| 1 | Mon Nov 7 | vs TBD | W53-47 | 1-0 | 1.000 | - | | The Super Pit · Denton, TX |
| 2 | Sun Nov 13 | at Saint Mary's | L33-63 | 1-1 | .500 | - | | University Credit Union Pavilion · Moraga, CA |
| 3 | Sat Nov 19 | vs Fresno St | W61-52 | 2-1 | .667 | - | | The Super Pit · Denton, TX |
| 4 | Tue Nov 22 | vsTBD | W76-46 | 3-1 | .750 | - | | The Super Pit · Denton, TX |
| 5 | Fri Nov 25 | vs San Jose St | W69-54 | 4-1 | .800 | - | | The Super Pit · Denton, TX |
| 6 | Sat Nov 26 | vs Long Beach St | W68-47 | 5-1 | .833 | - | | The Super Pit · Denton, TX |
| 7 | Sun Nov 27 | at UNC Wilmington | L51-55 | 5-2 | .714 | - | | Trask Coliseum · Wilmington, NC |
| 8 | Sat Dec 3 | vs Omaha | W75-45 | 6-2 | .750 | - | | The Super Pit · Denton, TX |
| 9 | Tue Dec 6 | at UT Arlington | W60-57 | 7-2 | .778 | - | | College Park Center · Arlington, TX |
| 10 | Sat Dec 10 | at Grand Canyon | W60-58 | 8-2 | .800 | - | | GCU Arena · Phoenix, AZ |
| 11 | Sat Dec 17 | at UMass | W62-44 | 9-2 | .818 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Thu Dec 22 | at UTSA | W78-54 | 10-2 | .833 | - | | UTSA Convocation Center · San Antonio, TX |
| 13 | Thu Dec 29 | vs FAU | L46-50 | 10-3 | .769 | - | | The Super Pit · Denton, TX |
| 14 | Sat Dec 31 | vs FIU | W72-57 | 11-3 | .786 | - | | The Super Pit · Denton, TX |
| 15 | Thu Jan 5 | at Western KY | W70-66 | 12-3 | .800 | - | CBS | E. A. Diddle Arena · Bowling Green, KY |
| 16 | Sat Jan 7 | at MTSU | W56-51 | 13-3 | .813 | - | | Murphy Center · Murfreesboro, TN |
| 17 | Wed Jan 11 | vs Louisiana Tech | W67-65 | 14-3 | .824 | - | | The Super Pit · Denton, TX |
| 18 | Sat Jan 14 | atFAU | L62-66 | 14-4 | .778 | - | | FAU Arena · Boca Raton, FL |
| 19 | Mon Jan 16 | atFIU | W64-57 | 15-4 | .789 | - | | Ocean Bank Convocation Center · Miami, FL |
| 20 | Thu Jan 19 | vs Rice | L60-72 | 15-5 | .750 | - | | The Super Pit · Denton, TX |
| 21 | Sat Jan 21 | at UAB | W63-52 | 16-5 | .762 | - | | Bartow Arena · Birmingham, AL |
| 22 | Thu Jan 26 | vsUTSA | W63-59 | 17-5 | .773 | - | ESPNU | The Super Pit · Denton, TX |
| 23 | Sat Jan 28 | vs UTEP | W52-42 | 18-5 | .783 | - | | The Super Pit · Denton, TX |
| 24 | Sat Feb 4 | atRice | W74-64 | 19-5 | .792 | - | | Tudor Fieldhouse · Houston, TX |
| 25 | Thu Feb 9 | vsUAB | W82-79 (2OT) | 20-5 | .800 | - | | The Super Pit · Denton, TX |
| 26 | Sat Feb 11 | vs Charlotte | W67-43 | 21-5 | .808 | - | | The Super Pit · Denton, TX |
| 27 | Thu Feb 16 | atLouisiana Tech | W72-62 | 22-5 | .815 | - | | Thomas Assembly Center · Ruston, LA |
| 28 | Sat Feb 18 | atUTEP | W80-72 (OT) | 23-5 | .821 | - | | Don Haskins Center · El Paso, TX |
| 29 | Thu Feb 23 | atCharlotte | L49-55 | 23-6 | .793 | - | | Dale F. Halton Arena · Charlotte, NC |
| 30 | Thu Mar 2 | vsMTSU | W64-50 | 24-6 | .800 | - | | The Super Pit · Denton, TX |
| 31 | Sat Mar 4 | vsWestern KY | W67-33 | 25-6 | .806 | - | | The Super Pit · Denton, TX |
| 32 | Thu Mar 9 | vsLouisiana Tech | W74-46 | 26-6 | .813 | - | | The Super Pit · Denton, TX |
| 33 | Fri Mar 10 | vsUAB | L69-76 | 26-7 | .788 | - | CBS | The Super Pit · Denton, TX |
| 34 | Wed Mar 15 | vs Alcorn St | W69-53 | 27-7 | .794 | - | | The Super Pit · Denton, TX |
| 35 | Sun Mar 19 | vs Sam Houston | W75-55 | 28-7 | .800 | - | | The Super Pit · Denton, TX |
| 36 | Tue Mar 21 | at Oklahoma St | W65-59 (OT) | 29-7 | .806 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 37 | Tue Mar 28 | vs Wisconsin | W56-54 | 30-7 | .811 | - | ESPN | The Super Pit · Denton, TX |
| 38 | Thu Mar 30 | vsUAB | W68-61 | 31-7 | .816 | - | ESPN2 | The Super Pit · Denton, TX |
