| 1 | Tue Nov 5 | at UMass | L64-79 | 0-1 | .000 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Fri Nov 8 | atLong Island | W87-74 | 1-1 | .500 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 3 | Sun Nov 10 | at#18Ohio State | L56-76 | 1-2 | .333 | - | ESPNU | Value City Arena · Columbus, OH |
| 4 | Tue Nov 12 | vsTBD | W88-45 | 2-2 | .500 | - | | Costello Athletic Center · Lowell, MA |
| 5 | Fri Nov 15 | vsJacksonville | L78-80 | 2-3 | .400 | - | | Costello Athletic Center · Lowell, MA |
| 6 | Sat Nov 16 | vsMerrimack | L58-60 | 2-4 | .333 | - | | Costello Athletic Center · Lowell, MA |
| 7 | Sun Nov 17 | vsDartmouth | L75-80 (OT) | 2-5 | .286 | - | | Costello Athletic Center · Lowell, MA |
| 8 | Tue Nov 26 | vsBrown | W75-63 | 3-5 | .375 | - | | Costello Athletic Center · Lowell, MA |
| 9 | Sun Dec 1 | vsC Connecticut | W73-71 | 4-5 | .444 | - | | Costello Athletic Center · Lowell, MA |
| 10 | Wed Dec 4 | vsSacred Heart | L86-89 | 4-6 | .400 | - | | Costello Athletic Center · Lowell, MA |
| 11 | Sat Dec 7 | vsSt Francis BK | W94-63 | 5-6 | .455 | - | | Costello Athletic Center · Lowell, MA |
| 12 | Wed Dec 11 | atNJIT | W72-66 | 6-6 | .500 | - | | NJIT Wellness and Events Center · Newark, NJ |
| 13 | Sat Dec 21 | vsBoston Univ | L62-74 | 6-7 | .462 | - | | Costello Athletic Center · Lowell, MA |
| 14 | Fri Dec 27 | atLoyola MD | L81-93 | 6-8 | .429 | - | | Reitz Arena · Baltimore, MD |
| 15 | Sun Dec 29 | at#11Michigan | L60-86 | 6-9 | .400 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 16 | Sat Jan 4 | atUMBC | W86-73 (OT) | 7-9 | .438 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 17 | Wed Jan 8 | vsTBD | L68-80 | 7-10 | .412 | - | | Costello Athletic Center · Lowell, MA |
| 18 | Sat Jan 11 | vsBinghamton | W85-66 | 8-10 | .444 | - | | Costello Athletic Center · Lowell, MA |
| 19 | Wed Jan 15 | atMaine | L98-104 (OT) | 8-11 | .421 | - | | Cross Insurance Center · Bangor, ME |
| 20 | Wed Jan 22 | atAlbany | L75-101 | 8-12 | .400 | - | | SEFCU Arena · Albany, NY |
| 21 | Sat Jan 25 | atVermont | L62-92 | 8-13 | .381 | - | | Patrick Gymnasium · Burlington, VT |
| 22 | Wed Jan 29 | vsStony Brook | L76-84 | 8-14 | .364 | - | | Costello Athletic Center · Lowell, MA |
| 23 | Sat Feb 1 | vsNew Hampshire | W77-75 | 9-14 | .391 | - | | Costello Athletic Center · Lowell, MA |
| 24 | Wed Feb 5 | atStony Brook | L70-77 | 9-15 | .375 | - | | Island FCU Arena · Stony Brook, NY |
| 25 | Sat Feb 8 | vsUMBC | L50-60 | 9-16 | .360 | - | | Costello Athletic Center · Lowell, MA |
| 26 | Wed Feb 12 | vsMaine | W71-63 | 10-16 | .385 | - | | Costello Athletic Center · Lowell, MA |
| 27 | Sat Feb 15 | atTBD | W74-67 | 11-16 | .407 | - | | Chase Arena |
| 28 | Thu Feb 20 | atBinghamton | L84-86 | 11-17 | .393 | - | | Events Center (Binghamton) · Binghamton, NY |
| 29 | Wed Feb 26 | vsAlbany | W88-69 | 12-17 | .414 | - | | Costello Athletic Center · Lowell, MA |
| 30 | Sat Feb 29 | vsVermont | L77-94 | 12-18 | .400 | - | | Costello Athletic Center · Lowell, MA |
| 31 | Tue Mar 3 | atNew Hampshire | W63-54 | 13-18 | .419 | - | | Lundholm Gymnasium · Durham, NH |
| 32 | Sat Mar 7 | atTBD | L75-89 | 13-19 | .406 | - | | Chase Arena |
