| 1 | Tue Nov 9 | vs TBD | W84-53 | 1-0 | 1.000 | - | | The Super Pit · Denton, TX |
| 2 | Mon Nov 15 | vs Buffalo | L66-69 | 1-1 | .500 | - | | The Super Pit · Denton, TX |
| 3 | Thu Nov 18 | vs UT Arlington | W64-36 | 2-1 | .667 | - | | The Super Pit · Denton, TX |
| 4 | Thu Nov 25 | at Kansas | L59-71 | 2-2 | .500 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 5 | Fri Nov 26 | vs Miami | L63-69 | 2-3 | .400 | - | ESPN2 | The Super Pit · Denton, TX |
| 6 | Sun Nov 28 | at Drake | W57-54 | 3-3 | .500 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 7 | Sat Dec 4 | vsTBD | W73-35 | 4-3 | .571 | - | | The Super Pit · Denton, TX |
| 8 | Sat Dec 11 | at UMass | W66-57 | 5-3 | .625 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 9 | Tue Dec 14 | vs Sam Houston | W65-55 | 6-3 | .667 | - | | The Super Pit · Denton, TX |
| 10 | Sat Dec 18 | at Wichita St | W62-52 | 7-3 | .700 | - | | Charles Koch Arena · Wichita, KS |
| 13 | Sat Jan 1 | vs Rice | W75-43 | 8-3 | .727 | - | | The Super Pit · Denton, TX |
| 14 | Thu Jan 6 | vs UAB | L63-69 | 8-4 | .667 | - | CBS | The Super Pit · Denton, TX |
| 15 | Sat Jan 8 | vs MTSU | W70-63 | 9-4 | .692 | - | | The Super Pit · Denton, TX |
| 16 | Thu Jan 13 | at Marshall | W69-65 | 10-4 | .714 | - | | Cam Henderson Center · Huntington, WV |
| 17 | Sat Jan 15 | at Western KY | W65-60 | 11-4 | .733 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 18 | Thu Jan 20 | vs Charlotte | W65-51 | 12-4 | .750 | - | ESPNU | The Super Pit · Denton, TX |
| 19 | Sat Jan 22 | vs Old Dominion | W69-56 | 13-4 | .765 | - | | The Super Pit · Denton, TX |
| 20 | Thu Jan 27 | at Southern Miss | W63-54 | 14-4 | .778 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 21 | Sat Jan 29 | at Louisiana Tech | W63-62 | 15-4 | .789 | - | | Thomas Assembly Center · Ruston, LA |
| 22 | Sat Feb 5 | vs UTSA | W69-45 | 16-4 | .800 | - | | The Super Pit · Denton, TX |
| 23 | Mon Feb 7 | vs UTEP | W66-58 | 17-4 | .810 | - | | The Super Pit · Denton, TX |
| 24 | Sat Feb 12 | atRice | W67-44 | 18-4 | .818 | - | | Tudor Fieldhouse · Houston, TX |
| 25 | Thu Feb 17 | at FAU | W54-51 | 19-4 | .826 | - | | FAU Arena · Boca Raton, FL |
| 26 | Sat Feb 19 | atUAB | W58-57 | 20-4 | .833 | - | | Bartow Arena · Birmingham, AL |
| 27 | Thu Feb 24 | vsSouthern Miss | W85-61 | 21-4 | .840 | - | | The Super Pit · Denton, TX |
| 28 | Sat Feb 26 | vsLouisiana Tech | W56-49 | 22-4 | .846 | - | | The Super Pit · Denton, TX |
| 29 | Thu Mar 3 | atUTSA | W59-48 | 23-4 | .852 | - | | UTSA Convocation Center · San Antonio, TX |
| 30 | Sat Mar 5 | atUTEP | L68-70 | 23-5 | .821 | - | | Don Haskins Center · El Paso, TX |
| 31 | Thu Mar 10 | vsRice | W68-50 | 24-5 | .828 | - | | The Super Pit · Denton, TX |
| 32 | Fri Mar 11 | vsLouisiana Tech | L36-42 | 24-6 | .800 | - | CBS | The Super Pit · Denton, TX |
| 33 | Tue Mar 15 | vs Texas St | W67-63 (OT) | 25-6 | .806 | - | | The Super Pit · Denton, TX |
| 34 | Sun Mar 20 | vs Virginia | L69-71 (OT) | 25-7 | .781 | - | | The Super Pit · Denton, TX |
