| 1 | Tue Nov 5 | vs TBD | W87-43 | 1-0 | 1.000 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 2 | Sat Nov 9 | atEvansville | L75-79 | 1-1 | .500 | - | ESPN3 | Ford Center · Evansville, IN |
| 3 | Wed Nov 13 | atUIC | W67-48 | 2-1 | .667 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 4 | Sun Nov 17 | vsIndiana St | W69-55 | 3-1 | .750 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 5 | Wed Nov 20 | vsN Kentucky | L57-59 | 3-2 | .600 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 6 | Sat Nov 23 | vsHoward | W100-69 | 4-2 | .667 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 7 | Tue Nov 26 | vsW Illinois | L62-69 | 4-3 | .571 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 8 | Tue Dec 3 | vsLoyola Chicago | L58-70 | 4-4 | .500 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 9 | Sat Dec 7 | vsIU Indy | W102-54 | 5-4 | .556 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 10 | Wed Dec 18 | atGeorgia Tech | W65-47 | 6-4 | .600 | - | ACC Extra | McCamish Pavilion · Atlanta, GA |
| 11 | Sun Dec 22 | atWashington | L64-85 | 6-5 | .545 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 12 | Tue Dec 24 | atUTEP | L70-71 | 6-6 | .500 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | vsPortland | W61-46 | 7-6 | .538 | - | ESPNU | Stan Sheriff Center · Honolulu, HI |
| 14 | Fri Jan 3 | vsToledo | W61-57 | 8-6 | .571 | - | CBSSN | Worthen Arena · Muncie, IN |
| 15 | Tue Jan 7 | vsBuffalo | W88-68 | 9-6 | .600 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 16 | Fri Jan 10 | atAkron | L60-75 | 9-7 | .563 | - | CBSSN | James A. Rhodes Arena · Akron, OH |
| 17 | Tue Jan 14 | atE Michigan | W69-52 | 10-7 | .588 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 18 | Sat Jan 18 | vsMiami OH | W71-62 | 11-7 | .611 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 19 | Sat Jan 25 | atC Michigan | L66-71 | 11-8 | .579 | - | ESPN3 | McGuirk Arena · Mount Pleasant, MI |
| 20 | Tue Jan 28 | atBowling Green | L61-67 | 11-9 | .550 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 21 | Sat Feb 1 | vsOhio | W65-54 | 12-9 | .571 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 22 | Tue Feb 4 | atKent State | W62-54 | 13-9 | .591 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 23 | Sat Feb 8 | atW Michigan | L64-68 | 13-10 | .565 | - | ESPN3 | University Arena (MI) · Kalamazoo, MI |
| 24 | Tue Feb 11 | vsN Illinois | W63-59 | 14-10 | .583 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 25 | Sat Feb 15 | vsBowling Green | L71-77 | 14-11 | .560 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 26 | Tue Feb 18 | atBuffalo | L59-72 | 14-12 | .538 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 27 | Sat Feb 22 | vsE Michigan | W64-55 | 15-12 | .556 | - | ESPN3 | Worthen Arena · Muncie, IN |
| 28 | Tue Feb 25 | vsW Michigan | W71-61 | 16-12 | .571 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 29 | Sat Feb 29 | atToledo | L63-69 | 16-13 | .552 | - | ESPN3 | Savage Arena · Toledo, OH |
| 30 | Tue Mar 3 | vsC Michigan | W85-68 | 17-13 | .567 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 31 | Fri Mar 6 | atN Illinois | W75-54 | 18-13 | .581 | - | ESPN3 | NIU Convocation Center · Dekalb, IL |
