| 1 | Wed Oct 11 | vs Senators | W5-3 | 1-0-0 | 2 PTS | PNC Arena · Raleigh, NC |
| 2 | Sat Oct 14 | atKings | W6-5 (SO) | 2-0-0 | 4 PTS | Crypto.com Arena · Los Angeles, CA |
| 3 | Sun Oct 15 | atDucks | L3-6 | 2-1-0 | 4 PTS | Honda Center · Anaheim, CA |
| 4 | Tue Oct 17 | atSharks | W6-3 | 3-1-0 | 6 PTS | SAP Center · San Jose, CA |
| 5 | Thu Oct 19 | atKraken | L4-7 | 3-2-0 | 6 PTS | Climate Pledge Arena · Seattle, WA |
| 6 | Sat Oct 21 | atAvalanche | L4-6 | 3-3-0 | 6 PTS | Ball Arena · Denver, CO |
| 7 | Tue Oct 24 | atLightning | L0-3 | 3-4-0 | 6 PTS | AMALIE Arena · Tampa, FL |
| 8 | Thu Oct 26 | vsKraken | W3-2 (OT) | 4-4-0 | 8 PTS | PNC Arena · Raleigh, NC |
| 9 | Fri Oct 27 | vsSharks | W3-0 | 5-4-0 | 10 PTS | PNC Arena · Raleigh, NC |
| 10 | Mon Oct 30 | atFlyers | W3-2 | 6-4-0 | 12 PTS | Wells Fargo Center · Philadelphia, PA |
| 11 | Thu Nov 2 | atRangers | L1-2 | 6-5-0 | 12 PTS | Madison Square Garden · Manhattan, NY |
| 12 | Sat Nov 4 | atIslanders | W4-3 (OT) | 7-5-0 | 14 PTS | UBS Arena · Elmont, NY |
| 13 | Tue Nov 7 | vsSabres | W3-2 (OT) | 8-5-0 | 16 PTS | PNC Arena · Raleigh, NC |
| 14 | Fri Nov 10 | atPanthers | L2-5 | 8-6-0 | 16 PTS | Amerant Bank Arena · Sunrise, FL |
| 15 | Sat Nov 11 | atLightning | W4-0 | 9-6-0 | 18 PTS | AMALIE Arena · Tampa, FL |
| 16 | Wed Nov 15 | vsFlyers | L1-3 | 9-7-0 | 18 PTS | PNC Arena · Raleigh, NC |
| 17 | Sat Nov 18 | vsPenguins | W4-2 | 10-7-0 | 20 PTS | PNC Arena · Raleigh, NC |
| 18 | Wed Nov 22 | vsOilers | W6-3 | 11-7-0 | 22 PTS | PNC Arena · Raleigh, NC |
| 19 | Fri Nov 24 | vsLightning | L2-8 | 11-8-0 | 22 PTS | PNC Arena · Raleigh, NC |
| 20 | Sun Nov 26 | vsJackets | W3-2 | 12-8-0 | 24 PTS | PNC Arena · Raleigh, NC |
| 21 | Tue Nov 28 | atFlyers | W4-1 | 13-8-0 | 26 PTS | Wells Fargo Center · Philadelphia, PA |
| 22 | Thu Nov 30 | vsIslanders | L4-5 (OT) | 13-8-1 | 27 PTS | PNC Arena · Raleigh, NC |
| 23 | Sat Dec 2 | vsSabres | W6-2 | 14-8-1 | 29 PTS | PNC Arena · Raleigh, NC |
| 24 | Mon Dec 4 | atJets | L1-2 | 14-9-1 | 29 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 25 | Wed Dec 6 | atOilers | L1-6 | 14-10-1 | 29 PTS | Rogers Place · Edmonton, AB |
| 26 | Thu Dec 7 | atFlames | L2-3 | 14-11-1 | 29 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 27 | Sat Dec 9 | atCanucks | L3-4 | 14-12-1 | 29 PTS | Rogers Arena · Vancouver, British Columbia |
| 28 | Tue Dec 12 | atSenators | W4-1 | 15-12-1 | 31 PTS | Canadian Tire Centre · Ottawa, ON |
| 29 | Thu Dec 14 | atRed Wings | W2-1 | 16-12-1 | 33 PTS | Little Caesars Arena · Detroit, MI |
| 30 | Fri Dec 15 | vsPredators | L5-6 (OT) | 16-12-2 | 34 PTS | PNC Arena · Raleigh, NC |
| 31 | Sun Dec 17 | vsCapitals | L1-2 (SO) | 16-12-3 | 35 PTS | PNC Arena · Raleigh, NC |
| 32 | Tue Dec 19 | vsKnights | W6-3 | 17-12-3 | 37 PTS | PNC Arena · Raleigh, NC |
| 33 | Thu Dec 21 | atPenguins | L1-2 (SO) | 17-12-4 | 38 PTS | PPG Paints Arena · Pittsburgh, PA |
| 34 | Sat Dec 23 | vsIslanders | L4-5 | 17-13-4 | 38 PTS | PNC Arena · Raleigh, NC |
| 35 | Wed Dec 27 | atPredators | W5-2 | 18-13-4 | 40 PTS | Bridgestone Arena · Nashville, TN |
| 36 | Thu Dec 28 | vsCanadiens | W5-3 | 19-13-4 | 42 PTS | PNC Arena · Raleigh, NC |
| 37 | Sat Dec 30 | atMaple Leafs | W3-2 | 20-13-4 | 44 PTS | Scotiabank Arena · Toronto, ON |
| 38 | Tue Jan 2 | atRangers | W6-1 | 21-13-4 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 39 | Fri Jan 5 | atCapitals | W6-2 | 22-13-4 | 48 PTS | Capital One Arena · Washington, D.C. |
| 40 | Sat Jan 6 | vsBlues | L1-2 (SO) | 22-13-5 | 49 PTS | PNC Arena · Raleigh, NC |
| 41 | Thu Jan 11 | vsDucks | W6-3 | 23-13-5 | 51 PTS | PNC Arena · Raleigh, NC |
| 42 | Sat Jan 13 | vsPenguins | W3-2 (OT) | 24-13-5 | 53 PTS | PNC Arena · Raleigh, NC |
| 43 | Mon Jan 15 | vsKings | L2-5 | 24-14-5 | 53 PTS | PNC Arena · Raleigh, NC |
| 44 | Fri Jan 19 | vsRed Wings | W4-2 | 25-14-5 | 55 PTS | PNC Arena · Raleigh, NC |
| 45 | Sun Jan 21 | vsWild | L2-5 | 25-15-5 | 55 PTS | PNC Arena · Raleigh, NC |
| 46 | Wed Jan 24 | atBruins | W3-2 | 26-15-5 | 57 PTS | TD Garden · Boston, MA |
| 47 | Thu Jan 25 | vsDevils | W3-2 | 27-15-5 | 59 PTS | PNC Arena · Raleigh, NC |
| 48 | Sat Jan 27 | vsCoyotes | W3-1 | 28-15-5 | 61 PTS | PNC Arena · Raleigh, NC |
| 49 | Tue Feb 6 | vsCanucks | L2-3 | 28-16-5 | 61 PTS | PNC Arena · Raleigh, NC |
| 50 | Thu Feb 8 | vsAvalanche | W5-2 | 29-16-5 | 63 PTS | PNC Arena · Raleigh, NC |
| 51 | Sat Feb 10 | vsDevils | W1-0 (OT) | 30-16-5 | 65 PTS | PNC Arena · Raleigh, NC |
| 52 | Tue Feb 13 | atStars | L2-4 | 30-17-5 | 65 PTS | American Airlines Center · Dallas, TX |
| 53 | Fri Feb 16 | atCoyotes | W5-1 | 31-17-5 | 67 PTS | Mullett Arena · Tempe, AZ |
| 54 | Sat Feb 17 | atKnights | W3-1 | 32-17-5 | 69 PTS | T-Mobile Arena · Las Vegas, NV |
| 55 | Mon Feb 19 | vsBlackhawks | W6-3 | 33-17-5 | 71 PTS | PNC Arena · Raleigh, NC |
| 56 | Thu Feb 22 | vsPanthers | W1-0 | 34-17-5 | 73 PTS | PNC Arena · Raleigh, NC |
| 57 | Sat Feb 24 | vsStars | L1-2 | 34-18-5 | 73 PTS | PNC Arena · Raleigh, NC |
| 58 | Sun Feb 25 | atSabres | L2-3 (SO) | 34-18-6 | 74 PTS | KeyBank Center · Buffalo, NY |
| 59 | Tue Feb 27 | atWild | W3-2 | 35-18-6 | 76 PTS | Xcel Energy Center · St. Paul, MN |
| 60 | Thu Feb 29 | atJackets | W4-2 | 36-18-6 | 78 PTS | Nationwide Arena · Columbus, OH |
| 61 | Sat Mar 2 | vsJets | L3-5 | 36-19-6 | 78 PTS | PNC Arena · Raleigh, NC |
| 62 | Thu Mar 7 | vsCanadiens | W4-1 | 37-19-6 | 80 PTS | PNC Arena · Raleigh, NC |
| 63 | Sat Mar 9 | atDevils | W4-2 | 38-19-6 | 82 PTS | Prudential Center · Newark, NJ |
| 64 | Sun Mar 10 | vsFlames | W7-2 | 39-19-6 | 84 PTS | PNC Arena · Raleigh, NC |
| 65 | Tue Mar 12 | vsRangers | L0-1 | 39-20-6 | 84 PTS | PNC Arena · Raleigh, NC |
| 66 | Thu Mar 14 | vsPanthers | W4-0 | 40-20-6 | 86 PTS | PNC Arena · Raleigh, NC |
| 67 | Sat Mar 16 | atMaple Leafs | W5-4 (SO) | 41-20-6 | 88 PTS | Scotiabank Arena · Toronto, ON |
| 68 | Sun Mar 17 | atSenators | W7-2 | 42-20-6 | 90 PTS | Canadian Tire Centre · Ottawa, ON |
| 69 | Tue Mar 19 | atIslanders | W4-1 | 43-20-6 | 92 PTS | UBS Arena · Elmont, NY |
| 70 | Thu Mar 21 | vsFlyers | W3-2 (OT) | 44-20-6 | 94 PTS | PNC Arena · Raleigh, NC |
| 71 | Fri Mar 22 | atCapitals | L6-7 (SO) | 44-20-7 | 95 PTS | Capital One Arena · Washington, D.C. |
| 72 | Sun Mar 24 | vsMaple Leafs | W2-1 | 45-20-7 | 97 PTS | PNC Arena · Raleigh, NC |
| 73 | Tue Mar 26 | atPenguins | L1-4 | 45-21-7 | 97 PTS | PPG Paints Arena · Pittsburgh, PA |
| 74 | Thu Mar 28 | vsRed Wings | W4-0 | 46-21-7 | 99 PTS | PNC Arena · Raleigh, NC |
| 75 | Sat Mar 30 | atCanadiens | W3-0 | 47-21-7 | 101 PTS | Bell Centre · Montreal, QC |
| 76 | Thu Apr 4 | vsBruins | L1-4 | 47-22-7 | 101 PTS | PNC Arena · Raleigh, NC |
| 77 | Fri Apr 5 | vsCapitals | W4-2 | 48-22-7 | 103 PTS | PNC Arena · Raleigh, NC |
| 78 | Sun Apr 7 | vsJackets | W3-0 | 49-22-7 | 105 PTS | PNC Arena · Raleigh, NC |
| 79 | Tue Apr 9 | atBruins | W4-1 | 50-22-7 | 107 PTS | TD Garden · Boston, MA |
| 80 | Fri Apr 12 | atBlues | W5-2 | 51-22-7 | 109 PTS | Enterprise Center · St. Louis, MO |
| 81 | Sun Apr 14 | atBlackhawks | W4-2 | 52-22-7 | 111 PTS | United Center · Chicago, IL |
| 82 | Tue Apr 16 | atJackets | L3-6 | 52-23-7 | 111 PTS | Nationwide Arena · Columbus, OH |
| 1 | Sat Apr 20 | vsIslanders | W3-1 | 1-0 | 1.000 | PNC Arena · Raleigh, NC |
| 2 | Mon Apr 22 | vsIslanders | W5-3 | 2-0 | 1.000 | PNC Arena · Raleigh, NC |
| 3 | Thu Apr 25 | atIslanders | W3-2 | 3-0 | 1.000 | UBS Arena · Elmont, NY |
| 4 | Sat Apr 27 | atIslanders | L2-3 (OT) | 3-1 | .750 | UBS Arena · Elmont, NY |
| 5 | Tue Apr 30 | vsIslanders | W6-3 | 4-1 | .800 | PNC Arena · Raleigh, NC |
| 1 | Sun May 5 | atRangers | L3-4 | 0-1 | .000 | Madison Square Garden · Manhattan, NY |
| 2 | Tue May 7 | atRangers | L3-4 (OT) | 0-2 | .000 | Madison Square Garden · Manhattan, NY |
| 3 | Thu May 9 | vsRangers | L2-3 (OT) | 0-3 | .000 | PNC Arena · Raleigh, NC |
| 4 | Sat May 11 | vsRangers | W4-3 | 1-3 | .250 | PNC Arena · Raleigh, NC |
| 5 | Mon May 13 | atRangers | W4-1 | 2-3 | .400 | Madison Square Garden · Manhattan, NY |
| 6 | Thu May 16 | vsRangers | L3-5 | 2-4 | .333 | PNC Arena · Raleigh, NC |
