| 1 | Mon Nov 3 | vs TBD | W88-54 | 1-0 | 1.000 | - | ESPN+ | The Super Pit · Denton, TX |
| 2 | Thu Nov 6 | vsN'Western St | W80-53 | 2-0 | 1.000 | - | ESPN+ | The Super Pit · Denton, TX |
| 3 | Sun Nov 9 | atLoyola Chicago | W64-62 | 3-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Wed Nov 12 | atOregon St | L64-66 | 3-1 | .750 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 5 | Fri Nov 14 | atSaint Mary's | L49-80 | 3-2 | .600 | - | ESPN+ | University Credit Union Pavilion · Moraga, CA |
| 6 | Thu Nov 20 | vsC Arkansas | W74-56 | 4-2 | .667 | - | ESPN+ | The Super Pit · Denton, TX |
| 7 | Tue Nov 25 | vsE Washington | W79-71 (OT) | 5-2 | .714 | - | ESPN+ | The Super Pit · Denton, TX |
| 8 | Sun Nov 30 | vsPrairie View | W72-69 | 6-2 | .750 | - | ESPN+ | The Super Pit · Denton, TX |
| 9 | Tue Dec 2 | vsHou Christian | W77-75 | 7-2 | .778 | - | ESPN+ | The Super Pit · Denton, TX |
| 10 | Sun Dec 7 | vsTCU | L55-65 | 7-3 | .700 | - | ESPN+ | The Super Pit · Denton, TX |
| 11 | Sun Dec 14 | atSouth Alabama | W58-57 | 8-3 | .727 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 12 | Wed Dec 17 | atSanta Clara | L60-63 | 8-4 | .667 | - | | Leavey Center · Santa Clara, CA |
| 13 | Mon Dec 22 | vsTBD | W109-56 | 9-4 | .692 | - | ESPN+ | The Super Pit · Denton, TX |
| 14 | Wed Dec 31 | atMemphis | L48-57 | 9-5 | .643 | - | ESPN2 | FedExForum · Memphis, TN |
| 15 | Sun Jan 4 | vsTulsa | W72-67 | 10-5 | .667 | - | ESPN+ | The Super Pit · Denton, TX |
| 16 | Wed Jan 7 | vsSouth Florida | L70-74 | 10-6 | .625 | - | ESPN+ | The Super Pit · Denton, TX |
| 17 | Sun Jan 11 | atWichita St | L67-78 | 10-7 | .588 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 18 | Sun Jan 18 | atTulane | W71-63 | 11-7 | .611 | - | ESPN2 | Devlin Fieldhouse · New Orleans, LA |
| 19 | Wed Jan 21 | vsUTSA | W81-62 | 12-7 | .632 | - | ESPN+ | The Super Pit · Denton, TX |
| 20 | Fri Jan 23 | vsE Carolina | L59-63 | 12-8 | .600 | - | ESPN+ | The Super Pit · Denton, TX |
| 21 | Wed Jan 28 | atTulsa | L66-82 | 12-9 | .571 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Sat Jan 31 | vsUAB | L68-72 | 12-10 | .545 | - | ESPNU | The Super Pit · Denton, TX |
| 23 | Wed Feb 4 | atRice | L83-86 (2OT) | 12-11 | .522 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 24 | Sat Feb 7 | atUTSA | W81-58 | 13-11 | .542 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 25 | Thu Feb 12 | vsMemphis | W76-69 | 14-11 | .560 | - | ESPN | The Super Pit · Denton, TX |
| 26 | Sun Feb 15 | atTemple | W65-62 | 15-11 | .577 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 27 | Thu Feb 19 | vsTulane | L71-77 | 15-12 | .556 | - | ESPN2 | The Super Pit · Denton, TX |
| 28 | Sun Feb 22 | vsFAU | W73-72 | 16-12 | .571 | - | ESPNU | The Super Pit · Denton, TX |
| 29 | Wed Feb 25 | atCharlotte | L79-80 | 16-13 | .552 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 30 | Sun Mar 1 | atUAB | W62-58 | 17-13 | .567 | - | ESPNU | Bartow Arena · Birmingham, AL |
