| 1 | Mon Apr 6 | at Astros | L0-2 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Wed Apr 8 | at Astros | W2-0 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Thu Apr 9 | at Astros | W5-1 | 2-1 | .667 | Minute Maid Park · Houston, TX |
| 4 | Fri Apr 10 | vs Tigers | L4-8 | 2-2 | .500 | Progressive Field · Cleveland, OH |
| 5 | Sat Apr 11 | vs Tigers | L6-9 | 2-3 | .400 | Progressive Field · Cleveland, OH |
| 6 | Sun Apr 12 | vs Tigers | L5-8 | 2-4 | .333 | Progressive Field · Cleveland, OH |
| 7 | Tue Apr 14 | vs White Sox | L1-4 | 2-5 | .286 | Progressive Field · Cleveland, OH |
| 8 | Wed Apr 15 | vs White Sox | W4-2 | 3-5 | .375 | Progressive Field · Cleveland, OH |
| 9 | Fri Apr 17 | at Twins | L2-3 (11) | 3-6 | .333 | Target Field · Minneapolis, MN |
| 10 | Sat Apr 18 | at Twins | W4-2 | 4-6 | .400 | Target Field · Minneapolis, MN |
| 11 | Sun Apr 19 | at Twins | L2-7 | 4-7 | .364 | Target Field · Minneapolis, MN |
| 12 | Mon Apr 20 | at White Sox | L3-4 | 4-8 | .333 | Guaranteed Rate Field · Chicago, IL |
| 13 | Tue Apr 21 | at White Sox | W6-2 | 5-8 | .385 | Guaranteed Rate Field · Chicago, IL |
| 14 | Wed Apr 22 | at White Sox | L0-6 | 5-9 | .357 | Guaranteed Rate Field · Chicago, IL |
| 15 | Fri Apr 24 | at Tigers | W13-1 | 6-9 | .400 | Comerica Park · Detroit, MI |
| 16 | Sat Apr 25 | at Tigers | L1-4 | 6-10 | .375 | Comerica Park · Detroit, MI |
| 17 | Sun Apr 26 | at Tigers | L6-8 | 6-11 | .353 | Comerica Park · Detroit, MI |
| 18 | Mon Apr 27 | vs Royals | L2-6 | 6-12 | .333 | Progressive Field · Cleveland, OH |
| 19 | Tue Apr 28 | vs Royals | L5-11 | 6-13 | .316 | Progressive Field · Cleveland, OH |
| 20 | Wed Apr 29 | vs Royals | W7-5 | 7-13 | .350 | Progressive Field · Cleveland, OH |
| 21 | Thu Apr 30 | vs Blue Jays | L1-5 | 7-14 | .333 | Progressive Field · Cleveland, OH |
| 22 | Fri May 1 | vs Blue Jays | W9-4 | 8-14 | .364 | Progressive Field · Cleveland, OH |
| 23 | Sat May 2 | vs Blue Jays | L4-11 | 8-15 | .348 | Progressive Field · Cleveland, OH |
| 24 | Sun May 3 | vs Blue Jays | W10-7 | 9-15 | .375 | Progressive Field · Cleveland, OH |
| 25 | Tue May 5 | at Royals | L3-5 | 9-16 | .360 | Kauffman Stadium · Kansas City, MO |
| 26 | Wed May 6 | at Royals | W10-3 | 10-16 | .385 | Kauffman Stadium · Kansas City, MO |
| 27 | Thu May 7 | at Royals | L4-7 | 10-17 | .370 | Kauffman Stadium · Kansas City, MO |
| 28 | Fri May 8 | vs Twins | L3-9 | 10-18 | .357 | Progressive Field · Cleveland, OH |
| 29 | Sat May 9 | vs Twins | L4-7 | 10-19 | .345 | Progressive Field · Cleveland, OH |
| 30 | Sun May 10 | vs Twins | W8-2 | 11-19 | .367 | Progressive Field · Cleveland, OH |
| 31 | Tue May 12 | vs Cardinals | L3-8 | 11-20 | .355 | Progressive Field · Cleveland, OH |
| 32 | Wed May 13 | vs Cardinals | W2-0 | 12-20 | .375 | Progressive Field · Cleveland, OH |
| 33 | Thu May 14 | vs Cardinals | L1-2 | 12-21 | .364 | Progressive Field · Cleveland, OH |
| 34 | Fri May 15 | at Rangers | W8-3 | 13-21 | .382 | Globe Life Field · Arlington, TX |
| 35 | Sat May 16 | at Rangers | W10-8 | 14-21 | .400 | Globe Life Field · Arlington, TX |
| 36 | Sun May 17 | at Rangers | L1-5 | 14-22 | .389 | Globe Life Field · Arlington, TX |
| 37 | Mon May 18 | at White Sox | L1-2 (10) | 14-23 | .378 | Guaranteed Rate Field · Chicago, IL |
| 38 | Tue May 19 | at White Sox | W3-1 | 15-23 | .395 | Guaranteed Rate Field · Chicago, IL |
| 39 | Wed May 20 | at White Sox | W4-3 | 16-23 | .410 | Guaranteed Rate Field · Chicago, IL |
| 40 | Thu May 21 | at White Sox | W5-2 | 17-23 | .425 | Guaranteed Rate Field · Chicago, IL |
| 41 | Fri May 22 | vs Reds | W7-3 | 18-23 | .439 | Progressive Field · Cleveland, OH |
| 42 | Sat May 23 | vs Reds | W2-1 | 19-23 | .452 | Progressive Field · Cleveland, OH |
| 43 | Sun May 24 | vs Reds | W5-2 | 20-23 | .465 | Progressive Field · Cleveland, OH |
| 44 | Mon May 25 | vs Rangers | L8-10 | 20-24 | .455 | Progressive Field · Cleveland, OH |
| 45 | Tue May 26 | vs Rangers | L3-4 | 20-25 | .444 | Progressive Field · Cleveland, OH |
| 46 | Wed May 27 | vs Rangers | W12-3 | 21-25 | .457 | Progressive Field · Cleveland, OH |
| 47 | Thu May 28 | at Mariners | W5-3 | 22-25 | .468 | T-Mobile Park · Seattle, WA |
| 48 | Fri May 29 | at Mariners | L1-2 | 22-26 | .458 | T-Mobile Park · Seattle, WA |
| 49 | Sat May 30 | at Mariners | W4-3 | 23-26 | .469 | T-Mobile Park · Seattle, WA |
| 50 | Sun May 31 | at Mariners | W6-3 (12) | 24-26 | .480 | T-Mobile Park · Seattle, WA |
| 51 | Tue Jun 2 | at Royals | W2-1 | 25-26 | .490 | Kauffman Stadium · Kansas City, MO |
| 52 | Wed Jun 3 | at Royals | L2-4 | 25-27 | .481 | Kauffman Stadium · Kansas City, MO |
| 53 | Thu Jun 4 | at Royals | W6-2 | 26-27 | .491 | Kauffman Stadium · Kansas City, MO |
| 54 | Fri Jun 5 | vs Orioles | L2-5 | 26-28 | .481 | Progressive Field · Cleveland, OH |
| 55 | Sat Jun 6 | vs Orioles | W2-1 | 27-28 | .491 | Progressive Field · Cleveland, OH |
| 56 | Sun Jun 7 | vs Orioles | L3-7 | 27-29 | .482 | Progressive Field · Cleveland, OH |
| 57 | Tue Jun 9 | vs Mariners | L2-3 | 27-30 | .474 | Progressive Field · Cleveland, OH |
| 58 | Wed Jun 10 | vs Mariners | L3-9 | 27-31 | .466 | Progressive Field · Cleveland, OH |
| 59 | Thu Jun 11 | vs Mariners | W6-0 | 28-31 | .475 | Progressive Field · Cleveland, OH |
| 60 | Fri Jun 12 | at Tigers | L0-4 | 28-32 | .467 | Comerica Park · Detroit, MI |
| 61 | Sat Jun 13 | at Tigers | W5-4 | 29-32 | .475 | Comerica Park · Detroit, MI |
| 62 | Sun Jun 14 | at Tigers | L1-8 | 29-33 | .468 | Comerica Park · Detroit, MI |
| 63 | Tue Jun 16 | at Cubs | W6-0 | 30-33 | .476 | Wrigley Field · Chicago, IL |
| 64 | Wed Jun 17 | vs Cubs | L0-17 | 30-34 | .469 | Progressive Field · Cleveland, OH |
| 65 | Thu Jun 18 | vs Cubs | W4-3 | 31-34 | .477 | Progressive Field · Cleveland, OH |
| 66 | Fri Jun 19 | vs Rays | L1-4 | 31-35 | .470 | Progressive Field · Cleveland, OH |
| 67 | Sat Jun 20 | vs Rays | L1-4 | 31-36 | .463 | Progressive Field · Cleveland, OH |
| 68 | Sun Jun 21 | vs Rays | W1-0 | 32-36 | .471 | Progressive Field · Cleveland, OH |
| 69 | Mon Jun 22 | vs Tigers | L5-8 | 32-37 | .464 | Progressive Field · Cleveland, OH |
| 70 | Tue Jun 23 | vs Tigers | L3-7 | 32-38 | .457 | Progressive Field · Cleveland, OH |
| 71 | Wed Jun 24 | vs Tigers | W8-2 | 33-38 | .465 | Progressive Field · Cleveland, OH |
| 72 | Fri Jun 26 | at Orioles | L3-4 | 33-39 | .458 | Camden Yards · Baltimore, MD |
| 73 | Sun Jun 28 | at Orioles | L0-4 | 33-40 | .452 | Camden Yards · Baltimore, MD |
| 74 | Sun Jun 28 | at Orioles | L0-8 | 33-41 | .446 | Camden Yards · Baltimore, MD |
| 75 | Mon Jun 29 | at Rays | W7-1 | 34-41 | .453 | Tropicana Field · St. Petersburg, FL |
| 76 | Tue Jun 30 | at Rays | W6-2 | 35-41 | .461 | Tropicana Field · St. Petersburg, FL |
| 77 | Wed Jul 1 | at Rays | W8-1 | 36-41 | .468 | Tropicana Field · St. Petersburg, FL |
| 78 | Thu Jul 2 | at Rays | W5-4 (10) | 37-41 | .474 | Tropicana Field · St. Petersburg, FL |
| 79 | Fri Jul 3 | at Pirates | W5-2 | 38-41 | .481 | PNC Park · Pittsburgh, PA |
| 80 | Sat Jul 4 | at Pirates | L0-1 | 38-42 | .475 | PNC Park · Pittsburgh, PA |
| 81 | Sun Jul 5 | at Pirates | L3-5 | 38-43 | .469 | PNC Park · Pittsburgh, PA |
| 82 | Mon Jul 6 | vs Astros | L4-9 | 38-44 | .463 | Progressive Field · Cleveland, OH |
| 83 | Tue Jul 7 | vs Astros | W2-0 | 39-44 | .470 | Progressive Field · Cleveland, OH |
| 84 | Wed Jul 8 | vs Astros | W4-2 | 40-44 | .476 | Progressive Field · Cleveland, OH |
| 85 | Thu Jul 9 | vs Astros | W3-1 | 41-44 | .482 | Progressive Field · Cleveland, OH |
| 86 | Fri Jul 10 | vs Athletics | W5-1 | 42-44 | .488 | Progressive Field · Cleveland, OH |
| 87 | Sat Jul 11 | vs Athletics | L4-5 | 42-45 | .483 | Progressive Field · Cleveland, OH |
| 88 | Sun Jul 12 | vs Athletics | L0-2 | 42-46 | .477 | Progressive Field · Cleveland, OH |
| 89 | Fri Jul 17 | at Reds | L1-6 | 42-47 | .472 | Great American Ball Park · Cincinnati, OH |
| 90 | Sat Jul 18 | at Reds | W9-4 | 43-47 | .478 | Great American Ball Park · Cincinnati, OH |
| 91 | Sun Jul 19 | at Reds | W5-3 (11) | 44-47 | .484 | Great American Ball Park · Cincinnati, OH |
| 92 | Tue Jul 21 | at Brewers | L1-8 | 44-48 | .478 | American Family Field · Milwaukee, WI |
| 93 | Wed Jul 22 | at Brewers | W7-5 | 45-48 | .484 | American Family Field · Milwaukee, WI |
| 94 | Thu Jul 23 | vs White Sox | L1-8 | 45-49 | .479 | Progressive Field · Cleveland, OH |
| 95 | Fri Jul 24 | vs White Sox | L0-6 | 45-50 | .474 | Progressive Field · Cleveland, OH |
| 96 | Sat Jul 25 | vs White Sox | L3-10 | 45-51 | .469 | Progressive Field · Cleveland, OH |
| 97 | Sun Jul 26 | vs White Sox | L1-2 | 45-52 | .464 | Progressive Field · Cleveland, OH |
| 98 | Mon Jul 27 | vs Royals | L4-9 | 45-53 | .459 | Progressive Field · Cleveland, OH |
| 99 | Tue Jul 28 | vs Royals | L1-2 | 45-54 | .455 | Progressive Field · Cleveland, OH |
| 100 | Wed Jul 29 | vs Royals | W12-1 | 46-54 | .460 | Progressive Field · Cleveland, OH |
| 101 | Thu Jul 30 | at Athletics | W3-1 | 47-54 | .465 | RingCentral Coliseum · Oakland, CA |
| 102 | Fri Jul 31 | at Athletics | W2-1 | 48-54 | .471 | RingCentral Coliseum · Oakland, CA |
| 103 | Sat Aug 1 | at Athletics | L1-5 | 48-55 | .466 | RingCentral Coliseum · Oakland, CA |
| 104 | Sun Aug 2 | at Athletics | L1-2 (10) | 48-56 | .462 | RingCentral Coliseum · Oakland, CA |
| 105 | Mon Aug 3 | at Angels | L4-5 | 48-57 | .457 | Angel Stadium · Anaheim, CA |
| 106 | Tue Aug 4 | at Angels | W2-0 (12) | 49-57 | .462 | Angel Stadium · Anaheim, CA |
| 107 | Wed Aug 5 | at Angels | L3-4 | 49-58 | .458 | Angel Stadium · Anaheim, CA |
| 108 | Fri Aug 7 | vs Twins | L9-10 | 49-59 | .454 | Progressive Field · Cleveland, OH |
| 109 | Sat Aug 8 | vs Twins | W17-4 | 50-59 | .459 | Progressive Field · Cleveland, OH |
| 110 | Sun Aug 9 | vs Twins | W8-1 | 51-59 | .464 | Progressive Field · Cleveland, OH |
| 111 | Tue Aug 11 | vs Yankees | W5-4 (16) | 52-59 | .468 | Progressive Field · Cleveland, OH |
| 112 | Wed Aug 12 | vs Yankees | W2-1 | 53-59 | .473 | Progressive Field · Cleveland, OH |
| 113 | Thu Aug 13 | vs Yankees | L6-8 | 53-60 | .469 | Progressive Field · Cleveland, OH |
| 114 | Fri Aug 14 | at Twins | W6-1 | 54-60 | .474 | Target Field · Minneapolis, MN |
| 115 | Sat Aug 15 | at Twins | L1-4 | 54-61 | .470 | Target Field · Minneapolis, MN |
| 116 | Sun Aug 16 | at Twins | L1-4 | 54-62 | .466 | Target Field · Minneapolis, MN |
| 117 | Mon Aug 17 | at Red Sox | W8-2 | 55-62 | .470 | Fenway Park · Boston, MA |
| 118 | Tue Aug 18 | at Red Sox | L1-9 | 55-63 | .466 | Fenway Park · Boston, MA |
| 119 | Wed Aug 19 | at Red Sox | L4-6 | 55-64 | .462 | Fenway Park · Boston, MA |
| 120 | Thu Aug 20 | at Yankees | W3-2 | 56-64 | .467 | Yankee Stadium · The Bronx, NY |
| 121 | Fri Aug 21 | at Yankees | W7-3 | 57-64 | .471 | Yankee Stadium · The Bronx, NY |
| 122 | Sat Aug 22 | at Yankees | L2-6 | 57-65 | .467 | Yankee Stadium · The Bronx, NY |
| 123 | Sun Aug 23 | at Yankees | W4-3 | 58-65 | .472 | Yankee Stadium · The Bronx, NY |
| 124 | Mon Aug 24 | at Cubs | L1-2 | 58-66 | .468 | Wrigley Field · Chicago, IL |
| 125 | Tue Aug 25 | vs Brewers | W11-6 | 59-66 | .472 | Progressive Field · Cleveland, OH |
| 126 | Wed Aug 26 | vs Brewers | W6-2 | 60-66 | .476 | Progressive Field · Cleveland, OH |
| 127 | Fri Aug 28 | vs Angels | W3-1 | 61-66 | .480 | Progressive Field · Cleveland, OH |
| 128 | Sat Aug 29 | vs Angels | W8-3 | 62-66 | .484 | Progressive Field · Cleveland, OH |
| 129 | Sun Aug 30 | vs Angels | W9-2 | 63-66 | .488 | Progressive Field · Cleveland, OH |
| 130 | Mon Aug 31 | at Blue Jays | W4-2 | 64-66 | .492 | Rogers Centre · Toronto, ON |
| 131 | Tue Sep 1 | at Blue Jays | L3-5 (10) | 64-67 | .489 | Rogers Centre · Toronto, ON |
| 132 | Wed Sep 2 | at Blue Jays | L1-5 | 64-68 | .485 | Rogers Centre · Toronto, ON |
| 133 | Fri Sep 4 | at Tigers | W8-1 | 65-68 | .489 | Comerica Park · Detroit, MI |
| 134 | Sat Sep 5 | at Tigers | L0-6 | 65-69 | .485 | Comerica Park · Detroit, MI |
| 135 | Sun Sep 6 | at Tigers | W4-0 | 66-69 | .489 | Comerica Park · Detroit, MI |
| 136 | Mon Sep 7 | at White Sox | W3-2 | 67-69 | .493 | Guaranteed Rate Field · Chicago, IL |
| 137 | Tue Sep 8 | at White Sox | L4-7 | 67-70 | .489 | Guaranteed Rate Field · Chicago, IL |
| 138 | Wed Sep 9 | at White Sox | W6-4 | 68-70 | .493 | Guaranteed Rate Field · Chicago, IL |
| 139 | Thu Sep 10 | vs Tigers | W7-5 | 69-70 | .496 | Progressive Field · Cleveland, OH |
| 141 | Sun Sep 13 | vs Tigers | W7-2 | 70-70 | .500 | Progressive Field · Cleveland, OH |
| 142 | Sun Sep 13 | vs Tigers | L2-9 | 70-71 | .496 | Progressive Field · Cleveland, OH |
| 143 | Mon Sep 14 | vs Royals | W8-3 | 71-71 | .500 | Progressive Field · Cleveland, OH |
| 144 | Tue Sep 15 | vs Royals | L0-2 | 71-72 | .497 | Progressive Field · Cleveland, OH |
| 145 | Wed Sep 16 | vs Royals | W5-1 | 72-72 | .500 | Progressive Field · Cleveland, OH |
| 146 | Thu Sep 17 | vs Royals | L4-8 | 72-73 | .497 | Progressive Field · Cleveland, OH |
| 147 | Fri Sep 18 | vs White Sox | W12-1 | 73-73 | .500 | Progressive Field · Cleveland, OH |
| 148 | Sat Sep 19 | vs White Sox | L3-4 | 73-74 | .497 | Progressive Field · Cleveland, OH |
| 149 | Sun Sep 20 | vs White Sox | W6-3 | 74-74 | .500 | Progressive Field · Cleveland, OH |
| 150 | Tue Sep 22 | at Twins | L1-3 | 74-75 | .497 | Target Field · Minneapolis, MN |
| 151 | Wed Sep 23 | at Twins | L2-4 | 74-76 | .493 | Target Field · Minneapolis, MN |
| 152 | Thu Sep 24 | at Twins | W6-3 | 75-76 | .497 | Target Field · Minneapolis, MN |
| 153 | Fri Sep 25 | at Royals | W6-0 | 76-76 | .500 | Kauffman Stadium · Kansas City, MO |
| 154 | Sat Sep 26 | at Royals | W9-5 | 77-76 | .503 | Kauffman Stadium · Kansas City, MO |
| 155 | Sun Sep 27 | at Royals | L0-3 | 77-77 | .500 | Kauffman Stadium · Kansas City, MO |
| 156 | Mon Sep 28 | vs Twins | L2-4 | 77-78 | .497 | Progressive Field · Cleveland, OH |
| 157 | Wed Sep 30 | vs Twins | L1-7 | 77-79 | .494 | Progressive Field · Cleveland, OH |
| 158 | Wed Sep 30 | vs Twins | W10-2 | 78-79 | .497 | Progressive Field · Cleveland, OH |
| 159 | Thu Oct 1 | vs Twins | L2-4 | 78-80 | .494 | Progressive Field · Cleveland, OH |
| 160 | Fri Oct 2 | vs Red Sox | W8-2 | 79-80 | .497 | Progressive Field · Cleveland, OH |
| 161 | Sat Oct 3 | vs Red Sox | W2-0 | 80-80 | .500 | Progressive Field · Cleveland, OH |
| 162 | Sun Oct 4 | vs Red Sox | W3-1 | 81-80 | .503 | Progressive Field · Cleveland, OH |