| 1 | Mon Nov 6 | vs TBD | W96-51 | 1-0 | 1.000 | - | | Costello Athletic Center · Lowell, MA |
| 2 | Fri Nov 10 | at Dartmouth | W81-48 | 2-0 | 1.000 | - | | Edward Leede Arena · Hanover, NH |
| 3 | Tue Nov 14 | at Georgia Tech | W74-71 | 3-0 | 1.000 | - | | McCamish Pavilion · Atlanta, GA |
| 4 | Thu Nov 16 | at Arizona St | L69-71 | 3-1 | .750 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 5 | Mon Nov 20 | at Saint Peter's | W69-61 | 4-1 | .800 | - | | Yanitelli Center · Jersey City, NJ |
| 6 | Wed Nov 29 | at Stonehill | W80-74 | 5-1 | .833 | - | | placeholder · sf, ca |
| 7 | Sat Dec 2 | at Merrimack | L68-74 | 5-2 | .714 | - | | placeholder · sf, ca |
| 8 | Tue Dec 5 | vsTBD | W117-69 | 6-2 | .750 | - | | Costello Athletic Center · Lowell, MA |
| 9 | Sat Dec 9 | at UMass | L77-91 | 6-3 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Tue Dec 12 | vs Long Island | W78-65 | 7-3 | .700 | - | | Costello Athletic Center · Lowell, MA |
| 11 | Sat Dec 16 | vs C Connecticut | L54-57 | 7-4 | .636 | - | | Costello Athletic Center · Lowell, MA |
| 12 | Fri Dec 22 | at Boston Univ | W71-63 | 8-4 | .667 | - | | Case Gym · Boston, MA |
| 13 | Sun Dec 31 | vsTBD | W116-48 | 9-4 | .692 | - | | Costello Athletic Center · Lowell, MA |
| 14 | Sat Jan 6 | at New Hampshire | W82-75 | 10-4 | .714 | - | | Lundholm Gymnasium · Durham, NH |
| 15 | Thu Jan 11 | vs NJIT | W70-62 | 11-4 | .733 | - | | Costello Athletic Center · Lowell, MA |
| 16 | Sat Jan 13 | vs UMBC | W86-82 | 12-4 | .750 | - | | Costello Athletic Center · Lowell, MA |
| 17 | Thu Jan 18 | at Albany | W97-76 | 13-4 | .765 | - | | SEFCU Arena · Albany, NY |
| 18 | Sat Jan 20 | at Binghamton | W80-60 | 14-4 | .778 | - | | Events Center (Binghamton) · Binghamton, NY |
| 19 | Thu Jan 25 | vs Vermont | L65-72 (OT) | 14-5 | .737 | - | | Costello Athletic Center · Lowell, MA |
| 20 | Thu Feb 1 | vs Maine | W76-62 | 15-5 | .750 | - | | Costello Athletic Center · Lowell, MA |
| 21 | Sat Feb 3 | vsNew Hampshire | L73-89 | 15-6 | .714 | - | | Costello Athletic Center · Lowell, MA |
| 22 | Thu Feb 8 | atUMBC | W93-80 | 16-6 | .727 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 23 | Sat Feb 10 | atNJIT | L64-71 | 16-7 | .696 | - | | NJIT Wellness and Events Center · Newark, NJ |
| 24 | Sat Feb 17 | at Bryant | W86-77 | 17-7 | .708 | - | | Chace Athletic Center · Smithfield, RI |
| 25 | Thu Feb 22 | vsBinghamton | W87-80 | 18-7 | .720 | - | | Costello Athletic Center · Lowell, MA |
| 26 | Sat Feb 24 | vsAlbany | W104-95 | 19-7 | .731 | - | | Costello Athletic Center · Lowell, MA |
| 27 | Thu Feb 29 | vsBryant | W89-67 | 20-7 | .741 | - | | Costello Athletic Center · Lowell, MA |
| 28 | Sat Mar 2 | atVermont | L62-74 | 20-8 | .714 | - | | Patrick Gymnasium · Burlington, VT |
| 29 | Tue Mar 5 | atMaine | L65-71 | 20-9 | .690 | - | | Cross Insurance Center · Bangor, ME |
| 30 | Sat Mar 9 | vsUMBC | W94-89 (OT) | 21-9 | .700 | - | | Costello Athletic Center · Lowell, MA |
| 31 | Tue Mar 12 | vsBryant | W77-70 | 22-9 | .710 | - | | Costello Athletic Center · Lowell, MA |
| 32 | Sat Mar 16 | atVermont | L61-66 | 22-10 | .688 | - | ESPN2 | Patrick Gymnasium · Burlington, VT |
