| 1 | Thu Mar 26 | vs Guardians | L4-6 | 0-1 | .000 | T-Mobile Park · Seattle, WA |
| 2 | Fri Mar 27 | vs Guardians | W5-1 | 1-1 | .500 | T-Mobile Park · Seattle, WA |
| 3 | Sat Mar 28 | vs Guardians | L5-6 (10) | 1-2 | .333 | T-Mobile Park · Seattle, WA |
| 4 | Sun Mar 29 | vs Guardians | W8-0 | 2-2 | .500 | T-Mobile Park · Seattle, WA |
| 5 | Mon Mar 30 | vs Yankees | W2-1 | 3-2 | .600 | T-Mobile Park · Seattle, WA |
| 6 | Tue Mar 31 | vs Yankees | L0-5 | 3-3 | .500 | T-Mobile Park · Seattle, WA |
| 7 | Wed Apr 1 | vs Yankees | L3-5 | 3-4 | .429 | T-Mobile Park · Seattle, WA |
| 8 | Fri Apr 3 | at Angels | W3-1 (10) | 4-4 | .500 | Angel Stadium · Anaheim, CA |
| 9 | Sat Apr 4 | at Angels | L0-1 | 4-5 | .444 | Angel Stadium · Anaheim, CA |
| 10 | Sun Apr 5 | at Angels | L7-8 (11) | 4-6 | .400 | Angel Stadium · Anaheim, CA |
| 11 | Mon Apr 6 | at Rangers | L1-2 | 4-7 | .364 | Globe Life Field · Arlington, TX |
| 12 | Tue Apr 7 | at Rangers | L2-3 | 4-8 | .333 | Globe Life Field · Arlington, TX |
| 13 | Wed Apr 8 | at Rangers | L0-3 | 4-9 | .308 | Globe Life Field · Arlington, TX |
| 14 | Fri Apr 10 | vs Astros | W9-6 | 5-9 | .357 | T-Mobile Park · Seattle, WA |
| 15 | Sat Apr 11 | vs Astros | W8-7 | 6-9 | .400 | T-Mobile Park · Seattle, WA |
| 16 | Sun Apr 12 | vs Astros | W6-1 | 7-9 | .438 | T-Mobile Park · Seattle, WA |
| 17 | Mon Apr 13 | vs Astros | W6-2 | 8-9 | .471 | T-Mobile Park · Seattle, WA |
| 18 | Tue Apr 14 | at Padres | L1-4 | 8-10 | .444 | Petco Park · San Diego, CA |
| 19 | Wed Apr 15 | at Padres | L6-7 | 8-11 | .421 | Petco Park · San Diego, CA |
| 20 | Thu Apr 16 | at Padres | L2-5 | 8-12 | .400 | Petco Park · San Diego, CA |
| 21 | Fri Apr 17 | vs Rangers | L0-5 | 8-13 | .381 | T-Mobile Park · Seattle, WA |
| 22 | Sat Apr 18 | vs Rangers | W7-3 | 9-13 | .409 | T-Mobile Park · Seattle, WA |
| 23 | Sun Apr 19 | vs Rangers | W5-2 | 10-13 | .435 | T-Mobile Park · Seattle, WA |
| 24 | Mon Apr 20 | vs Athletics | L4-6 | 10-14 | .417 | T-Mobile Park · Seattle, WA |
| 25 | Tue Apr 21 | vs Athletics | L2-5 | 10-15 | .400 | T-Mobile Park · Seattle, WA |
| 26 | Wed Apr 22 | vs Athletics | W5-4 | 11-15 | .423 | T-Mobile Park · Seattle, WA |
| 27 | Fri Apr 24 | at Cardinals | W3-2 | 12-15 | .444 | Busch Stadium · St. Louis, MO |
| 28 | Sat Apr 25 | at Cardinals | W11-9 | 13-15 | .464 | Busch Stadium · St. Louis, MO |
| 29 | Sun Apr 26 | at Cardinals | W3-2 | 14-15 | .483 | Busch Stadium · St. Louis, MO |
| 30 | Mon Apr 27 | at Twins | L4-11 | 14-16 | .467 | Target Field · Minneapolis, MN |
| 31 | Tue Apr 28 | at Twins | W7-1 | 15-16 | .484 | Target Field · Minneapolis, MN |
| 32 | Wed Apr 29 | at Twins | W5-3 | 16-16 | .500 | Target Field · Minneapolis, MN |
| 33 | Fri May 1 | vs Royals | L6-7 | 16-17 | .485 | T-Mobile Park · Seattle, WA |
| 34 | Sat May 2 | vs Royals | L2-3 (10) | 16-18 | .471 | T-Mobile Park · Seattle, WA |
| 35 | Sun May 3 | vs Royals | L1-4 | 16-19 | .457 | T-Mobile Park · Seattle, WA |
| 36 | Mon May 4 | vs Braves | W5-4 | 17-19 | .472 | T-Mobile Park · Seattle, WA |
| 37 | Tue May 5 | vs Braves | L2-3 | 17-20 | .459 | T-Mobile Park · Seattle, WA |
| 38 | Wed May 6 | vs Braves | W3-1 | 18-20 | .474 | T-Mobile Park · Seattle, WA |
| 39 | Fri May 8 | at White Sox | W12-8 | 19-20 | .487 | Guaranteed Rate Field · Chicago, IL |
| 40 | Sat May 9 | at White Sox | L1-6 | 19-21 | .475 | Guaranteed Rate Field · Chicago, IL |
| 41 | Sun May 10 | at White Sox | L1-2 | 19-22 | .463 | Guaranteed Rate Field · Chicago, IL |
| 42 | Mon May 11 | at Astros | W3-1 | 20-22 | .476 | Minute Maid Park · Houston, TX |
| 43 | Tue May 12 | at Astros | W10-2 | 21-22 | .488 | Minute Maid Park · Houston, TX |
| 44 | Wed May 13 | at Astros | L3-4 (10) | 21-23 | .477 | Minute Maid Park · Houston, TX |
| 45 | Thu May 14 | at Astros | W8-3 | 22-23 | .489 | Minute Maid Park · Houston, TX |
| 46 | Fri May 15 | vs Padres | L0-2 | 22-24 | .478 | T-Mobile Park · Seattle, WA |
| 47 | Sat May 16 | vs Padres | L4-7 | 22-25 | .468 | T-Mobile Park · Seattle, WA |
| 48 | Sun May 17 | vs Padres | L3-8 | 22-26 | .458 | T-Mobile Park · Seattle, WA |
| 49 | Mon May 18 | vs White Sox | W6-1 | 23-26 | .469 | T-Mobile Park · Seattle, WA |
| 50 | Tue May 19 | vs White Sox | L1-2 | 23-27 | .460 | T-Mobile Park · Seattle, WA |
| 51 | Wed May 20 | vs White Sox | W5-4 | 24-27 | .471 | T-Mobile Park · Seattle, WA |
| 52 | Fri May 22 | at Royals | W2-0 | 25-27 | .481 | Kauffman Stadium · Kansas City, MO |
| 53 | Sat May 23 | at Royals | L0-5 | 25-28 | .472 | Kauffman Stadium · Kansas City, MO |
| 54 | Sun May 24 | at Royals | L6-8 | 25-29 | .463 | Kauffman Stadium · Kansas City, MO |
| 55 | Mon May 25 | at Athletics | W9-2 | 26-29 | .473 | Sutter Health Park · West Sacramento, CA |
| 56 | Tue May 26 | at Athletics | W4-1 | 27-29 | .482 | Sutter Health Park · West Sacramento, CA |
| 57 | Wed May 27 | at Athletics | W9-1 | 28-29 | .491 | Sutter Health Park · West Sacramento, CA |
| 58 | Fri May 29 | vs D-backs | W7-6 (10) | 29-29 | .500 | T-Mobile Park · Seattle, WA |
| 59 | Sat May 30 | vs D-backs | W5-1 | 30-29 | .508 | T-Mobile Park · Seattle, WA |
| 60 | Sun May 31 | vs D-backs | W3-2 (10) | 31-29 | .517 | T-Mobile Park · Seattle, WA |
| 61 | Mon Jun 1 | vs Mets | W3-2 (10) | 32-29 | .525 | T-Mobile Park · Seattle, WA |
| 62 | Tue Jun 2 | vs Mets | W8-3 | 33-29 | .532 | T-Mobile Park · Seattle, WA |
| 63 | Wed Jun 3 | vs Mets | L1-7 | 33-30 | .524 | T-Mobile Park · Seattle, WA |
| 64 | Fri Jun 5 | at Tigers | L3-7 | 33-31 | .516 | Comerica Park · Detroit, MI |
| 65 | Sat Jun 6 | at Tigers | W4-0 | 34-31 | .523 | Comerica Park · Detroit, MI |
| 66 | Sun Jun 7 | at Tigers | L4-5 | 34-32 | .515 | Comerica Park · Detroit, MI |
| 67 | Mon Jun 8 | at Orioles | W6-3 | 35-32 | .522 | Camden Yards · Baltimore, MD |
| 68 | Tue Jun 9 | at Orioles | W6-5 (10) | 36-32 | .529 | Camden Yards · Baltimore, MD |
| 69 | Wed Jun 10 | at Orioles | L2-7 | 36-33 | .522 | Camden Yards · Baltimore, MD |
| 70 | Thu Jun 11 | at Orioles | L5-7 | 36-34 | .514 | Camden Yards · Baltimore, MD |
| 71 | Fri Jun 12 | at Nationals | W10-2 | 37-34 | .521 | Nationals Park · Washington, D.C. |
| 72 | Sat Jun 13 | at Nationals | L3-8 | 37-35 | .514 | Nationals Park · Washington, D.C. |
| 73 | Sun Jun 14 | at Nationals | L1-10 | 37-36 | .507 | Nationals Park · Washington, D.C. |
| 74 | Tue Jun 16 | vs Orioles | W3-1 | 38-36 | .514 | T-Mobile Park · Seattle, WA |
| 75 | Wed Jun 17 | vs Orioles | L3-5 | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 76 | Thu Jun 18 | vs Orioles | W3-0 | 39-37 | .513 | T-Mobile Park · Seattle, WA |
| 77 | Fri Jun 19 | vs Red Sox | L2-6 | 39-38 | .506 | T-Mobile Park · Seattle, WA |
| 78 | Sat Jun 20 | vs Red Sox | L1-5 | 39-39 | .500 | T-Mobile Park · Seattle, WA |
| 79 | Sun Jun 21 | vs Red Sox | W3-1 | 40-39 | .506 | T-Mobile Park · Seattle, WA |
| 80 | Tue Jun 23 | at Pirates | W3-2 | 41-39 | .512 | PNC Park · Pittsburgh, PA |
| 81 | Wed Jun 24 | at Pirates | L1-11 | 41-40 | .506 | PNC Park · Pittsburgh, PA |
| 82 | Thu Jun 25 | at Pirates | L1-5 | 41-41 | .500 | PNC Park · Pittsburgh, PA |
| 83 | Fri Jun 26 | at Guardians | W3-1 | 42-41 | .506 | Progressive Field · Cleveland, OH |
| 84 | Sat Jun 27 | at Guardians | L3-4 | 42-42 | .500 | Progressive Field · Cleveland, OH |
| 85 | Sun Jun 28 | at Guardians | L5-6 | 42-43 | .494 | Progressive Field · Cleveland, OH |
| 86 | Mon Jun 29 | vs Angels | W6-2 | 43-43 | .500 | T-Mobile Park · Seattle, WA |
| 87 | Tue Jun 30 | vs Angels | W8-3 | 44-43 | .506 | T-Mobile Park · Seattle, WA |
| 88 | Thu Jul 2 | vs Angels | W1-0 | 45-43 | .511 | T-Mobile Park · Seattle, WA |
| 89 | Fri Jul 3 | vs Blue Jays | L0-2 | 45-44 | .506 | T-Mobile Park · Seattle, WA |
| 90 | Sat Jul 4 | vs Blue Jays | W11-0 | 46-44 | .511 | T-Mobile Park · Seattle, WA |
| 91 | Sun Jul 5 | vs Blue Jays | W4-0 | 47-44 | .516 | T-Mobile Park · Seattle, WA |
| 92 | Tue Jul 7 | at Marlins | L5-6 (10) | 47-45 | .511 | LoanDepot Park · Miami, FL |
| 93 | Wed Jul 8 | at Marlins | L0-2 | 47-46 | .505 | LoanDepot Park · Miami, FL |
| 94 | Thu Jul 9 | at Marlins | L4-8 | 47-47 | .500 | LoanDepot Park · Miami, FL |
| 95 | Fri Jul 10 | at Rays | L2-7 | 47-48 | .495 | Tropicana Field · St. Petersburg, FL |
| 96 | Sat Jul 11 | at Rays | L1-6 | 47-49 | .490 | Tropicana Field · St. Petersburg, FL |
| 97 | Sun Jul 12 | at Rays | W8-2 | 48-49 | .495 | Tropicana Field · St. Petersburg, FL |