| 1 | Tue Apr 5 | vs Red Sox | L2-6 | 0-1 | .000 | Progressive Field · Cleveland, OH |
| 2 | Wed Apr 6 | vs Red Sox | W7-6 | 1-1 | .500 | Progressive Field · Cleveland, OH |
| 3 | Fri Apr 8 | at White Sox | W7-1 | 2-1 | .667 | Guaranteed Rate Field · Chicago, IL |
| 4 | Sat Apr 9 | at White Sox | L3-7 | 2-2 | .500 | Guaranteed Rate Field · Chicago, IL |
| 5 | Tue Apr 12 | at Rays | L1-5 | 2-3 | .400 | Tropicana Field · St. Petersburg, FL |
| 6 | Wed Apr 13 | at Rays | W4-1 | 3-3 | .500 | Tropicana Field · St. Petersburg, FL |
| 7 | Thu Apr 14 | at Rays | W6-0 | 4-3 | .571 | Tropicana Field · St. Petersburg, FL |
| 8 | Fri Apr 15 | vs Mets | L5-6 | 4-4 | .500 | Progressive Field · Cleveland, OH |
| 9 | Sat Apr 16 | vs Mets | W7-5 | 5-4 | .556 | Progressive Field · Cleveland, OH |
| 10 | Sun Apr 17 | vs Mets | L0-6 | 5-5 | .500 | Progressive Field · Cleveland, OH |
| 11 | Tue Apr 19 | vs Mariners | W3-2 | 6-5 | .545 | Progressive Field · Cleveland, OH |
| 12 | Wed Apr 20 | vs Mariners | L1-2 | 6-6 | .500 | Progressive Field · Cleveland, OH |
| 13 | Thu Apr 21 | vs Mariners | L7-10 (10) | 6-7 | .462 | Progressive Field · Cleveland, OH |
| 14 | Fri Apr 22 | at Tigers | W2-1 | 7-7 | .500 | Comerica Park · Detroit, MI |
| 15 | Sat Apr 23 | at Tigers | W10-1 | 8-7 | .533 | Comerica Park · Detroit, MI |
| 16 | Sun Apr 24 | at Tigers | W6-3 | 9-7 | .563 | Comerica Park · Detroit, MI |
| 17 | Mon Apr 25 | at Twins | L3-4 | 9-8 | .529 | Target Field · Minneapolis, MN |
| 18 | Tue Apr 26 | at Twins | L5-6 | 9-9 | .500 | Target Field · Minneapolis, MN |
| 19 | Wed Apr 27 | at Twins | W6-5 | 10-9 | .526 | Target Field · Minneapolis, MN |
| 20 | Fri Apr 29 | at Phillies | L3-4 (11) | 10-10 | .500 | Citizens Bank Park · Philadelphi, PA |
| 21 | Sat Apr 30 | at Phillies | L3-4 | 10-11 | .476 | Citizens Bank Park · Philadelphi, PA |
| 22 | Sun May 1 | at Phillies | L1-2 | 10-12 | .455 | Citizens Bank Park · Philadelphi, PA |
| 23 | Tue May 3 | vs Tigers | W7-3 | 11-12 | .478 | Progressive Field · Cleveland, OH |
| 24 | Wed May 4 | vs Tigers | W4-0 | 12-12 | .500 | Progressive Field · Cleveland, OH |
| 25 | Thu May 5 | vs Tigers | W9-4 | 13-12 | .520 | Progressive Field · Cleveland, OH |
| 26 | Fri May 6 | vs Royals | W7-1 | 14-12 | .538 | Progressive Field · Cleveland, OH |
| 27 | Sat May 7 | vs Royals | L0-7 | 14-13 | .519 | Progressive Field · Cleveland, OH |
| 28 | Sun May 8 | vs Royals | W5-4 | 15-13 | .536 | Progressive Field · Cleveland, OH |
| 29 | Mon May 9 | at Astros | L1-7 | 15-14 | .517 | Minute Maid Park · Houston, TX |
| 30 | Tue May 10 | at Astros | W4-0 | 16-14 | .533 | Minute Maid Park · Houston, TX |
| 31 | Wed May 11 | at Astros | L3-5 (16) | 16-15 | .516 | Minute Maid Park · Houston, TX |
| 32 | Fri May 13 | vs Twins | W7-6 | 17-15 | .531 | Progressive Field · Cleveland, OH |
| 33 | Sat May 14 | vs Twins | L3-6 | 17-16 | .515 | Progressive Field · Cleveland, OH |
| 34 | Sun May 15 | vs Twins | L1-5 | 17-17 | .500 | Progressive Field · Cleveland, OH |
| 35 | Mon May 16 | vs Reds | W15-6 | 18-17 | .514 | Progressive Field · Cleveland, OH |
| 36 | Tue May 17 | vs Reds | W13-1 | 19-17 | .528 | Progressive Field · Cleveland, OH |
| 37 | Wed May 18 | at Reds | W8-7 (12) | 20-17 | .541 | Great American Ball Park · Cincinnati, OH |
| 38 | Thu May 19 | at Reds | W7-2 | 21-17 | .553 | Great American Ball Park · Cincinnati, OH |
| 39 | Fri May 20 | at Red Sox | W4-2 | 22-17 | .564 | Fenway Park · Boston, MA |
| 40 | Sat May 21 | at Red Sox | L1-9 | 22-18 | .550 | Fenway Park · Boston, MA |
| 41 | Sun May 22 | at Red Sox | L2-5 | 22-19 | .537 | Fenway Park · Boston, MA |
| 42 | Mon May 23 | at White Sox | L6-7 | 22-20 | .524 | Guaranteed Rate Field · Chicago, IL |
| 43 | Mon May 23 | at White Sox | W5-1 | 23-20 | .535 | Guaranteed Rate Field · Chicago, IL |
| 44 | Tue May 24 | at White Sox | W6-2 | 24-20 | .545 | Guaranteed Rate Field · Chicago, IL |
| 45 | Wed May 25 | at White Sox | W4-3 | 25-20 | .556 | Guaranteed Rate Field · Chicago, IL |
| 46 | Fri May 27 | vs Orioles | L4-6 | 25-21 | .543 | Progressive Field · Cleveland, OH |
| 47 | Sat May 28 | vs Orioles | W11-4 | 26-21 | .553 | Progressive Field · Cleveland, OH |
| 48 | Sun May 29 | vs Orioles | L4-6 | 26-22 | .542 | Progressive Field · Cleveland, OH |
| 49 | Mon May 30 | vs Rangers | L2-9 | 26-23 | .531 | Progressive Field · Cleveland, OH |
| 50 | Tue May 31 | vs Rangers | L3-7 | 26-24 | .520 | Progressive Field · Cleveland, OH |
| 51 | Wed Jun 1 | vs Rangers | W5-4 (11) | 27-24 | .529 | Progressive Field · Cleveland, OH |
| 52 | Thu Jun 2 | vs Royals | W5-4 | 28-24 | .538 | Progressive Field · Cleveland, OH |
| 53 | Fri Jun 3 | vs Royals | W6-1 | 29-24 | .547 | Progressive Field · Cleveland, OH |
| 54 | Sat Jun 4 | vs Royals | W7-1 | 30-24 | .556 | Progressive Field · Cleveland, OH |
| 55 | Sun Jun 5 | vs Royals | W7-0 | 31-24 | .564 | Progressive Field · Cleveland, OH |
| 56 | Mon Jun 6 | at Mariners | W3-1 | 32-24 | .571 | T-Mobile Park · Seattle, WA |
| 57 | Tue Jun 7 | at Mariners | L1-7 | 32-25 | .561 | T-Mobile Park · Seattle, WA |
| 58 | Wed Jun 8 | at Mariners | L0-5 | 32-26 | .552 | T-Mobile Park · Seattle, WA |
| 59 | Thu Jun 9 | at Mariners | W5-3 | 33-26 | .559 | T-Mobile Park · Seattle, WA |
| 60 | Fri Jun 10 | at Angels | W6-2 | 34-26 | .567 | Angel Stadium · Anaheim, CA |
| 61 | Sat Jun 11 | at Angels | L3-4 | 34-27 | .557 | Angel Stadium · Anaheim, CA |
| 62 | Sun Jun 12 | at Angels | W8-3 | 35-27 | .565 | Angel Stadium · Anaheim, CA |
| 63 | Mon Jun 13 | at Royals | L1-2 | 35-28 | .556 | Kauffman Stadium · Kansas City, MO |
| 64 | Tue Jun 14 | at Royals | L2-3 | 35-29 | .547 | Kauffman Stadium · Kansas City, MO |
| 65 | Wed Jun 15 | at Royals | L4-9 | 35-30 | .538 | Kauffman Stadium · Kansas City, MO |
| 66 | Fri Jun 17 | vs White Sox | W3-2 | 36-30 | .545 | Progressive Field · Cleveland, OH |
| 67 | Sat Jun 18 | vs White Sox | W13-2 | 37-30 | .552 | Progressive Field · Cleveland, OH |
| 68 | Sun Jun 19 | vs White Sox | W3-2 (10) | 38-30 | .559 | Progressive Field · Cleveland, OH |
| 69 | Mon Jun 20 | vs Rays | W7-4 | 39-30 | .565 | Progressive Field · Cleveland, OH |
| 70 | Tue Jun 21 | vs Rays | W6-0 | 40-30 | .571 | Progressive Field · Cleveland, OH |
| 71 | Wed Jun 22 | vs Rays | W6-1 | 41-30 | .577 | Progressive Field · Cleveland, OH |
| 72 | Fri Jun 24 | at Tigers | W7-5 | 42-30 | .583 | Comerica Park · Detroit, MI |
| 73 | Sat Jun 25 | at Tigers | W6-0 | 43-30 | .589 | Comerica Park · Detroit, MI |
| 74 | Sun Jun 26 | at Tigers | W9-3 | 44-30 | .595 | Comerica Park · Detroit, MI |
| 75 | Mon Jun 27 | at Braves | W8-3 | 45-30 | .600 | Truist Park · Cumberland, GA |
| 76 | Tue Jun 28 | at Braves | W5-3 | 46-30 | .605 | Truist Park · Cumberland, GA |
| 77 | Wed Jun 29 | at Braves | W3-0 | 47-30 | .610 | Truist Park · Cumberland, GA |
| 78 | Thu Jun 30 | at Blue Jays | W4-1 | 48-30 | .615 | Rogers Centre · Toronto, ON |
| 79 | Fri Jul 1 | at Blue Jays | W2-1 (19) | 49-30 | .620 | Rogers Centre · Toronto, ON |
| 80 | Sat Jul 2 | at Blue Jays | L6-9 | 49-31 | .613 | Rogers Centre · Toronto, ON |
| 81 | Sun Jul 3 | at Blue Jays | L1-17 | 49-32 | .605 | Rogers Centre · Toronto, ON |
| 82 | Mon Jul 4 | vs Tigers | W5-3 | 50-32 | .610 | Progressive Field · Cleveland, OH |
| 83 | Tue Jul 5 | vs Tigers | W12-1 | 51-32 | .614 | Progressive Field · Cleveland, OH |
| 84 | Wed Jul 6 | vs Tigers | L2-12 | 51-33 | .607 | Progressive Field · Cleveland, OH |
| 85 | Thu Jul 7 | vs Yankees | L4-5 | 51-34 | .600 | Progressive Field · Cleveland, OH |
| 86 | Fri Jul 8 | vs Yankees | W10-2 | 52-34 | .605 | Progressive Field · Cleveland, OH |
| 87 | Sat Jul 9 | vs Yankees | L6-7 (11) | 52-35 | .598 | Progressive Field · Cleveland, OH |
| 88 | Sun Jul 10 | vs Yankees | L7-11 | 52-36 | .591 | Progressive Field · Cleveland, OH |
| 89 | Fri Jul 15 | at Twins | W5-2 | 53-36 | .596 | Target Field · Minneapolis, MN |
| 90 | Sat Jul 16 | at Twins | L4-5 (11) | 53-37 | .589 | Target Field · Minneapolis, MN |
| 91 | Sun Jul 17 | at Twins | W6-1 | 54-37 | .593 | Target Field · Minneapolis, MN |
| 92 | Mon Jul 18 | at Royals | L3-7 | 54-38 | .587 | Kauffman Stadium · Kansas City, MO |
| 93 | Tue Jul 19 | at Royals | W7-3 | 55-38 | .591 | Kauffman Stadium · Kansas City, MO |
| 94 | Wed Jul 20 | at Royals | W11-4 | 56-38 | .596 | Kauffman Stadium · Kansas City, MO |
| 95 | Fri Jul 22 | at Orioles | L1-5 | 56-39 | .589 | Camden Yards · Baltimore, MD |
| 96 | Sat Jul 23 | at Orioles | L2-5 | 56-40 | .583 | Camden Yards · Baltimore, MD |
| 97 | Sun Jul 24 | at Orioles | L3-5 | 56-41 | .577 | Camden Yards · Baltimore, MD |
| 98 | Tue Jul 26 | vs Nationals | W7-6 | 57-41 | .582 | Progressive Field · Cleveland, OH |
| 99 | Wed Jul 27 | vs Nationals | L1-4 | 57-42 | .576 | Progressive Field · Cleveland, OH |
| 100 | Fri Jul 29 | vs Athletics | W5-3 | 58-42 | .580 | Progressive Field · Cleveland, OH |
| 101 | Sat Jul 30 | vs Athletics | W6-3 | 59-42 | .584 | Progressive Field · Cleveland, OH |
| 102 | Sun Jul 31 | vs Athletics | W8-0 | 60-42 | .588 | Progressive Field · Cleveland, OH |
| 103 | Mon Aug 1 | vs Twins | L5-12 | 60-43 | .583 | Progressive Field · Cleveland, OH |
| 104 | Tue Aug 2 | vs Twins | L6-10 | 60-44 | .577 | Progressive Field · Cleveland, OH |
| 105 | Wed Aug 3 | vs Twins | L5-13 | 60-45 | .571 | Progressive Field · Cleveland, OH |
| 106 | Thu Aug 4 | vs Twins | W9-2 | 61-45 | .575 | Progressive Field · Cleveland, OH |
| 107 | Fri Aug 5 | at Yankees | L7-13 | 61-46 | .570 | Yankee Stadium · The Bronx, NY |
| 108 | Sat Aug 6 | at Yankees | W5-2 | 62-46 | .574 | Yankee Stadium · The Bronx, NY |
| 109 | Sun Aug 7 | at Yankees | L2-3 | 62-47 | .569 | Yankee Stadium · The Bronx, NY |
| 110 | Tue Aug 9 | at Nationals | W3-1 | 63-47 | .573 | Nationals Park · Washington, D.C. |
| 111 | Wed Aug 10 | at Nationals | L4-7 | 63-48 | .568 | Nationals Park · Washington, D.C. |
| 112 | Thu Aug 11 | vs Angels | W14-4 | 64-48 | .571 | Progressive Field · Cleveland, OH |
| 113 | Fri Aug 12 | vs Angels | W13-3 | 65-48 | .575 | Progressive Field · Cleveland, OH |
| 114 | Sat Aug 13 | vs Angels | W5-1 | 66-48 | .579 | Progressive Field · Cleveland, OH |
| 115 | Sun Aug 14 | vs Angels | W5-4 | 67-48 | .583 | Progressive Field · Cleveland, OH |
| 116 | Mon Aug 15 | vs Red Sox | L2-3 | 67-49 | .578 | Progressive Field · Cleveland, OH |
| 117 | Tue Aug 16 | vs White Sox | W3-1 | 68-49 | .581 | Progressive Field · Cleveland, OH |
| 118 | Wed Aug 17 | vs White Sox | L7-10 | 68-50 | .576 | Progressive Field · Cleveland, OH |
| 119 | Thu Aug 18 | vs White Sox | W5-4 | 69-50 | .580 | Progressive Field · Cleveland, OH |
| 120 | Fri Aug 19 | vs Blue Jays | W3-2 | 70-50 | .583 | Progressive Field · Cleveland, OH |
| 121 | Sat Aug 20 | vs Blue Jays | L5-6 | 70-51 | .579 | Progressive Field · Cleveland, OH |
| 122 | Sun Aug 21 | vs Blue Jays | W3-2 | 71-51 | .582 | Progressive Field · Cleveland, OH |
| 123 | Mon Aug 22 | at Athletics | W1-0 | 72-51 | .585 | RingCentral Coliseum · Oakland, CA |
| 124 | Tue Aug 23 | at Athletics | L1-9 | 72-52 | .581 | RingCentral Coliseum · Oakland, CA |
| 125 | Wed Aug 24 | at Athletics | L1-5 | 72-53 | .576 | RingCentral Coliseum · Oakland, CA |
| 126 | Thu Aug 25 | at Rangers | L0-9 | 72-54 | .571 | Globe Life Field · Arlington, TX |
| 127 | Fri Aug 26 | at Rangers | W12-1 | 73-54 | .575 | Globe Life Field · Arlington, TX |
| 128 | Sat Aug 27 | at Rangers | L0-7 | 73-55 | .570 | Globe Life Field · Arlington, TX |
| 129 | Sun Aug 28 | at Rangers | L1-2 | 73-56 | .566 | Globe Life Field · Arlington, TX |
| 130 | Mon Aug 29 | vs Twins | W1-0 (10) | 74-56 | .569 | Progressive Field · Cleveland, OH |
| 131 | Tue Aug 30 | vs Twins | W5-4 | 75-56 | .573 | Progressive Field · Cleveland, OH |
| 132 | Wed Aug 31 | vs Twins | W8-4 | 76-56 | .576 | Progressive Field · Cleveland, OH |
| 133 | Fri Sep 2 | vs Marlins | W6-2 | 77-56 | .579 | Progressive Field · Cleveland, OH |
| 134 | Sat Sep 3 | vs Marlins | W8-3 | 78-56 | .582 | Progressive Field · Cleveland, OH |
| 135 | Sun Sep 4 | vs Marlins | W6-5 | 79-56 | .585 | Progressive Field · Cleveland, OH |
| 136 | Mon Sep 5 | vs Astros | L2-6 | 79-57 | .581 | Progressive Field · Cleveland, OH |
| 137 | Tue Sep 6 | vs Astros | L3-4 | 79-58 | .577 | Progressive Field · Cleveland, OH |
| 138 | Wed Sep 7 | vs Astros | W6-5 | 80-58 | .580 | Progressive Field · Cleveland, OH |
| 139 | Thu Sep 8 | vs Astros | W10-7 | 81-58 | .583 | Progressive Field · Cleveland, OH |
| 140 | Fri Sep 9 | at Twins | W5-4 | 82-58 | .586 | Target Field · Minneapolis, MN |
| 141 | Sat Sep 10 | at Twins | L1-2 (12) | 82-59 | .582 | Target Field · Minneapolis, MN |
| 142 | Sun Sep 11 | at Twins | W7-1 | 83-59 | .585 | Target Field · Minneapolis, MN |
| 143 | Mon Sep 12 | at White Sox | L4-11 | 83-60 | .580 | Guaranteed Rate Field · Chicago, IL |
| 144 | Tue Sep 13 | at White Sox | L1-8 | 83-61 | .576 | Guaranteed Rate Field · Chicago, IL |
| 145 | Wed Sep 14 | at White Sox | W6-1 | 84-61 | .579 | Guaranteed Rate Field · Chicago, IL |
| 146 | Thu Sep 15 | at White Sox | L1-2 | 84-62 | .575 | Guaranteed Rate Field · Chicago, IL |
| 147 | Fri Sep 16 | vs Tigers | W11-4 | 85-62 | .578 | Progressive Field · Cleveland, OH |
| 148 | Sat Sep 17 | vs Tigers | W1-0 (10) | 86-62 | .581 | Progressive Field · Cleveland, OH |
| 149 | Sun Sep 18 | vs Tigers | L5-9 | 86-63 | .577 | Progressive Field · Cleveland, OH |
| 150 | Tue Sep 20 | vs Royals | W2-1 | 87-63 | .580 | Progressive Field · Cleveland, OH |
| 151 | Wed Sep 21 | vs Royals | W4-3 | 88-63 | .583 | Progressive Field · Cleveland, OH |
| 152 | Thu Sep 22 | vs Royals | W5-2 | 89-63 | .586 | Progressive Field · Cleveland, OH |
| 153 | Fri Sep 23 | vs White Sox | W10-4 | 90-63 | .588 | Progressive Field · Cleveland, OH |
| 154 | Sat Sep 24 | vs White Sox | L1-8 | 90-64 | .584 | Progressive Field · Cleveland, OH |
| 155 | Sun Sep 25 | vs White Sox | L0-3 | 90-65 | .581 | Progressive Field · Cleveland, OH |
| 156 | Mon Sep 26 | at Tigers | W7-4 | 91-65 | .583 | Comerica Park · Detroit, MI |
| 157 | Tue Sep 27 | at Tigers | L0-12 | 91-66 | .580 | Comerica Park · Detroit, MI |
| 158 | Wed Sep 28 | at Tigers | L3-6 | 91-67 | .576 | Comerica Park · Detroit, MI |
| 159 | Fri Sep 30 | at Royals | W7-2 | 92-67 | .579 | Kauffman Stadium · Kansas City, MO |
| 160 | Sat Oct 1 | at Royals | W6-3 | 93-67 | .581 | Kauffman Stadium · Kansas City, MO |
| 161 | Sun Oct 2 | at Royals | W3-2 | 94-67 | .584 | Kauffman Stadium · Kansas City, MO |
| 163 | Thu Oct 6 | vs Red Sox | W5-4 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 164 | Fri Oct 7 | vs Red Sox | W6-0 | 2-0 | 1.000 | Progressive Field · Cleveland, OH |
| 165 | Mon Oct 10 | at Red Sox | W4-3 | 3-0 | 1.000 | Fenway Park · Boston, MA |
| 166 | Fri Oct 14 | vs Blue Jays | W2-0 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 167 | Sat Oct 15 | vs Blue Jays | W2-1 | 2-0 | 1.000 | Progressive Field · Cleveland, OH |
| 168 | Mon Oct 17 | at Blue Jays | W4-2 | 3-0 | 1.000 | Rogers Centre · Toronto, ON |
| 169 | Tue Oct 18 | at Blue Jays | L1-5 | 3-1 | .750 | Rogers Centre · Toronto, ON |
| 170 | Wed Oct 19 | at Blue Jays | W3-0 | 4-1 | .800 | Rogers Centre · Toronto, ON |
| 171 | Tue Oct 25 | vs Cubs | W6-0 | 1-0 | 1.000 | Progressive Field · Cleveland, OH |
| 172 | Wed Oct 26 | vs Cubs | L1-5 | 1-1 | .500 | Progressive Field · Cleveland, OH |
| 173 | Fri Oct 28 | at Cubs | W1-0 | 2-1 | .667 | Wrigley Field · Chicago, IL |
| 174 | Sat Oct 29 | at Cubs | W7-2 | 3-1 | .750 | Wrigley Field · Chicago, IL |
| 175 | Sun Oct 30 | at Cubs | L2-3 | 3-2 | .600 | Wrigley Field · Chicago, IL |
| 176 | Tue Nov 1 | vs Cubs | L3-9 | 3-3 | .500 | Progressive Field · Cleveland, OH |
| 177 | Wed Nov 2 | vs Cubs | L7-8 (10) | 3-4 | .429 | Progressive Field · Cleveland, OH |