| 1 | Mon Nov 7 | vs TBD | W108-43 | 1-0 | 1.000 | - | | Costello Athletic Center · Lowell, MA |
| 2 | Thu Nov 10 | atColumbia | W89-62 | 2-0 | 1.000 | - | | Francis S. Levien Gymnasium · New York, NY |
| 3 | Sat Nov 12 | atRutgers | L65-73 | 2-1 | .667 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 4 | Wed Nov 16 | vsSacred Heart | W90-81 | 3-1 | .750 | - | | Costello Athletic Center · Lowell, MA |
| 5 | Sat Nov 19 | vsTBD | W105-53 | 4-1 | .800 | - | | Costello Athletic Center · Lowell, MA |
| 6 | Wed Nov 23 | atBrown | W73-62 | 5-1 | .833 | - | | Pizzitola Sports Center · Providence, RI |
| 7 | Sun Nov 27 | vsStonehill | W73-59 | 6-1 | .857 | - | | Costello Athletic Center · Lowell, MA |
| 8 | Wed Nov 30 | vsMerrimack | W77-51 | 7-1 | .875 | - | | Costello Athletic Center · Lowell, MA |
| 9 | Sat Dec 3 | atSacred Heart | W70-59 | 8-1 | .889 | - | | William H. Pitt Center · Fairfield, CT |
| 10 | Mon Dec 5 | atLong Island | W84-64 | 9-1 | .900 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 11 | Thu Dec 8 | atUMass | W85-80 | 10-1 | .909 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Sat Dec 10 | vsSt Francis BK | W68-59 | 11-1 | .917 | - | | Costello Athletic Center · Lowell, MA |
| 13 | Tue Dec 13 | atRhode Island | L75-77 (OT) | 11-2 | .846 | - | | Ryan Center · Kingston, RI |
| 14 | Wed Dec 21 | vsBoston Univ | W68-60 | 12-2 | .857 | - | | Costello Athletic Center · Lowell, MA |
| 15 | Sat Dec 31 | atNJIT | W67-64 | 13-2 | .867 | - | | NJIT Wellness and Events Center · Newark, NJ |
| 16 | Thu Jan 5 | vsMaine | W72-70 | 14-2 | .875 | - | | Costello Athletic Center · Lowell, MA |
| 17 | Sun Jan 8 | atAlbany | L63-89 | 14-3 | .824 | - | | SEFCU Arena · Albany, NY |
| 18 | Wed Jan 11 | vsVermont | W80-65 | 15-3 | .833 | - | | Costello Athletic Center · Lowell, MA |
| 19 | Sat Jan 14 | atBinghamton | L65-66 | 15-4 | .789 | - | | Events Center (Binghamton) · Binghamton, NY |
| 20 | Wed Jan 18 | vsUMBC | W81-75 | 16-4 | .800 | - | | Costello Athletic Center · Lowell, MA |
| 21 | Sun Jan 22 | vsBryant | W98-79 | 17-4 | .810 | - | | Costello Athletic Center · Lowell, MA |
| 22 | Wed Jan 25 | atMaine | L70-75 | 17-5 | .773 | - | | Cross Insurance Center · Bangor, ME |
| 23 | Sat Jan 28 | atNew Hampshire | L65-69 | 17-6 | .739 | - | | Lundholm Gymnasium · Durham, NH |
| 24 | Wed Feb 1 | vsAlbany | W66-50 | 18-6 | .750 | - | | Costello Athletic Center · Lowell, MA |
| 25 | Sat Feb 4 | vsNJIT | W90-61 | 19-6 | .760 | - | | Costello Athletic Center · Lowell, MA |
| 26 | Mon Feb 6 | atTBD | W70-48 | 20-6 | .769 | - | | Chase Arena |
| 27 | Sat Feb 11 | atVermont | L81-93 | 20-7 | .741 | - | | Patrick Gymnasium · Burlington, VT |
| 28 | Wed Feb 15 | atBryant | W85-71 | 21-7 | .750 | - | | Chace Athletic Center · Smithfield, RI |
| 29 | Sat Feb 18 | vsBinghamton | W84-70 | 22-7 | .759 | - | | Costello Athletic Center · Lowell, MA |
| 30 | Wed Feb 22 | atUMBC | W75-70 | 23-7 | .767 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 31 | Sat Feb 25 | vsNew Hampshire | W92-55 | 24-7 | .774 | - | | Costello Athletic Center · Lowell, MA |
| 32 | Sat Mar 4 | vsMaine | W85-54 | 25-7 | .781 | - | | Costello Athletic Center · Lowell, MA |
| 33 | Tue Mar 7 | vsNew Hampshire | W75-64 | 26-7 | .788 | - | | Costello Athletic Center · Lowell, MA |
| 34 | Sat Mar 11 | atVermont | L59-72 | 26-8 | .765 | - | ESPN2 | Patrick Gymnasium · Burlington, VT |
