1 | 1-1 | .500 | Target Field · Minneapolis, MN |
| 3 | Sun Mar 31 | at Twins | L3-9 | 1-2 | .333 | Target Field · Minneapolis, MN |
| 4 | Mon Apr 1 | vs White Sox | W5-3 | 2-2 | .500 | Progressive Field · Cleveland, OH |
| 5 | Wed Apr 3 | vs White Sox | L3-8 | 2-3 | .400 | Progressive Field · Cleveland, OH |
| 6 | Thu Apr 4 | vs Blue Jays | W4-1 | 3-3 | .500 | Progressive Field · Cleveland, OH |
| 7 | Fri Apr 5 | vs Blue Jays | W3-2 | 4-3 | .571 | Progressive Field · Cleveland, OH |
| 8 | Sat Apr 6 | vs Blue Jays | W7-2 | 5-3 | .625 | Progressive Field · Cleveland, OH |
| 9 | Sun Apr 7 | vs Blue Jays | W3-1 | 6-3 | .667 | Progressive Field · Cleveland, OH |
| 10 | Tue Apr 9 | at Tigers | W8-2 | 7-3 | .700 | Comerica Park · Detroit, MI |
| 11 | Wed Apr 10 | at Tigers | L1-4 | 7-4 | .636 | Comerica Park · Detroit, MI |
| 12 | Thu Apr 11 | at Tigers | W4-0 | 8-4 | .667 | Comerica Park · Detroit, MI |
| 13 | Fri Apr 12 | at Royals | L1-8 | 8-5 | .615 | Kauffman Stadium · Kansas City, MO |
| 14 | Sat Apr 13 | at Royals | L0-3 | 8-6 | .571 | Kauffman Stadium · Kansas City, MO |
| 15 | Sun Apr 14 | at Royals | L8-9 | 8-7 | .533 | Kauffman Stadium · Kansas City, MO |
| 16 | Mon Apr 15 | at Mariners | W6-4 | 9-7 | .563 | T-Mobile Park · Seattle, WA |
| 17 | Tue Apr 16 | at Mariners | W4-2 | 10-7 | .588 | T-Mobile Park · Seattle, WA |
| 18 | Wed Apr 17 | at Mariners | W1-0 | 11-7 | .611 | T-Mobile Park · Seattle, WA |
| 19 | Sat Apr 20 | vs Braves | W8-4 | 12-7 | .632 | Progressive Field · Cleveland, OH |
| 20 | Sat Apr 20 | vs Braves | L7-8 | 12-8 | .600 | Progressive Field · Cleveland, OH |
| 21 | Sun Apr 21 | vs Braves | L5-11 | 12-9 | .571 | Progressive Field · Cleveland, OH |
| 22 | Tue Apr 23 | vs Marlins | L1-3 | 12-10 | .545 | Progressive Field · Cleveland, OH |
| 23 | Wed Apr 24 | vs Marlins | W6-2 | 13-10 | .565 | Progressive Field · Cleveland, OH |
| 24 | Thu Apr 25 | at Astros | W2-1 | 14-10 | .583 | Minute Maid Park · Houston, TX |
| 25 | Fri Apr 26 | at Astros | W6-3 | 15-10 | .600 | Minute Maid Park · Houston, TX |
| 26 | Sat Apr 27 | at Astros | L3-4 (10) | 15-11 | .577 | Minute Maid Park · Houston, TX |
| 27 | Sun Apr 28 | at Astros | L1-4 | 15-12 | .556 | Minute Maid Park · Houston, TX |
| 28 | Tue Apr 30 | at Marlins | W7-4 | 16-12 | .571 | LoanDepot Park · Miami, FL |
| 29 | Wed May 1 | at Marlins | L2-4 | 16-13 | .552 | LoanDepot Park · Miami, FL |
| 30 | Fri May 3 | vs Mariners | W2-1 | 17-13 | .567 | Progressive Field · Cleveland, OH |
| 31 | Sat May 4 | vs Mariners | W5-4 | 18-13 | .581 | Progressive Field · Cleveland, OH |
| 32 | Sun May 5 | vs Mariners | L0-10 | 18-14 | .563 | Progressive Field · Cleveland, OH |
| 33 | Mon May 6 | vs White Sox | L1-9 | 18-15 | .545 | Progressive Field · Cleveland, OH |
| 34 | Tue May 7 | vs White Sox | L0-2 | 18-16 | .529 | Progressive Field · Cleveland, OH |
| 35 | Wed May 8 | vs White Sox | W5-3 | 19-16 | .543 | Progressive Field · Cleveland, OH |
| 36 | Thu May 9 | vs White Sox | W5-0 | 20-16 | .556 | Progressive Field · Cleveland, OH |
| 37 | Fri May 10 | at Athletics | L3-4 (12) | 20-17 | .541 | RingCentral Coliseum · Oakland, CA |
| 38 | Sat May 11 | at Athletics | L2-3 | 20-18 | .526 | RingCentral Coliseum · Oakland, CA |
| 39 | Sun May 12 | at Athletics | W5-3 | 21-18 | .538 | RingCentral Coliseum · Oakland, CA |
| 40 | Mon May 13 | at White Sox | L2-5 | 21-19 | .525 | Guaranteed Rate Field · Chicago, IL |
| 41 | Tue May 14 | at White Sox | W9-0 | 22-19 | .537 | Guaranteed Rate Field · Chicago, IL |
| 42 | Thu May 16 | vs Orioles | W14-7 | 23-19 | .548 | Progressive Field · Cleveland, OH |
| 43 | Fri May 17 | vs Orioles | L1-5 | 23-20 | .535 | Progressive Field · Cleveland, OH |
| 44 | Sat May 18 | vs Orioles | W4-1 | 24-20 | .545 | Progressive Field · Cleveland, OH |
| 45 | Sun May 19 | vs Orioles | W10-0 | 25-20 | .556 | Progressive Field · Cleveland, OH |
| 46 | Mon May 20 | vs Athletics | L4-6 | 25-21 | .543 | Progressive Field · Cleveland, OH |
| 47 | Tue May 21 | vs Athletics | L3-5 | 25-22 | .532 | Progressive Field · Cleveland, OH |
| 48 | Wed May 22 | vs Athletics | L2-7 | 25-23 | .521 | Progressive Field · Cleveland, OH |
| 49 | Thu May 23 | vs Rays | L2-7 | 25-24 | .510 | Progressive Field · Cleveland, OH |
| 50 | Fri May 24 | vs Rays | W3-1 | 26-24 | .520 | Progressive Field · Cleveland, OH |
| 51 | Sat May 25 | vs Rays | L2-6 | 26-25 | .510 | Progressive Field · Cleveland, OH |
| 52 | Sun May 26 | vs Rays | L3-6 | 26-26 | .500 | Progressive Field · Cleveland, OH |
| 53 | Mon May 27 | at Red Sox | L5-12 | 26-27 | .491 | Fenway Park · Boston, MA |
| 54 | Tue May 28 | at Red Sox | W7-5 | 27-27 | .500 | Fenway Park · Boston, MA |
| 55 | Wed May 29 | at Red Sox | W14-9 | 28-27 | .509 | Fenway Park · Boston, MA |
| 56 | Thu May 30 | at White Sox | L4-10 | 28-28 | .500 | Guaranteed Rate Field · Chicago, IL |
| 57 | Fri May 31 | at White Sox | L1-6 | 28-29 | .491 | Guaranteed Rate Field · Chicago, IL |
| 58 | Sat Jun 1 | at White Sox | W5-2 | 29-29 | .500 | Guaranteed Rate Field · Chicago, IL |
| 59 | Sun Jun 2 | at White Sox | L0-2 | 29-30 | .492 | Guaranteed Rate Field · Chicago, IL |
| 60 | Tue Jun 4 | vs Twins | W5-2 | 30-30 | .500 | Progressive Field · Cleveland, OH |
| 61 | Wed Jun 5 | vs Twins | W9-7 | 31-30 | .508 | Progressive Field · Cleveland, OH |
| 62 | Thu Jun 6 | vs Twins | L4-5 | 31-31 | .500 | Progressive Field · Cleveland, OH |
| 63 | Fri Jun 7 | vs Yankees | W5-2 | 32-31 | .508 | Progressive Field · Cleveland, OH |
| 64 | Sat Jun 8 | vs Yankees | W8-4 | 33-31 | .516 | Progressive Field · Cleveland, OH |
| 65 | Sun Jun 9 | vs Yankees | L6-7 (10) | 33-32 | .508 | Progressive Field · Cleveland, OH |
| 66 | Tue Jun 11 | vs Reds | W2-1 (10) | 34-32 | .515 | Progressive Field · Cleveland, OH |
| 67 | Wed Jun 12 | vs Reds | L2-7 | 34-33 | .507 | Progressive Field · Cleveland, OH |
| 68 | Fri Jun 14 | at Tigers | W13-4 | 35-33 | .515 | Comerica Park · Detroit, MI |
| 69 | Sat Jun 15 | at Tigers | W4-2 | 36-33 | .522 | Comerica Park · Detroit, MI |
| 70 | Sun Jun 16 | at Tigers | W8-0 | 37-33 | .529 | Comerica Park · Detroit, MI |
| 71 | Mon Jun 17 | at Rangers | L2-7 | 37-34 | .521 | Globe Life Field · Arlington, TX |
| 72 | Tue Jun 18 | at Rangers | W10-3 | 38-34 | .528 | Globe Life Field · Arlington, TX |
| 73 | Wed Jun 19 | at Rangers | W10-4 | 39-34 | .534 | Globe Life Field · Arlington, TX |
| 74 | Thu Jun 20 | at Rangers | L2-4 | 39-35 | .527 | Globe Life Field · Arlington, TX |
| 75 | Fri Jun 21 | vs Tigers | W7-6 | 40-35 | .533 | Progressive Field · Cleveland, OH |
| 76 | Sat Jun 22 | vs Tigers | W2-0 | 41-35 | .539 | Progressive Field · Cleveland, OH |
| 77 | Sun Jun 23 | vs Tigers | W8-3 | 42-35 | .545 | Progressive Field · Cleveland, OH |
| 78 | Mon Jun 24 | vs Royals | W3-2 (10) | 43-35 | .551 | Progressive Field · Cleveland, OH |
| 79 | Tue Jun 25 | vs Royals | L6-8 | 43-36 | .544 | Progressive Field · Cleveland, OH |
| 80 | Wed Jun 26 | vs Royals | W5-3 | 44-36 | .550 | Progressive Field · Cleveland, OH |
| 81 | Fri Jun 28 | at Orioles | L0-13 | 44-37 | .543 | Camden Yards · Baltimore, MD |
| 82 | Sat Jun 29 | at Orioles | L0-13 | 44-38 | .537 | Camden Yards · Baltimore, MD |
| 83 | Sun Jun 30 | at Orioles | W2-0 | 45-38 | .542 | Camden Yards · Baltimore, MD |
| 84 | Tue Jul 2 | at Royals | W9-5 | 46-38 | .548 | Kauffman Stadium · Kansas City, MO |
| 85 | Wed Jul 3 | at Royals | W4-0 | 47-38 | .553 | Kauffman Stadium · Kansas City, MO |
| 86 | Thu Jul 4 | at Royals | W8-4 | 48-38 | .558 | Kauffman Stadium · Kansas City, MO |
| 87 | Sat Jul 6 | at Reds | W7-2 | 49-38 | .563 | Great American Ball Park · Cincinnati, OH |
| 88 | Sun Jul 7 | at Reds | W11-1 | 50-38 | .568 | Great American Ball Park · Cincinnati, OH |
| 89 | Fri Jul 12 | vs Twins | L3-5 | 50-39 | .562 | Progressive Field · Cleveland, OH |
| 90 | Sat Jul 13 | vs Twins | L2-6 | 50-40 | .556 | Progressive Field · Cleveland, OH |
| 91 | Sun Jul 14 | vs Twins | W4-3 | 51-40 | .560 | Progressive Field · Cleveland, OH |
| 92 | Mon Jul 15 | vs Tigers | W8-6 | 52-40 | .565 | Progressive Field · Cleveland, OH |
| 93 | Tue Jul 16 | vs Tigers | W8-0 | 53-40 | .570 | Progressive Field · Cleveland, OH |
| 94 | Wed Jul 17 | vs Tigers | W7-2 | 54-40 | .574 | Progressive Field · Cleveland, OH |
| 95 | Thu Jul 18 | vs Tigers | W6-3 | 55-40 | .579 | Progressive Field · Cleveland, OH |
| 96 | Fri Jul 19 | vs Royals | W10-5 | 56-40 | .583 | Progressive Field · Cleveland, OH |
| 97 | Sat Jul 20 | vs Royals | L0-1 | 56-41 | .577 | Progressive Field · Cleveland, OH |
| 98 | Sun Jul 21 | vs Royals | W5-4 | 57-41 | .582 | Progressive Field · Cleveland, OH |
| 99 | Mon Jul 22 | at Blue Jays | W7-3 | 58-41 | .586 | Rogers Centre · Toronto, ON |
| 100 | Tue Jul 23 | at Blue Jays | L1-2 (10) | 58-42 | .580 | Rogers Centre · Toronto, ON |
| 101 | Wed Jul 24 | at Blue Jays | W4-0 | 59-42 | .584 | Rogers Centre · Toronto, ON |
| 102 | Thu Jul 25 | at Royals | W5-4 (14) | 60-42 | .588 | Kauffman Stadium · Kansas City, MO |
| 103 | Fri Jul 26 | at Royals | W8-3 | 61-42 | .592 | Kauffman Stadium · Kansas City, MO |
| 104 | Sat Jul 27 | at Royals | W9-1 | 62-42 | .596 | Kauffman Stadium · Kansas City, MO |
| 105 | Sun Jul 28 | at Royals | L6-9 | 62-43 | .590 | Kauffman Stadium · Kansas City, MO |
| 106 | Tue Jul 30 | vs Astros | L0-2 | 62-44 | .585 | Progressive Field · Cleveland, OH |
| 107 | Wed Jul 31 | vs Astros | W10-4 | 63-44 | .589 | Progressive Field · Cleveland, OH |
| 108 | Thu Aug 1 | vs Astros | L1-7 | 63-45 | .583 | Progressive Field · Cleveland, OH |
| 109 | Fri Aug 2 | vs Angels | W7-3 | 64-45 | .587 | Progressive Field · Cleveland, OH |
| 110 | Sat Aug 3 | vs Angels | W7-2 | 65-45 | .591 | Progressive Field · Cleveland, OH |
| 111 | Sun Aug 4 | vs Angels | W6-2 | 66-45 | .595 | Progressive Field · Cleveland, OH |
| 112 | Mon Aug 5 | vs Rangers | L0-1 | 66-46 | .589 | Progressive Field · Cleveland, OH |
| 113 | Wed Aug 7 | vs Rangers | W2-0 | 67-46 | .593 | Progressive Field · Cleveland, OH |
| 114 | Wed Aug 7 | vs Rangers | W5-1 | 68-46 | .596 | Progressive Field · Cleveland, OH |
| 115 | Thu Aug 8 | at Twins | W7-5 | 69-46 | .600 | Target Field · Minneapolis, MN |
| 116 | Fri Aug 9 | at Twins | W6-2 | 70-46 | .603 | Target Field · Minneapolis, MN |
| 117 | Sat Aug 10 | at Twins | L1-4 | 70-47 | .598 | Target Field · Minneapolis, MN |
| 118 | Sun Aug 11 | at Twins | W7-3 (10) | 71-47 | .602 | Target Field · Minneapolis, MN |
| 119 | Mon Aug 12 | vs Red Sox | W6-5 | 72-47 | .605 | Progressive Field · Cleveland, OH |
| 120 | Tue Aug 13 | vs Red Sox | L6-7 (10) | 72-48 | .600 | Progressive Field · Cleveland, OH |
| 121 | Wed Aug 14 | vs Red Sox | L1-5 | 72-49 | .595 | Progressive Field · Cleveland, OH |
| 122 | Thu Aug 15 | at Yankees | W19-5 | 73-49 | .598 | Yankee Stadium · The Bronx, NY |
| 123 | Fri Aug 16 | at Yankees | L2-3 | 73-50 | .593 | Yankee Stadium · The Bronx, NY |
| 124 | Sat Aug 17 | at Yankees | L5-6 | 73-51 | .589 | Yankee Stadium · The Bronx, NY |
| 125 | Sun Aug 18 | at Yankees | W8-4 | 74-51 | .592 | Yankee Stadium · The Bronx, NY |
| 126 | Tue Aug 20 | at Mets | L2-9 | 74-52 | .587 | Citi Field · Queens, NY |
| 127 | Wed Aug 21 | at Mets | L3-4 (10) | 74-53 | .583 | Citi Field · Queens, NY |
| 128 | Thu Aug 22 | at Mets | L0-2 | 74-54 | .578 | Citi Field · Queens, NY |
| 129 | Fri Aug 23 | vs Royals | W4-1 | 75-54 | .581 | Progressive Field · Cleveland, OH |
| 130 | Sat Aug 24 | vs Royals | W4-2 | 76-54 | .585 | Progressive Field · Cleveland, OH |
| 131 | Sun Aug 25 | vs Royals | L8-9 (10) | 76-55 | .580 | Progressive Field · Cleveland, OH |
| 132 | Tue Aug 27 | at Tigers | W10-1 | 77-55 | .583 | Comerica Park · Detroit, MI |
| 133 | Wed Aug 28 | at Tigers | W4-2 | 78-55 | .586 | Comerica Park · Detroit, MI |
| 134 | Thu Aug 29 | at Tigers | W2-0 | 79-55 | .590 | Comerica Park · Detroit, MI |
| 135 | Fri Aug 30 | at Rays | L0-4 | 79-56 | .585 | Tropicana Field · St. Petersburg, FL |
| 136 | Sat Aug 31 | at Rays | L6-9 | 79-57 | .581 | Tropicana Field · St. Petersburg, FL |
| 137 | Sun Sep 1 | at Rays | L2-8 | 79-58 | .577 | Tropicana Field · St. Petersburg, FL |
| 138 | Mon Sep 2 | vs White Sox | W11-3 | 80-58 | .580 | Progressive Field · Cleveland, OH |
| 139 | Tue Sep 3 | vs White Sox | L5-6 | 80-59 | .576 | Progressive Field · Cleveland, OH |
| 140 | Wed Sep 4 | vs White Sox | W8-6 | 81-59 | .579 | Progressive Field · Cleveland, OH |
| 141 | Thu Sep 5 | vs White Sox | L1-7 | 81-60 | .574 | Progressive Field · Cleveland, OH |
| 142 | Fri Sep 6 | at Twins | W6-2 (11) | 82-60 | .577 | Target Field · Minneapolis, MN |
| 143 | Sat Sep 7 | at Twins | L3-5 | 82-61 | .573 | Target Field · Minneapolis, MN |
| 144 | Sun Sep 8 | at Twins | W5-2 | 83-61 | .576 | Target Field · Minneapolis, MN |
| 145 | Mon Sep 9 | at Angels | W6-2 | 84-61 | .579 | Angel Stadium · Anaheim, CA |
| 146 | Tue Sep 10 | at Angels | W8-0 | 85-61 | .582 | Angel Stadium · Anaheim, CA |
| 147 | Wed Sep 11 | at Angels | W4-3 | 86-61 | .585 | Angel Stadium · Anaheim, CA |
| 148 | Sat Sep 14 | vs Twins | L0-2 | 86-62 | .581 | Progressive Field · Cleveland, OH |
| 149 | Sat Sep 14 | vs Twins | L5-9 | 86-63 | .577 | Progressive Field · Cleveland, OH |
| 150 | Sun Sep 15 | vs Twins | W7-5 | 87-63 | .580 | Progressive Field · Cleveland, OH |
| 151 | Tue Sep 17 | vs Tigers | W7-2 | 88-63 | .583 | Progressive Field · Cleveland, OH |
| 152 | Wed Sep 18 | vs Tigers | W2-1 (10) | 89-63 | .586 | Progressive Field · Cleveland, OH |
| 153 | Thu Sep 19 | vs Tigers | W7-0 | 90-63 | .588 | Progressive Field · Cleveland, OH |
| 154 | Fri Sep 20 | vs Phillies | W5-2 | 91-63 | .591 | Progressive Field · Cleveland, OH |
| 155 | Sat Sep 21 | vs Phillies | L4-9 | 91-64 | .587 | Progressive Field · Cleveland, OH |
| 156 | Sun Sep 22 | vs Phillies | W10-1 | 92-64 | .590 | Progressive Field · Cleveland, OH |
| 157 | Tue Sep 24 | at White Sox | W11-0 | 93-64 | .592 | Guaranteed Rate Field · Chicago, IL |
| 158 | Wed Sep 25 | at White Sox | L3-8 | 93-65 | .589 | Guaranteed Rate Field · Chicago, IL |
| 159 | Thu Sep 26 | at White Sox | L0-8 | 93-66 | .585 | Guaranteed Rate Field · Chicago, IL |
| 160 | Fri Sep 27 | at Nationals | L2-8 | 93-67 | .581 | Nationals Park · Washington, D.C. |
| 161 | Sat Sep 28 | at Nationals | L7-10 | 93-68 | .578 | Nationals Park · Washington, D.C. |
| 162 | Sun Sep 29 | at Nationals | L2-8 | 93-69 | .574 | Nationals Park · Washington, D.C. |