| 1 | Tue Oct 8 | at Utah HC | L2-5 | 0-1-0 | 0 PTS | Delta Center · Salt Lake City, UT |
| 2 | Fri Oct 11 | atJets | L1-2 (OT) | 0-1-1 | 1 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 3 | Sat Oct 12 | atOilers | W5-2 | 1-1-1 | 3 PTS | Rogers Place · Edmonton, AB |
| 4 | Tue Oct 15 | atFlames | L1-3 | 1-2-1 | 3 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 5 | Thu Oct 17 | vsSharks | W4-2 | 2-2-1 | 5 PTS | United Center · Chicago, IL |
| 6 | Sat Oct 19 | vsSabres | L2-4 | 2-3-1 | 5 PTS | United Center · Chicago, IL |
| 7 | Tue Oct 22 | vsCanucks | L3-6 | 2-4-1 | 5 PTS | United Center · Chicago, IL |
| 8 | Fri Oct 25 | vsPredators | L2-3 | 2-5-1 | 5 PTS | United Center · Chicago, IL |
| 9 | Sat Oct 26 | atStars | L2-4 | 2-6-1 | 5 PTS | American Airlines Center · Dallas, TX |
| 10 | Mon Oct 28 | atAvalanche | W5-2 | 3-6-1 | 7 PTS | Ball Arena · Denver, CO |
| 11 | Thu Oct 31 | atSharks | L2-3 | 3-7-1 | 7 PTS | SAP Center · San Jose, CA |
| 12 | Sat Nov 2 | atKings | W4-3 (SO) | 4-7-1 | 9 PTS | Crypto.com Arena · Los Angeles, CA |
| 13 | Sun Nov 3 | atDucks | W4-2 | 5-7-1 | 11 PTS | Honda Center · Anaheim, CA |
| 14 | Wed Nov 6 | vsRed Wings | L1-4 | 5-8-1 | 11 PTS | United Center · Chicago, IL |
| 15 | Thu Nov 7 | atStars | L1-3 | 5-9-1 | 11 PTS | American Airlines Center · Dallas, TX |
| 16 | Sun Nov 10 | vsWild | W2-1 (OT) | 6-9-1 | 13 PTS | United Center · Chicago, IL |
| 17 | Thu Nov 14 | atKraken | L1-3 | 6-10-1 | 13 PTS | Climate Pledge Arena · Seattle, WA |
| 18 | Sat Nov 16 | atCanucks | L1-4 | 6-11-1 | 13 PTS | Rogers Arena · Vancouver, British Columbia |
| 19 | Tue Nov 19 | vsDucks | L2-3 | 6-12-1 | 13 PTS | United Center · Chicago, IL |
| 20 | Thu Nov 21 | vsPanthers | W3-1 | 7-12-1 | 15 PTS | United Center · Chicago, IL |
| 21 | Sat Nov 23 | atFlyers | L2-3 (OT) | 7-12-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 22 | Wed Nov 27 | vsStars | W6-2 | 8-12-2 | 18 PTS | United Center · Chicago, IL |
| 23 | Fri Nov 29 | atWild | L2-3 | 8-13-2 | 18 PTS | Xcel Energy Center · St. Paul, MN |
| 24 | Sun Dec 1 | vsJackets | L3-6 | 8-14-2 | 18 PTS | United Center · Chicago, IL |
| 25 | Mon Dec 2 | atMaple Leafs | L1-4 | 8-15-2 | 18 PTS | Scotiabank Arena · Toronto, ON |
| 26 | Wed Dec 4 | vsBruins | L2-4 | 8-16-2 | 18 PTS | United Center · Chicago, IL |
| 27 | Sat Dec 7 | vsJets | L2-4 | 8-17-2 | 18 PTS | United Center · Chicago, IL |
| 28 | Mon Dec 9 | atRangers | W2-1 | 9-17-2 | 20 PTS | Madison Square Garden · Manhattan, NY |
| 29 | Thu Dec 12 | atIslanders | L4-5 | 9-18-2 | 20 PTS | UBS Arena · Elmont, NY |
| 30 | Sat Dec 14 | atDevils | L1-4 | 9-19-2 | 20 PTS | Prudential Center · Newark, NJ |
| 31 | Sun Dec 15 | vsIslanders | W5-3 | 10-19-2 | 22 PTS | United Center · Chicago, IL |
| 32 | Tue Dec 17 | vsCapitals | W3-2 | 11-19-2 | 24 PTS | United Center · Chicago, IL |
| 33 | Thu Dec 19 | vsKraken | W3-1 | 12-19-2 | 26 PTS | United Center · Chicago, IL |
| 34 | Sat Dec 21 | atFlames | L4-6 | 12-20-2 | 26 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 35 | Mon Dec 23 | atWild | L3-4 | 12-21-2 | 26 PTS | Xcel Energy Center · St. Paul, MN |
| 36 | Fri Dec 27 | atSabres | L2-6 | 12-22-2 | 26 PTS | KeyBank Center · Buffalo, NY |
| 37 | Sun Dec 29 | vsStars | L1-5 | 12-23-2 | 26 PTS | United Center · Chicago, IL |
| 38 | Tue Dec 31 | vsBlues | L2-6 | 12-24-2 | 26 PTS | United Center · Chicago, IL |
| 39 | Fri Jan 3 | vsCanadiens | W4-2 | 13-24-2 | 28 PTS | United Center · Chicago, IL |
| 40 | Sun Jan 5 | vsRangers | L2-6 | 13-25-2 | 28 PTS | United Center · Chicago, IL |
| 41 | Wed Jan 8 | vsAvalanche | W3-1 | 14-25-2 | 30 PTS | United Center · Chicago, IL |
| 42 | Fri Jan 10 | atRed Wings | L3-5 | 14-26-2 | 30 PTS | Little Caesars Arena · Detroit, MI |
| 43 | Sat Jan 11 | vsOilers | L3-4 | 14-27-2 | 30 PTS | United Center · Chicago, IL |
| 44 | Mon Jan 13 | vsFlames | L2-5 | 14-28-2 | 30 PTS | United Center · Chicago, IL |
| 45 | Thu Jan 16 | atPredators | L2-3 (SO) | 14-28-3 | 31 PTS | Bridgestone Arena · Nashville, TN |
| 46 | Sat Jan 18 | vsKnights | W5-3 | 15-28-3 | 33 PTS | United Center · Chicago, IL |
| 47 | Mon Jan 20 | vsHurricanes | L3-4 (OT) | 15-28-4 | 34 PTS | United Center · Chicago, IL |
| 48 | Fri Jan 24 | vsLightning | L3-4 (OT) | 15-28-5 | 35 PTS | United Center · Chicago, IL |
| 49 | Sun Jan 26 | vsWild | L2-4 | 15-29-5 | 35 PTS | United Center · Chicago, IL |
| 50 | Tue Jan 28 | atLightning | W4-1 | 16-29-5 | 37 PTS | AMALIE Arena · Tampa, FL |
| 51 | Thu Jan 30 | atHurricanes | L2-3 | 16-30-5 | 37 PTS | PNC Arena · Raleigh, NC |
| 52 | Sat Feb 1 | atPanthers | L1-5 | 16-31-5 | 37 PTS | Amerant Bank Arena · Sunrise, FL |
| 53 | Wed Feb 5 | vsOilers | L3-4 (OT) | 16-31-6 | 38 PTS | United Center · Chicago, IL |
| 54 | Fri Feb 7 | vsPredators | W6-2 | 17-31-6 | 40 PTS | United Center · Chicago, IL |
| 55 | Sat Feb 8 | atBlues | L5-6 (SO) | 17-31-7 | 41 PTS | Enterprise Center · St. Louis, MO |
| 56 | Sat Feb 22 | atJackets | L1-5 | 17-32-7 | 41 PTS | Nationwide Arena · Columbus, OH |
| 57 | Sun Feb 23 | vsMaple Leafs | L2-5 | 17-33-7 | 41 PTS | United Center · Chicago, IL |
| 58 | Tue Feb 25 | atUtah HC | L1-2 | 17-34-7 | 41 PTS | Delta Center · Salt Lake City, UT |
| 59 | Thu Feb 27 | atKnights | L5-7 | 17-35-7 | 41 PTS | T-Mobile Arena · Las Vegas, NV |
| 60 | Sat Mar 1 | atDucks | W6-3 | 18-35-7 | 43 PTS | Honda Center · Anaheim, CA |
| 61 | Mon Mar 3 | vsKings | W5-1 | 19-35-7 | 45 PTS | United Center · Chicago, IL |
| 62 | Wed Mar 5 | vsSenators | L3-4 (OT) | 19-35-8 | 46 PTS | United Center · Chicago, IL |
| 63 | Fri Mar 7 | vsUtah HC | W4-3 (OT) | 20-35-8 | 48 PTS | United Center · Chicago, IL |
| 64 | Sat Mar 8 | atPredators | L2-3 (OT) | 20-35-9 | 49 PTS | Bridgestone Arena · Nashville, TN |
| 65 | Mon Mar 10 | atAvalanche | L0-3 | 20-36-9 | 49 PTS | Ball Arena · Denver, CO |
| 66 | Thu Mar 13 | atSharks | L2-4 | 20-37-9 | 49 PTS | SAP Center · San Jose, CA |
| 67 | Sat Mar 15 | atCanucks | L2-6 | 20-38-9 | 49 PTS | Rogers Arena · Vancouver, British Columbia |
| 68 | Tue Mar 18 | vsKraken | L2-6 | 20-39-9 | 49 PTS | United Center · Chicago, IL |
| 69 | Thu Mar 20 | vsKings | L1-3 | 20-40-9 | 49 PTS | United Center · Chicago, IL |
| 70 | Sat Mar 22 | atBlues | L1-4 | 20-41-9 | 49 PTS | Enterprise Center · St. Louis, MO |
| 71 | Sun Mar 23 | vsFlyers | W7-4 | 21-41-9 | 51 PTS | United Center · Chicago, IL |
| 72 | Wed Mar 26 | vsDevils | L3-5 | 21-42-9 | 51 PTS | United Center · Chicago, IL |
| 73 | Fri Mar 28 | vsKnights | L3-5 | 21-43-9 | 51 PTS | United Center · Chicago, IL |
| 74 | Sun Mar 30 | vsUtah HC | L2-5 | 21-44-9 | 51 PTS | United Center · Chicago, IL |
| 75 | Wed Apr 2 | vsAvalanche | L2-3 (SO) | 21-44-10 | 52 PTS | United Center · Chicago, IL |
| 76 | Fri Apr 4 | atCapitals | L3-5 | 21-45-10 | 52 PTS | Capital One Arena · Washington, D.C. |
| 77 | Sun Apr 6 | vsPenguins | W3-1 | 22-45-10 | 54 PTS | United Center · Chicago, IL |
| 78 | Tue Apr 8 | atPenguins | L0-5 | 22-46-10 | 54 PTS | PPG Paints Arena · Pittsburgh, PA |
| 79 | Thu Apr 10 | atBruins | W5-2 | 23-46-10 | 56 PTS | TD Garden · Boston, MA |
| 80 | Sat Apr 12 | vsJets | L4-5 (SO) | 23-46-11 | 57 PTS | United Center · Chicago, IL |
| 81 | Mon Apr 14 | atCanadiens | W4-3 (SO) | 24-46-11 | 59 PTS | Bell Centre · Montreal, QC |
| 82 | Tue Apr 15 | atSenators | W4-3 (OT) | 25-46-11 | 61 PTS | Canadian Tire Centre · Ottawa, ON |
