| 1 | Mon Nov 3 | vs Louisiana | W75-64 | 1-0 | 1.000 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 2 | Fri Nov 7 | vsTBD | W84-54 | 2-0 | 1.000 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 3 | Tue Nov 11 | at24Wisconsin | L55-86 | 2-1 | .667 | - | BTN | Kohl Center · Madison, WI |
| 4 | Sat Nov 15 | vsLittle Rock | L62-68 | 2-2 | .500 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 5 | Sat Nov 22 | atIndiana St | L52-70 | 2-3 | .400 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 6 | Fri Nov 28 | vsMonmouth | L73-80 | 2-4 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 7 | Sat Nov 29 | atLafayette | L37-55 | 2-5 | .286 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 8 | Sun Nov 30 | vsLe Moyne | W96-85 | 3-5 | .375 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Wed Dec 3 | atEvansville | L52-64 | 3-6 | .333 | - | ESPN+ | Ford Center · Evansville, IN |
| 10 | Tue Dec 9 | vsS Dakota St | L64-68 | 3-7 | .300 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 11 | Sun Dec 14 | atCampbell | L64-69 | 3-8 | .273 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 12 | Sat Dec 20 | vsMiami OH | L77-86 | 3-9 | .250 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 13 | Mon Dec 29 | vsTBD | W93-30 | 4-9 | .308 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 14 | Sat Jan 3 | atBuffalo | L72-85 | 4-10 | .286 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 15 | Tue Jan 6 | vsE Michigan | L52-74 | 4-11 | .267 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 16 | Sat Jan 10 | atUMass | L71-79 | 4-12 | .250 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 17 | Tue Jan 13 | atAkron | L77-87 | 4-13 | .235 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 18 | Fri Jan 16 | vsOhio | W76-71 | 5-13 | .278 | - | CBSSN | Worthen Arena · Muncie, IN |
| 19 | Tue Jan 20 | atC Michigan | W68-67 | 6-13 | .316 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 20 | Sat Jan 24 | vsN Illinois | W58-53 | 7-13 | .350 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 21 | Sat Jan 31 | atToledo | L55-73 | 7-14 | .333 | - | ESPN+ | Savage Arena · Toledo, OH |
| 22 | Tue Feb 3 | atBowling Green | L52-77 | 7-15 | .318 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 23 | Sat Feb 7 | atUL Monroe | W73-68 | 8-15 | .348 | - | ESPN+ | Fant-Ewing Coliseum · Monroe, LA |
| 24 | Wed Feb 11 | vsBuffalo | L53-63 | 8-16 | .333 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 25 | Sat Feb 14 | vsKent State | L68-75 | 8-17 | .320 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 26 | Tue Feb 17 | atOhio | L57-69 | 8-18 | .308 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 27 | Fri Feb 20 | vsAkron | L65-78 | 8-19 | .296 | - | CBSSN | Worthen Arena · Muncie, IN |
| 28 | Tue Feb 24 | vsUMass | W74-73 (OT) | 9-19 | .321 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 29 | Sat Feb 28 | atN Illinois | W79-43 | 10-19 | .345 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
