| 1 | Mon Nov 4 | at Wisconsin | L61-85 | 0-1 | .000 | - | B1G+ | Kohl Center · Madison, WI |
| 2 | Fri Nov 8 | at Rhode Island | L77-91 | 0-2 | .000 | - | ESPN+ | Ryan Center · Kingston, RI |
| 3 | Fri Nov 15 | at Sacred Heart | W82-75 | 1-2 | .333 | - | ESPN+ | William H. Pitt Center · Fairfield, CT |
| 4 | Sat Nov 16 | at Brown | W73-65 | 2-2 | .500 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 5 | Sun Nov 17 | vs New Hampshire | W74-72 | 3-2 | .600 | - | ESPN+ | Hart Center · Worcester, MA |
| 6 | Wed Nov 20 | vs TBD | W88-49 | 4-2 | .667 | - | ESPN+ | Hart Center · Worcester, MA |
| 7 | Sun Nov 24 | at Maine | L55-80 | 4-3 | .571 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 8 | Fri Nov 29 | at Virginia | L41-67 | 4-4 | .500 | - | ESPN+ | John Paul Jones Arena · Charlottesville, VA |
| 9 | Wed Dec 4 | vs Harvard | W68-67 | 5-4 | .556 | - | ESPN+ | Hart Center · Worcester, MA |
| 10 | Sat Dec 7 | vs C Connecticut | L56-69 | 5-5 | .500 | - | ESPN+ | Hart Center · Worcester, MA |
| 11 | Tue Dec 17 | at Quinnipiac | W70-69 | 6-5 | .545 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 12 | Fri Dec 20 | at Siena | W78-70 | 7-5 | .583 | - | ESPN+ | MVP Arena · Albany, NY |
| 13 | Sun Dec 29 | vsTBD | W82-46 | 8-5 | .615 | - | ESPN+ | Hart Center · Worcester, MA |
| 14 | Thu Jan 2 | vs Loyola MD | W74-72 | 9-5 | .643 | - | ESPN+ | Hart Center · Worcester, MA |
| 15 | Sun Jan 5 | at American | L64-75 | 9-6 | .600 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 16 | Wed Jan 8 | vs Navy | W70-59 | 10-6 | .625 | - | ESPN+ | Hart Center · Worcester, MA |
| 17 | Sat Jan 11 | at Lafayette | L65-82 | 10-7 | .588 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 18 | Wed Jan 15 | at Bucknell | L82-86 | 10-8 | .556 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 19 | Sat Jan 18 | vsAmerican | L65-74 | 10-9 | .526 | - | ESPN+ | Hart Center · Worcester, MA |
| 20 | Wed Jan 22 | vs Army | L71-76 | 10-10 | .500 | - | ESPN+ | Hart Center · Worcester, MA |
| 21 | Sat Jan 25 | atLoyola MD | W70-65 | 11-10 | .524 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 22 | Mon Jan 27 | at Boston Univ | L59-69 | 11-11 | .500 | - | CBS | Case Gym · Boston, MA |
| 23 | Sat Feb 1 | vs Lehigh | L67-69 | 11-12 | .478 | - | ESPN+ | Hart Center · Worcester, MA |
| 24 | Wed Feb 5 | atArmy | L65-68 | 11-13 | .458 | - | ESPN+ | Christl Arena · West Point, NY |
| 25 | Sat Feb 8 | vsBoston Univ | W72-52 | 12-13 | .480 | - | ESPN+ | Hart Center · Worcester, MA |
| 26 | Wed Feb 12 | vs Colgate | L65-87 | 12-14 | .462 | - | ESPN+ | Hart Center · Worcester, MA |
| 27 | Sat Feb 15 | atLehigh | L60-72 | 12-15 | .444 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 28 | Wed Feb 19 | vsLafayette | W74-69 (OT) | 13-15 | .464 | - | ESPN+ | Hart Center · Worcester, MA |
