| 1 | Mon Nov 4 | vs TBD | W115-59 | 1-0 | 1.000 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 2 | Fri Nov 8 | vs Saint Peter's | W81-74 | 2-0 | 1.000 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 3 | Fri Nov 15 | at #4Gonzaga | L54-113 | 2-1 | .667 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 4 | Sun Nov 17 | at Washington | L69-74 | 2-2 | .500 | - | B1G+ | Alaska Airlines Arena · Seattle, WA |
| 5 | Wed Nov 20 | vsTBD | W121-66 | 3-2 | .600 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 6 | Sat Nov 23 | vs Quinnipiac | W80-70 | 4-2 | .667 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 7 | Mon Nov 25 | vs Merrimack | W81-74 | 5-2 | .714 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 8 | Wed Nov 27 | at Saint Louis | L90-93 | 5-3 | .625 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 9 | Sun Dec 1 | at C Connecticut | L67-69 | 5-4 | .556 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 10 | Sat Dec 7 | at UMass | W96-83 | 6-4 | .600 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Wed Dec 11 | vs Long Island | W69-62 | 7-4 | .636 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 12 | Sat Dec 14 | vs Dartmouth | W92-83 | 8-4 | .667 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 13 | Wed Dec 18 | vs Stonehill | W78-67 | 9-4 | .692 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 14 | Sat Dec 21 | vs Boston Univ | W83-71 | 10-4 | .714 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 15 | Mon Dec 30 | vsTBD | W101-39 | 11-4 | .733 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 16 | Sat Jan 4 | at Albany | W73-69 | 12-4 | .750 | - | ESPN+ | SEFCU Arena · Albany, NY |
| 17 | Thu Jan 9 | vs Vermont | L63-67 | 12-5 | .706 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 18 | Sat Jan 11 | vs NJIT | W70-62 | 13-5 | .722 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 19 | Sat Jan 18 | at Bryant | L62-85 | 13-6 | .684 | - | ESPN+ | Chace Athletic Center · Smithfield, RI |
| 20 | Thu Jan 23 | vs Maine | L85-86 (OT) | 13-7 | .650 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 21 | Sat Jan 25 | vs New Hampshire | W97-80 | 14-7 | .667 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 22 | Thu Jan 30 | atNJIT | L62-83 | 14-8 | .636 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
| 23 | Sat Feb 1 | at UMBC | W83-67 | 15-8 | .652 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 24 | Thu Feb 6 | at Binghamton | L54-66 | 15-9 | .625 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 25 | Thu Feb 13 | vsAlbany | L88-90 (OT) | 15-10 | .600 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 26 | Sat Feb 15 | atNew Hampshire | L79-80 | 15-11 | .577 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 27 | Thu Feb 20 | vsUMBC | W98-79 | 16-11 | .593 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
